{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:04:15Z","timestamp":1789196655469,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-025-07126-4","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:27:16Z","timestamp":1762252036000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of postoperative bleeding and pain following tooth extraction in patients using direct oral anticoagulants: a prospective case-control study with blinded evaluation"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-9658","authenticated-orcid":false,"given":"\u0130lhan","family":"Kaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"7126_CR1","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1097\/SCS.0000000000002713","volume":"27","author":"D Dudek","year":"2016","unstructured":"Dudek D, Marchionni S, Gabriele M, Iurlaro A, Helewski K, Toti P, Gelpi F, Bertossi D, Barone A. Bleeding rate after tooth extraction in patients under oral anticoagulant therapy. J Craniofac Surg. 2016;27:1228\u201333.","journal-title":"J Craniofac Surg"},{"key":"7126_CR2","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/sj.ebd.6401226","volume":"18","author":"C Watterson","year":"2017","unstructured":"Watterson C, Beacher N. Preventing perioperative bleeding in patients with inherited bleeding disorders. Evid Based Dent. 2017;18:28\u20139.","journal-title":"Evid Based Dent"},{"key":"7126_CR3","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.joms.2018.09.024","volume":"77","author":"N Cocero","year":"2019","unstructured":"Cocero N, Basso M, Grosso S, Carossa S. Direct oral anticoagulants and medical comorbidities in patients needing dental extractions: management of the risk of bleeding. J Oral Maxillofac Surg. 2019;77:463\u201370.","journal-title":"J Oral Maxillofac Surg"},{"key":"7126_CR4","doi-asserted-by":"publisher","first-page":"e015952","DOI":"10.1136\/bmjopen-2017-015952","volume":"7","author":"T Yagyuu","year":"2017","unstructured":"Yagyuu T, Kawakami M, Ueyama Y, Imada M, Kurihara M, Matsusue Y, Imai Y, Yamamoto K, Kirita T. Risks of Postextraction bleeding after receiving direct oral anticoagulants or warfarin: a retrospective cohort study. BMJ Open. 2017;7:e015952.","journal-title":"BMJ Open"},{"key":"7126_CR5","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1016\/j.oooo.2016.06.003","volume":"122","author":"C Mauprivez","year":"2016","unstructured":"Mauprivez C, Khonsari RH, Razouk O, Goudot P, Lesclous P, Descroix V. Management of dental extraction in patients undergoing anticoagulant oral direct treatment: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:e146\u201355.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"7126_CR6","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.joms.2018.11.032","volume":"77","author":"F Cabbar","year":"2019","unstructured":"Cabbar F, Cabbar AT, Co\u015fansu K, \u00c7ekirdek\u00e7i E\u0130. Effects of direct oral anticoagulants on quality of life during periprocedural management for dental extractions. J Oral Maxillofac Surg. 2019;77:904\u201311.","journal-title":"J Oral Maxillofac Surg"},{"key":"7126_CR7","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.jcms.2024.03.035","volume":"52","author":"BV Bajkin","year":"2024","unstructured":"Bajkin BV, Tadic AJ, Komsic JJ, Vuckovic BA. Risk of Dentoalveolar surgery postoperative bleeding in patients taking direct oral anticoagulants and vitamin K antagonists: A prospective observational study. J Craniomaxillofac Surg. 2024;52:772\u20137.","journal-title":"J Craniomaxillofac Surg"},{"key":"7126_CR8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/sj.bdj.2017.165","volume":"222","author":"JP Patel","year":"2017","unstructured":"Patel JP, Woolcombe SA, Patel RK, Obisesan O, Roberts LN, Bryant C, Arya R. Managing direct oral anticoagulants in patients undergoing Dentoalveolar surgery. Br Dent J. 2017;222:245\u20139.","journal-title":"Br Dent J"},{"key":"7126_CR9","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1186\/s12903-021-01868-7","volume":"21","author":"M Buchbender","year":"2021","unstructured":"Buchbender M, Schlee N, Kesting MR, Grimm J, Fehlhofer J, Rau A. A prospective comparative study to assess the risk of postoperative bleeding after dental surgery while on medication with direct oral anticoagulants, antiplatelet agents, or vitamin K antagonists. BMC Oral Health. 2021;21:504.","journal-title":"BMC Oral Health"},{"key":"7126_CR10","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1186\/s12903-024-05275-6","volume":"24","author":"MS Katz","year":"2024","unstructured":"Katz MS, Benidamou R, Ooms M, Heitzer M, Bock A, Elvers D, Steiner T, Peters F, H\u00f6lzle F, Modabber A. Influence of antiplatelet medication and anticoagulation therapy after dental extractions on hospitalization: a retrospective 10-year study. BMC Oral Health. 2024;24:1485.","journal-title":"BMC Oral Health"},{"key":"7126_CR11","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/odi.12698","volume":"24","author":"SG Miller","year":"2018","unstructured":"Miller SG, Miller CS. Direct oral anticoagulants: A retrospective study of bleeding, behavior, and Documentation. Oral Dis. 2018;24:243\u20138.","journal-title":"Oral Dis"},{"key":"7126_CR12","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.ijom.2018.03.009","volume":"47","author":"E Lababidi","year":"2018","unstructured":"Lababidi E, Breik O, Savage J, Engelbrecht H, Kumar R, Crossley CW. Assessing an oral surgery specific protocol for patients on direct oral anticoagulants: a retrospective controlled cohort study. Int J Oral Maxillofac Surg. 2018;47:940\u20136.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"7126_CR13","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1186\/s12903-025-05949-9","volume":"25","author":"K Johansson","year":"2025","unstructured":"Johansson K, Becktor JP, Naimi-Akbar A, Svensson PJ, G\u00f6trick B. Continuous use of direct oral anticoagulants during and after simple and surgical tooth extractions: a prospective clinical cohort study. BMC Oral Health. 2025;25:554.","journal-title":"BMC Oral Health"},{"key":"7126_CR14","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jormas.2021.07.002","volume":"123","author":"E Bedelo\u011flu","year":"2022","unstructured":"Bedelo\u011flu E. Evaluation of the effect of conscious sedation on patient satisfaction and pain after wisdom tooth extraction. J Stomatol Oral Maxillofac Surg. 2022;123:292\u20136.","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"7126_CR15","doi-asserted-by":"publisher","first-page":"S2247","DOI":"10.4103\/jpbs.jpbs_190_24","volume":"16","author":"N Shaik","year":"2024","unstructured":"Shaik N, Rajoli SDR, Sarika PS, Bejagam V, Shajahan SF, Snehika G. Comparative analysis of two different techniques for ridge preservation following tooth extraction: A clinical and radiographic study. J Pharm Bioallied Sci. 2024;16:S2247\u20139.","journal-title":"J Pharm Bioallied Sci"},{"key":"7126_CR16","first-page":"e58262","volume":"16","author":"R Sharma","year":"2024","unstructured":"Sharma R, George M, Krishnan M. Efficacy of preemptive analgesia on pain perception after simple tooth extraction: A prospective study. Cureus. 2024;16:e58262.","journal-title":"Cureus"},{"key":"7126_CR17","first-page":"169","volume":"33","author":"V Candotto","year":"2019","unstructured":"Candotto V, Oberti L, Gabrione F, Scarano A, Rossi D, Romano M. Complication in third molar extractions. J Biol Regul Homeost Agents. 2019;33:169\u201372.","journal-title":"J Biol Regul Homeost Agents"},{"key":"7126_CR18","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","volume":"61","author":"E von Elm","year":"2008","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP, STROBE Initiative. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344\u20139.","journal-title":"J Clin Epidemiol"},{"key":"7126_CR19","doi-asserted-by":"publisher","first-page":"548","DOI":"10.33314\/jnhrc.v17i4.1042","volume":"17","author":"B Shrestha","year":"2020","unstructured":"Shrestha B, Dunn L. The declaration of Helsinki on medical research involving human subjects: A review of seventh revision. J Nepal Health Res Counc. 2020;17:548\u201352.","journal-title":"J Nepal Health Res Counc"},{"key":"7126_CR20","doi-asserted-by":"publisher","first-page":"e005777","DOI":"10.1136\/bmjopen-2014-005777","volume":"4","author":"H Iwabuchi","year":"2014","unstructured":"Iwabuchi H, Imai Y, Asanami S, Shirakawa M, Yamane GY, Ogiuchi H, Kurashina K, Miyata M, Nakao H, Imai H. Evaluation of Postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study. BMJ Open. 2014;4:e005777.","journal-title":"BMJ Open"},{"key":"7126_CR21","doi-asserted-by":"crossref","unstructured":"Hiroshi I, Natsuko SY, Yutaka I, Masayori S, Hiroyuki N, Hirohisa I. Frequency of hemorrhage after tooth extraction in patients treated with a direct oral anticoagulant: A multicenter cross-sectional study. PLoS One. 2022;17:e0266011. Erratum in: PLoS One. 2024;19:e0303944.","DOI":"10.1371\/journal.pone.0303944"},{"key":"7126_CR22","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1620\/tjem.246.257","volume":"246","author":"M Hayashi","year":"2018","unstructured":"Hayashi M, Morimoto Y, Iida T, Tanaka Y, Sugiyama S. Risk of delayed healing of tooth extraction wounds and osteonecrosis of the jaw among patients treated with potential immunosuppressive drugs: A retrospective cohort study. Tohoku J Exp Med. 2018;246:257\u201364.","journal-title":"Tohoku J Exp Med"},{"key":"7126_CR23","doi-asserted-by":"publisher","first-page":"e0290050","DOI":"10.1371\/journal.pone.0290050","volume":"19","author":"AB Rodriguez","year":"2024","unstructured":"Rodriguez AB, Alhachache S, Velasquez D, Chan HL. A systematic review of oral wound healing indices. PLoS ONE. 2024;19:e0290050.","journal-title":"PLoS ONE"},{"key":"7126_CR24","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1007\/s00784-018-2676-7","volume":"23","author":"M M\u00fcller","year":"2019","unstructured":"M\u00fcller M, Schlittler F, Schaller B, Nagler M, Exadaktylos AK, Sauter TC. Characteristics, treatment and outcome of bleeding after tooth extraction in patients on DOAC and phenprocoumon compared to non-anticoagulated patients-a retrospective study of emergency department consultations. Clin Oral Investig. 2019;23:2273\u20138.","journal-title":"Clin Oral Investig"},{"key":"7126_CR25","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.ijom.2019.01.013","volume":"48","author":"H Yoshikawa","year":"2019","unstructured":"Yoshikawa H, Yoshida M, Yasaka M, Yoshida H, Murasato Y, Fukunaga D, Shintani A, Okada Y. Safety of tooth extraction in patients receiving direct oral anticoagulant treatment versus warfarin: a prospective observation study. Int J Oral Maxillofac Surg. 2019;48:1102\u20138.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"7126_CR26","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1007\/s00784-020-03559-z","volume":"25","author":"M Inokoshi","year":"2021","unstructured":"Inokoshi M, Kubota K, Yamaga E, Ueda K, Minakuchi S. Postoperative bleeding after dental extraction among elderly patients under anticoagulant therapy. Clin Oral Investig. 2021;25:2363\u201371.","journal-title":"Clin Oral Investig"},{"key":"7126_CR27","first-page":"e767","volume":"22","author":"M Caliskan","year":"2017","unstructured":"Caliskan M, T\u00fckel HC, Benlidayi ME, Deniz A. Is it necessary to alter anticoagulation therapy for tooth extraction in patients taking direct oral anticoagulants? Med Oral Patol Oral Cir Bucal. 2017;22:e767\u201373.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"7126_CR28","doi-asserted-by":"publisher","first-page":"189","DOI":"10.5125\/jkaoms.2024.50.4.189","volume":"50","author":"MJ Kim","year":"2024","unstructured":"Kim MJ, Kim MK, Kang SH. Post-extraction bleeding in patients on direct oral anticoagulants. J Korean Assoc Oral Maxillofac Surg. 2024;50:189\u201396.","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"7126_CR29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.thromres.2022.12.007","volume":"222","author":"S Ono","year":"2023","unstructured":"Ono S, Ishimaru M, Yokota I, Konishi T, Okada A, Ono Y, Matsui H, Itai S, Yonenaga K, Tonosaki K, Watanabe R, Hoshi K, Yasunaga H. Risk of post-extraction bleeding with direct oral anticoagulant compared with warfarin: retrospective cohort study using large scale claims data in Japan. Thromb Res. 2023;222:24\u201330.","journal-title":"Thromb Res"},{"key":"7126_CR30","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s10006-022-01039-0","volume":"26","author":"E Iwata","year":"2022","unstructured":"Iwata E, Tachibana A, Kusumoto J, Hasegawa T, Kadoya R, Enomoto Y, Takata N, Akashi M. Risk factors associated with post-extraction bleeding in patients on warfarin or direct-acting oral anticoagulants: a retrospective cohort study. Oral Maxillofac Surg. 2022;26:641\u20138.","journal-title":"Oral Maxillofac Surg"},{"key":"7126_CR31","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.oooo.2011.10.005","volume":"113","author":"FJ Firriolo","year":"2012","unstructured":"Firriolo FJ, Hupp WS. Beyond warfarin: the new generation of oral anticoagulants and their implications for the management of dental patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:431\u201341.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"7126_CR32","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.oooo.2011.10.006","volume":"113","author":"JW Little","year":"2012","unstructured":"Little JW. New oral anticoagulants: will they replace warfarin? Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:575\u201380.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"7126_CR33","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3390\/dj12090279","volume":"12","author":"R Izzetti","year":"2024","unstructured":"Izzetti R, Cinquini C, Nisi M, Mattiozzi M, Marotta M, Barone A. Direct oral anticoagulants and bleeding management following tooth Extractions-A prospective cohort study. Dent J (Basel). 2024;12:279.","journal-title":"Dent J (Basel)"},{"key":"7126_CR34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jds.2015.09.002","volume":"11","author":"Y Morimoto","year":"2016","unstructured":"Morimoto Y, Yokoe C, Imai Y, Sugihara M, Futatsuki T. Tooth extraction in patients taking nonvitamin K antagonist oral anticoagulants. J Dent Sci. 2016;11:59\u201364.","journal-title":"J Dent Sci"},{"key":"7126_CR35","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.ijom.2018.03.016","volume":"47","author":"C Bensi","year":"2018","unstructured":"Bensi C, Belli S, Paradiso D, Lomurno G. Postoperative bleeding risk of direct oral anticoagulants after oral surgery procedures: a systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2018;47:923\u201332.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"7126_CR36","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1007\/s00784-018-2739-9","volume":"23","author":"F Berton","year":"2019","unstructured":"Berton F, Costantinides F, Rizzo R, Franco A, Contarin J, Stacchi C, Maglione M, Visintini E, Di Lenarda A, Di Lenarda R. Should we fear direct oral anticoagulants more than vitamin K antagonists in simple single tooth extraction? A prospective comparative study. Clin Oral Investig. 2019;23:3183\u201392.","journal-title":"Clin Oral Investig"},{"key":"7126_CR37","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1007\/s00784-023-04880-z","volume":"27","author":"F Berton","year":"2023","unstructured":"Berton F, Costantinides F, Stacchi C, Corradini A, Di Lenarda A, Di Lenarda R. Is L-PRF an effective hemostatic agent in single tooth extractions? A cohort study on VKA and DOAC patients. Clin Oral Investig. 2023;27:2865\u201374.","journal-title":"Clin Oral Investig"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-07126-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-025-07126-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-07126-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:26:57Z","timestamp":1762295217000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-025-07126-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7126"],"URL":"https:\/\/doi.org\/10.1186\/s12903-025-07126-4","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"9 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for the research protocol of this study was obtained from Clinical Research Ethics Committee of Bursa Uluda\u011f University Faculty of Medicine on 13\/06\/2022, with decision number 12\/26. Verbal and written informed consent forms were approved by all the patients. The study protocol was also conducted in accordance with the World Medical Association (WMA) Declaration of Helsinki ethical principles for medical research involving human participants, including research using identifiable human material or data (\n                      \n                      ).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1741"}}