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The prevalence of oral lichen planus (OLP) in the general population is estimated to be between 0.5% and 2%, with a higher incidence observed in women aged between 30 and 80 years. The etiology of OLP remains unclear, which presents a significant challenge in terms of diagnosis and treatment. This systematic review assessed the efficacy of platelet-rich plasma (PRP) and injectable platelet-rich fibrin (i-PRF) in the treatment of OLP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A comprehensive literature search was conducted via multiple databases in accordance with the PRISMA 2020 guidelines.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of seven randomized controlled trials were subjected to analysis. It has been demonstrated that both PRP and i-PRF have the capacity to significantly improve clinical outcomes, including pain and lesion severity. However, the majority of studies have not demonstrated statistically significant differences between PRP\/i-PRF and corticosteroid treatments.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>While PRP and i-PRF demonstrate potential in alleviating symptoms and promoting tissue healing, their effectiveness appears to be analogous to that of corticosteroids in the majority of RCTs. Further high-quality, standardized studies are required to substantiate their function as alternative or adjunctive therapies in the management of OLP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>This systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) on 28 November 2024 (PROSPERO 2024 CRD42024615291).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12903-025-06189-7","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T13:41:23Z","timestamp":1748439683000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Use of platelet-rich plasma (PRP) and injectable platelet-rich fibrin (i-PRF) in oral lichen planus treatment: a systematic review of randomized controlled trials"],"prefix":"10.1186","volume":"25","author":[{"given":"Wojciech","family":"Niemczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Janik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw","family":"Niemczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"\u017burek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Cronshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Skaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Wiench","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"issue":"3","key":"6189_CR1","first-page":"129","volume":"87","author":"S Asch","year":"2011","unstructured":"Asch S, Goldenberg G. 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