{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:20:06Z","timestamp":1779250806473,"version":"3.51.4"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005322","name":"Recep Tayyip Erdogan \u00dcniversitesi","doi-asserted-by":"publisher","award":["TSA-2021-1249"],"award-info":[{"award-number":["TSA-2021-1249"]}],"id":[{"id":"10.13039\/501100005322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-025-06074-3","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:13:16Z","timestamp":1747224796000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of AMY1 gene copy number variation in dental caries susceptibility: insights from a Turkish population"],"prefix":"10.1186","volume":"25","author":[{"given":"\u00d6mer","family":"Hatipo\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faruk","family":"Saydam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"issue":"9","key":"6074_CR1","first-page":"711","volume":"83","author":"RG Watt","year":"2005","unstructured":"Watt RG. Strategies and approaches in oral disease prevention and health promotion. Bull WHO. 2005;83(9):711\u20138.","journal-title":"Bull WHO"},{"issue":"9555","key":"6074_CR2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","volume":"369","author":"RH Selwitz","year":"2007","unstructured":"Selwitz RH, Ismail AI, Pitts NB. Dental caries. Lancet. 2007;369(9555):51\u20139.","journal-title":"Lancet"},{"issue":"3","key":"6074_CR3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1177\/10454411940050030201","volume":"5","author":"FA Scannapieco","year":"1994","unstructured":"Scannapieco FA. Saliva-bacterium interactions in oral microbial ecology. Crit Rev Oral Biol Med. 1994;5(3):203\u201348.","journal-title":"Crit Rev Oral Biol Med"},{"issue":"3","key":"6074_CR4","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0272-2712(18)30802-3","volume":"6","author":"TE Mifflin","year":"1986","unstructured":"Mifflin TE, Hortin G, Bruns DE. Electrophoretic assays of amylase isoenzymes and isoforms. Clin Lab Med. 1986;6(3):583\u201399.","journal-title":"Clin Lab Med"},{"issue":"2","key":"6074_CR5","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1128\/AEM.02581-12","volume":"79","author":"AE Nikitkova","year":"2013","unstructured":"Nikitkova AE, Haase EM, Scannapieco FA. Taking the starch out of oral biofilm formation: molecular basis and functional significance of salivary \u03b1-amylase binding to oral Streptococci. Appl Environ Microbiol. 2013;79(2):416\u201323.","journal-title":"Appl Environ Microbiol"},{"issue":"3\u20134","key":"6074_CR6","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.micpath.2011.01.005","volume":"50","author":"N Okahashi","year":"2011","unstructured":"Okahashi N, Nakata M, Terao Y, Isoda R, Sakurai A, Sumitomo T, et al. Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation. Microb Pathog. 2011;50(3\u20134):148\u201354.","journal-title":"Microb Pathog"},{"issue":"6","key":"6074_CR7","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/eos.12743","volume":"128","author":"S Hancock","year":"2020","unstructured":"Hancock S, Zinn C, Schofield G. The consumption of processed sugar-and starch\u2010containing foods, and dental caries: a systematic review. Eur J Oral Sci. 2020;128(6):467\u201375.","journal-title":"Eur J Oral Sci"},{"issue":"2","key":"6074_CR8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.14295\/bds.2016.v19i2.1227","volume":"19","author":"F Ahmadi-Motamayel","year":"2016","unstructured":"Ahmadi-Motamayel F, Goodarzi MT, Jamshidi Z, Mahdavinezhad A, Rafieian N. Evaluation of salivary and serum alpha amylase level in dental caries of adolescence. Braz Dent Sci. 2016;19(2):40\u20136.","journal-title":"Braz Dent Sci"},{"issue":"3\u20134","key":"6074_CR9","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1177\/10454411930040030701","volume":"4","author":"FA Scannapieco","year":"1993","unstructured":"Scannapieco FA, Torres G, Levine MJ. Salivary alpha-amylase: role in dental plaque and caries formation. Crit Rev Oral Biol Med. 1993;4(3\u20134):301\u20137.","journal-title":"Crit Rev Oral Biol Med"},{"issue":"2","key":"6074_CR10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jobcr.2015.05.001","volume":"5","author":"S Singh","year":"2015","unstructured":"Singh S, Sharma A, Sood PB, Sood A, Zaidi I, Sinha A. Saliva as a prediction tool for dental caries: an in vivo study. J Oral Biol Craniofac Res. 2015;5(2):59\u201364.","journal-title":"J Oral Biol Craniofac Res"},{"issue":"1","key":"6074_CR11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40246-017-0097-3","volume":"11","author":"D Carpenter","year":"2017","unstructured":"Carpenter D, Mitchell LM, Armour JA. Copy number variation of human AMY1 is a minor contributor to variation in salivary amylase expression and activity. Hum Genomics. 2017;11(1):2.","journal-title":"Hum Genomics"},{"issue":"1","key":"6074_CR12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0888-7543(89)90083-9","volume":"5","author":"PC Groot","year":"1989","unstructured":"Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, et al. The human \u03b1-amylase multigene family consists of haplotypes with variable numbers of genes. Genomics. 1989;5(1):29\u201342.","journal-title":"Genomics"},{"issue":"12","key":"6074_CR13","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.1093\/hmg\/ddv098","volume":"24","author":"D Carpenter","year":"2015","unstructured":"Carpenter D, Dhar S, Mitchell LM, Fu B, Tyson J, Shwan NA, et al. Obesity, starch digestion and amylase: association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes. Hum Mol Genet. 2015;24(12):3472\u201380.","journal-title":"Hum Mol Genet"},{"issue":"10","key":"6074_CR14","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/ng1007-1188","volume":"39","author":"J Novembre","year":"2007","unstructured":"Novembre J, Pritchard JK, Coop G. Adaptive drool in the gene pool. Nat Genet. 2007;39(10):1188.","journal-title":"Nat Genet"},{"issue":"5","key":"6074_CR15","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0003-9969(00)00008-X","volume":"45","author":"M Lenander-Lumikari","year":"2000","unstructured":"Lenander-Lumikari M, Ihalin R, L\u00e4hteenoja H. Changes in whole saliva in patients with coeliac disease. Arch Oral Biol. 2000;45(5):347\u201354.","journal-title":"Arch Oral Biol"},{"issue":"12","key":"6074_CR16","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1111\/dme.12808","volume":"32","author":"YJ Choi","year":"2015","unstructured":"Choi YJ, Nam YS, Yun JM, Park JH, Cho BL, Son HY, et al. Association between salivary amylase (AMY1) gene copy numbers and insulin resistance in asymptomatic Korean men. Diabet Med. 2015;32(12):1588\u201395.","journal-title":"Diabet Med"},{"issue":"11","key":"6074_CR17","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1039\/c3mb70196d","volume":"9","author":"S Bencharit","year":"2013","unstructured":"Bencharit S, Baxter SS, Carlson J, Byrd WC, Mayo MV, Border MB, et al. Salivary proteins associated with hyperglycemia in diabetes: a proteomic analysis. Mol Biosyst. 2013;9(11):2785\u201397.","journal-title":"Mol Biosyst"},{"issue":"5","key":"6074_CR18","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/ng.2939","volume":"46","author":"M Falchi","year":"2014","unstructured":"Falchi M, Moustafa JSE-S, Takousis P, Pesce F, Bonnefond A, Andersson-Assarsson JC, et al. Low copy number of the salivary amylase gene predisposes to obesity. Nat Genet. 2014;46(5):492.","journal-title":"Nat Genet"},{"issue":"7","key":"6074_CR19","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1093\/infdis\/jiu231","volume":"210","author":"GT Spear","year":"2014","unstructured":"Spear GT, French AL, Gilbert D, Zariffard MR, Mirmonsef P, Sullivan TH, et al. Human \u03b1-amylase present in lower-genital-tract mucosal fluid processes glycogen to support vaginal colonization by Lactobacillus. J Infect Dis. 2014;210(7):1019\u201328.","journal-title":"J Infect Dis"},{"issue":"3","key":"6074_CR20","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nrg3871","volume":"16","author":"M Zarrei","year":"2015","unstructured":"Zarrei M, MacDonald JR, Merico D, Scherer SW. A copy number variation map of the human genome. Nat Rev Genet. 2015;16(3):172.","journal-title":"Nat Rev Genet"},{"issue":"3","key":"6074_CR21","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1159\/000514667","volume":"55","author":"L Stangvaltaite-Mouhat","year":"2021","unstructured":"Stangvaltaite-Mouhat L, P\u016brien\u0117 A, Aleksej\u016bnien\u0117 J, Stankeviciene I, Tommeras B, Al-Haroni M. Amylase alpha 1 gene (AMY1) copy number variation and dental caries experience: a pilot study among adults in Lithuania. Caries Res. 2021;55(3):174\u201382.","journal-title":"Caries Res"},{"key":"6074_CR22","doi-asserted-by":"crossref","unstructured":"Landis J. The measurement of observer agreement for categorical data. Biometrics. 1977.","DOI":"10.2307\/2529310"},{"issue":"2","key":"6074_CR23","doi-asserted-by":"publisher","first-page":"5986","DOI":"10.4238\/2015.June.1.16","volume":"14","author":"ZQ Li","year":"2015","unstructured":"Li ZQ, Hu XP, Zhou JY, Xie XD, Zhang JM. Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility. Genet Mol Res. 2015;14(2):5986\u201393.","journal-title":"Genet Mol Res"},{"issue":"4","key":"6074_CR24","doi-asserted-by":"publisher","first-page":"395","DOI":"10.17219\/dmp\/110453","volume":"56","author":"O Hatipoglu","year":"2019","unstructured":"Hatipoglu O, Saydam F. Effects of the carbonic anhydrase VI gene polymorphisms on dental caries: A meta-analysis. Dent Med Probl. 2019;56(4):395\u2013400.","journal-title":"Dent Med Probl"},{"issue":"3","key":"6074_CR25","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1159\/000345652","volume":"47","author":"GV Kulkarni","year":"2013","unstructured":"Kulkarni GV, Chng T, Eny KM, Nielsen D, Wessman C, El-Sohemy A. Association of GLUT2 and TAS1R2 genotypes with risk for dental caries. Caries Res. 2013;47(3):219\u201325.","journal-title":"Caries Res"},{"issue":"4","key":"6074_CR26","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1159\/000430958","volume":"49","author":"L Izakovicova Holla","year":"2015","unstructured":"Izakovicova Holla L, Borilova Linhartova P, Lucanova S, Kastovsky J, Musilova K, Bartosova M, et al. GLUT2 and TAS1R2 polymorphisms and susceptibility to dental caries. Caries Res. 2015;49(4):417\u201324.","journal-title":"Caries Res"},{"key":"6074_CR27","doi-asserted-by":"publisher","first-page":"100866","DOI":"10.1016\/j.mgene.2021.100866","volume":"28","author":"R Sharifi","year":"2021","unstructured":"Sharifi R, Shayan A, Jamshidy L, Mozaffari HR, Hatipo\u011flu \u00d6, Tadakamadla SK, et al. A systematic review and meta-analysis of CA VI, AMBN, and TUFT1 polymorphisms and dental caries risk. Meta Gene. 2021;28:100866.","journal-title":"Meta Gene"},{"issue":"4","key":"6074_CR28","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1601-0825.2011.01887.x","volume":"18","author":"T Olszowski","year":"2012","unstructured":"Olszowski T, Adler G, Janiszewska-Olszowska J, Safranow K, Kaczmarczyk M. MBL2, MASP2, AMELX, and ENAM gene polymorphisms and dental caries in Polish children. Oral Dis. 2012;18(4):389\u201395.","journal-title":"Oral Dis"},{"issue":"3","key":"6074_CR29","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.job.2020.06.004","volume":"62","author":"\u00d6 Hatipo\u011flu","year":"2020","unstructured":"Hatipo\u011flu \u00d6, Saydam F. Association between rs11362 polymorphism in the beta-defensin 1 (DEFB1) gene and dental caries: A meta-analysis. J Oral Biosci. 2020;62(3):272\u20139.","journal-title":"J Oral Biosci"},{"issue":"2","key":"6074_CR30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1080\/00016357.2020.1788722","volume":"79","author":"CLB Reis","year":"2021","unstructured":"Reis CLB, Barbosa MCF, Machado BMSM, Baratto SSP, de Lima DC, Paza AO, et al. Genetic polymorphisms in interleukin-6 and interleukin-1-beta were associated with dental caries and gingivitis. Acta Odontol Scand. 2021;79(2):96\u2013102.","journal-title":"Acta Odontol Scand"},{"issue":"2","key":"6074_CR31","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1590\/S1678-77572010000200011","volume":"18","author":"LF Azevedo","year":"2010","unstructured":"Azevedo LF, Pecharki GD, Brancher JA, Cordeiro Junior CA, Medeiros KGS, Antunes AA, et al. Analysis of the association between lactotransferrin (LTF) gene polymorphism and dental caries. J Appl Oral Sci. 2010;18(2):166\u201370.","journal-title":"J Appl Oral Sci"},{"issue":"1","key":"6074_CR32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1177\/0022034515605281","volume":"95","author":"G Yildiz","year":"2016","unstructured":"Yildiz G, Ermis RB, Calapoglu NS, Celik EU, Turel GY. Gene-environment interactions in the etiology of dental caries. J Dent Res. 2016;95(1):74\u20139.","journal-title":"J Dent Res"},{"issue":"3","key":"6074_CR33","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1177\/10454411930040030701","volume":"4","author":"FA Scannapieco","year":"1993","unstructured":"Scannapieco FA, Torres G, Levine MJ. Salivary \u03b1-amylase: role in dental plaque and caries formation. Crit Rev Oral Biol Med. 1993;4(3):301\u20137.","journal-title":"Crit Rev Oral Biol Med"},{"issue":"1","key":"6074_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.14295\/bds.2013.v16i1.873","volume":"16","author":"F Mojarad","year":"2013","unstructured":"Mojarad F, Fazlollahifar S, Poorolajal J, Hajilooi M. Effect of alpha amylase on early childhood caries: a matched case-control study. Braz Dent Sci. 2013;16(1):41\u20135.","journal-title":"Braz Dent Sci"},{"issue":"3","key":"6074_CR35","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/ipd.12249","volume":"27","author":"GN Borghi","year":"2017","unstructured":"Borghi GN, Rodrigues LP, Lopes LM, Parisotto TM, Steiner-Oliveira C, Nobre\u2010dos\u2010Santos M. Relationship among \u03b1 amylase and carbonic anhydrase VI in saliva, visible biofilm, and early childhood caries: a longitudinal study. Int J Paediatr Dent. 2017;27(3):174\u201382.","journal-title":"Int J Paediatr Dent"},{"issue":"5","key":"6074_CR36","doi-asserted-by":"publisher","first-page":"323","DOI":"10.17796\/1053-4625-45.5.6","volume":"45","author":"A Ahmad","year":"2021","unstructured":"Ahmad A, Kumar D, Singh A, Anand S, Agarwal N, Ahmad R. A comparative quantitative assessment of salivary Iga and alpha amylase in caries free and caries active children. J Clin Pediatr Dent. 2021;45(5):323\u20139.","journal-title":"J Clin Pediatr Dent"},{"issue":"12","key":"6074_CR37","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.37358\/RC.17.12.6022","volume":"68","author":"A Sitaru","year":"2017","unstructured":"Sitaru A, Tohati A, Pop AM, Bica C. Correlation between the salivary level of alpha-amylase and the risk for dental caries in young permanent teeth. Rev Chim. 2017;68(12):2984\u20136.","journal-title":"Rev Chim"},{"issue":"3\u20134","key":"6074_CR38","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1177\/00220345450240030401","volume":"24","author":"O Bergeim","year":"1945","unstructured":"Bergeim O, Barnfield WF. Lack of correlation between dental caries and salivary amylase. J Dent Res. 1945;24(3\u20134):141\u20132.","journal-title":"J Dent Res"},{"issue":"2","key":"6074_CR39","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/S1079-2104(97)90012-3","volume":"83","author":"MW Dodds","year":"1997","unstructured":"Dodds MW, Johnson DA, Mobley CC, Hattaway KM. Parotid saliva protein profiles in caries-free and caries-active adults. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83(2):244\u201351.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"3","key":"6074_CR40","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s00784-003-0222-7","volume":"7","author":"DG de Farias","year":"2003","unstructured":"de Farias DG, Bezerra ACB. Salivary antibodies, amylase and protein from children with early childhood caries. Clin Oral Investig. 2003;7(3):154\u20137.","journal-title":"Clin Oral Investig"},{"key":"6074_CR41","unstructured":"Prabhakar A, Shubha A, Mahantesh T. Estimation of calcium, phosphate and alpha amylase concentrations in stimulated whole saliva of children with different caries status: A comparative study. Malays Dent J 2008;29(1)."},{"key":"6074_CR42","doi-asserted-by":"crossref","unstructured":"da Silveira EG, Prato LS, Pilati SFM, Arthur RA. Comparison of oral cavity protein abundance among caries-free and caries-affected individuals\u2014a systematic review and meta-analysis. Front Oral Health 2023;4.","DOI":"10.3389\/froh.2023.1265817"},{"issue":"2","key":"6074_CR43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2334\/josnusd.42.83","volume":"42","author":"RE Noble","year":"2000","unstructured":"Noble RE. Salivary \u03b1-amylase and lysozyme levels: A non-invasive technique for measuring Parotid vs Submandibular\/sublingual gland activity. J Oral Sci. 2000;42(2):83\u20136.","journal-title":"J Oral Sci"},{"issue":"3","key":"6074_CR44","first-page":"117","volume":"5","author":"JL Santos","year":"2012","unstructured":"Santos JL, Saus E, Smalley SV, Cataldo LR, Alberti G, Parada J, et al. Copy number polymorphism of the salivary amylase gene: implications in human nutrition research. J Nutrigenet Nutrigenomics. 2012;5(3):117\u201331.","journal-title":"J Nutrigenet Nutrigenomics"},{"issue":"6","key":"6074_CR45","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.3390\/nu11061379","volume":"11","author":"CM Venkatapoorna","year":"2019","unstructured":"Venkatapoorna CM, Ayine P, Parra EP, Koenigs T, Phillips M, Babu JR, et al. Association of salivary amylase (AMY1) gene copy number with obesity in Alabama elementary school children. Nutrients. 2019;11(6):1379.","journal-title":"Nutrients"},{"issue":"3","key":"6074_CR46","doi-asserted-by":"publisher","first-page":"e0264692","DOI":"10.1371\/journal.pone.0264692","volume":"17","author":"N Al-Akl","year":"2022","unstructured":"Al-Akl N, Thompson RI, Arredouani A. Elevated levels of salivary \u03b1-amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study. PLoS ONE. 2022;17(3):e0264692.","journal-title":"PLoS ONE"},{"issue":"4","key":"6074_CR47","doi-asserted-by":"publisher","first-page":"e19091","DOI":"10.1371\/journal.pone.0019091","volume":"6","author":"JS Bae","year":"2011","unstructured":"Bae JS, Cheong HS, Kim J-H, Park BL, Kim J-H, Park TJ, et al. The genetic effect of copy number variations on the risk of type 2 diabetes in a Korean population. PLoS ONE. 2011;6(4):e19091.","journal-title":"PLoS ONE"},{"issue":"6","key":"6074_CR48","doi-asserted-by":"publisher","first-page":"112","DOI":"10.4239\/wjd.v7.i6.112","volume":"7","author":"K Nakajima","year":"2016","unstructured":"Nakajima K. Low serum amylase and obesity, diabetes and metabolic syndrome: A novel interpretation. World J Diabetes. 2016;7(6):112.","journal-title":"World J Diabetes"},{"issue":"1","key":"6074_CR49","first-page":"1","volume":"2","author":"T Shah","year":"2023","unstructured":"Shah T, Sugumaran S, Mehta A. The relationship between Insulin-dependent diabetes mellitus (Type 1 diabetes) and dental caries: A Meta-Analysis. J Endod Restor Dent. 2023;2(1):1\u20137.","journal-title":"J Endod Restor Dent"},{"issue":"3","key":"6074_CR50","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1159\/000484988","volume":"52","author":"D Chen","year":"2018","unstructured":"Chen D, Zhi Q, Zhou Y, Tao Y, Wu L, Lin H. Association between dental caries and BMI in children: A systematic review and Meta-Analysis. Caries Res. 2018;52(3):230\u201345.","journal-title":"Caries Res"},{"issue":"5","key":"6074_CR51","doi-asserted-by":"publisher","first-page":"e3527","DOI":"10.1002\/dmrr.3527","volume":"38","author":"\u00d6 Hatipo\u011flu","year":"2022","unstructured":"Hatipo\u011flu \u00d6, \u00d6ns\u00fcren AS, Hatipo\u011flu FP, Kurt A. Caries-related salivary parameters and oral microbial flora in patients with type 1 diabetes: A meta\u2010analysis. Diabetes Metab Res Rev. 2022;38(5):e3527.","journal-title":"Diabetes Metab Res Rev"},{"issue":"7","key":"6074_CR52","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.4103\/njcp.njcp_1760_21","volume":"25","author":"\u00d6 Hatipo\u011flu","year":"2022","unstructured":"Hatipo\u011flu \u00d6, Mara\u015f E, Hatipo\u011flu FP, Saygin A. Salivary flow rate, pH, and buffer capacity in the individuals with obesity and overweight; A meta-analysis. Niger J Clin Pract. 2022;25(7):1126\u201342.","journal-title":"Niger J Clin Pract"},{"key":"6074_CR53","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s40368-019-00463-3","volume":"21","author":"K Boustedt","year":"2020","unstructured":"Boustedt K, Dahlgren J, Twetman S, Roswall J. Tooth brushing habits and prevalence of early childhood caries: a prospective cohort study. Eur Arch Paediatr Dent. 2020;21:155\u20139.","journal-title":"Eur Arch Paediatr Dent"},{"issue":"3","key":"6074_CR54","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jdsr.2014.04.001","volume":"50","author":"H Hayasaki","year":"2014","unstructured":"Hayasaki H, Saitoh I, Nakakura-Ohshima K, Hanasaki M, Nogami Y, Nakajima T, et al. Tooth brushing for oral prophylaxis. Jpn Dent Sci Rev. 2014;50(3):69\u201377.","journal-title":"Jpn Dent Sci Rev"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-06074-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-025-06074-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-06074-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:06:14Z","timestamp":1747227974000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-025-06074-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6074"],"URL":"https:\/\/doi.org\/10.1186\/s12903-025-06074-3","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"28 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants provided an online informed consent to participate in the study and were assured that their information would be kept confdential. All study procedures were conducted in accordance with the ethical standards of the Declaration of Helsinki. Ethical approval was obtained by Clinical Research Ethics Committee of the Faculty of Medicine at Sutcu Imam University, during its meeting held on 02.10.2019. The study received approval, as it was deemed suitable with the committee\u2019s decision, numbered 2019\/254.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"722"}}