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One notable oral effect is glossitis, which manifested as tongue inflammation. Chronic alcohol consumption can lead to sialadenosis, disrupting salivary gland function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to demonstrate how alcohol intoxication induces histopathological and ultrastructural degenerative alterations in the tongue and parotid tissues of experimental rats and the therapeutic potential of 10-dehydrogingerdione (10-DHGD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 40 albino male rats were categorized equally into four groups for the purpose of investigation. The control group received no medication. For 45 days, the alcohol-treated group was given ethyl alcohol daily orally at a rate of 3.7\u00a0g\/kg body weight; 10-DHGD-treated group was given a daily orally dosage of 10\u00a0mg\/kg of freshly prepared extract; and the last group was administered a combination of alcohol and 10-DHGD. Histopathological analysis was performed in all the groups, while Ki-67 was used as an immunohistochemical investigation for any nuclear proliferative activity. Additionally, a transmission electron microscope (TEM) ultrastructural assessment was carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The alcohol-treated group displayed destructive alterations in their tongue and parotid tissues. 10-DHGD intake in combination with alcohol ameliorated such alterations to a certain extent. When comparing the alcohol-treated group\u2019s tissues to those of the other groups under inquiry, an immunohistochemical analysis showed a highly significant decrease in Ki-67 expression. In addition, TEM examination of alcohol examined groups revealed fragmented myofibrils of the muscle of the tongue with dilated RER and swollen mitochondria in both the tongue and parotid samples, which were minimized by concomitant 10-DHGD ingestion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long-term alcohol intake provoked intoxication in oral tissues, and 10-DHGD treatment dramatically ameliorated these deteriorating consequences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-07830-9","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:44:58Z","timestamp":1771613098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Histopathological and ultrastructure alterations in tongue and parotid tissues of rats in consequence to long-term alcohol intoxication and ameliorative role of 10-dehydrogingerdione"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4504-3859","authenticated-orcid":false,"given":"Nadia Fathy","family":"Hassabou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Elseweidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-7839","authenticated-orcid":false,"given":"Amina Fouad","family":"Farag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"issue":"2","key":"7830_CR1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.21101\/cejph.a5745","volume":"28","author":"H Cetinkaya","year":"2020","unstructured":"\u00c7etinkaya H, Romaniuk P. 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