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Randomized clinical trials (RCTs) addressing the management of TMJ-ID and TMJ-OA with i-PRF were included. Two reviewers independently evaluated the suitability of the RCTs, followed by data extraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The electronic search revealed 274 articles, but only 6 studies were deemed suitable for selection, with a total of 270 subjects; 75% were females, and 25% were males. Meta-analysis revealed a significant reduction in pain levels with i-PRF compared to controls (pooled SMD = \u2212\u20092.16; 95% CI = \u2212\u20093.43 to \u2212\u20090.89;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Significant improvement was also observed in maximum mouth opening (SMD\u2009=\u20092.46; 95% CI\u2009=\u20090.56 to 4.36;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). i-PRF significantly enhanced lateral mandibular movements compared with controls (SMD\u2009=\u20091.35; 95% CI\u2009=\u20090.03 to 2.67;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.048), whereas no significant difference was found for protrusive movements (SMD\u2009=\u20091.76; 95% CI = \u2212\u20090.97 to 4.48;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.11). Improvements in joint sounds and disc position were qualitatively reported in smaller subsets of studies. Substantial heterogeneity (I\u00b2 = 83\u201393%) was observed across outcomes, reflecting variability in study design and treatment protocols.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence suggests that i-PRF provides improvements in TMJ pain, joint sounds, and mandibular movements for up to 12 months. However, more RCTs are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-025-07331-1","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T09:21:27Z","timestamp":1765272087000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Is injectable platelet rich fibrin beneficial in managing intracapsular temporomandibular disorders? 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