{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:34:30Z","timestamp":1780619670511,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2022M720289"],"award-info":[{"award-number":["2022M720289"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chinese Stomatological Association Clinical Research Fund","award":["CSA-SIS2022-01"],"award-info":[{"award-number":["CSA-SIS2022-01"]}]},{"name":"Program for New clinical Techniques and Therapies of Peking University School and Hospital of Stomatology","award":["PKUSSNCT-23B02"],"award-info":[{"award-number":["PKUSSNCT-23B02"]}]},{"name":"Program for New clinical Techniques and Therapies of Peking University School and Hospital of Stomatology","award":["PKUSSNCT-20A09"],"award-info":[{"award-number":["PKUSSNCT-20A09"]}]},{"name":"Program for Health Technologies Promotion of National Center for Stomatology","award":["2023NCSHTP03"],"award-info":[{"award-number":["2023NCSHTP03"]}]},{"name":"Beijing Health Technologies Promotion Program","award":["BHTPP2024021"],"award-info":[{"award-number":["BHTPP2024021"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To analyze and summarize the clinical efficacy of mucoperiosteal flap combined with perforation technique for tooth extraction in medication-related osteonecrosis of the jaw risk (MRONJ) population, and to provide clinical treatment options for such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included 51 patients receiving antiresorptive drug (ARD) treatment who underwent tooth extraction at the Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology between November 2016 and February 2024. Preoperative clinical data were collected and analyzed. Based on their drug history, patients were categorized into two groups: (1) low-dose ARD group for patients with non-neoplastic lesion like osteoporosis (LDA), (2) high-dose ARD group for patients with bone metastatic lesions like breast cancer (HDA). All patients underwent tooth extraction using mucoperiosteal flap combined with perforation technique. Follow-up assessments were conducted at 1 week, 2 weeks, 1 month, 3 month and 6 months postoperatively. The primary evaluation outcome was whether the patient had developed MRONJ at the extraction site at 6 months. The secondary evaluation outcome was whether the extraction socket mucosa healed completely within 1 month. Statistical analysis included Chi-square, Fisher\u2019s exact, Mann\u2013Whitney U\/t tests and survival analysis to contrast between LDA and HDA group. Significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 82 extraction sites in 51 patients (31 females in LDA group with a mean age of 66.58\u2009\u00b1\u200913.29 years. 14 females and 6 males in HDA group with a mean age of 58.24\u2009\u00b1\u200911.63 years) were included in the study. Of these, 47 extraction sites in the LDA group, 35 extraction sites in the HDA group. During postoperative follow-up, MRONJ only occurred in 2 extraction sites in HDA group in two patients, resulting in a postoperative clinical healing rate of 100% (47\/47) in LDA group and 94.3% (33\/35) in HDA group. A significant difference in the time to extraction socket mucosal healing was observed between the LDA and HDA groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that in patients with potential risks of MRONJ, the application of mucoperiosteal flap combined with perforation technique based teeth extraction method could safely and effectively alleviate the dental inflammation in the oral cavity, and mitigates the risk of MRONJ development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-025-07130-8","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:27:18Z","timestamp":1762252038000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical efficacy analysis of mucoperiosteal flap combined with perforation technique for tooth extraction in medication-related osteonecrosis of the jaw risk population: a retrospective study"],"prefix":"10.1186","volume":"25","author":[{"given":"Ying","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"issue":"5","key":"7130_CR1","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","volume":"80","author":"SL Ruggiero","year":"2022","unstructured":"Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D. American association of oral and maxillofacial surgeons\u2019 position paper on medication-related osteonecrosis of the jaws-2022 update. J Oral Maxillofac Surg. 2022;80(5):920\u201343.","journal-title":"J Oral Maxillofac Surg"},{"issue":"6","key":"7130_CR2","doi-asserted-by":"publisher","first-page":"3679","DOI":"10.1111\/odi.14887","volume":"30","author":"A Bedogni","year":"2024","unstructured":"Bedogni A, Mauceri R, Fusco V, Bertoldo F, Bettini G, Di Fede O, et al. Italian position paper (SIPMO-SICMF) on medication-related osteonecrosis of the jaw (MRONJ). Oral Dis. 2024;30(6):3679\u2013709.","journal-title":"Oral Dis"},{"issue":"9","key":"7130_CR3","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","volume":"61","author":"RE Marx","year":"2003","unstructured":"Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61(9):1115\u20137.","journal-title":"J Oral Maxillofac Surg"},{"key":"7130_CR4","first-page":"80","volume":"48","author":"YX Guo","year":"2016","unstructured":"Guo YX, Wang DC, Wang Y, et al. Clinical features of osteonecrosis of jaws after bisphosphonates therapy for bone metastasis of breast cancer.J Peking. Univ(Healt Sci. 2016;48:80\u20133.","journal-title":"Univ(Healt Sci"},{"issue":"6","key":"7130_CR5","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.oooo.2018.08.015","volume":"126","author":"F Hallmer","year":"2018","unstructured":"Hallmer F, Andersson G, G\u00f6trick B, Warfvinge G, Anderud J, Bj\u00f8rnland T. Prevalence, initiating factor, and treatment outcome of medication-related osteonecrosis of the jaw-a 4-year prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(6):477\u201385.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"7130_CR6","first-page":"313","volume":"21","author":"Y He","year":"2023","unstructured":"He Y, Chen Y, An JG, et al. Expert consensus on diagnosis and clinical management of medication-related osteonecrosis of the jaw. China J Oral Maxillofacial Surg. 2023;21:313\u201325.","journal-title":"China J Oral Maxillofacial Surg"},{"issue":"5","key":"7130_CR7","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1590\/0103-6440201601558","volume":"28","author":"R-P Fran\u00e7a TRTd","year":"2017","unstructured":"Fran\u00e7a TRTd R-P, Pontual FMM, Castro ADA, JFLd, Bonan PRF, Perez DEC. Effects of Zoledronic acid in experimental periapical lesions in rats: an imaging and histological analysis. Braz Dent J. 2017;28(5):566\u201372.","journal-title":"Braz Dent J"},{"issue":"5","key":"7130_CR8","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1111\/odi.13294","volume":"26","author":"O Nicolatou-Galitis","year":"2020","unstructured":"Nicolatou-Galitis O, Papadopoulou E, Vardas E, Kouri M, Galiti D, Galitis E, Alexiou K-E, Tsiklakis K, Ardavanis A, Razis E, et al. Alveolar bone histological necrosis observed prior to extractions in patients, who received bone-targeting agents. Oral Dis. 2020;26(5):955\u201366.","journal-title":"Oral Dis"},{"issue":"3","key":"7130_CR9","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/jop.12963","volume":"49","author":"AI Lorenzo-Pouso","year":"2020","unstructured":"Lorenzo-Pouso AI, P\u00e9rez-Say\u00e1ns M, Chamorro-Petronacci C, G\u00e1ndara-Vila P, L\u00f3pez-Jornet P, Carballo J, et al. Association between periodontitis and medication-related osteonecrosis of the jaw: a systematic review and meta-analysis. J Oral Pathol Med. 2020;49(3):190\u2013200.","journal-title":"J Oral Pathol Med"},{"issue":"1","key":"7130_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.11607\/prd.4674","volume":"41","author":"R Guarnieri","year":"2021","unstructured":"Guarnieri R, Di Nardo D, Di Giorgio G, Miccoli G, Testarelli L. Longevity of teeth and dental implants in patients treated for chronic periodontitis following periodontal maintenance therapy in a private specialist practice: a retrospective study with a 10-year follow-up. Int J Periodontics Restorative Dent. 2021;41(1):89\u201398.","journal-title":"Int J Periodontics Restorative Dent"},{"key":"7130_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11071807","author":"G Avishai","year":"2022","unstructured":"Avishai G, Muchnik D, Masri D, Zlotogorski-Hurvitz A, Chaushu L. Minimizing MRONJ after tooth extraction in cancer patients receiving bone-modifying agents. J Clin Med. 2022. https:\/\/doi.org\/10.3390\/jcm11071807.","journal-title":"J Clin Med"},{"key":"7130_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17165998","author":"G Campisi","year":"2020","unstructured":"Campisi G, Mauceri R, Bertoldo F, Bettini G, Biasotto M, Colella G, et al. Medication-related osteonecrosis of jaws (MRONJ) prevention and diagnosis: Italian consensus update 2020. Int J Environ Res Public Health. 2020. https:\/\/doi.org\/10.3390\/ijerph17165998.","journal-title":"Int J Environ Res Public Health"},{"key":"7130_CR13","first-page":"1190","volume":"54","author":"YX Guo","year":"2022","unstructured":"Guo YX, Zhang JY, Wang DC, Guo CB. Analysis of pathological characteristics of medication-related osteonecrosis of the jaw and discussion of clinical treatment strategies based on the pathological analysis results. J Peking Univ(Healt Sci. 2022;54:1190\u20135.","journal-title":"J Peking Univ(Healt Sci"},{"issue":"6","key":"7130_CR14","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.ijom.2020.07.036","volume":"50","author":"Y Guo","year":"2021","unstructured":"Guo Y, Guo C. Enhancement of bone perfusion through cortical perforations to improve healing of medication-related osteonecrosis of the jaw: a retrospective study. Int J Oral Maxillofac Surg. 2021;50(6):740\u20135.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"5","key":"7130_CR15","first-page":"452","volume":"56","author":"YX Guo","year":"2021","unstructured":"Guo YX, Wang DC, Liu XJ, Wang EB, An JG, Peng X, et al. [Evaluation of the preliminary clinical effect of flap-raising combined with cortical-perforation technique in tooth extraction cases of patients with potential risk of medication-related osteonecrosis of the jaw]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2021;56(5):452\u20137.","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"issue":"4","key":"7130_CR16","doi-asserted-by":"publisher","first-page":"406","DOI":"10.14219\/jada.archive.2013.0134","volume":"144","author":"CA Migliorati","year":"2013","unstructured":"Migliorati CA, Saunders D, Conlon MS, Ingstad HK, Vaagen P, Palazzolo MJ, et al. Assessing the association between bisphosphonate exposure and delayed mucosal healing after tooth extraction. J Am Dent Assoc. 2013;144(4):406\u201314.","journal-title":"J Am Dent Assoc"},{"issue":"3","key":"7130_CR17","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2334\/josnusd.21-0016","volume":"63","author":"M Cabras","year":"2021","unstructured":"Cabras M, Gambino A, Broccoletti R, Sciascia S, Arduino PG. Lack of evidence in reducing risk of MRONJ after teeth extractions with systemic antibiotics. J Oral Sci. 2021;63(3):217\u201326.","journal-title":"J Oral Sci"},{"issue":"8","key":"7130_CR18","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1007\/s00784-012-0873-3","volume":"17","author":"PJ Hansen","year":"2013","unstructured":"Hansen PJ, Knitschke M, Draenert FG, Irle S, Neff A. Incidence of bisphosphonate-related osteonecrosis of the jaws (BRONJ) in patients taking bisphosphonates for osteoporosis treatment - a grossly underestimated risk? Clin Oral Investig. 2013;17(8):1829\u201337.","journal-title":"Clin Oral Investig"},{"issue":"7","key":"7130_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2013.327","volume":"214","author":"T Taylor","year":"2013","unstructured":"Taylor T, Bryant C, Popat S. A study of 225 patients on bisphosphonates presenting to the bisphosphonate clinic at King\u2019s college hospital. Br Dent J. 2013;214(7):E18.","journal-title":"Br Dent J"},{"issue":"1","key":"7130_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.5624\/isd.2017.47.1.45","volume":"47","author":"H-G Jeong","year":"2017","unstructured":"Jeong H-G, Hwang JJ, Lee J-H, Kim YH, Na JY, Han S-S. Risk factors of osteonecrosis of the jaw after tooth extraction in osteoporotic patients on oral bisphosphonates. Imaging Sci Dent. 2017;47(1):45\u201350.","journal-title":"Imaging Sci Dent"},{"issue":"4","key":"7130_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196419","volume":"13","author":"W-Y Chiu","year":"2018","unstructured":"Chiu W-Y, Yang W-S, Chien J-Y, Lee J-J, Tsai K-S. The influence of alendronate and tooth extraction on the incidence of osteonecrosis of the jaw among osteoporotic subjects. PLoS ONE. 2018;13(4):e0196419.","journal-title":"PLoS ONE"},{"issue":"4","key":"7130_CR22","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1016\/j.jds.2022.03.014","volume":"17","author":"K Seki","year":"2022","unstructured":"Seki K, Kaneko T, Kamimoto A, Wada M, Takeuchi Y, Furuchi M, et al. Medication-related osteonecrosis of the jaw after tooth extraction in patients receiving pharmaceutical treatment for osteoporosis: a retrospective cohort study. J Dent Sci. 2022;17(4):1619\u201325.","journal-title":"J Dent Sci"},{"issue":"4","key":"7130_CR23","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.joms.2009.10.026","volume":"68","author":"G Saia","year":"2010","unstructured":"Saia G, Blandamura S, Bettini G, Tronchet A, Totola A, Bedogni G, et al. Occurrence of bisphosphonate-related osteonecrosis of the jaw after surgical tooth extraction. J Oral Maxillofac Surg. 2010;68(4):797\u2013804.","journal-title":"J Oral Maxillofac Surg"},{"issue":"4","key":"7130_CR24","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.jcms.2015.02.018","volume":"43","author":"JP Bodem","year":"2015","unstructured":"Bodem JP, Kargus S, Eckstein S, Saure D, Engel M, Hoffmann J, et al. Incidence of bisphosphonate-related osteonecrosis of the jaw in high-risk patients undergoing surgical tooth extraction. J Craniomaxillofac Surg. 2015;43(4):510\u20134.","journal-title":"J Craniomaxillofac Surg"},{"issue":"10","key":"7130_CR25","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1007\/s00198-018-4621-7","volume":"29","author":"A Shudo","year":"2018","unstructured":"Shudo A, Kishimoto H, Takaoka K, Noguchi K. Long-term oral bisphosphonates delay healing after tooth extraction: a single institutional prospective study. Osteoporos Int. 2018;29(10):2315\u201321.","journal-title":"Osteoporos Int"},{"key":"7130_CR26","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.bone.2019.03.031","volume":"123","author":"I Gkouveris","year":"2019","unstructured":"Gkouveris I, Hadaya D, Soundia A, Bezouglaia O, Chau Y, Dry SM, et al. Vasculature submucosal changes at early stages of osteonecrosis of the jaw (ONJ). Bone. 2019;123:234\u201345.","journal-title":"Bone"},{"issue":"3","key":"7130_CR27","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1177\/0022034517732770","volume":"97","author":"A Soundia","year":"2018","unstructured":"Soundia A, Hadaya D, Esfandi N, Gkouveris I, Christensen R, Dry SM, et al. Zoledronate impairs socket healing after extraction of teeth with experimental periodontitis. J Dent Res. 2018;97(3):312\u201320.","journal-title":"J Dent Res"},{"issue":"4","key":"7130_CR28","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/adj.12648","volume":"63","author":"A Khominsky","year":"2018","unstructured":"Khominsky A, Lim M. Spontaneous medication-related osteonecrosis of the jaw; two case reports and a systematic review. Aust Dent J. 2018;63(4):441\u201354.","journal-title":"Aust Dent J"},{"issue":"3","key":"7130_CR29","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.oraloncology.2010.11.007","volume":"47","author":"P Vescovi","year":"2011","unstructured":"Vescovi P, Campisi G, Fusco V, Mergoni G, Manfredi M, Merigo E, et al. Surgery-triggered and non surgery-triggered bisphosphonate-related osteonecrosis of the jaws (BRONJ): a retrospective analysis of 567 cases in an Italian multicenter study. Oral Oncol. 2011;47(3):191\u20134.","journal-title":"Oral Oncol"},{"issue":"7","key":"7130_CR30","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1111\/odi.13160","volume":"25","author":"M Schiodt","year":"2019","unstructured":"Schiodt M, Otto S, Fedele S, Bedogni A, Nicolatou-Galitis O, Guggenberger R, et al. Workshop of European task force on medication-related osteonecrosis of the jaw-current challenges. Oral Dis. 2019;25(7):1815\u201321.","journal-title":"Oral Dis"},{"issue":"6","key":"7130_CR31","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.jcms.2015.03.039","volume":"43","author":"S Otto","year":"2015","unstructured":"Otto S, Tr\u00f6ltzsch M, Jambrovic V, Panya S, Probst F, Ristow O, et al. Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: a trigger for BRONJ development? J Craniomaxillofac Surg. 2015;43(6):847\u201354.","journal-title":"J Craniomaxillofac Surg"},{"issue":"25","key":"7130_CR32","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1200\/JCO.19.01186","volume":"37","author":"N Yarom","year":"2019","unstructured":"Yarom N, Shapiro CL, Peterson DE, Van Poznak CH, Bohlke K, Ruggiero SL, et al. Medication-related osteonecrosis of the jaw: MASCC\/ISOO\/ASCO clinical practice guideline. J Clin Oncol. 2019;37(25):2270\u201390.","journal-title":"J Clin Oncol"},{"issue":"5","key":"7130_CR33","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.oooo.2018.02.003","volume":"125","author":"AA Owosho","year":"2018","unstructured":"Owosho AA, Liang STY, Sax AZ, Wu K, Yom SK, Huryn JM, et al. Medication-related osteonecrosis of the jaw: an update on the memorial sloan kettering cancer center experience and the role of premedication dental evaluation in prevention. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(5):440\u20135.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"7130_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10020195","author":"EM Varoni","year":"2021","unstructured":"Varoni EM, Lombardi N, Villa G, Pispero A, Sardella A, Lodi G. Conservative management of Medication-Related osteonecrosis of the jaws (MRONJ): a retrospective cohort study. Antibiotics. 2021. https:\/\/doi.org\/10.3390\/antibiotics10020195.","journal-title":"Antibiotics"},{"issue":"1","key":"7130_CR35","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00784-016-1762-y","volume":"21","author":"A Matsumoto","year":"2017","unstructured":"Matsumoto A, Sasaki M, Schmelzeisen R, Oyama Y, Mori Y, Voss PJ. Primary wound closure after tooth extraction for prevention of medication-related osteonecrosis of the jaw in patients under denosumab. Clin Oral Investig. 2017;21(1):127\u201334.","journal-title":"Clin Oral Investig"},{"key":"7130_CR36","doi-asserted-by":"crossref","unstructured":"Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O\u2019Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S et al. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Min Res. 2015;30(1):3-23.","DOI":"10.1002\/jbmr.2405"},{"key":"7130_CR37","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ctrv.2018.06.007","volume":"69","author":"S Otto","year":"2018","unstructured":"Otto S, Pautke C, Van den Wyngaert T, Niepel D, Schi\u00f8dt M. Medication-related osteonecrosis of the jaw: prevention, diagnosis and management in patients with cancer and bone metastases. Cancer Treat Rev. 2018;69:177\u201387.","journal-title":"Cancer Treat Rev"},{"key":"7130_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-03034-7","author":"N Zhao","year":"2023","unstructured":"Zhao N, Li Q-x, Wang Y-f, Qiao Q, Huang H-y, Guo C-b, et al. Anti-angiogenic drug aggravates the degree of anti-resorptive drug-based medication-related osteonecrosis of the jaw by impairing the proliferation and migration function of gingival fibroblasts. BMC Oral Health. 2023. https:\/\/doi.org\/10.1186\/s12903-023-03034-7.","journal-title":"BMC Oral Health"},{"issue":"7","key":"7130_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70279","volume":"6","author":"H Huang","year":"2025","unstructured":"Huang H, Zhao N, Zhu J, Li Q, Qiao Q, Yang Y, et al. Antiangiogenic medications impede the oral mucosal microcirculation and interfere with oral wound healing: a complication deserving of attention. MedComm. 2025;6(7):e70279.","journal-title":"MedComm"},{"issue":"1","key":"7130_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96480-8","volume":"11","author":"S Soutome","year":"2021","unstructured":"Soutome S, Otsuru M, Hayashida S, Murata M, Yanamoto S, Sawada S, et al. Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients. Sci Rep. 2021;11(1):17226.","journal-title":"Sci Rep"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-07130-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-025-07130-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-025-07130-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:27:02Z","timestamp":1762295222000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcoralhealth.biomedcentral.com\/articles\/10.1186\/s12903-025-07130-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7130"],"URL":"https:\/\/doi.org\/10.1186\/s12903-025-07130-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7003645\/v1","asserted-by":"object"}]},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"29 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures in this study were conducted in accordance with the ethical standards of the Declaration of Helsinki. The study protocol was reviewed and approved by the Biomedical Ethics Committee of Peking University School and Hospital of Stomatology (Approval No. PKUSSIRB-201949113). Written informed consent was obtained from all individual participants involved in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1740"}}