{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:53:46Z","timestamp":1781610826698,"version":"3.54.5"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Ulm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Caregivers of people with Angelman syndrome (AS) in Germany were surveyed to amend a lack of information on supportive and preventive oral care for persons in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Returned anonymized questionnaires that had been sent to the approx. 600 members of the German Angelman Syndrome Association were evaluated. The study was approved by the ethics committee of Witten\/Herdecke University (# 121\/2021).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 220 questionnaires for people with AS aged between 1 and 54 years old (mean age 17.0 years) were evaluated. Overall, 38.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200984) of the people with AS were younger than three years at their first dental appointment; 60.0% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009132) tooth brushed twice daily; 15.9% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935) brushed for 2\u20133\u00a0min; and 78.5% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009172) did not use dental hygiene products other than toothbrushes. Age-specific differences emerged: Although only 45.0% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945) of people with AS\u2009\u2265\u200918 years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009100) began tooth brushing in the first year of life, this increased to 69.7% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200989) for people with AS\u2009&lt;\u200918 years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009119). Also, while 76.5% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200991) of people with AS\u2009&lt;\u200918 years were usually assisted with tooth brushing by the same person, this applied to only 50.0% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950) of people with AS\u2009\u2265\u200918 years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; Chi-Square-Test).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There are age-dependent differences in tooth brushing behavior among people with AS. Irrespective of age and sex, nearly all people with AS required life-long oral health support at home. Professional oral health support, e.g., regular check-ups, individual prophylactic measures, and dental cleaning, remains essential for this group. Hence, efforts must be increased to develop and offer more interprofessional dental prophylaxis concepts for people with AS of all ages, from infancy to senescence. These findings accord with those for other groups of people with syndromic disorders, such as Down syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial number<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-025-06357-9","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T11:36:00Z","timestamp":1750851360000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral health care of people with Angelman syndrome in Germany \u2013 a questionnaire-based study"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5700-3144","authenticated-orcid":false,"given":"Peter","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Tantzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Fricke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Gerhard","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"issue":"6","key":"6357_CR1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1111\/j.1469-8749.2008.03035.x","volume":"7","author":"H Angelman","year":"1965","unstructured":"Angelman H, \u2018Puppet\u2019 Children A, Report on Three Cases. 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The study was approved by the ethics committee of Witten\/Herdecke University (#121\/2021).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"The consent to participate was given through voluntary anonymous participation in the questionnaire survey. Together with the questionnaire all members received an information letter about the procedure, the intention, etc. of the study. Due to the anonymous procedure, that was not appropriate to send an informed consent paper to be signed by a caregiver, because this would no longer have ensured anonymization. Thus sending a completed questionnaire to the study office constitutes an active decision to participate. Furthermore, the board of the \u201cAngelman e.V.\u201d consented to publication of the data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent statement and human ethics and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"959"}}