{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:19:21Z","timestamp":1772165961748,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-025-06197-7","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:58:35Z","timestamp":1751435915000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Syndromic gingival fibromatosis associated with pathogenic variation in the voltage-gated potassium channel gene KCNH1: a case report and proposed treatment protocol"],"prefix":"10.1186","volume":"25","author":[{"given":"Nhat Minh","family":"Do","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Klienkoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"de Saint Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Jimenez-Armijo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00e9tan","family":"Caravello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Baer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Marcoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Clauss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Bloch-Zupan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"issue":"9","key":"6197_CR1","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.47391\/JPMA.6766","volume":"73","author":"P Chand","year":"2023","unstructured":"Chand P, Sulaiman A, Kirmani S. Potassium voltage-gated channel subfamily H member 1 (KCNH1) missense mutation causing epileptic encephalopathy and autistic behavior. J Pak Med Assoc. 2023;73(9):1894\u20136. https:\/\/doi.org\/10.47391\/JPMA.6766.","journal-title":"J Pak Med Assoc."},{"issue":"9","key":"6197_CR2","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1038\/s41431-021-00818-9","volume":"29","author":"KW Gripp","year":"2021","unstructured":"Gripp KW, et al. Syndromic disorders caused by gain-of-function variants in KCNH1, KCNK4, and KCNN3\u2014a subgroup of K+ channelopathies. Eur J Hum Genet. 2021;29(9):1384\u201395. https:\/\/doi.org\/10.1038\/s41431-021-00818-9.","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"6197_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/ng.3153","volume":"47","author":"C Simons","year":"2015","unstructured":"Simons C, et al. Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy. Nat Genet. 2015;47(1):73\u20137. https:\/\/doi.org\/10.1038\/ng.3153.","journal-title":"Nat Genet"},{"issue":"6","key":"6197_CR4","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/ng.3282","volume":"47","author":"F Kort\u00fcm","year":"2015","unstructured":"Kort\u00fcm F, et al. Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome. Nat Genet. 2015;47(6):661\u20137. https:\/\/doi.org\/10.1038\/ng.3282.","journal-title":"Nat Genet"},{"issue":"1","key":"6197_CR5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12881-016-0304-4","volume":"17","author":"A M\u00e9garban\u00e9","year":"2016","unstructured":"M\u00e9garban\u00e9 A, et al. Temple-Baraitser Syndrome and Zimmermann-Laband Syndrome: one clinical entity? BMC Med Genet. 2016;17(1):42. https:\/\/doi.org\/10.1186\/s12881-016-0304-4.","journal-title":"BMC Med Genet"},{"key":"6197_CR6","doi-asserted-by":"publisher","unstructured":"M Aubert Mucca et al. Patients with KCNH1 -related intellectual disability without distinctive features of Zimmermann-Laband\/Temple-Baraitser syndrome. J Med Genet. 2022; 59(5):505\u2011510 https:\/\/doi.org\/10.1136\/jmedgenet-2020-107511.","DOI":"10.1136\/jmedgenet-2020-107511"},{"issue":"6","key":"6197_CR7","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1007\/s00784-020-03682-x","volume":"25","author":"E Boutiou","year":"2021","unstructured":"Boutiou E, Ziogas IA, Giannis D, Doufexi AE. Hereditary gingival fibromatosis in children: a systematic review of the literature. Clin Oral Invest. 2021;25(6):3599\u2013607. https:\/\/doi.org\/10.1007\/s00784-020-03682-x.","journal-title":"Clin Oral Invest"},{"key":"6197_CR8","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","volume":"89","author":"DS Riley","year":"2017","unstructured":"Riley DS, et al. CARE guidelines for case reports: explanation and elaboration document. J Clin Epidemiol. 2017;89:218\u201335. https:\/\/doi.org\/10.1016\/j.jclinepi.2017.04.026.","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"6197_CR9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1684\/epd.2016.0830","volume":"18","author":"M Mastrangelo","year":"2016","unstructured":"Mastrangelo M, et al. Epilepsy in KCNH1 -related syndromes. Epileptic Disorders. 2016;18(2):123\u201336. https:\/\/doi.org\/10.1684\/epd.2016.0830.","journal-title":"Epileptic Disorders"},{"issue":"6","key":"6197_CR10","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1902\/jop.1967.38.6.610","volume":"38","author":"H L\u00f6e","year":"1967","unstructured":"L\u00f6e H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol. 1967;38(6):610\u20136. https:\/\/doi.org\/10.1902\/jop.1967.38.6.610.","journal-title":"J Periodontol"},{"key":"6197_CR11","doi-asserted-by":"publisher","unstructured":"V Geoffroy, et al. VaRank: a simple and powerful tool for ranking genetic variants. Peer J. 2015;3:e796 https:\/\/doi.org\/10.7717\/peerj.796.","DOI":"10.7717\/peerj.796"},{"issue":"1","key":"6197_CR12","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/cns.14001","volume":"29","author":"M Tian","year":"2023","unstructured":"Tian M, et al. Phenotypic expansion of KCNH1 -associated disorders to include isolated epilepsy and its associations with genotypes and molecular sub-regional locations. CNS Neurosci Ther. 2023;29(1):270\u201381. https:\/\/doi.org\/10.1111\/cns.14001.","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"6197_CR13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3390\/genes12020132","volume":"12","author":"R Von Wrede","year":"2021","unstructured":"Von Wrede R, et al. Novel KCNH1 Mutations Associated with Epilepsy: Broadening the Phenotypic Spectrum of KCNH1-Associated Diseases. Genes. 2021;12(2):132. https:\/\/doi.org\/10.3390\/genes12020132.","journal-title":"Genes"},{"key":"6197_CR14","doi-asserted-by":"publisher","unstructured":"J Law, Z Garrett, C Nye, et al. Speech and language therapy interventions for children with primary speech and language delay or disorder. Cochrane Database of Systematic Reviews, 2003;2015(5), https:\/\/doi.org\/10.1002\/14651858.CD004110.","DOI":"10.1002\/14651858.CD004110"},{"key":"6197_CR15","doi-asserted-by":"publisher","unstructured":"AS Lee, FE Gibbon. Non-speech oral motor treatment for children with developmental speech sound disorders. Cochrane Database of Systematic Reviews, 2019(9) https:\/\/doi.org\/10.1002\/14651858.CD009383.pub2.","DOI":"10.1002\/14651858.CD009383.pub2"},{"key":"6197_CR16","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jpeds.2021.11.010","volume":"242","author":"DL Putnick","year":"2022","unstructured":"Putnick DL, Bell EM, Ghassabian A, Robinson SL, Sundaram R, Yeung E, et al. Feeding problems as an indicator of developmental delay in early childhood. J Pediatr. 2022;242:184-191.e5. https:\/\/doi.org\/10.1016\/j.jpeds.2021.11.010.","journal-title":"J Pediatr"},{"key":"6197_CR17","doi-asserted-by":"publisher","unstructured":"K Charoenkwan, Z Iheozor-Ejiofor, K Rerkasem, E Matovinovic et al. Scalpel versus electrosurgery for major abdominal incisions. Cochrane Database Syst Rev 2017;2017(6) https:\/\/doi.org\/10.1002\/14651858.CD005987.pub3.","DOI":"10.1002\/14651858.CD005987.pub3"},{"issue":"6","key":"6197_CR18","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1089\/photob.2019.4713","volume":"38","author":"R Kawamura","year":"2020","unstructured":"Kawamura R, et al. Ex vivo evaluation of gingival ablation with various laser systems and electroscalpel. Photobiomodulation Photomedicine Laser Surg. 2020;38(6):364\u201373. https:\/\/doi.org\/10.1089\/photob.2019.4713.","journal-title":"Photobiomodulation Photomedicine Laser Surg"},{"issue":"1","key":"6197_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ijom.2019.05.012","volume":"49","author":"VGA Suter","year":"2020","unstructured":"Suter VGA, Altermatt HJ, Bornstein MM. A randomized controlled trial comparing surgical excisional biopsies using CO2 laser, Er:YAG laser and scalpel. Int J Oral Maxillofacial Surg. 2020;49(1):99\u2013106. https:\/\/doi.org\/10.1016\/j.ijom.2019.05.012.","journal-title":"Int J Oral Maxillofacial Surg"},{"key":"6197_CR20","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fgene.2018.00028","volume":"9","author":"TLR Silveira","year":"2018","unstructured":"Silveira TLR, et al. Gene and blood analysis reveal that transfer from brackish water to freshwater is more stressful to the silverside odontesthes humensis. Front Genet. 2018;9:28. https:\/\/doi.org\/10.3389\/fgene.2018.00028.","journal-title":"Front Genet"},{"key":"6197_CR21","doi-asserted-by":"publisher","unstructured":"Y Sang, MRoest, B De Laat, PG De Groot, D Huskens, et al. Interplay between platelets and coagulation. Blood Rev. 2021;46:100733 https:\/\/doi.org\/10.1016\/j.blre.2020.100733.","DOI":"10.1016\/j.blre.2020.100733"},{"key":"6197_CR22","doi-asserted-by":"publisher","unstructured":"A Fajardo, F Olmos, L Sarmiento, et al. Valproic acid and the risk of perioperative bleeding. Case report and literature review. Colombian J Anesthesiol. 2013;41(1):61\u201164 https:\/\/doi.org\/10.1016\/j.rcae.2012.07.007.","DOI":"10.1016\/j.rcae.2012.07.007"},{"issue":"2","key":"6197_CR23","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4103\/0970-2113.152646","volume":"32","author":"F Inzirillo","year":"2015","unstructured":"Inzirillo F, Giorgetta C, Ravalli E, Pona C, et al. Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature. Lung India. 2015;32(2):175. https:\/\/doi.org\/10.4103\/0970-2113.152646.","journal-title":"Lung India"},{"issue":"4","key":"6197_CR24","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/S2352-4642(22)00346-7","volume":"7","author":"SZ Raskoff","year":"2023","unstructured":"Raskoff SZ, Thurm A, Miguel HO, Kim SYH, Quezado ZMN, et al. Pain research and children and adolescents with severe intellectual disability: ethical challenges and imperatives. Lancet Child Adolescent Health. 2023;7(4):288\u201396. https:\/\/doi.org\/10.1016\/S2352-4642(22)00346-7.","journal-title":"Lancet Child Adolescent Health."},{"issue":"5","key":"6197_CR25","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/cch.12873","volume":"47","author":"D Reddihough","year":"2021","unstructured":"Reddihough D, et al. Comorbidities and quality of life in children with intellectual disability. Child. 2021;47(5):654\u201366. https:\/\/doi.org\/10.1111\/cch.12873.","journal-title":"Child"},{"issue":"11","key":"6197_CR26","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1097\/j.pain.0000000000000305","volume":"156","author":"DJ Crellin","year":"2015","unstructured":"Crellin DJ, Harrison D, Santamaria N, Babl FE, et al. Systematic review of the face, legs, activity, cry and consolability scale for assessing pain in infants and children: is it reliable, valid, and feasible for use? Pain. 2015;156(11):2132\u201351. https:\/\/doi.org\/10.1097\/j.pain.0000000000000305.","journal-title":"Pain"},{"issue":"1","key":"6197_CR27","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3390\/children10010090","volume":"10","author":"NM Do","year":"2023","unstructured":"Do NM, Clauss F, Schmitt M, Mani\u00e8re MC, et al. Influence of child\u2019s temperament on behaviour management problems in the dental office: a literature review. Children. 2023;10(1):90. https:\/\/doi.org\/10.3390\/children10010090.","journal-title":"Children."},{"issue":"9","key":"6197_CR28","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/S1474-4422(12)70153-9","volume":"11","author":"P Perucca","year":"2012","unstructured":"Perucca P, Gilliam FG, et al. Adverse effects of antiepileptic drugs. Lancet Neurol. 2012;11(9):792\u2013802. https:\/\/doi.org\/10.1016\/S1474-4422(12)70153-9.","journal-title":"Lancet Neurol"},{"issue":"1","key":"6197_CR29","doi-asserted-by":"publisher","first-page":"420","DOI":"10.2174\/1874210601711010420","volume":"11","author":"A Ram\u00edrez-R\u00e1miz","year":"2017","unstructured":"Ram\u00edrez-R\u00e1miz A, Brunet-LLobet L, Lahor-Soler E, Miranda-Rius J, et al. On the cellular and molecular mechanisms of drug-induced gingival overgrowth. Todent J. 2017;11(1):420\u201335. https:\/\/doi.org\/10.2174\/1874210601711010420.","journal-title":"Todent J"},{"issue":"9","key":"6197_CR30","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1902\/jop.1999.70.9.967","volume":"70","author":"T Ilgenli","year":"1999","unstructured":"Ilgenli T, Atilla G, Baylas H, et al. Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth Long-Term Results. J Periodontol. 1999;70(9):967\u201372. https:\/\/doi.org\/10.1902\/jop.1999.70.9.967.","journal-title":"J Periodontol"},{"key":"6197_CR31","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/16443.7069","author":"B Suneja","year":"2016","unstructured":"Suneja B. A clinical evaluation of gingival overgrowth in children on antiepileptic drug therapy. JCDR. 2016. https:\/\/doi.org\/10.7860\/JCDR\/2016\/16443.7069.","journal-title":"JCDR"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-06197-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-025-06197-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-06197-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:58:36Z","timestamp":1751435916000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-025-06197-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6197"],"URL":"https:\/\/doi.org\/10.1186\/s12903-025-06197-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6188721\/v1","asserted-by":"object"}]},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"9 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent about clinical management was obtained from the parents in this case.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the parents for the publication of any potentially identifiable images or data included in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"997"}}