{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:45:46Z","timestamp":1794563146254,"version":"4.9.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Orofacial cleft impacts jawbone and dental development and function, often with consequences for oral health. The first in this two-part systematic review of the literature on oral health in persons with cleft lip and\/or palate focuses on periodontal parameters and composition of oral bacterial flora, while the second analyzes data on dental caries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Four databases (PubMed, Cochrane, Scopus, Web of Science) were searched for studies that compared periodontal parameters, caries index, and microbiota composition between persons with cleft lip and\/or palate and healthy controls. The Newcastle\u2013Ottawa scale and the Joanna Briggs Institute checklist were applied to evaluate study quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 24 studies underwent systematic review, 18 of which entered meta-analysis. Twenty studies included a control group, while four included only persons with orofacial cleft. The first part (18 studies) compared periodontal parameters and oral microbiota.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Meta-analysis of periodontal parameters (plaque index, gingival index, bleeding index, probing pocket depth, clinical attachment level) revealed an association between orofacial cleft and greater risk for poor oral health and periodontal disease. Good oral health relies on correct home oral hygiene and regular visits to the dentist starting at an early age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-025-05494-5","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T01:12:04Z","timestamp":1738113124000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oral health in patients with cleft lip and palate: a systematic literature review and meta-analysis of periodontal and dental disease and oral microbiota (part 1)"],"prefix":"10.1186","volume":"25","author":[{"given":"A.","family":"Pardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lonardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Signoriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lobbia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Trevisiol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"D\u2019Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"5494_CR1","doi-asserted-by":"crossref","unstructured":"Zawi\u015blak A, Wo\u017aniak K, Kawala B, Gupta S, Znamirowska-Bajowska A, Janiszewska-Olszowska J, et al. IRF6 and FGF1 polymorphisms in non-syndromic cleft lip with or without cleft palate in the Polish population. Open Med (Poland). 2023;18(1):20230677.","DOI":"10.1515\/med-2023-0677"},{"issue":"1","key":"5494_CR2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/sj.bdj.2017.581","volume":"223","author":"V Worth","year":"2017","unstructured":"Worth V, Perry R, Ireland T, Wills AK, Sandy J, Ness A. Are people with an orofacial cleft at a higher risk of dental caries? A systematic review and meta-analysis. Br Dent J. 2017;223(1):37\u201347.","journal-title":"Br Dent J"},{"key":"5494_CR3","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1111\/ipd.12934","volume":"32","author":"T Marzouk","year":"2022","unstructured":"Marzouk T, Youssef M, Tsigarida A, McKinney C, Wong C, DeLucia L, et al. Association between oral clefts and periodontal clinical measures: A meta-analysis. Int J Paediatr Dent. 2022;32:558\u201375.","journal-title":"Int J Paediatr Dent."},{"key":"5494_CR4","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1111\/odi.14183","volume":"28","author":"RE Grewcock","year":"2022","unstructured":"Grewcock RE, Innes NPT, Mossey PA, Robertson MD. Caries in children with and without orofacial clefting: A systematic review and meta-analysis. Oral Dis. 2022;28:1400\u201311.","journal-title":"Oral Dis."},{"key":"5494_CR5","doi-asserted-by":"crossref","unstructured":"Perdikogianni H, Papaioannou W, Nakou M, Oulis C, Papagiannoulis L. Periodontal and microbiological parameters in children and adolescents with cleft lip and \/or palate. Int J Paediatr Dent. 2009;19(6):455\u201367.","DOI":"10.1111\/j.1365-263X.2009.01020.x"},{"key":"5494_CR6","doi-asserted-by":"crossref","unstructured":"Machorowska-Pieniazek A, Skucha-Nowak M, Mertas A, Tanasiewicz M, Niedzielska I, Morawiec T, et al. Effects of Brazilian Propolis on Dental Plaque and Gingiva in Patients with Oral Cleft Malformation Treated with Multibracket and Removable Appliances: A Comparative Study. Evid-based Complement Altern Med. 2016;2016:2038407.","DOI":"10.1155\/2016\/2038407"},{"issue":"18","key":"5494_CR7","doi-asserted-by":"publisher","first-page":"5867","DOI":"10.3390\/jcm12185867","volume":"12","author":"J \u015awita\u0142a","year":"2023","unstructured":"\u015awita\u0142a J, Syci\u0144ska-Dziarnowska M, Spagnuolo G, Wo\u017aniak K, Ma\u0144kowska K, Szyszka-Sommerfeld L. Oral microbiota in children with cleft lip and palate: a systematic review. J Clin Med. 2023;12(18):5867.","journal-title":"J Clin Med"},{"key":"5494_CR8","doi-asserted-by":"crossref","unstructured":"Arboleda V, Elsouri KN, Heiser SE, Bernal I, Kesselman MM, Demory Beckler M. Oral microbiome as a tool of systemic disease on cleft patients: a new landscape. Cureus. 2023;15(2):e35444.","DOI":"10.7759\/cureus.35444"},{"key":"5494_CR9","unstructured":"GA Wells, B Shea, D O'Connell, J Peterson, V Welch, M Losos, P Tugwell. The Newcastle-Ottawa Scale (NOS) for assessing the quality of non randomised studies in meta-analyses. 2018."},{"key":"5494_CR10","unstructured":"https:\/\/jbi.global\/critical-appraisal-tools [Internet]. Critical Appraisal Tools; accessed on 02\/01\/2024"},{"key":"5494_CR11","unstructured":"Veiga KA, Porto AN, Matos FZ, de Brito PC, Borges \u00c1H, Volpato LE, Aranha AM. Caries experience and periodontal status in children and adolescents with cleft lip and palate. Pediatr Dent. 2017;39(2):139\u2013144."},{"key":"5494_CR12","unstructured":"Sunderji S, Acharya B, Flaitz C, Chiquet B. Dental caries experience in texan children with cleft lip and palate. 2017."},{"issue":"1","key":"5494_CR13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4103\/njms.njms_127_22","volume":"14","author":"I Khan","year":"2023","unstructured":"Khan I, Ahmedi S, Ahmad T, Alam Rizvi MM, Manzoor N. Incidence and prevalence of oral candidal colonization in patients with cleft lip and palate. Natl J Maxillofac Surg. 2023;14(1):72.","journal-title":"Natl J Maxillofac Surg."},{"key":"5494_CR14","unstructured":"Gheller Passinato SA, Porto AN, Borba AM, Veiga KA, Aranha AMF. Periodontal findings in children and adolescents with cleft lip and\/or palate: a case- control study. 2021;43(2):133\u20139."},{"issue":"6","key":"5494_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/1947-2714.134371","volume":"6","author":"A Chopra","year":"2014","unstructured":"Chopra A, Lakhanpal M, Rao NC, Gupta N, Vashisth S. Oral health in 4\u20136 years children with cleft lip\/palate: a case control study. N Am J Med Sci. 2014;6(6):27\u201330.","journal-title":"N Am J Med Sci"},{"issue":"2","key":"5494_CR16","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1597\/11-143","volume":"50","author":"ABDA Freitas","year":"2013","unstructured":"Freitas ABDA, De Barros LM, Fiorini JE, Boriollo MFG, Moreira AN, Magalh\u00e3es CS. Caries experience in a sample of adolescents and young adults with cleft lip and palate in Brazil. Cleft Palate Craniofac J. 2013;50(2):187\u201391.","journal-title":"Cleft Palate Craniofac J"},{"key":"5494_CR17","unstructured":"Pisek A, Pitiphat W, Chowchuen B, Pradubwong S. Oral Health Status and Oral Impacts on Quality of Life in Early Adolescent Cleft Patients. J Med Assoc Thai. 2014; Available from: http:\/\/www.jmatonline.com"},{"key":"5494_CR18","doi-asserted-by":"crossref","unstructured":"Sundell AL, Ullbro C, Marcusson A, Twetman S. Comparing caries risk profiles between 5- and 10- year-old children with cleft lip and\/or palate and non-cleft controls. BMC Oral Health. 2015;15:85.","DOI":"10.1186\/s12903-015-0067-x"},{"issue":"1","key":"5494_CR19","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s40368-018-0326-z","volume":"19","author":"AL Sundell","year":"2018","unstructured":"Sundell AL, Ullbro C, Dahl\u00e9n G, Marcusson A, Twetman S. Salivary microbial profiles in 5-year old children with oral clefts: a comparative study. Eur Arch Paediatr Dent. 2018;19(1):57\u201360.","journal-title":"Eur Arch Paediatr Dent"},{"key":"5494_CR20","doi-asserted-by":"crossref","unstructured":"Liu L, Zhang Q, Lin J, Ma L, Zhou Z, He X, et al. Investigating oral microbiome profiles in children with cleft lip and palate for prognosis of alveolar bone grafting. PLoS One. 2016;11(5):e0155683.","DOI":"10.1371\/journal.pone.0155683"},{"key":"5494_CR21","unstructured":"Liu H, Li Y, Li Y. Original Article Expression of hBDs in gingival tissue in patients with cleft alveolus. Int J Clin Exp Med. 2017;10. Available from: www.ijcem.com\/"},{"issue":"3","key":"5494_CR22","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1007\/s00784-021-04290-z","volume":"26","author":"MFG Boriollo","year":"2022","unstructured":"Boriollo MFG, Oliveira MC, Bassinello V, An\u00edbal PC, da Silva TA, da Silva JJ, et al. Candida species biotypes and polyclonality of potentially virulent Candida albicans isolated from oral cavity of patients with orofacial clefts. Clin Oral Investig. 2022;26(3):3061\u201384.","journal-title":"Clin Oral Investig"},{"issue":"3","key":"5494_CR23","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1177\/1055665618776428","volume":"56","author":"MA Durhan","year":"2019","unstructured":"Durhan MA, Topcuoglu N, Kulekci G, Ozgentas E, Tanboga I. Microbial profile and dental caries in cleft lip and palate babies between 0 and 3 years old. Cleft Palate Craniofac J. 2019;56(3):349\u201356.","journal-title":"Cleft Palate Craniofac J"},{"key":"5494_CR24","doi-asserted-by":"crossref","unstructured":"Kharaeva ZF, Vissarionov VA, Mustafaeva SM, Yusupova MM, Shogenova AR, Sarakaeva DI, et al. Oropharyngeal dysbiosis affects postoperative tissue reparative capacity in patients with congenital disorders of maxillofacial region. Russian Open Med J. 2021;10(4):e0429.","DOI":"10.15275\/rusomj.2021.0429"},{"issue":"1","key":"5494_CR25","doi-asserted-by":"publisher","first-page":"58","DOI":"10.4103\/0976-237X.149293","volume":"6","author":"R Shashni","year":"2015","unstructured":"Shashni R, Goyal A, Gauba K, Utreja AK, Ray P, Jena AK. Comparison of risk indicators of dental caries in children with and without cleft lip and palate deformities. Contemp Clin Dent. 2015;6(1):58\u201362.","journal-title":"Contemp Clin Dent"},{"issue":"2","key":"5494_CR26","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3109\/00016357.2015.1044562","volume":"74","author":"AL Sundell","year":"2016","unstructured":"Sundell AL, Nilsson AK, Ullbro C, Twetman S, Marcusson A. Caries prevalence and enamel defects in 5- and 10-year-old children with cleft lip and\/or palate: A case-control study. Acta Odontol Scand. 2016;74(2):90\u20135.","journal-title":"Acta Odontol Scand"},{"key":"5494_CR27","doi-asserted-by":"crossref","unstructured":"Lindhe J, Axelsson P, Tollskog G. Effect of proper oral hygiene on gingivitis and dental caries in Swedish schoolchildren. Commun Dent Oral Epidemiol. 1975;3(4):150\u20135.","DOI":"10.1111\/j.1600-0528.1975.tb00299.x"},{"key":"5494_CR28","doi-asserted-by":"crossref","unstructured":"Mutthineni RB, Nutalapati R, Kasagani SK. Comparison of oral hygiene and periodontal status in patients with clefts of palate and patients with unilateral cleft lip, palate and alveolus. J Indian Soc Periodontol. 2010;14(4):236\u201340.","DOI":"10.4103\/0972-124X.76928"},{"issue":"6","key":"5494_CR29","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.11607\/prd.3461","volume":"37","author":"P Plakwicz","year":"2017","unstructured":"Plakwicz P, Wyr\u0119bek B, G\u00f3rska R, Cudzi\u0142o D. Periodontal indices and status in 34 growing patients with unilateral cleft lip and palate: a split-mouth study. Int J Periodontics Restorative Dent. 2017;37(6):e344\u201353.","journal-title":"Int J Periodontics Restorative Dent"},{"key":"5494_CR30","doi-asserted-by":"crossref","unstructured":"Quirynen M DSMDK van SD. The intra-oral translocation of periodontopathogens jeopardises the outcome of periodontal therapy. A review of the literature. J Clin Periodontol. 2001;28(6):499\u2013507.","DOI":"10.1034\/j.1600-051x.2001.028006499.x"},{"key":"5494_CR31","doi-asserted-by":"publisher","first-page":"852","DOI":"10.37349\/emed.2024.00260","volume":"5","author":"A Pardo","year":"2024","unstructured":"Pardo A, Barilli A, Signoriello A, Gualtieri M, Brancato G, Colapinto G, et al. Oral health conditions and hygiene procedures in patients with Parkinson\u2019s disease: a systematic review. Explor Med. 2024;5:852\u201369. https:\/\/doi.org\/10.37349\/emed.2024.00260.","journal-title":"Explor Med."},{"key":"5494_CR32","doi-asserted-by":"publisher","first-page":"3874","DOI":"10.3390\/jcm10173874","volume":"10","author":"A Pardo","year":"2021","unstructured":"Pardo A, Signoriello A, Signoretto C, Messina E, Carelli M, Tessari M, De Manna ND, Rossetti C, Albanese M, Lombardo G, et al. Detection of periodontal pathogens in oral samples and cardiac specimens in patients undergoing aortic valve replacement: a pilot study. J Clin Med. 2021;10:3874.","journal-title":"J Clin Med"},{"issue":"6","key":"5494_CR33","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/MBC.0000000000000928","volume":"31","author":"R Nocini","year":"2020","unstructured":"Nocini R, Favaloro EJ, Sanchis-Gomar F, Lippi G. Periodontitis, coronary heart disease and myocardial infarction: treat one, benefit all. Blood Coagul Fibrinolysis. 2020;31(6):339\u201345. https:\/\/doi.org\/10.1097\/MBC.0000000000000928. PMID: 32815910.","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"1","key":"5494_CR34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/prd.12398","volume":"87","author":"YL Kapila","year":"2021","unstructured":"Kapila YL. Oral health\u2019s inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions. Periodontol 2000. 2021;87(1):11\u20136. https:\/\/doi.org\/10.1111\/prd.12398.","journal-title":"Periodontol 2000."},{"key":"5494_CR35","doi-asserted-by":"crossref","unstructured":"Nocini R, Lippi G, Mattiuzzi C. Periodontal disease: the portrait of an epidemic. J Publ Health Emerg. 2020;4[0]. [cited 2024 November 25]. Available from: https:\/\/jphe.amegroups.org\/article\/view\/5774.","DOI":"10.21037\/jphe.2020.03.01"},{"key":"5494_CR36","doi-asserted-by":"crossref","unstructured":"Wu Q, Li Z, Zhang Y, Peng X, Zhou X. Dental caries and periodontitis risk factors in cleft lip and palate patients. Front Pediatr. 2023;10:1092809","DOI":"10.3389\/fped.2022.1092809"},{"key":"5494_CR37","doi-asserted-by":"crossref","unstructured":"Fritz A, Jodeh DS, Qamar F, Cray JJ, Rottgers SA. Patients with a history of oronasal fistula repair exhibit lower oral health measured with patient-centric outcomes measures. Cleft Palate Craniofac J. 2021;58(9):1142\u20139.","DOI":"10.1177\/1055665620981331"},{"key":"5494_CR38","doi-asserted-by":"crossref","unstructured":"Salvi GE, Br\u00e4gger U, Lang NP. Periodontal attachment loss over 14 years in cleft lip, alveolus and palate (CLAP, CL, CP) subjects not enrolled in a supportive periodontal therapy program. J Clin Periodontol. 2003;30(9):840\u20135.","DOI":"10.1034\/j.1600-051X.2003.00390.x"},{"issue":"10","key":"5494_CR39","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1111\/j.1600-051X.2009.01469.x","volume":"36","author":"G Huynh-Ba","year":"2009","unstructured":"Huynh-Ba G, Br\u00e4gger U, Zwahlen M, Lang NP, Salvi GE. Periodontal disease progression in subjects with orofacial clefts over a 25-year follow-up period. J Clin Periodontol. 2009;36(10):836\u201342.","journal-title":"J Clin Periodontol"},{"key":"5494_CR40","doi-asserted-by":"crossref","unstructured":"Nyman S LJRB. Periodontal surgery in plaque-infected dentitions. J Clin Periodontol. 1977;4(4):240\u20139.","DOI":"10.1111\/j.1600-051X.1977.tb01896.x"},{"key":"5494_CR41","doi-asserted-by":"crossref","unstructured":"Wilson TG Jr, Glover ME, Malik AK, Schoen JA, Dorsett D. Tooth loss in maintenance patients in a private periodontal practice. J Periodontol. 1987;58(4):231\u20135.","DOI":"10.1902\/jop.1987.58.4.231"},{"key":"5494_CR42","doi-asserted-by":"crossref","unstructured":"L\u00f6e H, Anerud A, Boysen H, Morrison E. Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. J Clin Periodontol. 1986;13(5):431\u201345.","DOI":"10.1111\/j.1600-051X.1986.tb01487.x"},{"key":"5494_CR43","doi-asserted-by":"crossref","unstructured":"Vale F, Correia L, Guimar\u00e3es A, Caramelo F, Francisco I. Salivary counts of Streptococcus mutans and Lactobacillus in patients with and without cleft lip and\/or palate undergoing orthodontic treatment: A meta-analysis. Int J Dent Hyg. 2022;20(1):112-9.","DOI":"10.1111\/idh.12503"},{"key":"5494_CR44","doi-asserted-by":"crossref","unstructured":"Alansari N, Abed H, Abid M. Oral flora and functional dysbiosis of cleft lip and palate patients: A scoping review. Special Care in Dentistry. John Wiley and Sons Inc; 2023.","DOI":"10.1111\/scd.12872"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-05494-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-025-05494-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-05494-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T01:12:17Z","timestamp":1738113137000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-025-05494-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5494"],"URL":"https:\/\/doi.org\/10.1186\/s12903-025-05494-5","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]},"assertion":[{"value":"29 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"154"}}