{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:51:45Z","timestamp":1767901905983,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002597","name":"Kyung Hee University","doi-asserted-by":"publisher","award":["20230360"],"award-info":[{"award-number":["20230360"]}],"id":[{"id":"10.13039\/501100002597","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Oxyresveratrol is the main constituent of mulberries and has many bioactive properties beneficial to human health. The purpose of this study was to assess the anti-inflammatory effects of oxyresveratrol on in vitro periodontitis model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Human periodontal ligament cells were treated with oxyresveratrol (0, 10, and 20\u00a0\u00b5g\/mL) for 72\u00a0h. Cell viability and flow cytometry assays were performed. To investigate anti-inflammatory effect of oxyresveratrol on periodontal inflammation, nitric oxide production under lipopolysaccharide stimulation was assessed. Next, expression of biomarkers associated periodontal inflammation was evaluated. Scratch wound assay was performed to evaluate cell migration\/proliferation potential of oxyresveratrol under lipopolysaccharide stimulation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Periodontal ligament cell toxicity was not observed in oxyresveratrol treatment. Oxyresveratrol treatment significantly inhibited nitric oxide production and reduced MMP-2, MMP-9, TNF-\u03b1, IL-6, and IL-8 expressions after lipopolysaccharide stimulation. Regarding cell migration\/proliferation, open wound area in oxyresveratrol (33.28\u2009\u00b1\u20096.80%) was the lowest (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Within the limits of this study, oxyresveratrol inhibited lipopolysaccharide-induced inflammation in periodontal ligament cells and promoted periodontal ligament cell migration\/proliferation. These findings suggest that oxyresveratrol could be valuable for the management of periodontal diseases.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-024-05128-2","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T09:34:17Z","timestamp":1731663257000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of oxyresveratrol under in vitro lipopolysaccharide-induced periodontitis environment"],"prefix":"10.1186","volume":"24","author":[{"given":"Ju Ri","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hwan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Wook","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Hwan","family":"Kwack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Kwon","family":"Chae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Seol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Chul","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ok Hyung","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"issue":"6","key":"5128_CR1","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/idj.12630","volume":"71","author":"T Kwon","year":"2021","unstructured":"Kwon T, Lamster IB, Levin L. Current concepts in the management of Periodontitis. Int Dent J. 2021;71(6):462\u201376.","journal-title":"Int Dent J"},{"issue":"11","key":"5128_CR2","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","volume":"93","author":"N Kassebaum","year":"2014","unstructured":"Kassebaum N, Bernab\u00e9 E, Dahiya M, Bhandari B, Murray C, Marcenes W. Global burden of severe periodontitis in 1990\u20132010: a systematic review and meta-regression. J Dent Res. 2014;93(11):1045\u201353.","journal-title":"J Dent Res"},{"key":"5128_CR3","doi-asserted-by":"crossref","unstructured":"K\u00f6n\u00f6nen E, Gursoy M, Gursoy UK. Periodontitis: a multifaceted disease of tooth-supporting tissues. J Clin Med. 2019;8(8):1135.","DOI":"10.3390\/jcm8081135"},{"key":"5128_CR4","doi-asserted-by":"publisher","first-page":"151744","DOI":"10.1016\/j.aanat.2021.151744","volume":"237","author":"Y Chen","year":"2021","unstructured":"Chen Y, Zhou T, Zhang HH, Kang N. Bovine lactoferrin inhibits alveolar bone destruction in an orthodontic rat model with periodontitis. Ann Anat. 2021;237:151744.","journal-title":"Ann Anat"},{"issue":"9","key":"5128_CR5","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1111\/apm.13440","volume":"132","author":"R Nadaf","year":"2024","unstructured":"Nadaf R, Kumbar VM, Ghagane S. Unravelling the intricacies of Porphyromonas gingivalis: virulence factors, lifecycle dynamics and phytochemical interventions for periodontal disease management. APMIS. 2024;132(9):611\u201324.","journal-title":"Apmis"},{"key":"5128_CR6","doi-asserted-by":"crossref","unstructured":"Kim S, Choi SI, Kim GH, Imm JY. Anti-inflammatory effect of Ecklonia cava extract on porphyromonas gingivalis lipopolysaccharide-stimulated macrophages and a periodontitis rat model. Nutrients. 2019;11(5):1143.","DOI":"10.3390\/nu11051143"},{"issue":"4 Suppl","key":"5128_CR7","first-page":"S106","volume":"84","author":"IL Chapple","year":"2013","unstructured":"Chapple IL, Genco R. Diabetes and periodontal diseases: consensus report of the Joint EFP\/AAP workshop on periodontitis and systemic diseases. J Periodontol. 2013;84(4 Suppl):S106\u201312.","journal-title":"J Periodontol"},{"issue":"3","key":"5128_CR8","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1055\/s-0040-1712718","volume":"14","author":"DE Ramadan","year":"2020","unstructured":"Ramadan DE, Hariyani N, Indrawati R, Ridwan RD, Diyatri I. Cytokines and chemokines in Periodontitis. Eur J Dent. 2020;14(3):483\u201395.","journal-title":"Eur J Dent"},{"key":"5128_CR9","doi-asserted-by":"publisher","first-page":"151877","DOI":"10.1016\/j.aanat.2021.151877","volume":"240","author":"MS Shaikh","year":"2022","unstructured":"Shaikh MS, Zafar MS, Alnazzawi A, Javed F. Nanocrystalline hydroxyapatite in regeneration of periodontal intrabony defects: a systematic review and meta-analysis. Ann Anat. 2022;240:151877.","journal-title":"Ann Anat"},{"issue":"2","key":"5128_CR10","doi-asserted-by":"publisher","first-page":"114230","DOI":"10.1016\/j.yexcr.2024.114230","volume":"442","author":"SM Kim","year":"2024","unstructured":"Kim SM, Jang YJ. Enzymatic activity of fibroblast activation protein-\u03b1 is essential for TGF-\u03b21-induced fibroblastic differentiation of human periodontal ligament cells. Exp Cell Res. 2024;442(2):114230.","journal-title":"Exp Cell Res"},{"key":"5128_CR11","doi-asserted-by":"crossref","unstructured":"Laforgia A, Inchingolo AD, Piras F, Colonna V, Giorgio RV, Carone C, et al. Therapeutic strategies and genetic implications for periodontal disease management: a systematic review. Int J Mol Sci. 2024;25(13):7217.","DOI":"10.3390\/ijms25137217"},{"issue":"3","key":"5128_CR12","doi-asserted-by":"publisher","first-page":"439","DOI":"10.17219\/dmp\/158925","volume":"61","author":"D Z\u00fa\u00f1iga-Loor","year":"2024","unstructured":"Z\u00fa\u00f1iga-Loor D, Parise-Vasco JM, Montesinos-Guevara C. Mechanical debridement combined with Amoxicillin and metronidazole compared with mechanical debridement alone for the treatment of chronic periodontitis: an overview of systematic reviews. Dent Med Probl. 2024;61(3):439\u201346.","journal-title":"Dent Med Probl"},{"issue":"7","key":"5128_CR13","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1111\/odi.14288","volume":"29","author":"CM Ardila","year":"2023","unstructured":"Ardila CM, Bedoya-Garc\u00eda JA, Arrubla-Escobar DE. Antibiotic resistance in periodontitis patients: a systematic scoping review of randomized clinical trials. Oral Dis. 2023;29(7):2501\u201311.","journal-title":"Oral Dis"},{"issue":"4","key":"5128_CR14","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/jre.13118","volume":"58","author":"H Chen","year":"2023","unstructured":"Chen H, Liu Y, Yu S, Li C, Gao B, Zhou X. Cannabidiol attenuates periodontal inflammation through inhibiting TLR4\/NF-\u03baB pathway. J Periodontal Res. 2023;58(4):697\u2013707.","journal-title":"J Periodontal Res"},{"issue":"3","key":"5128_CR15","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/omi.12260","volume":"34","author":"A Ben Lagha","year":"2019","unstructured":"Ben Lagha A, Andrian E, Grenier D. Resveratrol attenuates the pathogenic and inflammatory properties of Porphyromonas gingivalis. Mol Oral Microbiol. 2019;34(3):118\u201330.","journal-title":"Mol Oral Microbiol"},{"key":"5128_CR16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.intimp.2018.01.014","volume":"56","author":"YN Jia","year":"2018","unstructured":"Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L. Oxyresveratrol prevents lipopolysaccharide\/d-galactosamine-induced acute liver injury in mice. Int Immunopharmacol. 2018;56:105\u201312.","journal-title":"Int Immunopharmacol"},{"key":"5128_CR17","doi-asserted-by":"crossref","unstructured":"Suriyaprom S, Srisai P, Intachaisri V, Kaewkod T, Pekkoh J, Desvaux M, et al. Antioxidant and anti-inflammatory activity on LPS-stimulated RAW 264.7 macrophage cells of white mulberry (Morus alba L.) leaf extracts. Molecules. 2023;28(11):4395.","DOI":"10.3390\/molecules28114395"},{"key":"5128_CR18","doi-asserted-by":"crossref","unstructured":"Zhou J, Li SX, Wang W, Guo XY, Lu XY, Yan XP, et al. Variations in the levels of mulberroside A, oxyresveratrol, and resveratrol in mulberries in different seasons and during growth. ScientificWorldJournal. 2013;2013:380692.","DOI":"10.1155\/2013\/380692"},{"key":"5128_CR19","doi-asserted-by":"publisher","first-page":"105371","DOI":"10.1016\/j.jff.2022.105371","volume":"100","author":"X Shi","year":"2023","unstructured":"Shi X, Xu L, Zhang J, Mo J, Zhuang P, Zheng L. Oxyresveratrol from mulberry branch extract protects HUVECs against oxidized low-density lipoprotein-induced oxidative injury via activation of the Nrf-2\/HO-1 pathway. J Funct Foods. 2023;100:105371.","journal-title":"J Funct Foods"},{"issue":"2","key":"5128_CR20","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jtcme.2019.03.006","volume":"10","author":"T Wongwat","year":"2020","unstructured":"Wongwat T, Srihaphon K, Pitaksutheepong C, Boonyo W, Pitaksuteepong T. Suppression of inflammatory mediators and matrix metalloproteinase (MMP)-13 by Morus alba stem extract and oxyresveratrol in RAW 264.7 cells and C28\/I2 human chondrocytes. J Tradit Complement Med. 2020;10(2):132\u201340.","journal-title":"J Tradit Complement Med"},{"issue":"5","key":"5128_CR21","first-page":"1934578X1300800","volume":"8","author":"W Phoolcharoen","year":"2013","unstructured":"Phoolcharoen W, Sooampon S, Sritularak B, Likhitwitayawuid K, Kuvatanasuchati J, Pavasant P. Anti-periodontal pathogen and anti-inflammatory activities of oxyresveratrol. Nat Prod Commun. 2013;8(5):613\u2013-6.","journal-title":"Nat Prod Commun"},{"issue":"3","key":"5128_CR22","doi-asserted-by":"publisher","first-page":"728","DOI":"10.3390\/cells9030728","volume":"9","author":"S Park","year":"2020","unstructured":"Park S, Shin J, Bae J, Han D, Park S-R, Shin J, Lee SK, Park H-W. SIRT1 alleviates LPS-Induced IL-1\u03b2 production by suppressing NLRP3 inflammasome activation and ROS production in Trophoblasts. Cells. 2020;9(3):728.","journal-title":"Cells"},{"issue":"8","key":"5128_CR23","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1177\/0960327114559989","volume":"34","author":"HS Lee","year":"2015","unstructured":"Lee HS, Kim DH, Hong JE, Lee JY, Kim EJ. Oxyresveratrol suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages. Hum Exp Toxicol. 2015;34(8):808\u201318.","journal-title":"Hum Exp Toxicol"},{"key":"5128_CR24","doi-asserted-by":"crossref","unstructured":"Thaweesest W, Buranasudja V, Phumsuay R, Muangnoi C, Vajragupta O, Sritularak B, et al. Anti-inflammatory activity of oxyresveratrol tetraacetate, an Ester prodrug of oxyresveratrol, on lipopolysaccharide-stimulated RAW264.7 macrophage cells. Molecules. 2022;27(12):3922.","DOI":"10.3390\/molecules27123922"},{"issue":"5","key":"5128_CR25","first-page":"e60779","volume":"16","author":"RT Patil","year":"2024","unstructured":"Patil RT, Dhadse PV, Salian SS, Punse SD. Role of oxidative stress in Periodontal diseases. Cureus. 2024;16(5):e60779.","journal-title":"Cureus"},{"key":"5128_CR26","doi-asserted-by":"crossref","unstructured":"Sunilkumar D, Bose C, Sanu SK, Pandurangan N, Kumar G, Banerji A, et al. Coconut shell derived bioactive compound oxyresveratrol mediates regulation of Matrix metalloproteinase 9. Int J Pharma Bio Sci. 2017;8(1):202\u201310.","DOI":"10.22376\/ijpbs.2017.8.1p202-210"},{"key":"5128_CR27","doi-asserted-by":"crossref","unstructured":"Checchi V, Maravic T, Bellini P, Generali L, Consolo U, Breschi L, et al. The role of Matrix metalloproteinases in periodontal disease. Int J Environ Res Public Health. 2020;17(14):4923.","DOI":"10.3390\/ijerph17144923"},{"key":"5128_CR28","doi-asserted-by":"crossref","unstructured":"Luchian I, Goriuc A, Sandu D, Covasa M. The role of Matrix metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-implant pathological processes. Int J Mol Sci. 2022;23(3):1806.","DOI":"10.3390\/ijms23031806"},{"issue":"1","key":"5128_CR29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12903-023-02713-9","volume":"23","author":"OH Nam","year":"2023","unstructured":"Nam OH, Ro ST, Lee HW, Jeong J, Chae YK, Lee KE, Choi SC, Kang SW. Evaluation of delphinidin as a storage medium for avulsed teeth. BMC Oral Health. 2023;23(1):21.","journal-title":"BMC Oral Health"},{"issue":"1","key":"5128_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1590\/0103-6440201801731","volume":"29","author":"D Barreiros","year":"2018","unstructured":"Barreiros D, Nelson PF, Paula-Silva FWG, Oliveira KMH, Lucisano MP, Rossi A, Silva LAB, K\u00fcchler EC, Silva RAB. MMP2 and MMP9 are Associated with apical periodontitis progression and might be modulated by TLR2 and MyD88. Braz Dent J. 2018;29(1):43\u20137.","journal-title":"Braz Dent J"},{"key":"5128_CR31","doi-asserted-by":"crossref","unstructured":"Radzki D, Negri A, Kusiak A, Obuchowski M. Matrix metalloproteinases in the Periodontium-Vital in tissue turnover and unfortunate in Periodontitis. Int J Mol Sci. 2024;25(5):2763.","DOI":"10.3390\/ijms25052763"},{"issue":"1","key":"5128_CR32","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10266-023-00831-y","volume":"112","author":"P Gonz\u00e1lez-Alva","year":"2024","unstructured":"Gonz\u00e1lez-Alva P, Sol\u00eds-Su\u00e1rez DL, Cifuentes-Mendiola SE, Garc\u00eda-Hern\u00e1ndez AL. A diet rich in omega-3 fatty acid improves periodontitis and tissue destruction by MMP2- and MMP9-linked inflammation in a murine model. Odontology. 2024;112(1):185\u201399.","journal-title":"Odontology"},{"issue":"4","key":"5128_CR33","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1007\/s10266-024-00907-3","volume":"112","author":"F U\u00e7an Yarka\u00e7","year":"2024","unstructured":"U\u00e7an Yarka\u00e7 F, Babayi\u011fit O, Gokturk O. Associations between immune-inflammatory markers, age, and periodontal status: a cross-sectional study. Odontology. 2024;112(4):1296\u2013306.","journal-title":"Odontology"},{"key":"5128_CR34","doi-asserted-by":"crossref","unstructured":"Yeom J, Ma S, Kim JK, Lim YH. Oxyresveratrol ameliorates dextran sulfate sodium-induced colitis in rats by suppressing inflammation. Molecules. 2021;26(9):2630.","DOI":"10.3390\/molecules26092630"},{"key":"5128_CR35","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.biopha.2018.12.002","volume":"110","author":"RS Aziz","year":"2019","unstructured":"Aziz RS, Siddiqua A, Shahzad M, Shabbir A, Naseem N. Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-\u03b1, NF-\u0138B, and COX-2 levels, and upregulation of TFF-2 levels. Biomed Pharmacother. 2019;110:554\u201360.","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"5128_CR36","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/idh.12639","volume":"21","author":"AP Kolte","year":"2023","unstructured":"Kolte AP, Kolte RA, Bawankar PV, Bajaj VA. Assessment and correlation of the influence of non-surgical periodontal therapy on serum lipid profile and cytokines in patients with stage III periodontitis. Int J Dent Hyg. 2023;21(2):298\u2013304.","journal-title":"Int J Dent Hyg"},{"key":"5128_CR37","doi-asserted-by":"crossref","unstructured":"Tran HG, Shuayprom A, Kueanjinda P, Leelahavanichkul A, Wongsinkongman P, Chaisomboonpan S, et al. Oxyresveratrol attenuates inflammation in human keratinocyte via regulating NF-kB signaling and ameliorates Eczematous Lesion in DNCB-Induced Dermatitis mice. Pharmaceutics. 2023;15(6):1709.","DOI":"10.3390\/pharmaceutics15061709"},{"key":"5128_CR38","first-page":"101823","volume":"40","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Deng Q, Vong CT, Khan H, Cheang WS. Oxyresveratrol reduces lipopolysaccharide-induced inflammation and oxidative stress through inactivation of MAPK and NF-\u03baB signaling in brain endothelial cells. Biochem Biophys Rep. 2024;40:101823.","journal-title":"Biochem Biophys Rep"},{"key":"5128_CR39","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.freeradbiomed.2014.07.034","volume":"75","author":"N Tamaki","year":"2014","unstructured":"Tamaki N, Cristina Orihuela-Campos R, Inagaki Y, Fukui M, Nagata T, Ito HO. Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1\/AMPK and the Nrf2\/antioxidant defense pathways in a rat periodontitis model. Free Radic Biol Med. 2014;75:222\u20139.","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"5128_CR40","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1600-051X.2010.01654.x","volume":"38","author":"G L\u00f6hr","year":"2011","unstructured":"L\u00f6hr G, Beikler T, Podbielski A, Standar K, Redanz S, Hensel A. Polyphenols from Myrothamnus Flabellifolia Welw. Inhibit in vitro adhesion of Porphyromonas gingivalis and exert anti-inflammatory cytoprotective effects in KB cells. J Clin Periodontol. 2011;38(5):457\u201369.","journal-title":"J Clin Periodontol"},{"issue":"9","key":"5128_CR41","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1089\/ten.tea.2008.0442","volume":"15","author":"W Singhatanadgit","year":"2009","unstructured":"Singhatanadgit W, Donos N, Olsen I. Isolation and characterization of stem cell clones from adult human ligament. Tissue Eng Part A. 2009;15(9):2625\u201336.","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"5128_CR42","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/prd.12023","volume":"63","author":"J Xiong","year":"2013","unstructured":"Xiong J, Gronthos S, Bartold PM. Role of the epithelial cell rests of Malassez in the development, maintenance and regeneration of periodontal ligament tissues. Periodontol 2000. 2013;63(1):217\u201333.","journal-title":"Periodontol 2000"},{"issue":"3","key":"5128_CR43","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/jre.12120","volume":"49","author":"M Padial-Molina","year":"2014","unstructured":"Padial-Molina M, Volk SL, Rios HF. Periostin increases migration and proliferation of human periodontal ligament fibroblasts challenged by tumor necrosis factor -\u03b1 and Porphyromonas gingivalis lipopolysaccharides. J Periodontal Res. 2014;49(3):405\u201314.","journal-title":"J Periodontal Res"},{"issue":"2","key":"5128_CR44","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1111\/jcmm.14023","volume":"23","author":"M Kawamura","year":"2019","unstructured":"Kawamura M, Yamamoto T, Yamashiro K, Kochi S, Yoshihara-Hirata C, Ideguchi H, Aoyagi H, Omori K, Takashiba S. Induction of migration of periodontal ligament cells by selective regulation of integrin subunits. J Cell Mol Med. 2019;23(2):1211\u201323.","journal-title":"J Cell Mol Med"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-024-05128-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-024-05128-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-024-05128-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T10:04:24Z","timestamp":1731665064000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-024-05128-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,15]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5128"],"URL":"https:\/\/doi.org\/10.1186\/s12903-024-05128-2","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,15]]},"assertion":[{"value":"12 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1382"}}