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In addition to the treatment time, periodontal parameters such as PPD and bleeding on probing (BOP) before NSPT (T0) and after NSPT (T1: 5\u2009\u00b1\u20092 months after T0) were documented by two calibrated and blinded examiners (Ethics vote\/ Trial-register: Kiel-D509-18\/ DRKS00026041).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Data of 60 patients were analyzed (stage III\/IV: <jats:italic>n<\/jats:italic>\u2009=\u200936\/ <jats:italic>n<\/jats:italic>\u2009=\u200924; grade A\/ B\/ C: <jats:italic>n<\/jats:italic>\u2009=\u20091\/ <jats:italic>n<\/jats:italic>\u2009=\u200931\/ <jats:italic>n<\/jats:italic>\u2009=\u200928). At T1, a PPD reduction of all diseased tooth surfaces was observed in 57.0% of the GBT group and 58.7% of the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.067). The target endpoint (PPD\u2009\u2264\u20094 mm without BOP) was achieved in 11.5% for GBT (conventional treatment: 11.2%; <jats:italic>p<\/jats:italic>\u2009=\u20090.714). With the exception for number of sites with BOP, which was at T1 15.9% in the GBT group and 14.3% in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) no significant differences between the outcomes of the study were found. At 30.3(28.3) min, the treatment time was significantly shorter in GBT than in the control group at 34.6(24.5) min (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>With both protocols (GBT\/ conventional instrumentation) comparably good clinical treatment results can be achieve in NSPT in stage III-IV periodontitis patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>The study was registered before the start of the study and can be found under the number DRKS00026041 in the German Clinical Trials Register. The registration date was 19\/08\/2021.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-024-04898-z","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T22:05:46Z","timestamp":1726783546000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Guided biofilm therapy versus conventional protocol\u2014clinical outcomes in non-surgical periodontal therapy"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8183-9200","authenticated-orcid":false,"given":"Miriam","family":"Cyris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Festerling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Kahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Springer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof E.","family":"D\u00f6rfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Graetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"issue":"6","key":"4898_CR1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1600-051X.2012.01870.x","volume":"39","author":"JM Goodson","year":"2012","unstructured":"Goodson JM, et al. 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The clinical trial was registered in the German Clinical Trials Register (DKRS): DRKS00026041.Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Author M. Cyris declares that she has no competing interests. Author J. Festerling declares that she has no competing interests. Author M. Kahl declares that she has no competing interests. Author C. Springer declares that she has no competing interests. Author C.E. D\u00f6rfer declares that he has already given lectures on GBT as an honorary activity, but the investigations within the scope of this study were not influenced by this. Author G. Graetz declares that he has already given lectures on GBT as an honorary activity, but the investigations within the scope of this study were not influenced by this.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1105"}}