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All participants underwent DEXA at the L1\u2013L4 vertebral levels according to World Health Organization (WHO) criteria. The osteoporosis group consisted of 50 patients with a T-score \u2264 \u22122.5 and a clinical diagnosis of osteoporosis by the Physical Therapy Department, while the control group comprised 50 individuals with T-scores \u2265 \u22121 and no diagnosis of osteoporosis. Bilateral measurements of CTMI, CTI(S), and CTI(I) were averaged, and HU values were recorded from predefined mandibular regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All radiomorphometric indices and HU values were significantly lower in osteoporotic individuals compared to the control group. ROC analysis demonstrated threshold values for CTMI\u2009\u2264\u20093.35\u00a0mm (sensitivity: 86%, specificity: 98%), CTI(I)\u2009\u2264\u20090.36 (sensitivity: 78%, specificity: 92%), and CTI(S)\u2009\u2264\u20090.27 (sensitivity: 78%, specificity: 98%). Threshold HU values were observed as \u2264\u2009337 for the mandibular angle, \u2264 209 for the mandibular corpus, and \u2264\u2009470 for the interradicular area between teeth 3 and 4. Among these regions, the mandibular angle showed the highest area under the curve (AUC: 0.857; sensitivity: 90%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mandibular CT-derived radiomorphometric and densitometric measurements are associated with osteoporosis as defined by DEXA and may provide complementary information within an opportunistic screening framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>Not applicable. This retrospective study did not require registration in a clinical trial registry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-07829-2","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:33:58Z","timestamp":1770341638000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mandibular CT-Based radiomorphometric and density indices for opportunistic osteoporosis screening"],"prefix":"10.1186","volume":"26","author":[{"given":"Yakup","family":"\u015een","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcmeyye Co\u015fgun","family":"Baybars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda So\u011fukp\u0131nar","family":"Karaa\u011fa\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"issue":"3","key":"7829_CR1","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00198-023-06949-7","volume":"35","author":"J Heuchert","year":"2024","unstructured":"Heuchert J, Kozie\u0142 S, Spinek AE. 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