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Our provisional plan of pulp regenerative cell therapy as a clinical treatment was approved by a Category II Certified Committee for Regenerative Medicine and was officially accepted by the Japanese Ministry of Health, Labour and Welfare (approval numbers #PB3220153, and #PB4210005, approval data: 11 January 2023, and 7 July 2021) under the Act on the Safety of Regenerative Medicine. Clinical trial number: not applicable. Written informed consent was obtained from each patient after discussing the risks and benefits compared to alternative treatments (including conventional root canal therapy).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from both patients for publication of their case details and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"MN, NY and KI declare no competing interests. HT is a director of Air Water Aeras Bio Inc. These affiliations did not influence the conduct or outcomes of this work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1976"}}