{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:08:33Z","timestamp":1787857713019,"version":"build-2784847793"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K20996"],"award-info":[{"award-number":["22K20996"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K09942"],"award-info":[{"award-number":["20K09942"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-024-05043-6","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T14:02:04Z","timestamp":1729346524000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between total functional tooth unit score and hemoglobin A1c levels in Japanese community-dwelling individuals: the Nagasaki Islands study"],"prefix":"10.1186","volume":"24","author":[{"given":"Masayuki","family":"Oohira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayasu","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Luigi Fabian","family":"Capati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kawashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakiko","family":"Soutome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsutoshi","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"5043_CR1","first-page":"195","volume":"17","author":"RQ Catunda","year":"2019","unstructured":"Catunda RQ, Levin L, Kornerup I, Gibson MP. Prevalence of periodontitis in young populations: a systematic review. Oral Health Prev Dent. 2019;17:195\u2013202.","journal-title":"Oral Health Prev Dent"},{"key":"5043_CR2","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","volume":"366","author":"BL Pihlstrom","year":"2005","unstructured":"Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366:1809\u201320.","journal-title":"Lancet"},{"key":"5043_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/epirev\/mxx006","volume":"39","author":"DS Michaud","year":"2017","unstructured":"Michaud DS, Fu Z, Shi J, Chung M. Periodontal disease, tooth loss, and cancer risk. Epidemiol Rev. 2017;39:49\u201358.","journal-title":"Epidemiol Rev"},{"key":"5043_CR4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1902\/jop.2012.120069","volume":"84","author":"F Borges Tde","year":"2013","unstructured":"Borges Tde F, Regalo SC, Taba M Jr., Siessere S, Mestriner W Jr., Semprini M. Changes in masticatory performance and quality of life in individuals with chronic periodontitis. J Periodontol. 2013;84:325\u201331.","journal-title":"J Periodontol"},{"key":"5043_CR5","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.1128\/JCM.43.11.5721-5732.2005","volume":"43","author":"JA Aas","year":"2005","unstructured":"Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol. 2005;43:5721\u201332.","journal-title":"J Clin Microbiol"},{"key":"5043_CR6","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1902\/jop.2004.75.8.1077","volume":"75","author":"HW Yang","year":"2004","unstructured":"Yang HW, Huang YF, Chou MY. Occurrence of Porphyromonas gingivalis and Tannerella forsythensis in periodontally diseased and healthy subjects. J Periodontol. 2004;75:1077\u201383.","journal-title":"J Periodontol"},{"key":"5043_CR7","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/j.1600-051X.2009.01449.x","volume":"36","author":"M Faveri","year":"2009","unstructured":"Faveri M, Figueiredo LC, Duarte PM, Mestnik MJ, Mayer MP, Feres M. Microbiological profile of untreated subjects with localized aggressive periodontitis. J Clin Periodontol. 2009;36:739\u201349.","journal-title":"J Clin Periodontol"},{"key":"5043_CR8","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1399-302X.2004.00154.x","volume":"19","author":"M Kawada","year":"2004","unstructured":"Kawada M, Yoshida A, Suzuki N, Nakano Y, Saito T, Oho T, Koga T. Prevalence of Porphyromonas gingivalis in relation to periodontal status assessed by real-time PCR. Oral Microbiol Immunol. 2004;19:289\u201392.","journal-title":"Oral Microbiol Immunol"},{"key":"5043_CR9","unstructured":"Sapra A, Bhandari P. In: StatPearls, editor. Diabetes. Treasure Island (FL); 2023."},{"key":"5043_CR10","doi-asserted-by":"crossref","unstructured":"Jiang S, Yu T, Di D, Wang Y, Li W. Worldwide burden and trends of diabetes among people aged 70 years and older, 1990\u20132019: a systematic analysis for the global burden of disease study 2019. Diabetes Metab Res Rev. 2023;e3745.","DOI":"10.1002\/dmrr.3745"},{"key":"5043_CR11","unstructured":"Goyal R, Jialal I. In: StatPearls, editor. Diabetes mellitus type 2. Treasure Island (FL); 2022."},{"key":"5043_CR12","first-page":"CD004714","volume":"4","author":"TC Simpson","year":"2022","unstructured":"Simpson TC, Clarkson JE, Worthington HV, MacDonald L, Weldon JC, Needleman I, Iheozor-Ejiofor Z, Wild SH, Qureshi A, Walker A, et al. Treatment of periodontitis for glycaemic control in people with diabetes mellitus. Cochrane Database Syst Rev. 2022;4:CD004714.","journal-title":"Cochrane Database Syst Rev"},{"key":"5043_CR13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","volume":"55","author":"PM Preshaw","year":"2012","unstructured":"Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, Taylor R. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55:21\u201331.","journal-title":"Diabetologia"},{"key":"5043_CR14","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12903-020-01180-w","volume":"20","author":"CZ Wu","year":"2020","unstructured":"Wu CZ, Yuan YH, Liu HH, Li SS, Zhang BW, Chen W, An ZJ, Chen SY, Wu YZ, Han B, et al. Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health. 2020;20:204.","journal-title":"BMC Oral Health"},{"key":"5043_CR15","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41415-019-0794-5","volume":"227","author":"PM Preshaw","year":"2019","unstructured":"Preshaw PM, Bissett SM. Periodontitis and diabetes. Br Dent J. 2019;227:577\u201384.","journal-title":"Br Dent J"},{"key":"5043_CR16","doi-asserted-by":"crossref","unstructured":"Genco RJ, Graziani F, Hasturk H. Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus. Periodontol. 2000. 2020;83:59\u201365.","DOI":"10.1111\/prd.12271"},{"key":"5043_CR17","unstructured":"Muniyappa R, Madan R, Varghese RT, Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, et al. In: Endotext, editor. Assessing insulin sensitivity and resistance in humans. South Dartmouth (MA); 2000."},{"key":"5043_CR18","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1111\/jre.12474","volume":"52","author":"V Ilievski","year":"2017","unstructured":"Ilievski V, Bhat UG, Suleiman-Ata S, Bauer BA, Toth PT, Olson ST, Unterman TG, Watanabe K. Oral application of a periodontal pathogen impacts SerpinE1 expression and pancreatic islet architecture in prediabetes. J Periodontal Res. 2017;52:1032\u201341.","journal-title":"J Periodontal Res"},{"key":"5043_CR19","doi-asserted-by":"crossref","unstructured":"Ohara-Nemoto Y, Nakasato M, Shimoyama Y, Baba TT, Kobayakawa T, Ono T, Yaegashi T, Kimura S, Nemoto TK. Degradation of incretins and modulation of blood glucose levels by periodontopathic bacterial dipeptidyl peptidase 4. Infect Immun. 2017;85.","DOI":"10.1128\/IAI.00277-17"},{"key":"5043_CR20","doi-asserted-by":"crossref","unstructured":"Ohara-Nemoto Y, Shimoyama Y, Nakasato M, Nishimata H, Ishikawa T, Sasaki M, Kimura S, Nemoto TK. Distribution of dipeptidyl peptidase (DPP) 4, DPP5, DPP7 and DPP11 in human oral microbiota-potent biomarkers indicating presence of periodontopathic bacteria. FEMS Microbiol Lett. 2018;365.","DOI":"10.1093\/femsle\/fny221"},{"key":"5043_CR21","doi-asserted-by":"publisher","first-page":"103265","DOI":"10.1016\/j.jdent.2019.103265","volume":"92","author":"D Logan","year":"2020","unstructured":"Logan D, McEvoy CT, McKenna G, Kee F, Linden G, Woodside JV. Association between oral health status and future dietary intake and diet quality in older men: the PRIME study. J Dent. 2020;92:103265.","journal-title":"J Dent"},{"key":"5043_CR22","doi-asserted-by":"crossref","unstructured":"Jing T, Zhang S, Bai M, Chen Z, Gao S, Li S, Zhang J. Effect of dietary approaches on glycemic control in patients with type 2 diabetes: a systematic review with network meta-analysis of randomized trials. Nutrients. 2023;15.","DOI":"10.3390\/nu15143156"},{"key":"5043_CR23","doi-asserted-by":"publisher","first-page":"110037","DOI":"10.1016\/j.diabres.2022.110037","volume":"191","author":"A Kazemi","year":"2022","unstructured":"Kazemi A, Ryul Shim S, Jamali N, Hassanzadeh-Rostami Z, Soltani S, Sasani N, Mohsenpour MA, Firoozi D, Basirat R, Hosseini R, et al. Comparison of nutritional supplements for glycemic control in type 2 diabetes: a systematic review and network meta-analysis of randomized trials. Diabetes Res Clin Pract. 2022;191:110037.","journal-title":"Diabetes Res Clin Pract"},{"key":"5043_CR24","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1902\/jop.2013.130306","volume":"85","author":"H Haririan","year":"2014","unstructured":"Haririan H, Andrukhov O, Bertl K, Lettner S, Kierstein S, Moritz A, Rausch-Fan X. Microbial analysis of subgingival plaque samples compared to that of whole saliva in patients with periodontitis. J Periodontol. 2014;85:819\u201328.","journal-title":"J Periodontol"},{"key":"5043_CR25","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1111\/jcpe.12463","volume":"42","author":"Y Li","year":"2015","unstructured":"Li Y, Feng X, Xu L, Zhang L, Lu R, Shi D, Wang X, Chen F, Li J, Meng H. Oral microbiome in Chinese patients with aggressive periodontitis and their family members. J Clin Periodontol. 2015;42:1015\u201323.","journal-title":"J Clin Periodontol"},{"key":"5043_CR26","doi-asserted-by":"crossref","unstructured":"World Health Organization. Oral health surveys: basic methods. 4th edn. 1997; WHO publications, 1211 Geneva 27, Switzerland.","DOI":"10.2307\/2528861"},{"key":"5043_CR27","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.archger.2014.08.005","volume":"59","author":"A Tada","year":"2014","unstructured":"Tada A, Miura H. Systematic review of the association of mastication with food and nutrient intake in the independent elderly. Arch Gerontol Geriatr. 2014;59:497\u2013505.","journal-title":"Arch Gerontol Geriatr"},{"key":"5043_CR28","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s12275-012-0459-4","volume":"50","author":"Y Ito","year":"2012","unstructured":"Ito Y, Sato T, Yamaki K, Mayanagi G, Hashimoto K, Shimauchi H, Takahashi N. Microflora profiling of infected root canal before and after treatment using culture-independent methods. J Microbiol. 2012;50:58\u201362.","journal-title":"J Microbiol"},{"key":"5043_CR29","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.mimet.2004.06.006","volume":"59","author":"C Nonnenmacher","year":"2004","unstructured":"Nonnenmacher C, Dalpke A, Mutters R, Heeg K. Quantitative detection of periodontopathogens by real-time PCR. J Microbiol Methods. 2004;59:117\u201325.","journal-title":"J Microbiol Methods"},{"key":"5043_CR30","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1752-7325.2009.00122.x","volume":"69","author":"H Hayashida","year":"2009","unstructured":"Hayashida H, Kawasaki K, Yoshimura A, Kitamura M, Furugen R, Nakazato M, Takamura N, Hara Y, Maeda T, Saito T. Relationship between periodontal status and HbA1c in nondiabetics. J Public Health Dent. 2009;69:204\u20136.","journal-title":"J Public Health Dent"},{"key":"5043_CR31","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.2337\/dc09-1778","volume":"33","author":"RT Demmer","year":"2010","unstructured":"Demmer RT, Desvarieux M, Holtfreter B, Jacobs DR Jr., Wallaschofski H, Nauck M, Volzke H, Kocher T. Periodontal status and A1C change: longitudinal results from the study of health in Pomerania (SHIP). Diabetes Care. 2010;33:1037\u201343.","journal-title":"Diabetes Care"},{"key":"5043_CR32","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/j.1399-302X.2007.00426.x","volume":"23","author":"N Makiura","year":"2008","unstructured":"Makiura N, Ojima M, Kou Y, Furuta N, Okahashi N, Shizukuishi S, Amano A. Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment. Oral Microbiol Immunol. 2008;23:348\u201351.","journal-title":"Oral Microbiol Immunol"},{"key":"5043_CR33","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/ejcn.2013.231","volume":"68","author":"V Ranawana","year":"2014","unstructured":"Ranawana V, Leow MK, Henry CJ. Mastication effects on the glycaemic index: impact on variability and practical implications. Eur J Clin Nutr. 2014;68:137\u20139.","journal-title":"Eur J Clin Nutr"},{"key":"5043_CR34","doi-asserted-by":"crossref","unstructured":"Masri D, Masri-Iraqi H, Nissan J, Nemcovsky C, Gillman L, Naishlos S, Chaushu L. On the association between implant-supported prosthesis and glycemic control (HbA1c values). Int J Environ Res Public Health. 2022,19.","DOI":"10.3390\/ijerph19116923"},{"key":"5043_CR35","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0003-9969(01)00023-1","volume":"46","author":"JP Hatch","year":"2001","unstructured":"Hatch JP, Shinkai RS, Sakai S, Rugh JD, Paunovich ED. Determinants of masticatory performance in dentate adults. Arch Oral Biol. 2001;46:641\u20138.","journal-title":"Arch Oral Biol"},{"key":"5043_CR36","doi-asserted-by":"publisher","first-page":"934274","DOI":"10.3389\/fendo.2022.934274","volume":"13","author":"D Da","year":"2022","unstructured":"Da D, Ge S, Zhang H, Zeng X, Jiang Y, Yu J, Wang H, Wu W, Xiao Z, Liang X, et al. Association of occlusal support with type 2 diabetes: a community-based study. Front Endocrinol (Lausanne). 2022;13:934274.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5043_CR37","doi-asserted-by":"publisher","first-page":"82","DOI":"10.4248\/IJOS10025","volume":"2","author":"M Ueno","year":"2010","unstructured":"Ueno M, Takeuchi S, Oshiro A, Shinada K, Ohara S, Kawaguchi Y. Association between diabetes mellitus and oral health status in Japanese adults. Int J Oral Sci. 2010;2:82\u20139.","journal-title":"Int J Oral Sci"},{"key":"5043_CR38","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/B978-0-12-800263-6.00007-0","volume":"64","author":"M Koga","year":"2014","unstructured":"Koga M. 1,5-Anhydroglucitol and glycated albumin in glycemia. Adv Clin Chem. 2014;64:269\u2013301.","journal-title":"Adv Clin Chem"},{"key":"5043_CR39","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/j.jdiacomp.2016.07.007","volume":"30","author":"JM Lu","year":"2016","unstructured":"Lu JM, Ji LN, Li YF, Li QM, Lin SS, Lv XF, Wang L, Xu Y, Guo XH, Guo QY, et al. Glycated albumin is superior to glycated hemoglobin for glycemic control assessment at an early stage of diabetes treatment: a multicenter, prospective study. J Diabetes Complications. 2016;30:1609\u201313.","journal-title":"J Diabetes Complications"},{"key":"5043_CR40","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/j.1600-051X.2008.01249.x","volume":"35","author":"W Nesse","year":"2008","unstructured":"Nesse W, Abbas F, van der Ploeg I, Spijkervet FK, Dijkstra PU, Vissink A. Periodontal inflamed surface area: quantifying inflammatory burden. J Clin Periodontol. 2008;35:668\u201373.","journal-title":"J Clin Periodontol"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-024-05043-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-024-05043-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-024-05043-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T06:03:23Z","timestamp":1729490603000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-024-05043-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,19]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5043"],"URL":"https:\/\/doi.org\/10.1186\/s12903-024-05043-6","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,19]]},"assertion":[{"value":"3 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the Nagasaki University Graduate School of Biomedical Sciences (study registration number: 14051404-13) and conformed to the tenets of the Declaration of Helsinki. Written informed consent forms were provided in Japanese to ensure a comprehensive understanding of the study objectives and informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1254"}}