{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:09:17Z","timestamp":1793844557066,"version":"4.6.1"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Klinikum der Universit\u00e4t M\u00fcnchen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the influence of adjunctive antibiotic therapy and patient-related factors on the success, survival, and prognosis of autogenous canine transplants over a two-year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty-seven patients (aged 11\u201337\u00a0years) underwent canine autotransplantation. According to extraoral storage time (EST: 0\u20133, 4\u20136, or 7\u201315\u00a0min), patients received either (1) no antibiotics, (2) a single intraoperative intravenous dose of doxycycline, or (3) the same dose followed by a five-day oral regimen. Because allocation of systemic adjunctive antibiotic therapy was EST-based, their effects could not be assessed independently. Clinical and radiographic evaluations were performed. Primary outcomes were survival and success. The secondary outcome was a composite prognostic estimate (percentage of criteria fulfilled). Associations were analysed using linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After two years, the success rate was 90% (95% CI: 82\u201397%), survival was 100%, and the mean prognostic estimate was 86% (95% CI: 82\u201389%). The adjunctive antibiotic therapy regimen had no significant effect. Success decreased with smoking (\u03b2\u2009=\u2009-8.03; p\u2009=\u20090.025). The prognostic estimate declined with increasing age (\u03b2\u2009=\u2009-1.30 per year), closed apex (\u03b2\u2009=\u2009-11.84), ankylosis (\u03b2\u2009=\u2009-13.80), orthodontic extrusion (\u03b2\u2009=\u2009-12.04) and its duration (\u03b2\u2009=\u2009-0.49 per month), and smoking (\u03b2\u2009=\u2009-14.15) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Routine adjunctive antibiotic therapy did not improve outcomes when allocated according to EST, supporting antibiotic stewardship. Prognosis was mainly influenced by patient-specific factors, highlighting the importance of individualised risk assessment in canine autotransplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      DRKS00034011 (German Clinical Trials Register and WHO International Clinical Trials Registry Platform); registered retrospectively on 4 April 2024.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/trialsearch.who.int\/Trial2.aspx?TrialID=DRKS00034011\" ext-link-type=\"uri\">https:\/\/trialsearch.who.int\/Trial2.aspx?TrialID=DRKS00034011<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-07697-w","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:26:15Z","timestamp":1769840775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autogenous tooth transplantation of canines: a prospective clinical study on the influence of extraoral storage time-guided adjunctive antibiotic therapy and patient-related risk factors affecting success, survival, and prognosis after two years of follow-up"],"prefix":"10.1186","volume":"26","author":[{"given":"Sebastian","family":"Meinzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin Christine","family":"Huth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"7697_CR1","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.14219\/jada.archive.2009.0099","volume":"140","author":"MM Bedoya","year":"2009","unstructured":"Bedoya MM, Park JH. 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