{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:15:21Z","timestamp":1770909321941,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Datta Meghe Institute of Higher Education and Research"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Accelerating orthodontic treatment is crucial in reducing complications such as root resorption, caries, and oral hygiene compromise, especially in adults. Piezocision and corticotomy are surgical techniques that accelerate tooth movement by causing bone remodelling. This study compares and evaluates changes in Interleukin-1\u03b2 (IL-1\u03b2) levels in gingival crevicular fluid (GCF) following piezocision and corticotomy-facilitated orthodontics in adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aim<\/jats:title>\n            <jats:p>To assess and compare IL-1\u03b2 fluctuations in GCF of adult patients undergoing corticotomy and piezocision-assisted orthodontic treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials &amp; methods<\/jats:title>\n            <jats:p>This split-mouth study consisted of 16 adult patients (18\u201325 years) who needed premolar extractions. One half of the maxilla was randomly assigned for piezocision and the other half for corticotomy. GCF samples were taken from maxillary canines at varying time intervals: pre-treatment (T0), before surgery (T1), and 24\u00a0h (T2), 7 days (T3), and 21 days (T4) following surgery. IL-1\u03b2 concentrations were quantified using an ELISA kit, and statistical analysis was done.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>IL-1\u03b2 concentrations were highest at 24\u00a0h after surgery (T2) in both groups and decreased steadily by day 21 (T4), but were still elevated above pre-treatment levels. IL-1\u03b2 concentrations were significantly greater in the piezocision group at all time points after surgery than in the corticotomy group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), reflecting a more intense inflammatory reaction and greater bone cell metabolism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study suggests that piezocision elicits a more intense biological response than corticotomy, as reflected by higher IL-1\u03b2 levels in gingival crevicular fluid. While this may indicate a potential for enhanced bone remodelling and accelerated tooth movement, further research is needed to directly correlate cytokine expression with the rate of orthodontic tooth movement.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12903-025-06686-9","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T16:15:44Z","timestamp":1755965744000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative evaluation of changes in levels of cytokine \u2013 IL-1\u03b2 in GCF of adult population who have undergone piezocision and corticotomy assisted orthodontics- an in vivo study"],"prefix":"10.1186","volume":"25","author":[{"given":"Karthika","family":"Nambiar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjit","family":"Kamble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srushti","family":"Atole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandlal","family":"Toshniwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchika","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"6686_CR1","doi-asserted-by":"publisher","first-page":"4934128","DOI":"10.1155\/2019\/4934128","volume":"2019","author":"M Zou","year":"2019","unstructured":"Zou M, Li C, Zheng Z. Remote corticotomy accelerates orthodontic tooth movement in a rat model. BioMed Res Int. 2019;2019:4934128.","journal-title":"BioMed Res Int"},{"issue":"10","key":"6686_CR2","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.jdent.2014.07.013","volume":"42","author":"N Gkantidis","year":"2014","unstructured":"Gkantidis N, Mistakidis I, Kouskoura T, Pandis N. Effectiveness of non-conventional methods for accelerated orthodontic tooth movement: a systematic review and meta-analysis. J Dent. 2014;42(10):1300\u201319.","journal-title":"J Dent"},{"issue":"4","key":"6686_CR3","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1177\/10454411910020040101","volume":"2","author":"Z Davidovitch","year":"1991","unstructured":"Davidovitch Z. Tooth movement. 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This research has been ethically accepted by the Institutional Ethical Committee of Datta Meghe Institute of Higher Education and Research (DU), Sawangi (Meghe), Wardha (Ref. No.: DMIHER(DU)\/IEC\/2021). Before enrolment, informed consent to participate was obtained from all of the participants in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1368"}}