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Silver zeolite X (Ag-Zeo) and Zeo were set as control. The chemical structure, morphology, crystal structure and elemental composition of Ca-Ag-Zeo was characterized by X-ray diffraction spectrum, scanning electron microscopy, transmission electron microscopy and energy dispersive spectroscopy, respectively. Its biocompatibility on the human gingival fibroblasts was assessed by cell counting kit-8 assay. Its physiochemical properties were determined by the released calcium and silver ion using Inductive Coupled Plasma Emission Spectrometry for up to 12 weeks. The antimicrobial properties on <jats:italic>Streptococcus mutans<\/jats:italic>, <jats:italic>Lactobacillus acidophilus<\/jats:italic>, <jats:italic>Lactobacillus casei<\/jats:italic>, <jats:italic>and Candida albicans<\/jats:italic> were assessed by minimum bactericidal concentration (MBC) or minimum fungicidal concentration (MFC) assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Ca-Ag-Zeo with a hexagonal cage structure was synthesized. As for biocompatibility, the half-maximal inhibitory concentration (\u00b1\u2009SD in mg\/mL) of Ca-Ag-Zeo, Ag-Zeo and Zeo in human gingival fibroblasts were 0.52\u2009\u00b1\u20090.05, 0.15\u2009\u00b1\u20090.01 and 3.35\u2009\u00b1\u20090.58, respectively (Zeo\u2009&gt;\u2009Ca-Ag-Zeo\u2009&gt;\u2009Ag-Zeo; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). As for physiochemical properties, the accumulated ion release (\u00b1\u2009SD in mg) of Ca-Ag-Zeo, Ag-Zeo and Zeo were 0.011\u2009\u00b1\u20090.003, 0 and 0 for calcium ion, respectively (Ca-Ag-Zeo\u2009&gt;\u2009Ag-Zeo, Zeo; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and 0.213\u2009\u00b1\u20090.032, 0.209\u2009\u00b1\u20090.019 and 0 for silver ion, respectively (Ca-Ag-Zeo, Ag-Zeo\u2009&gt;\u2009Zeo; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). As for anti-microbial ability, the MBC\/MFC (mg\/mL) of Ca-Ag-Zeo, Ag-Zeo and Zeo were 32, 16 and &gt;\u2009256 against <jats:italic>Streptococcus mutans<\/jats:italic>; 32, 16, &gt;\u2009256 against <jats:italic>Lactobacillus acidophilus<\/jats:italic>; 16, 16, and 256 against <jats:italic>Lactobacillus casei<\/jats:italic>; 0.25, 0.125; and 2, 1, &gt; 256 against <jats:italic>Candida albicans<\/jats:italic>, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A novel Ca-Ag-Zeo was developed. It presented better biocompatibility compared to Ag-Zeo. It released calcium and silver ions sustainably, and it could inhibit the growth of common cariogenic microorganisms.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-024-04878-3","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:03:00Z","timestamp":1726502580000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Developing a novel calcium silver zeolite for caries management"],"prefix":"10.1186","volume":"24","author":[{"given":"Laura Jiaxuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie Ying-Kei","family":"Lung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey Xingyun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hung","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ollie Yiru","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"issue":"9","key":"4878_CR1","first-page":"661","volume":"83","author":"PE Petersen","year":"2005","unstructured":"Petersen PE, Bourgeois D, Ogawa H, Estupinan-Day S, Ndiaye C. 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