{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:19:20Z","timestamp":1772165960735,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-025-05514-4","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:19:26Z","timestamp":1738235966000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Denosumab usage in atypical cemento-osseous dysplasia involving the entire mandible: a case report"],"prefix":"10.1186","volume":"25","author":[{"given":"Chieh","family":"Ling Chiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu","family":"Huan Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"issue":"3","key":"5514_CR1","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/0030-4220(73)90072-8","volume":"35","author":"CA Waldron","year":"1973","unstructured":"Waldron CA, Giansanti JS. Benign fibro-osseous lesions of the jaws: a clinical-radiologic-histologic review of sixty-five cases. II. Benign fibro-osseous lesions of periodontal ligament origin. Oral Surg Oral Med Oral Pathol. 1973;35(3):340\u201350.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"5514_CR2","doi-asserted-by":"publisher","first-page":"108074","DOI":"10.1016\/j.ijscr.2023.108074","volume":"105","author":"P Gr\u00fcn","year":"2023","unstructured":"Gr\u00fcn P, Schneider B, Bandura P, Pfaffeneder-Mantai F, Bytyqi D, Turhani D. Bone remodelling after minimally invasive surgical management of a recurrent florid cemento-osseous dysplasia in a caucasian woman \u2013 18 years follow-up of a unique case - a case report. Int J Surg Case Rep. 2023;105:108074.","journal-title":"Int J Surg Case Rep"},{"key":"5514_CR3","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.ijscr.2018.11.036","volume":"53","author":"P Gr\u00fcn","year":"2018","unstructured":"Gr\u00fcn P, Bandura P, Gr\u00fcn A, Sutter W, Meller O, Turhani D. Sensory disturbance along the inferior alveolar nerve as a first clinical sign of multiple florid cemento-osseous dysplasia of the mandible-A case report. Int J Surg Case Rep. 2018;53:452\u20137.","journal-title":"Int J Surg Case Rep"},{"issue":"8","key":"5514_CR4","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1097\/SCS.0000000000003095","volume":"27","author":"MB Cavalcante","year":"2016","unstructured":"Cavalcante MB, de Oliveira Lima AL, J\u00fanior MA, Santos MB. Florid Cemento-Osseous Dysplasia Simultaneous the Chronic Suppurative Osteomyelitis in Mandible. J Craniofac Surg. 2016;27(8):2173\u20136.","journal-title":"J Craniofac Surg"},{"issue":"2","key":"5514_CR5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s11914-021-00657-z","volume":"19","author":"KS Pan","year":"2021","unstructured":"Pan KS, Boyce AM. Denosumab Treatment for Giant Cell Tumors, Aneurysmal Bone cysts, and fibrous dysplasia-risks and benefits. Curr Osteoporos Rep. 2021;19(2):141\u201350.","journal-title":"Curr Osteoporos Rep"},{"issue":"12","key":"5514_CR6","doi-asserted-by":"publisher","first-page":"6069","DOI":"10.1210\/jc.2018-02543","volume":"104","author":"BCJ Majoor","year":"2019","unstructured":"Majoor BCJ, Papapoulos SE, Dijkstra PDS, Fiocco M, Hamdy NAT, Appelman-Dijkstra NM. Denosumab in patients with fibrous dysplasia previously treated with bisphosphonates. J Clin Endocrinol Metab. 2019;104(12):6069\u201378.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"5514_CR7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s12105-021-01404-7","volume":"16","author":"M Vered","year":"2022","unstructured":"Vered M, Wright JM. Update from the 5th Edition of the World Health Organization Classification of Head and Neck tumors: odontogenic and maxillofacial bone tumours. Head Neck Pathol. 2022;16(1):63\u201375.","journal-title":"Head Neck Pathol"},{"issue":"4","key":"5514_CR8","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s12105-014-0590-0","volume":"8","author":"SK El-Mofty","year":"2014","unstructured":"El-Mofty SK. Fibro-Osseous lesions of the Craniofacial Skeleton: an update. Head Neck Pathol. 2014;8(4):432\u201344.","journal-title":"Head Neck Pathol"},{"issue":"1","key":"5514_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.crad.2014.06.022","volume":"70","author":"DS MacDonald","year":"2015","unstructured":"MacDonald DS. Maxillofacial fibro-osseous lesions. Clin Radiol. 2015;70(1):25\u201336.","journal-title":"Clin Radiol"},{"issue":"1","key":"5514_CR10","doi-asserted-by":"publisher","first-page":"e2277","DOI":"10.1002\/mgg3.2277","volume":"12","author":"Z Zhou","year":"2024","unstructured":"Zhou Z, Zhang Y, Zhu L, Cui Y, Gao Y, Zhou CX. Familial gigantiform cementoma with recurrent ANO5 p.Cys356Tyr mutations: Clinicopathological and genetic study with literature review. Mol Genet Genom Med. 2024;12(1):e2277.","journal-title":"Mol Genet Genom Med"},{"issue":"12 Suppl","key":"5514_CR11","doi-asserted-by":"publisher","first-page":"S87","DOI":"10.1016\/j.joms.2015.05.010","volume":"73","author":"SB Woo","year":"2015","unstructured":"Woo SB. Central Cemento-Ossifying Fibroma: primary odontogenic or osseous neoplasm? J Oral Maxillofac Surg. 2015;73(12 Suppl):S87\u201393.","journal-title":"J Oral Maxillofac Surg"},{"issue":"2","key":"5514_CR12","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.tripleo.2005.06.011","volume":"101","author":"MJ Aldred","year":"2006","unstructured":"Aldred MJ, Talacko AA, Savarirayan R, Murdolo V, Mills AE, Radden BG, Alimov A, Villablanca A, Larsson C. Dental findings in a family with hyperparathyroidism\u2013jaw tumor syndrome and a novel HRPT2 gene mutation. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology. 2006;101(2):212\u20138.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology"},{"key":"5514_CR13","doi-asserted-by":"publisher","first-page":"101058","DOI":"10.1016\/j.bonr.2021.101058","volume":"14","author":"ME Meier","year":"2021","unstructured":"Meier ME, van der Bruggen W, van de Sande MAJ, Appelman-Dijkstra NM. Regression of fibrous dysplasia in response to denosumab therapy: a report of two cases. Bone Rep. 2021;14:101058.","journal-title":"Bone Rep"},{"issue":"1","key":"5514_CR14","doi-asserted-by":"publisher","first-page":"105260","DOI":"10.1016\/j.jbspin.2021.105260","volume":"89","author":"J Maximen","year":"2022","unstructured":"Maximen J, Robin F, Tronchot A, Rossetti A, Ropars M, Guggenbuhl P. Denosumab in the management of Aneurysmal bone cyst. Joint Bone Spine. 2022;89(1):105260.","journal-title":"Joint Bone Spine"},{"key":"5514_CR15","doi-asserted-by":"crossref","unstructured":"Borkowska AM, Szumera-Cie\u0107kiewicz A, Szostakowski B, Pie\u0144kowski A, Rutkowski PL. Denosumab in Giant Cell Tumor of bone: Multidisciplinary Medical Management based on pathophysiological mechanisms and real-world evidence. Cancers (Basel) 2022, 14(9).","DOI":"10.3390\/cancers14092290"},{"issue":"5","key":"5514_CR16","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.tripleo.2009.12.016","volume":"109","author":"MM Patel","year":"2010","unstructured":"Patel MM, Wilkey JF, Abdelsayed R, D\u2019Silva NJ, Malchoff C, Mallya SM. Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(5):739\u201343.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"7","key":"5514_CR17","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1038\/modpathol.2012.223","volume":"26","author":"F Tabareau-Delalande","year":"2013","unstructured":"Tabareau-Delalande F, Collin C, Gomez-Brouchet A, Decouvelaere AV, Bouvier C, Larousserie F, Marie B, Delfour C, Aubert S, Rosset P, et al. Diagnostic value of investigating GNAS mutations in fibro-osseous lesions: a retrospective study of 91 cases of fibrous dysplasia and 40 other fibro-osseous lesions. Mod Pathol. 2013;26(7):911\u201321.","journal-title":"Mod Pathol"},{"key":"5514_CR18","doi-asserted-by":"crossref","unstructured":"Kim HY, Shim JH, Heo CY. A rare skeletal disorder, fibrous dysplasia: a review of its pathogenesis and therapeutic prospects. Int J Mol Sci 2023, 24(21).","DOI":"10.3390\/ijms242115591"},{"key":"5514_CR19","doi-asserted-by":"crossref","unstructured":"G\u00fcnhan \u00d6, Kahraman D, Yal\u00e7\u0131n \u00dcK. The possible pathogenesis of cemento-osseous dysplasia: a case series and discussion. Adv Oral Maxillofacial Surg 2021, 3.","DOI":"10.1016\/j.adoms.2021.100105"},{"issue":"3","key":"5514_CR20","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.pathol.2022.10.006","volume":"55","author":"S Haefliger","year":"2023","unstructured":"Haefliger S, Turek D, Andrei V, Alborelli I, Calgua B, Ameline B, Harder D, Baumhoer D. Cemento-osseous dysplasia is caused by RAS-MAPK activation. Pathology. 2023;55(3):324\u20138.","journal-title":"Pathology"},{"key":"5514_CR21","doi-asserted-by":"publisher","first-page":"116819","DOI":"10.1016\/j.bone.2023.116819","volume":"174","author":"MC Trojani","year":"2023","unstructured":"Trojani MC, Gensburger D, Bagouet F, Cortet B, Couture G, Marcelli C, Mehsen Cetre N, Breuil V, Chapurlat R. Denosumab use in bone fibrous dysplasia refractory to bisphosphonate: a retrospective multicentric study. Bone. 2023;174:116819.","journal-title":"Bone"},{"issue":"12","key":"5514_CR22","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/S1470-2045(19)30663-1","volume":"20","author":"S Chawla","year":"2019","unstructured":"Chawla S, Blay JY, Rutkowski P, Le Cesne A, Reichardt P, Gelderblom H, Grimer RJ, Choy E, Skubitz K, Seeger L, et al. Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study. Lancet Oncol. 2019;20(12):1719\u201329.","journal-title":"Lancet Oncol"},{"issue":"1","key":"5514_CR23","first-page":"e3989","volume":"11","author":"I Alhumaid","year":"2019","unstructured":"Alhumaid I, Abu-Zaid A. Denosumab Therapy in the management of Aneurysmal Bone cysts: a Comprehensive Literature Review. Cureus. 2019;11(1):e3989.","journal-title":"Cureus"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-05514-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-025-05514-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-05514-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:19:30Z","timestamp":1738235970000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-025-05514-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5514"],"URL":"https:\/\/doi.org\/10.1186\/s12903-025-05514-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5135664\/v1","asserted-by":"object"}]},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"assertion":[{"value":"23 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"A written informed consent was obtained from the patient for publication of this Case report and any accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"164"}}