{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T10:14:12Z","timestamp":1774779252722,"version":"3.50.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005771","name":"Dokuz Eylul University","doi-asserted-by":"crossref","award":["3274"],"award-info":[{"award-number":["3274"]}],"id":[{"id":"10.13039\/501100005771","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-025-06991-3","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:48:50Z","timestamp":1760014130000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In vivo biocompatibility of elderberry-enriched carboxymethyl chitosan in soft tissue and calvaria bone defects"],"prefix":"10.1186","volume":"25","author":[{"given":"Bilge Cansu","family":"Uzun Saylan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gizem","family":"Baysan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candan","family":"Efeoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap","family":"Cilaker Micili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevin","family":"Ersoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Mahmut","family":"Baris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaan","family":"Orhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Havitcioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"6991_CR1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ac6b07","author":"L Huang","year":"2022","unstructured":"Huang L, Gong W, Huang G, Li J, Wu J, Wang Y, et al. The additive effects of photobiomodulation and bioactive glasses on enhancing early angiogenesis. Biomed Mater. 2022. https:\/\/doi.org\/10.1088\/1748-605X\/ac6b07.","journal-title":"Biomed Mater"},{"key":"6991_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2022.05.011","author":"Y Deng","year":"2022","unstructured":"Deng Y, Liang Y, Liu X. Biomaterials for periodontal regeneration. Dent Clin North Am. 2022. https:\/\/doi.org\/10.1016\/j.cden.2022.05.011.","journal-title":"Dent Clin North Am"},{"key":"6991_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.09.031","author":"G Baysan","year":"2022","unstructured":"Baysan G, Colpankan Gunes O, Akokay P, Husemoglu RB, Ertugruloglu P, Ziylan Albayrak A, et al. Loofah-chitosan and Poly (\u2013\u20093-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) based hydrogel scaffolds for meniscus tissue engineering applications. Int J Biol Macromol. 2022. https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.09.031.","journal-title":"Int J Biol Macromol"},{"key":"6991_CR4","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12630","author":"T Kwon","year":"2021","unstructured":"Kwon T, Lamster IB, Levin L. Current concepts in the management of periodontitis. Int Dent J. 2021. https:\/\/doi.org\/10.1111\/idj.12630.","journal-title":"Int Dent J"},{"key":"6991_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2021.08.001","author":"A Kantarci","year":"2022","unstructured":"Kantarci A. Biological basis of periodontal regeneration. Dent Clin North Am. 2022. https:\/\/doi.org\/10.1016\/j.cden.2021.08.001.","journal-title":"Dent Clin North Am"},{"key":"6991_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84039-6","author":"P Tournier","year":"2021","unstructured":"Tournier P, Guicheux J, Par\u00e9 A, Maltezeanu A, Blondy T, Veziers J, et al. A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models. Sci Rep. 2021. https:\/\/doi.org\/10.1038\/s41598-021-84039-6.","journal-title":"Sci Rep"},{"key":"6991_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-02930-2","author":"E Solyom","year":"2023","unstructured":"Solyom E, Szalai E, Czumbel ML, Szabo B, V\u00e1ncsa S, Mikulas K, et al. The use of autogenous tooth bone graft is an efficient method of alveolar ridge preservation \u2013 meta-analysis and systematic review. BMC Oral Health. 2023. https:\/\/doi.org\/10.1186\/s12903-023-02930-2.","journal-title":"BMC Oral Health"},{"key":"6991_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242316598","author":"M Ciszy\u0144ski","year":"2023","unstructured":"Ciszy\u0144ski M, Dominiak S, Dominiak M, Gedrange T, Hadzik J. Allogenic bone graft in dentistry: A review of current trends and developments. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms242316598.","journal-title":"Int J Mol Sci"},{"key":"6991_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314987","author":"Y Ren","year":"2022","unstructured":"Ren Y, Fan L, Alkildani S, Liu L, Emmert S, Najman S, et al. Barrier membranes for guided bone regeneration (GBR): A focus on recent advances in collagen membranes. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms232314987.","journal-title":"Int J Mol Sci"},{"key":"6991_CR10","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514557331","author":"TE Van Dyke","year":"2015","unstructured":"Van Dyke TE, Hasturk H, Kantarci A, Freire MO, Nguyen D, Dalli J, et al. Proresolving nanomedicines activate bone regeneration in periodontitis. J Dent Res. 2015. https:\/\/doi.org\/10.1177\/0022034514557331.","journal-title":"J Dent Res"},{"key":"6991_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12504","author":"K Jepsen","year":"2003","unstructured":"Jepsen K, Sculean A, Jepsen S. Complications and treatment errors related to regenerative periodontal surgery. Periodontol 2000. 2003. https:\/\/doi.org\/10.1111\/prd.12504.","journal-title":"Periodontol 2000"},{"key":"6991_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/jfb15080233","author":"H Chen","year":"2024","unstructured":"Chen H, Song G, Xu T, Meng C, Zhang Y, Xin T, et al. Biomaterial scaffolds for periodontal tissue engineering. J Funct Biomater. 2024. https:\/\/doi.org\/10.3390\/jfb15080233.","journal-title":"J Funct Biomater"},{"key":"6991_CR13","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.87978","author":"L Signorini","year":"2023","unstructured":"Signorini L, Marenzi G, Facente A, Marrelli B, Marano RM, Valletta A, et al. Critical overview on pure Chitosan-based scaffolds for bone tissue engineering: clinical insights in dentistry. Int J Med Sci. 2023. https:\/\/doi.org\/10.7150\/ijms.87978.","journal-title":"Int J Med Sci"},{"key":"6991_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122233","author":"L Mu","year":"2024","unstructured":"Mu L, Wu L, Wu S, Ye Q, Zhong Z. Progress in chitin\/chitosan and their derivatives for biomedical applications: where we stand. Carbohydr Polym. 2024. https:\/\/doi.org\/10.1016\/j.carbpol.2024.122233.","journal-title":"Carbohydr Polym"},{"key":"6991_CR15","doi-asserted-by":"publisher","unstructured":"Atia GAN, Shalaby HK, Zehravi M, Ghobashy MM, Attia HAN, Ahmad Z et al. Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration. Polymers (Basel). 2022. https:\/\/doi.org\/10.3390\/polym14153192","DOI":"10.3390\/polym14153192"},{"key":"6991_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126574","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, Zhang Y, Zhou Y. Application progress of modified Chitosan and its composite biomaterials for bone tissue engineering. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms23126574.","journal-title":"Int J Mol Sci"},{"key":"6991_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120555","author":"Y Geng","year":"2023","unstructured":"Geng Y, Xue H, Zhang Z, Panayi AC, Knoedler S, Zhou W, et al. Recent advances in carboxymethyl chitosan-based materials for biomedical applications. Carbohydr Polym. 2023. https:\/\/doi.org\/10.1016\/j.carbpol.2023.120555.","journal-title":"Carbohydr Polym"},{"key":"6991_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.05.020","author":"S Sharma","year":"2018","unstructured":"Sharma S, Kumar A, Deepak, Kumar R, Rana NK, Koch B. Development of a novel Chitosan based biocompatible and self-healing hydrogel for controlled release of hydrophilic drug. Int J Biol Macromol. 2018. https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.05.020.","journal-title":"Int J Biol Macromol"},{"key":"6991_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/toxics9120354","author":"D-H Kim","year":"2021","unstructured":"Kim D-H, Han J-H, Kwon H-C, Lim S-J, Han S-G, Jung H-S, et al. Toxicity assessment of a single dose of Poly(ethylene glycol) diglycidyl ether (PEGDE) administered subcutaneously in mice. Toxics. 2021. https:\/\/doi.org\/10.3390\/toxics9120354.","journal-title":"Toxics"},{"key":"6991_CR20","doi-asserted-by":"publisher","unstructured":"Mar\u021bi\u0219 Petru\u021b GS, Mure\u0219an V, Marc Vlaic RM, Mure\u0219an CC, Pop CR, Buzg\u0103u G et al. The Physicochemical and Antioxidant Properties of Sambucus nigra L. and Sambucus nigra Haschberg during Growth Phases: From Buds to Ripening. Antioxidants (Basel). 2021. https:\/\/doi.org\/10.3390\/antiox10071093","DOI":"10.3390\/antiox10071093"},{"key":"6991_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2022.100437","author":"SS Ferreira","year":"2022","unstructured":"Ferreira SS, Martins-Gomes C, Nunes FM, Silva AM. Elderberry (Sambucus Nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity. Food Chem X. 2022. https:\/\/doi.org\/10.1016\/j.fochx.2022.100437.","journal-title":"Food Chem X"},{"key":"6991_CR22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c00010","author":"D Liu","year":"2022","unstructured":"Liu D, He X-Q, Wu D-T, Li H-B, Feng Y-B, Zou L, et al. Elderberry (Sambucus Nigra L.): bioactive Compounds, health Functions, and applications. J Agric Food Chem. 2022. https:\/\/doi.org\/10.1021\/acs.jafc.2c00010.","journal-title":"J Agric Food Chem"},{"key":"6991_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28176235","author":"AE St\u0119pie\u0144","year":"2023","unstructured":"St\u0119pie\u0144 AE, Trojniak J, Tabarkiewicz J, Health-Promoting, Properties. Anti-Inflammatory and anticancer properties of Sambucus Nigra L. Flowers and fruits. Molecules. 2023. https:\/\/doi.org\/10.3390\/molecules28176235.","journal-title":"Molecules"},{"key":"6991_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210286","author":"M W\u00f3jciak","year":"2023","unstructured":"W\u00f3jciak M, Ziemlewska A, Zag\u00f3rska-Dziok M, Nizio\u0142-\u0141ukaszewska Z, Szczepanek D, Oniszczuk T, et al. Anti-Inflammatory and protective effects of water extract and bioferment from Sambucus Nigra fruit in LPS-Induced human skin fibroblasts. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms241210286.","journal-title":"Int J Mol Sci"},{"key":"6991_CR25","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12372","author":"L Chaushu","year":"2015","unstructured":"Chaushu L, Weinreb M, Beitlitum I, Moses O, Nemcovsky CE. Evaluation of a topical herbal patch for soft tissue wound healing: an animal study. J Clin Periodontol. 2015. https:\/\/doi.org\/10.1111\/jcpe.12372.","journal-title":"J Clin Periodontol"},{"key":"6991_CR26","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050232","author":"E Harokopakis","year":"2006","unstructured":"Harokopakis E, Albzreh MH, Haase EM, Scannapieco FA, Hajishengallis G. Inhibition of Proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra). J Periodontol. 2006. https:\/\/doi.org\/10.1902\/jop.2006.050232.","journal-title":"J Periodontol"},{"key":"6991_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/app.55637","author":"G Baysan","year":"2024","unstructured":"Baysan G, Yilmaz PA, Husemoglu RB, Albayrak AZ, Sisman AR, Havitcioglu H. Elderberry (Sambucus nigra) and Hawthorn (Crataegus oxyacantha) extract additives in carboxymethyl Chitosan scaffolds for osteochondral tissue engineering applications. J Appl Polym Sci. 2024. https:\/\/doi.org\/10.1002\/app.55637.","journal-title":"J Appl Polym Sci"},{"issue":"1","key":"6991_CR28","first-page":"85","volume":"2","author":"G Baysan","year":"2020","unstructured":"Baysan G, Husemoglu B, Havitcioglu H. Cytotoxic effects of Hawthorn and Elderberry extracts on 3T3 fibroblast cell line. J Med Innov Technol. 2020;2(1):85\u201391.","journal-title":"J Med Innov Technol"},{"key":"6991_CR29","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/572586","author":"M Starecki","year":"2014","unstructured":"Starecki M, Schwartz JA, Grande DA. Evaluation of Amniotic-Derived membrane biomaterial as an adjunct for repair of critical sized bone defects. Adv Orthop Surg. 2014. https:\/\/doi.org\/10.1155\/2014\/572586.","journal-title":"Adv Orthop Surg"},{"key":"6991_CR30","unstructured":"Hou T, Liang D, He J, Chen X, Zhang Y. Primary peritoneal serous carcinoma: a clinicopathological and immunohistochemical study of six cases. Int J Clin Exp Pathol. 2012;5(8):762-769."},{"key":"6991_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0351","author":"L Tavelli","year":"2020","unstructured":"Tavelli L, McGuire MK, Zucchelli G, Rasperini G, Feinberg SE, Wang H, et al. Extracellular matrix-based scaffolding technologies for periodontal and peri\u2010implant soft tissue regeneration. J Periodontol. 2020. https:\/\/doi.org\/10.1002\/JPER.19-0351.","journal-title":"J Periodontol"},{"key":"6991_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2022.09.001","author":"N Abedi","year":"2022","unstructured":"Abedi N, Rajabi N, Kharaziha M, Nejatidanesh F, Tayebi L. Layered scaffolds in periodontal regeneration. J Oral Biol Craniofac Res. 2022. https:\/\/doi.org\/10.1016\/j.jobcr.2022.09.001.","journal-title":"J Oral Biol Craniofac Res"},{"key":"6991_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.12.046","author":"O Suzuki","year":"2023","unstructured":"Suzuki O, Hamai R, Sakai S. The material design of octacalcium phosphate bone substitute: increased dissolution and osteogenecity. Acta Biomater. 2023. https:\/\/doi.org\/10.1016\/j.actbio.2022.12.046.","journal-title":"Acta Biomater"},{"key":"6991_CR34","doi-asserted-by":"publisher","unstructured":"Zhang Y, Cheng X, Wang J, Wang Y, Shi B, Huang C, et al. Novel chitosan\/collagen scaffold containing transforming growth factor-beta1 DNA for periodontal tissue engineering. Biochem Biophys Res Commun. 2006. https:\/\/doi.org\/10.1016\/j.bbrc.2006.03.106.","DOI":"10.1016\/j.bbrc.2006.03.106"},{"key":"6991_CR35","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000670","author":"C-K Chen","year":"2018","unstructured":"Chen C-K, Chang N-J, Wu Y-T, Fu E, Shen E-C, Feng C-W, et al. Bone formation using Cross-Linked Chitosan scaffolds in rat calvarial defects. Implant Dent. 2018. https:\/\/doi.org\/10.1097\/ID.0000000000000670.","journal-title":"Implant Dent"},{"key":"6991_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2008.06.009","author":"FR de Abreu","year":"2009","unstructured":"de Abreu FR, Campana-Filho SP. Characteristics and properties of carboxymethylchitosan. Carbohydr Polym. 2009. https:\/\/doi.org\/10.1016\/j.carbpol.2008.06.009.","journal-title":"Carbohydr Polym"},{"key":"6991_CR37","doi-asserted-by":"publisher","DOI":"10.1039\/d4bm00928b","author":"K Neumann","year":"2024","unstructured":"Neumann K. The case for poly(ylides) as a class of charge-neutral, hydrophilic polymers with applications in biomaterials science. Biomater Sci. 2024. https:\/\/doi.org\/10.1039\/d4bm00928b.","journal-title":"Biomater Sci"},{"key":"6991_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119920","author":"JO Abaricia","year":"2020","unstructured":"Abaricia JO, Shah AH, Chaubal M, Hotchkiss KM, Olivares-Navarrete R. Wnt signaling modulates macrophage polarization and is regulated by biomaterial surface properties. Biomaterials. 2020. https:\/\/doi.org\/10.1016\/j.biomaterials.2020.119920.","journal-title":"Biomaterials"},{"key":"6991_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2705","author":"LC Davies","year":"2013","unstructured":"Davies LC, Jenkins SJ, Allen JE, Taylor PR. Tissue-resident macrophages. Nat Immunol. 2013. https:\/\/doi.org\/10.1038\/ni.2705.","journal-title":"Nat Immunol"},{"key":"6991_CR40","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13156","author":"C Garaicoa-Pazmino","year":"2019","unstructured":"Garaicoa-Pazmino C, Fretwurst T, Squarize CH, Berglundh T, Giannobile WV, Larsson L, et al. Characterization of macrophage polarization in periodontal disease. J Clin Periodontol. 2019. https:\/\/doi.org\/10.1111\/jcpe.13156.","journal-title":"J Clin Periodontol"},{"key":"6991_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/ma8095269","author":"Z Sheikh","year":"2015","unstructured":"Sheikh Z, Brooks PJ, Barzilay O, Fine N, Glogauer M. Macrophages, foreign body giant cells and their response to implantable biomaterials. Mater (Basel). 2015. https:\/\/doi.org\/10.3390\/ma8095269.","journal-title":"Mater (Basel)"},{"key":"6991_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1409-4","author":"J Liu","year":"2019","unstructured":"Liu J, Chen B, Bao J, Zhang Y, Lei L, Yan F. Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration. Stem Cell Res Ther. 2019. https:\/\/doi.org\/10.1186\/s13287-019-1409-4.","journal-title":"Stem Cell Res Ther"},{"key":"6991_CR43","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx107","author":"C Su","year":"2017","unstructured":"Su C, Jia S, Liu H. Immunolocalization of CD163\u2009+\u2009Tumor-Associated macrophages and symmetric proliferation of Ki-67 as biomarkers to differentiate new different grades of laryngeal dysplasia. Am J Clin Pathol. 2017. https:\/\/doi.org\/10.1093\/ajcp\/aqx107.","journal-title":"Am J Clin Pathol"},{"key":"6991_CR44","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19301","author":"JS Ham","year":"2017","unstructured":"Ham JS, Park HY, Ryu KJ, Ko YH, Kim WS, Kim SJ. Elevated serum interleukin-10 level and M2 macrophage infiltration are associated with poor survival in angioimmunoblastic T-cell lymphoma. Oncotarget. 2017. https:\/\/doi.org\/10.18632\/oncotarget.19301.","journal-title":"Oncotarget"},{"key":"6991_CR45","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03556-2","author":"ME Galarraga-Vinueza","year":"2021","unstructured":"Galarraga-Vinueza ME, Obreja K, Ramanauskaite A, Magini R, Begic A, Sader R, et al. Macrophage polarization in peri-implantitis lesions. Clin Oral Investig. 2021. https:\/\/doi.org\/10.1007\/s00784-020-03556-2.","journal-title":"Clin Oral Investig"},{"key":"6991_CR46","doi-asserted-by":"publisher","unstructured":"Fretwurst T, Garaicoa-Pazmino C, Nelson K, Giannobile WV, Squarize CH, Larsson L et al. Characterization of macrophages infiltrating peri\u2010implantitis lesions. 2020. https:\/\/doi.org\/10.1111\/clr.13568","DOI":"10.1111\/clr.13568"},{"key":"6991_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28073148","author":"AG Osman","year":"2023","unstructured":"Osman AG, Avula B, Katragunta K, Ali Z, Chittiboyina AG, Khan IA. Elderberry extracts: characterization of the polyphenolic chemical Composition, quality Consistency, Safety, Adulteration, and Attenuation of oxidative Stress- and Inflammation-Induced health disorders. Molecules. 2023. https:\/\/doi.org\/10.3390\/molecules28073148.","journal-title":"Molecules"},{"key":"6991_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28073099","author":"IM Ha\u0219","year":"2023","unstructured":"Ha\u0219 IM, Teleky B-E, Szabo K, Simon E, Ranga F, Diaconeasa ZM, et al. Bioactive potential of Elderberry (Sambucus Nigra L.): Antioxidant, antimicrobial Activity, bioaccessibility and prebiotic potential. Molecules. 2023. https:\/\/doi.org\/10.3390\/molecules28073099.","journal-title":"Molecules"},{"key":"6991_CR49","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.12844","author":"MP Fern\u00e1ndez","year":"2020","unstructured":"Fern\u00e1ndez MP, Witte F, Tozzi G. Applications of X-ray computed tomography for the evaluation of biomaterial-mediated bone regeneration in critical-sized defects. J Microsc. 2020. https:\/\/doi.org\/10.1111\/jmi.12844.","journal-title":"J Microsc"},{"key":"6991_CR50","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3402060","author":"MP Aparisi G\u00f3mez","year":"2020","unstructured":"Aparisi G\u00f3mez MP, Errani C, Lalam R, Vasilevska Nikodinovska V, Fanti S, Tagliafico AS, et al. The role of ultrasound in the diagnosis of soft tissue tumors. Semin Musculoskelet Radiol. 2020. https:\/\/doi.org\/10.1055\/s-0039-3402060.","journal-title":"Semin Musculoskelet Radiol"},{"key":"6991_CR51","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/61\/5\/1932","author":"H Estrada","year":"2016","unstructured":"Estrada H, Rebling J, Turner J, Razansky D. Broadband acoustic properties of a murine skull. Phys Med Biol. 2016. https:\/\/doi.org\/10.1088\/0031-9155\/61\/5\/1932.","journal-title":"Phys Med Biol"},{"key":"6991_CR52","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-018-6145-2","author":"N Zhang","year":"2018","unstructured":"Zhang N, Zhao D, Liu N, Wu Y, Yang J, Wang Y, et al. Assessment of the degradation rates and effectiveness of different coated Mg-Zn-Ca alloy scaffolds for in vivo repair of critical-size bone defects. J Mater Sci Mater Med. 2018. https:\/\/doi.org\/10.1007\/s10856-018-6145-2.","journal-title":"J Mater Sci Mater Med"},{"key":"6991_CR53","doi-asserted-by":"publisher","DOI":"10.1080\/01495739708936692","author":"T Hildebrand","year":"1997","unstructured":"Hildebrand T, R\u00fcegsegger P. Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Engin. 1997. https:\/\/doi.org\/10.1080\/01495739708936692.","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"6991_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14090473","author":"KK K\u0142osi\u0144ski","year":"2023","unstructured":"K\u0142osi\u0144ski KK, Wach RA, Kruczkowska W, Duda \u0141, Ko\u0142at D, Ka\u0142uzi\u0144ska-Ko\u0142at \u017b, et al. Carboxymethyl Chitosan hydrogels for effective wound Healing\u2014An animal study. J Funct Biomater. 2023. https:\/\/doi.org\/10.3390\/jfb14090473.","journal-title":"J Funct Biomater"},{"key":"6991_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.09.131","author":"Z Shariatinia","year":"2018","unstructured":"Shariatinia Z. Carboxymethyl chitosan: properties and biomedical applications. Int J Biol Macromol. 2018. https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.09.131.","journal-title":"Int J Biol Macromol"},{"key":"6991_CR56","doi-asserted-by":"publisher","unstructured":"Ho GTT, Wangensteen H, Barsett H, Elderberry, Extracts E. Phenolic Compounds, and metabolites and their effect on Complement, RAW 264. 7 macrophages and dendritic cells. 2017. https:\/\/doi.org\/10.3390\/ijms18030584","DOI":"10.3390\/ijms18030584"},{"key":"6991_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.11.003","author":"MJ Sandker","year":"2017","unstructured":"Sandker MJ, Duque LF, Redout EM, Chan A, Que I, L\u00f6wik CWGM, et al. Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers. Acta Biomater. 2017. https:\/\/doi.org\/10.1016\/j.actbio.2016.11.003.","journal-title":"Acta Biomater"},{"key":"6991_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255175","author":"L Zieglowski","year":"2021","unstructured":"Zieglowski L, K\u00fcmmecke AM, Ernst L, Palme R, Weiskirchen R, Talbot SR, et al. Assessing the severity of laparotomy and partial hepatectomy in male rats-A multimodal approach. PLoS ONE. 2021. https:\/\/doi.org\/10.1371\/journal.pone.0255175.","journal-title":"PLoS ONE"},{"key":"6991_CR59","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/aa78d0","author":"A Aussel","year":"2017","unstructured":"Aussel A, Th\u00e9baud NB, B\u00e9rard X, Brizzi V, Delmond S, Bareille R, et al. Chitosan-based hydrogels for developing a small-diameter vascular graft: in vitro and in vivo evaluation. Biomed Mater. 2017. https:\/\/doi.org\/10.1088\/1748-605X\/aa78d0.","journal-title":"Biomed Mater"},{"key":"6991_CR60","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-017-0045-0","author":"JM Townsend","year":"2017","unstructured":"Townsend JM, Dennis SC, Whitlow J, Feng Y, Wang J, Andrews B, et al. Colloidal gels with extracellular matrix particles and growth factors for bone regeneration in critical size rat calvarial defects. AAPS J. 2017. https:\/\/doi.org\/10.1208\/s12248-017-0045-0.","journal-title":"AAPS J"},{"key":"6991_CR61","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.22455","author":"E Chatzipetros","year":"2018","unstructured":"Chatzipetros E, Christopoulos P, Donta C, Tosios K, Tsiambas E, Tsiourvas D, et al. Application of nano-hydroxyapatite\/chitosan scaffolds on rat calvarial critical-sized defects: A pilot study. Med Oral Patol Oral Cir Bucal. 2018. https:\/\/doi.org\/10.4317\/medoral.22455.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"6991_CR62","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-021-00327-w","author":"E Chatzipetros","year":"2021","unstructured":"Chatzipetros E, Damaskos S, Tosios KI, Christopoulos P, Donta C, Kalogirou E-M, et al. The effect of nano-hydroxyapatite\/chitosan scaffolds on rat calvarial defects for bone regeneration. Int J Implant Dent. 2021. https:\/\/doi.org\/10.1186\/s40729-021-00327-w.","journal-title":"Int J Implant Dent"},{"key":"6991_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104779","author":"RS de Molon","year":"2020","unstructured":"de Molon RS, Fiori LC, Verzola MHA, Belluci MM, de Souza Faloni AP, Pereira RMR, et al. Long-term evaluation of alendronate treatment on the healing of calvaria bone defects in rats. Biochemical, histological and immunohistochemical analyses. Arch Oral Biol. 2020. https:\/\/doi.org\/10.1016\/j.archoralbio.2020.104779.","journal-title":"Arch Oral Biol"},{"key":"6991_CR64","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2376","author":"M Al-Qutub","year":"2016","unstructured":"Al-Qutub M, Al-Omar N, Ramalingam S, Javed F, Al-Kindi M, Ar-rejaie A, et al. Guided bone regeneration using biphasic calcium phosphate with adjunct Recombinant human bone morphogenetic Protein-2 with and without collagen membrane in standardized calvarial defects in rats: A histologic and Biomechanical analysis. Int J Periodontics Restor Dent. 2016. https:\/\/doi.org\/10.11607\/prd.2376.","journal-title":"Int J Periodontics Restor Dent"},{"key":"6991_CR65","doi-asserted-by":"publisher","DOI":"10.1177\/0885328220930714","author":"OC Gunes","year":"2020","unstructured":"Gunes OC, Albayrak AZ, Tasdemir S, Sendemir A. Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair. J Biomater Appl. 2020. https:\/\/doi.org\/10.1177\/0885328220930714.","journal-title":"J Biomater Appl"},{"key":"6991_CR66","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200700139","author":"JF Mano","year":"2008","unstructured":"Mano JF. Viscoelastic properties of Chitosan with different hydration degrees as studied by dynamic mechanical analysis. Macromol Biosci. 2008. https:\/\/doi.org\/10.1002\/mabi.200700139.","journal-title":"Macromol Biosci"},{"key":"6991_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2022.112690","author":"PMC Torres","year":"2022","unstructured":"Torres PMC, Ribeiro N, Nunes CMM, Rodrigues AFM, Sousa A, Olhero SM. Toughening robocast chitosan\/biphasic calcium phosphate composite scaffolds with silk fibroin: tuning printable inks and scaffold structure for bone regeneration. Biomaterials Adv. 2022. https:\/\/doi.org\/10.1016\/j.msec.2022.112690.","journal-title":"Biomaterials Adv"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-06991-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-025-06991-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-06991-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:48:52Z","timestamp":1760014132000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-025-06991-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6991"],"URL":"https:\/\/doi.org\/10.1186\/s12903-025-06991-3","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"assertion":[{"value":"13 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental protocol was approved by the Ethics Committee in Animal Use (28-2023) at the Experimental Animal Laboratory, Faculty of Medicine, Dokuz Eylul University, where all experimental procedures were carried out.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1582"}}