{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:19:17Z","timestamp":1772165957839,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Incisive Technologies Pty Ltd, Australia"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this study was to compare, in vitro, two dentinal caries lesion detector methods, Caries Finder and BlueCheck, to determine if they were substantially equivalent in their ability to aid visualization of demineralized dentin and to also to compare their performance compared to the traditional visual\/tactile method of dentinal caries lesion detection in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty-five extracted human teeth containing lesions rated as ICDAS 4,5 or 6 were chosen and then randomly assigned to two groups. Specimens were then evaluated in standard operatory conditions by three evaluators using the traditional visual and tactile method, the Caries Finder method, and the BlueCheck method of detection. The study employed a parallel, randomized controlled study design. To test the equivalence claim, a \u201ctwo-one sided test\u201d (TOST) approach was utilized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      As compared to the traditional method, the Caries Finder method had a 0.9742 accuracy, 95% confidence interval [0.9578, 0.9855], 94.80% sensitivity, 98.53% specificity, 96.47% positive predictive value, 97.82% negative predictive value, 0.938 Kappa value,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20092.2e-16). The BlueCheck method had a 0.9821 accuracy, 95% confidence interval [0.9682, 0.9910], 96.02% sensitivity, 99.09% specificity, 97.69% positive predictive value, 98.42% negative predictive value, 0.956 Kappa value,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20092.2e-16). Inter-rater reliability and intra-rater reliability ratings were good to excellent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of this study support the conclusion that the Caries Finder and BlueCheck methods compare favorably with the traditional method of carious dentin detection. Caries Finder and BlueCheck detection methods were found to have comparable performance in their ability to differentiate carious dentin from healthy tooth structure in vitro; however further in vivo validation is required to confirm clinical equivalence. Both show good to excellent inter-rater and intra-rater reliability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-025-05596-0","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T03:29:48Z","timestamp":1739935788000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of two methods for detecting carious dentin: an in vitro study"],"prefix":"10.1186","volume":"25","author":[{"given":"Joel","family":"White","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfa","family":"Yansane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja","family":"Kukreti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pragati","family":"Nahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Orobia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Plack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram","family":"Vaderhobli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Magnum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Jenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"issue":"4","key":"5596_CR1","first-page":"195","volume":"66","author":"D McComb","year":"2000","unstructured":"McComb D. 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Institutional Review Board was not required for using de-identified tooth specimens in an in vitro study. The samples used in this study were collected by the University of California, San Francisco School of Dentistry. Permission to use these materials was obtained from the University of California, San Francisco School of Dentistry.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable for this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Competing Interest Statement: Authors who are employees of Incisive Technologies and the independent statistical consultant paid by Incisive Technologies Pty Ltd, participated in the study design, analysis, review and editing of the manuscript. Author JM was\u00a0an employee of Incisive Technologies Pty Ltd. at the time of the study\u00a0and has no financial interest in Danville Materials Inc. Author RJ is a paid consultant for this paper and has no financial interest in Incisive Technologies Pty Ltd or Danville Materials Inc. Author LJ is an independent writing consultant paid, for this study, by Incisive Technologies Pty. Ltd. and has no other financial interest in Incisive Technologies Pty Ltd. or Danville Materials Inc. Authors, PK, PO, and PN are dental students at UCSF and have no financial interest in Incisive Technologies Pty Ltd. or Danville Materials Inc. Authors, JW and AY, RV and LP are employees of UCSF and have no financial interest in either Incisive Technologies Pty Ltd. or Danville Materials Inc.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"258"}}