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Oral health assessment was performed using the DMFT index, the Periodontal Screening Index (PSI), and the Plaque Index (PI).Oral hygiene practices were assessed through a structured questionnaire. Laboratory parameters, including GH, IGF-1, ACTH, cortisol, TSH, T4, fasting glucose, and HbA1c, were measured. Statistical analysis included group comparisons and correlation assessments with significance set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no significant differences between groups in oral hygiene scores, DMFT values, PSI, or PI scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, macroglossia (82.9%) and fissured tongue (51.4%) were significantly more common in patients with acromegaly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the acromegaly group, no significant associations were found between DMFT scores and clinical or hormonal parameters and a negative correlation was observed between oral hygiene and PSI scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and a positive correlation between PI and PSI scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant correlations were observed in the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tongue lesions were significantly more prevalent in patients with acromegaly, regardless of disease status or treatment. While general oral health parameters were similar between groups, periodontal inflammation in acromegaly was linked to poor oral hygiene. These findings suggest that acromegaly may be a risk factor for periodontal disease. Routine oral health monitoring is essential in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-025-07421-0","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:45:52Z","timestamp":1765079152000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral mucosal health in acromegaly: clinical insights and metabolic associations"],"prefix":"10.1186","volume":"26","author":[{"given":"Burak Can","family":"Cengiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sefika Burcak","family":"Polat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Yildizer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ihsan","family":"Ates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyhan","family":"Ersoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oya","family":"Topaloglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bekir","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"7421_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1750-1172-3-17","volume":"3","author":"P Chanson","year":"2008","unstructured":"Chanson P, Salenave S. 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