{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:07:56Z","timestamp":1781269676982,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Surgical site infections (SSIs) are a common complication after bimaxillary orthognathic surgery. While sulbactam\/ampicillin and cefmetazole are recommended in Japan, alternatives such as ampicillin and clindamycin are also used, with limited comparative evidence. This study assessed the impact of these antibiotics on SSI incidence and related risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 115 patients who underwent Le Fort I and bilateral sagittal split osteotomy at the University of Osaka Dental Hospital between January 1 and December 31 in 2023. Patients were categorized into four groups based on the prophylactic antibiotic administered: sulbactam\/ampicillin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200970), ampicillin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), cefmetazole (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925), and clindamycin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912). The duration of antibiotic administration was standardized within each group. Clinical variables such as age, sex, body mass index, third molar extraction, temporary anchorage devices insertion, operative time, and estimated blood loss were collected and compared between groups. SSI was defined as a postoperative infection requiring antibiotic treatment occurring within 30 days (or within 1 year if implants were used).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no significant differences in patient characteristics among the four antibiotic groups. SSI incidence was significantly higher in the ampicillin group compared to the sulbactam\/ampicillin group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046), while no other pairwise comparisons among the groups revealed statistically significant differences. Other clinical variables were not significantly associated with SSI occurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ampicillin monotherapy may be insufficient for preventing SSIs in bimaxillary orthognathic surgery. Sulbactam\/ampicillin demonstrated superior efficacy, whereas cefmetazole and clindamycin showed comparable effectiveness as alternative prophylactic agents. These findings underscore the importance of selecting appropriate antibiotics to minimize postoperative infection risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-025-07246-x","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T10:36:16Z","timestamp":1763980576000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between prophylactic antibiotics and surgical site infections in bimaxillary orthognathic surgery: a retrospective study"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0412-4118","authenticated-orcid":false,"given":"Ryuta","family":"Urakawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Horie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Ohishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Machida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumie","family":"Toda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Nozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Mima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soju","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko Tanaka","family":"Isomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"issue":"6","key":"7246_CR1","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1055\/s-0041-1735308","volume":"37","author":"RO Weiss","year":"2021","unstructured":"Weiss RO, et al. Orthognathic surgery-LeFort I osteotomy. Facial Plast Surg. 2021;37(6):703\u20138. https:\/\/doi.org\/10.1055\/s-0041-1735308.","journal-title":"Facial Plast Surg"},{"issue":"6","key":"7246_CR2","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1055\/s-0041-1735309","volume":"37","author":"S Bahmanyar","year":"2021","unstructured":"Bahmanyar S, et al. Orthognathic surgery of the mandible. Facial Plast Surg. 2021;37(6):716\u201321. https:\/\/doi.org\/10.1055\/s-0041-1735309.","journal-title":"Facial Plast Surg"},{"issue":"10","key":"7246_CR3","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.bjoms.2021.05.010","volume":"59","author":"APS Gil","year":"2021","unstructured":"Gil APS, et al. Antibiotic prophylaxis in orthognathic surgery: an overview of systematic reviews. Br J Oral Maxillofac Surg. 2021;59(10):1174\u201385. https:\/\/doi.org\/10.1016\/j.bjoms.2021.05.010.","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"6","key":"7246_CR4","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.bjoms.2020.09.020","volume":"59","author":"T Milic","year":"2021","unstructured":"Milic T, Raidoo P, Gebauer D. Antibiotic prophylaxis in oral and maxillofacial surgery: a systematic review. Br J Oral Maxillofac Surg. 2021;59(6):633\u201342. https:\/\/doi.org\/10.1016\/j.bjoms.2020.09.020.","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"4","key":"7246_CR5","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s15010-019-01303-8","volume":"47","author":"S Blatt","year":"2019","unstructured":"Blatt S, Al-Nawas B. A systematic review of latest evidence for antibiotic prophylaxis and therapy in oral and maxillofacial surgery. 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Because of the retrospective nature of the study, informed consent was waived.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1823"}}