{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:04:19Z","timestamp":1791644659310,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epidermolysis bullosa (EB) is a rare genetic disorder characterized by skin and mucosal fragility, leading to significant oral health challenges due to mucosal blisters, pain, up to microstomia and ankyloglossia in severe cases. This retrospective study aimed to assess oral health in EB patients compared to a healthy control group to develop tailored dental protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Medical records and panoramic x-rays of EB patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) treated at the Center for Dental Medicine, University Medical Center Freiburg (2014\u20132024), were analyzed and compared to a healthy control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) with similar age- and gender distribution. Oral health was evaluated using DMFT\/dmft index and treatment data including extractions and fillings. Statistical analysis was performed using the Wilcoxon-Mann-Whitney test (\u03b1\u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      37 EB patients (median (25\u201375%) age: 10 (5;17) years) and 37 controls (median age: 9 (5;16) years) were included after three exclusions each. EB patients exhibited significantly higher DMFT\/dmft scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), more carious teeth (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), resulting in more tooth extractions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) compared to the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EB patients had significantly higher caries burden and required more extractions compared to controls. The findings of this study highlight the necessity of specific dental interventions emphasizing preventive care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-025-07457-2","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:53:53Z","timestamp":1764917633000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral health of patients with epidermolysis bullosa compared to healthy controls \u2013 a retrospective study from a specialized center"],"prefix":"10.1186","volume":"25","author":[{"given":"Tara","family":"Gro\u00df","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia Aurelia","family":"Stocker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin J.","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Has","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstin","family":"Vach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Cieplik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"7457_CR1","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/jdv.18637","volume":"37","author":"C Has","year":"2023","unstructured":"Has C, Hess M, Anem\u00fcller W, Blume-Peytavi U, Emmert S, F\u00f6lster\u2010Holst R, et al. 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