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The aim of this study was investigate the association between mandible mobility with single nucleotide polymorphisms (SNPs) in gene encoding collagen type II alpha 1 chain (COL2A1).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Adolescents age from 10 to 14 years old without restrictions in mandibular movement were evaluated. The mandibular mobility was recorded using rule. Genomic DNA was obtained from saliva and the SNPs in COL2A1 gene (rs1793953 and rs2276454) were genotyped by real time polymerase chain reactions. One-way ANOVA with Tukey\u2019s post-test was used to compare the mean values of the mandibular mobility among genotypes in the co-dominant model. A linear regression analysis was also performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>99 adolescents were included (53 boys and 46 girls). Gender and age were not associated with mandibular movements. For the rs1793953, unassisted opening, assisted opening and contralateral movements were statistically different among genotypes. The rs2276454 was associated with larger protrusive movements, in patients carrying TT genotype presented higher protrusion mean values than CT and TT individuals (<jats:italic>p<\/jats:italic>\u2009=\u20090.0046).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our findings suggest that genes may play an essential role for the normal variation in mandibular movement and SNPs rs1793953 and rs2276454 in <jats:italic>COL2A1<\/jats:italic> may explain mandibular mobility variations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12903-025-06245-2","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T15:43:19Z","timestamp":1750866199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Involvement of the gene encoding the collagen type II alpha 1 chain in mandibular mobility"],"prefix":"10.1186","volume":"25","author":[{"given":"Bianca","family":"Cavalcante-Le\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Armando","family":"Brancher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Bertoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle Nascimento","family":"Meger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa Helena","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais","family":"Vilalba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ang\u00e9lica Hueb","family":"de Menezes-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flares","family":"Baratto-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kirschneck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Feltrin-Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika Calvano","family":"K\u00fcchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"6245_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.physbeh.2006.01.025","volume":"89","author":"A van der Bilt","year":"2006","unstructured":"van der Bilt A, Engelen L, Pereira LJ, van der Glas HW, Abbink JH. 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Clin Orthop Surg. 2014;6:379\u201384. https:\/\/doi.org\/10.4055\/cios.2014.6.4.379.","journal-title":"Clin Orthop Surg"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-06245-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-025-06245-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-06245-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T15:43:20Z","timestamp":1750866200000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-025-06245-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6245"],"URL":"https:\/\/doi.org\/10.1186\/s12903-025-06245-2","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"assertion":[{"value":"28 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This cross-sectional study followed the Declaration of Helsinki and was approved by the Research Ethics Committee of the Federal University of Paran\u00e1 (Process no. 2.006.086), participants received written information about the study, and signed consent was obtained from a parent for all parents\/guardians. The legal guardians who accepted that the minor take part in the study expressed their consent by providing a handwritten signature. Minor patients received a document suitable for their age and signed it with a handwritten signature. All patients were competent in reading and writing.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they did not use AI and AI-assisted technologies in the writing process.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of generative AI in scientific writing"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"958"}}