{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:38:13Z","timestamp":1788212293766,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Zunyi medical college graduate student scientific research funds","award":["ZYK259"],"award-info":[{"award-number":["ZYK259"]}]},{"name":"\"Future Clinical Doctor\" of Zunyi Medical University","award":["20211017"],"award-info":[{"award-number":["20211017"]}]},{"name":"Guizhou Health Planning Office Letter","award":["[2017] No. 24"],"award-info":[{"award-number":["[2017] No. 24"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81960204"],"award-info":[{"award-number":["81960204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-025-06484-3","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T07:44:58Z","timestamp":1751701498000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of platelet-derived bone enhancers used as adjuncts to deproteinized bovine bone matrix in maxillary sinus floor elevation: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"25","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-shan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni-ni","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,5]]},"reference":[{"issue":"6","key":"6484_CR1","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1007\/s00784-023-05005-2","volume":"27","author":"CAA Lemos","year":"2023","unstructured":"Lemos CAA, de Oliveira AS, Fa\u00e9 DS, et al. Do dental implants placed in patients with osteoporosis have higher risks of failure and marginal bone loss compared to those in healthy patients? A systematic review with meta-analysis. Clin Oral Investig. 2023;27(6):2483\u201393. https:\/\/doi.org\/10.1007\/s00784-023-05005-2.","journal-title":"Clin Oral Investig"},{"issue":"6","key":"6484_CR2","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1034\/j.1600-051x.2002.290601.x","volume":"29","author":"S Frankenthal","year":"2002","unstructured":"Frankenthal S, Nakhoul F, Machtei EE, et al. The effect of secondary hyperparathyroidism and hemodialysis therapy on alveolar bone and periodontium. J Clin Periodontol. 2002;29(6):479\u201383. https:\/\/doi.org\/10.1034\/j.1600-051x.2002.290601.x.","journal-title":"J Clin Periodontol"},{"issue":"1","key":"6484_CR3","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12903-023-03442-9","volume":"24","author":"L Song","year":"2024","unstructured":"Song L, Feng Z, Zhou Q, et al. Metagenomic analysis of healthy and diseased peri-implant microbiome under different periodontal conditions: a cross-sectional study. BMC Oral Health. 2024;24(1):105. https:\/\/doi.org\/10.1186\/s12903-023-03442-9. Published 2024 Jan 17.","journal-title":"BMC Oral Health."},{"issue":"5","key":"6484_CR4","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/j.1600-0501.2005.01148.x","volume":"16","author":"P Galindo-Moreno","year":"2005","unstructured":"Galindo-Moreno P, Fauri M, Avila-Ortiz G, Fern\u00e1ndez-Barbero JE, Cabrera-Le\u00f3n A, S\u00e1nchez-Fern\u00e1ndez E. Influence of alcohol and tobacco habits on peri-implant marginal bone loss: a prospective study. Clin Oral Implants Res. 2005;16(5):579\u201386. https:\/\/doi.org\/10.1111\/j.1600-0501.2005.01148.x.","journal-title":"Clin Oral Implants Res"},{"issue":"2","key":"6484_CR5","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/rb\/rby029","volume":"6","author":"E Wang","year":"2019","unstructured":"Wang E, Han J, Zhang X, Wu Y, Deng XL. Efficacy of a mineralized collagen bone-grafting material for peri-implant bone defect reconstruction in mini pigs. Regen Biomater. 2019;6(2):107\u201311. https:\/\/doi.org\/10.1093\/rb\/rby029.","journal-title":"Regen Biomater"},{"key":"6484_CR6","doi-asserted-by":"publisher","first-page":"e64","DOI":"10.1590\/1807-3107BOR-2018.vol32.0064IF","volume":"32","author":"MC Cavalcanti","year":"2018","unstructured":"Cavalcanti MC, Guirado TE, Sapata VM, et al. Maxillary sinus floor pneumatization and alveolar ridge resorption after tooth loss: a cross-sectional study. Braz Oral Res. 2018;32:e64. https:\/\/doi.org\/10.1590\/1807-3107BOR-2018.vol32.0064IF. 2.5 Q3. Published 2018 Aug 6.","journal-title":"Braz Oral Res."},{"issue":"10","key":"6484_CR7","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.3390\/molecules26103007","volume":"26","author":"R Zhao","year":"2021","unstructured":"Zhao R, Yang R, Cooper PR, Khurshid Z, Shavandi A, Ratnayake J. Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments. Molecules. 2021;26(10):3007. https:\/\/doi.org\/10.3390\/molecules26103007. Published 2021 May 18.","journal-title":"Molecules."},{"issue":"4","key":"6484_CR8","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/BOT.0000000000001420","volume":"33","author":"P Baldwin","year":"2019","unstructured":"Baldwin P, Li DJ, Auston DA, Mir HS, Yoon RS, Koval KJ. Autograft, Allograft, and Bone Graft Substitutes: Clinical Evidence and Indications for Use in the Setting of Orthopaedic Trauma Surgery. J Orthop Trauma. 2019;33(4):203\u201313. https:\/\/doi.org\/10.1097\/BOT.0000000000001420.","journal-title":"J Orthop Trauma"},{"issue":"Suppl 21","key":"6484_CR9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/jcpe.13058","volume":"46","author":"HJ Haugen","year":"2019","unstructured":"Haugen HJ, Lyngstadaas SP, Rossi F, Perale G. Bone grafts: which is the ideal biomaterial? J Clin Periodontol. 2019;46(Suppl 21):92\u2013102. https:\/\/doi.org\/10.1111\/jcpe.13058.","journal-title":"J Clin Periodontol"},{"issue":"2","key":"6484_CR10","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jpor.2017.08.010","volume":"62","author":"M Yamada","year":"2018","unstructured":"Yamada M, Egusa H. Current bone substitutes for implant dentistry. J Prosthodont Res. 2018;62(2):152\u201361. https:\/\/doi.org\/10.1016\/j.jpor.2017.08.010.","journal-title":"J Prosthodont Res"},{"issue":"1","key":"6484_CR11","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/jbm.b.34387","volume":"108","author":"AT Xu","year":"2020","unstructured":"Xu AT, Qi WT, Lin MN, Zhu YH, He FM. The optimization of sintering treatment on bovine-derived bone grafts for bone regeneration: in vitro and in vivo evaluation. J Biomed Mater Res B Appl Biomater. 2020;108(1):272\u201381. https:\/\/doi.org\/10.1002\/jbm.b.34387.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"2","key":"6484_CR12","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/cid.13070","volume":"24","author":"Y Wu","year":"2022","unstructured":"Wu Y, Xiao P, Xu A, He F. Radiographic assessment of deproteinized bovine bone mineral (DBBM) and collagen-stabilized DBBM for transalveolar sinus floor elevation: A 2-year retrospective cohort study. Clin Implant Dent Relat Res. 2022;24(2):176\u201387. https:\/\/doi.org\/10.1111\/cid.13070.","journal-title":"Clin Implant Dent Relat Res"},{"issue":"1","key":"6484_CR13","doi-asserted-by":"publisher","first-page":"93","DOI":"10.11607\/prd.4965","volume":"42","author":"YD Cho","year":"2022","unstructured":"Cho YD, Namgung DJ, Kim KH, et al. Long-Term Human Histologic Evaluation of Sinus Bone Augmentation and Simultaneous Implant Placement. Int J Periodontics Restorative Dent. 2022;42(1):93\u2013100. https:\/\/doi.org\/10.11607\/prd.4965.","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"2","key":"6484_CR14","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/cid.12730","volume":"21","author":"F Younes","year":"2019","unstructured":"Younes F, Cosyn J, De Bruyckere T, Cleymaet R, Eghbali A. A 2-year prospective case series on volumetric changes, PROMs, and clinical outcomes following sinus floor elevation using deproteinized bovine bone mineral as filling material. Clin Implant Dent Relat Res. 2019;21(2):301\u20139. https:\/\/doi.org\/10.1111\/cid.12730.","journal-title":"Clin Implant Dent Relat Res"},{"key":"6484_CR15","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.cytogfr.2021.11.003","volume":"64","author":"E Cecerska-Hery\u0107","year":"2022","unstructured":"Cecerska-Hery\u0107 E, Goszka M, Serwin N, et al. Applications of the regenerative capacity of platelets in modern medicine. Cytokine Growth Factor Rev. 2022;64:84\u201394. https:\/\/doi.org\/10.1016\/j.cytogfr.2021.11.003.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"4","key":"6484_CR16","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1016\/j.jcms.2013.05.029","volume":"42","author":"F Xuan","year":"2014","unstructured":"Xuan F, Lee CU, Son JS, Jeong SM, Choi BH. A comparative study of the regenerative effect of sinus bone grafting with platelet-rich fibrin-mixed Bio-Oss\u00ae and commercial fibrin-mixed Bio-Oss\u00ae: an experimental study. J Craniomaxillofac Surg. 2014;42(4):e47\u201350. https:\/\/doi.org\/10.1016\/j.jcms.2013.05.029.","journal-title":"J Craniomaxillofac Surg"},{"issue":"9","key":"6484_CR17","doi-asserted-by":"publisher","first-page":"5485","DOI":"10.1007\/s00784-023-05167-z","volume":"27","author":"CM de Almeida Malzoni","year":"2023","unstructured":"de Almeida Malzoni CM, Pichotano EC, Freitas de Paula LG, et al. Combination of leukocyte and platelet-rich fibrin and demineralized bovine bone graft enhanced bone formation and healing after maxillary sinus augmentation: a randomized clinical trial. Clin Oral Investig. 2023;27(9):5485\u201398. https:\/\/doi.org\/10.1007\/s00784-023-05167-z.","journal-title":"Clin Oral Investig."},{"key":"6484_CR18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535","volume":"339","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339: b2535.","journal-title":"BMJ"},{"issue":"8","key":"6484_CR19","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/j.1600-051X.2009.01437.x","volume":"36","author":"J Torres","year":"2009","unstructured":"Torres J, Tamimi F, Martinez PP, Alkhraisat MH, Linares R, Hern\u00e1ndez G, Torres-Macho J, L\u00f3pez-Cabarcos E. Effect of platelet-rich plasma on sinus lifting: a randomized-controlled clinical trial. J Clin Periodontol. 2009;36(8):677\u201387. https:\/\/doi.org\/10.1111\/j.1600-051X.2009.01437.x.","journal-title":"J Clin Periodontol"},{"issue":"4","key":"6484_CR20","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jcms.2011.04.020","volume":"40","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Tangl S, Huber CD, Lin Y, Qiu L, Rausch-Fan X. Effects of Choukroun\u2019s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a histological and histomorphometric study. J Craniomaxillofac Surg. 2012;40(4):321\u20138. https:\/\/doi.org\/10.1016\/j.jcms.2011.04.020.","journal-title":"J Craniomaxillofac Surg"},{"issue":"2","key":"6484_CR21","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/cid.12713","volume":"21","author":"EC Pichotano","year":"2019","unstructured":"Pichotano EC, de Molon RS, de Souza RV, Austin RS, Marcantonio E, Zandim-Barcelos DL. Evaluation of L-PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial. Clin Implant Dent Relat Res. 2019;21(2):253\u201362. https:\/\/doi.org\/10.1111\/cid.12713.","journal-title":"Clin Implant Dent Relat Res"},{"issue":"8","key":"6484_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00784-022-04515-9","volume":"26","author":"MM Harlos","year":"2022","unstructured":"Harlos MM, da Silva TB, Montagner PG, Teixeira LN, Gomes AV, Martinez EF. Histomorphometric evaluation of different graft associations for maxillary sinus elevation in wide antral cavities: a randomized controlled clinical trial. Clin Oral Investig. 2022;26(8):1\u20139. https:\/\/doi.org\/10.1007\/s00784-022-04515-9.","journal-title":"Clin Oral Investig"},{"issue":"10","key":"6484_CR23","doi-asserted-by":"publisher","first-page":"872","DOI":"10.7150\/ijms.5119","volume":"9","author":"M Tatullo","year":"2012","unstructured":"Tatullo M, Marrelli M, Cassetta M, Pacifici A, Stefanelli LV, Scacco S, Dipalma G, Pacifici L, Inchingolo F. Platelet Rich Fibrin (P.R.F.) in reconstructive surgery of atrophied maxillary bones: clinical and histological evaluations. Int J Med Sci. 2012;9(10):872\u201380. https:\/\/doi.org\/10.7150\/ijms.5119.","journal-title":"Int J Med Sci."},{"issue":"5","key":"6484_CR24","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1563\/AAID-JOI-D-13-00129","volume":"41","author":"N Bolukbasi","year":"2015","unstructured":"Bolukbasi N, Ersanl\u0131 S, Keklikoglu N, Basegmez C, Ozdemir T. Sinus Augmentation With Platelet-Rich Fibrin in Combination With Bovine Bone Graft Versus Bovine Bone Graft in Combination With Collagen Membrane. J Oral Implantol. 2015;41(5):586\u201395. https:\/\/doi.org\/10.1563\/AAID-JOI-D-13-00129.","journal-title":"J Oral Implantol"},{"issue":"10","key":"6484_CR25","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1016\/j.joms.2011.03.040","volume":"69","author":"F Cabbar","year":"2011","unstructured":"Cabbar F, G\u00fcler N, K\u00fcrkc\u00fc M, I\u015feri U, Sen\u00e7ift K. The effect of bovine bone graft with or without platelet-rich plasma on maxillary sinus floor augmentation. J Oral Maxillofac Surg. 2011;69(10):2537\u201347. https:\/\/doi.org\/10.1016\/j.joms.2011.03.040.","journal-title":"J Oral Maxillofac Surg"},{"issue":"5","key":"6484_CR26","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1097\/ID.0000000000000293","volume":"24","author":"S Taschieri","year":"2015","unstructured":"Taschieri S, Testori T, Corbella S, et al. Platelet-Rich Plasma and Deproteinized Bovine Bone Matrix in Maxillary Sinus Lift Surgery: A Split-Mouth Histomorphometric Evaluation. Implant Dent. 2015;24(5):592\u20137. https:\/\/doi.org\/10.1097\/ID.0000000000000293.","journal-title":"Implant Dent"},{"issue":"4","key":"6484_CR27","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3109\/09537104.2012.695033","volume":"24","author":"S Yilmaz","year":"2013","unstructured":"Yilmaz S, Karaca EO, Ipci SD, et al. Radiographic and histologic evaluation of platelet-rich plasma and bovine-derived xenograft combination in bilateral sinus augmentation procedure. Platelets. 2013;24(4):308\u201315. https:\/\/doi.org\/10.3109\/09537104.2012.695033.","journal-title":"Platelets"},{"issue":"1","key":"6484_CR28","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40729-019-0166-6","volume":"5","author":"L Batas","year":"2019","unstructured":"Batas L, Tsalikis L, Stavropoulos A. PRGF as adjunct to DBB in maxillary sinus floor augmentation: histological results of a pilot split-mouth study. Int J Implant Dent. 2019;5(1):14. https:\/\/doi.org\/10.1186\/s40729-019-0166-6.","journal-title":"Int J Implant Dent"},{"key":"6484_CR29","doi-asserted-by":"publisher","unstructured":"Elsharkawy RT, Khairy N, Elsharkawy RT. A 6-month histologic and histomorphometric assessment of xenograft or xenograft combined with plasma rich in growth factors versus autogenous bone in sinus augmentation: a randomized controlled trial. 2019;65:2067\u20132076. https:\/\/doi.org\/10.21608\/edj.2019.72034.","DOI":"10.21608\/edj.2019.72034"},{"issue":"1","key":"6484_CR30","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1708-8208.2009.00233.x","volume":"14","author":"E Anitua","year":"2012","unstructured":"Anitua E, Prado R, Orive G. Bilateral sinus elevation evaluating plasma rich in growth factors technology: a report of five cases. Clin Implant Dent Relat Res. 2012;14(1):51\u201360. https:\/\/doi.org\/10.1111\/j.1708-8208.2009.00233.x.","journal-title":"Clin Implant Dent Relat Res"},{"issue":"9","key":"6484_CR31","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.4103\/njcp.njcp_692_20","volume":"24","author":"HO Irdem","year":"2021","unstructured":"Irdem HO, Dolanmaz D, Esen A, \u00dcnl\u00fckal N, \u015eimsek S. Evaluation of the Effectiveness of Liquid Platelet-Rich Fibrin and Deproteinized Bovine Bone Mineral Mixture on Newly Formed Bone in Maxillary Sinus Augmentation: A Split-Mouth. Histomorphometric Study Niger J Clin Pract. 2021;24(9):1366\u201372. https:\/\/doi.org\/10.4103\/njcp.njcp_692_20.","journal-title":"Histomorphometric Study Niger J Clin Pract"},{"issue":"9","key":"6484_CR32","doi-asserted-by":"publisher","first-page":"5563","DOI":"10.1007\/s00784-021-03987-5","volume":"25","author":"G I\u015f\u0131k","year":"2021","unstructured":"I\u015f\u0131k G, \u00d6zden Y\u00fcce M, Ko\u00e7ak-Topba\u015f N, G\u00fcnbay T. Guided bone regeneration simultaneous with implant placement using bovine-derived xenograft with and without liquid platelet-rich fibrin: a randomized controlled clinical trial. Clin Oral Investig. 2021;25(9):5563\u201375. https:\/\/doi.org\/10.1007\/s00784-021-03987-5.","journal-title":"Clin Oral Investig"},{"issue":"3","key":"6484_CR33","doi-asserted-by":"publisher","first-page":"319","DOI":"10.11607\/prd.5491","volume":"43","author":"P Dragonas","year":"2023","unstructured":"Dragonas P, Prasad HS, Yu Q, Mayer ET, Fidel PL Jr. Bone Regeneration in Maxillary Sinus Augmentation Using Advanced Platelet-Rich Fibrin (A-PRF) and Plasma Rich in Growth Factors (PRGF): A Pilot Randomized Controlled Trial. Int J Periodontics Restorative Dent. 2023;43(3):319\u201327. https:\/\/doi.org\/10.11607\/prd.5491.","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"4","key":"6484_CR34","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.3390\/ma15041474","volume":"15","author":"E Gheno","year":"2022","unstructured":"Gheno E, Alves GG, Ghiretti R, et al. \u201cSticky Bone\u201d Preparation Device: A Pilot Study on the Release of Cytokines and Growth Factors. Materials (Basel). 2022;15(4):1474. https:\/\/doi.org\/10.3390\/ma15041474.","journal-title":"Materials (Basel)"},{"issue":"3","key":"6484_CR35","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1600-0501.2005.01115.x","volume":"16","author":"GM Raghoebar","year":"2005","unstructured":"Raghoebar GM, Schortinghuis J, Liem RS, Ruben JL, van der Wal JE, Vissink A. Does platelet-rich plasma promote remodeling of autologous bone grafts used for augmentation of the maxillary sinus floor? Clin Oral Implants Res. 2005;16(3):349\u201356. https:\/\/doi.org\/10.1111\/j.1600-0501.2005.01115.x.","journal-title":"Clin Oral Implants Res"},{"issue":"3","key":"6484_CR36","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.tripleo.2005.07.012","volume":"101","author":"J Choukroun","year":"2006","unstructured":"Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):299\u2013303. https:\/\/doi.org\/10.1016\/j.tripleo.2005.07.012.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"issue":"1","key":"6484_CR37","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/jbm.a.36792","volume":"108","author":"J Zhang","year":"2020","unstructured":"Zhang J, Yin C, Zhao Q, et al. Anti-inflammation effects of injectable platelet-rich fibrin via macrophages and dendritic cells. J Biomed Mater Res A. 2020;108(1):61\u20138. https:\/\/doi.org\/10.1002\/jbm.a.36792.","journal-title":"J Biomed Mater Res A"},{"issue":"1","key":"6484_CR38","doi-asserted-by":"publisher","first-page":"72","DOI":"10.2174\/156720212799297119","volume":"9","author":"EG Argando\u00f1a","year":"2012","unstructured":"Argando\u00f1a EG, Bengoetxea H, Ortuzar N, Bulnes S, Rico-Barrio I, Lafuente JV. Vascular endothelial growth factor: adaptive changes in the neuroglialvascular unit. Curr Neurovasc Res. 2012;9(1):72\u201381. https:\/\/doi.org\/10.2174\/156720212799297119.","journal-title":"Curr Neurovasc Res"},{"issue":"11","key":"6484_CR39","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1111\/j.1600-0501.2009.01747.x","volume":"20","author":"WF Pedrosa Jr","year":"2009","unstructured":"Pedrosa WF Jr, Okamoto R, Faria PE, Arnez MF, Xavier SP, Salata LA. Immunohistochemical, tomographic and histological study on onlay bone graft remodeling. Part II: calvarial bone. Clin Oral Implants Res. 2009;20(11):1254\u201364. https:\/\/doi.org\/10.1111\/j.1600-0501.2009.01747.x.","journal-title":"Clin Oral Implants Res."},{"issue":"2","key":"6484_CR40","doi-asserted-by":"publisher","first-page":"111705","DOI":"10.1016\/j.isci.2024.111705","volume":"28","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Liu P, Xue X, et al. The role of platelet-rich plasma in biomedicine: A comprehensive overview. iScience. 2025;28(2):111705. https:\/\/doi.org\/10.1016\/j.isci.2024.111705.","journal-title":"iScience"},{"issue":"2","key":"6484_CR41","doi-asserted-by":"publisher","first-page":"C360","DOI":"10.1152\/ajpcell.00614.2008","volume":"297","author":"E Abed","year":"2009","unstructured":"Abed E, Moreau R. Importance of melastatin-like transient receptor potential 7 and magnesium in the stimulation of osteoblast proliferation and migration by platelet-derived growth factor. Am J Physiol Cell Physiol. 2009;297(2):C360\u20138. https:\/\/doi.org\/10.1152\/ajpcell.00614.2008.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"6484_CR42","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/term.2475","volume":"12","author":"E Dohle","year":"2018","unstructured":"Dohle E, El Bagdadi K, Sader R, Choukroun J, James Kirkpatrick C, Ghanaati S. Platelet-rich fibrin-based matrices to improve angiogenesis in an in vitro co-culture model for bone tissue engineering. J Tissue Eng Regen Med. 2018;12(3):598\u2013610. https:\/\/doi.org\/10.1002\/term.2475.","journal-title":"J Tissue Eng Regen Med"},{"issue":"9","key":"6484_CR43","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.archoralbio.2012.03.004","volume":"57","author":"BS Herrera","year":"2012","unstructured":"Herrera BS, Coimbra LS, Bastos AS, et al. Platelet-rich plasma stimulates cytokine expression and alkaline phosphatase activity in osteoblast-derived osteosarcoma cells. Arch Oral Biol. 2012;57(9):1282\u20139. https:\/\/doi.org\/10.1016\/j.archoralbio.2012.03.004.","journal-title":"Arch Oral Biol"},{"issue":"7","key":"6484_CR44","doi-asserted-by":"publisher","first-page":"646","DOI":"10.2460\/ajvr.80.7.646","volume":"80","author":"TSL Machado","year":"2019","unstructured":"Machado TSL, Massoco CO, Silva LCLC, F\u00fclber J, Moreira JJ, Baccarin RYA. Effects of blood-derived products and sodium hyaluronate on equine synovial fluid cells and on synovial fluid from osteochondrotic joints of horses after arthroscopy and administration of treatment. Am J Vet Res. 2019;80(7):646\u201356. https:\/\/doi.org\/10.2460\/ajvr.80.7.646.","journal-title":"Am J Vet Res"},{"issue":"4","key":"6484_CR45","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3390\/biology10040317","volume":"10","author":"E Mijiritsky","year":"2021","unstructured":"Mijiritsky E, Assaf HD, Peleg O, Shacham M, Cerroni L, Mangani L. Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation-A Narrative Review. Biology (Basel). 2021;10(4):317. https:\/\/doi.org\/10.3390\/biology10040317.","journal-title":"Biology (Basel)"},{"issue":"3","key":"6484_CR46","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1016\/j.tripleo.2005.07.011","volume":"101","author":"J Choukroun","year":"2006","unstructured":"Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e56\u201360. https:\/\/doi.org\/10.1016\/j.tripleo.2005.07.011.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"6484_CR47","doi-asserted-by":"publisher","unstructured":"Inchingolo F, Inchingolo AM, Latini G, et al. Guided Bone Regeneration: CGF and PRF Combined With Various Types of Scaffolds-A Systematic Review. Int J Dent. 2024;2024:4990295. https:\/\/doi.org\/10.1155\/ijod\/4990295.","DOI":"10.1155\/ijod\/4990295"},{"key":"6484_CR48","doi-asserted-by":"publisher","unstructured":"Thor A, Wannfors K, Sennerby L, Rasmusson L. Reconstruction of the severely resorbed maxilla with autogenous bone, plateletrich plasma, and implants: 1-year results of a controlled prospective 5-year study. Clin Implant Dent Relat Res. 2005;7(4):209\u2013220. https:\/\/doi.org\/10.1111\/j.1708-8208.2005.tb00066.x.","DOI":"10.1111\/j.1708-8208.2005.tb00066.x"},{"key":"6484_CR49","doi-asserted-by":"publisher","unstructured":"Attia S, Narberhaus C, Schaaf H, et al. Long-Term Influence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Implant Survival and Success Rates. J Clin Med. 2020;9(2):391. Published 1 Feb 2020. https:\/\/doi.org\/10.3390\/jcm9020391.","DOI":"10.3390\/jcm9020391"},{"key":"6484_CR50","doi-asserted-by":"publisher","unstructured":"Kumar NK, Shaik M, Nadella KR, Chintapalli BM. Comparative study of alveolar bone height and implant survival rate between autogenous bone mixed with platelet rich plasma versus venous blood for maxillary sinus lift augmentation procedure. J Maxillofac Oral Surg. 2015;14(2):417\u2013422. https:\/\/doi.org\/10.1007\/s12663-014-0643-7.","DOI":"10.1007\/s12663-014-0643-7"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-06484-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-025-06484-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-06484-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T07:44:59Z","timestamp":1751701499000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-025-06484-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,5]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6484"],"URL":"https:\/\/doi.org\/10.1186\/s12903-025-06484-3","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,5]]},"assertion":[{"value":"24 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1120"}}