{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:54:31Z","timestamp":1781636071805,"version":"3.54.5"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate intraoral findings, oral-health-status, and their relationship with general and oral-health\u2013related-quality-of-life in children diagnosed with neurofibromatosis type1, compared to healthy children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Fifty children with neurofibromatosis-type1 and fifty healthy children of similar age and gender underwent thorough oral examinations. Evaluations included the presence of dental caries, enamel hypoplasia, malocclusions, gingiva and plaque levels, and soft tissue abnormalities. Additional assessments included panoramic dental imaging and clinical photographs. General-quality-of-life was measured using a validated child-health-questionnaire, and oral health\u2013related-quality-of-life was assessed through age-appropriate caregiver-reported surveys. Statistical comparisons between groups were conducted using appropriate significance tests, with a threshold of\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no significant differences between groups in terms of tooth decay, enamel defects, or jaw relationships. Children with neurofibromatosis type 1 had lower gingival health scores and significantly reduced general quality of life. Younger children reported better oral-health\u2013related-quality-of-life, while older children experienced greater family-related impacts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although oral health issues in children with neurofibromatosis type 1 were generally mild, their overall and oral health\u2013related quality of life were meaningfully reduced. These findings underscore the importance of including dental professionals in the multidisciplinary care of children with this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevances<\/jats:title>\n                    <jats:p>Recognizing oral signs of NF1 early helps pediatric dentists guide timely referrals and coordinated care. Even mild oral findings can impair children\u2019s quality of life, emphasizing the need for regular monitoring and tailored dental care. Including dentists in multidisciplinary NF1 teams supports both medical and psychosocial well-being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-07905-7","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:57:04Z","timestamp":1770965824000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral findings and oral health-related quality of life in children with neurofibromatosis type 1: a case-control study"],"prefix":"10.1186","volume":"26","author":[{"given":"Elif","family":"Kabacioglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nursel","family":"Elcioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat Can","family":"Metin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda","family":"K\u00f6kali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"issue":"8","key":"7905_CR1","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/S1474-4422(14)70063-8","volume":"13","author":"AC Hirbe","year":"2014","unstructured":"Hirbe AC, Gutmann DH. Neurofibromatosis type 1: a multidisciplinary approach to care. Lancet Neurol. 2014;13(8):834\u201343.","journal-title":"Lancet Neurol"},{"key":"7905_CR2","first-page":"362","volume-title":"Swaiman\u2019s pediatric neurology principles and practice","author":"EA Thiele","year":"2018","unstructured":"Thiele EA, Korf BR. Phakomatoses and allied conditions. In: Swaiman KF, Finkel RS, Ashwal S, et al. editors. Swaiman\u2019s pediatric neurology principles and practice. 6th ed. China: Elsevier; 2018. pp. 362\u201372.","edition":"6"},{"key":"7905_CR3","unstructured":"Le C, Bedocs PM. Neurofibromatosis. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2020. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459358\/."},{"issue":"20","key":"7905_CR4","first-page":"354","volume":"117","author":"S Farschtschi","year":"2020","unstructured":"Farschtschi S, Mautner VF, McLean ACL, Schulz A, Friedrich RE, Rosahl SK. The neurofibromatoses. Dtsch Arztebl Int. 2020;117(20):354\u201360.","journal-title":"Dtsch Arztebl Int"},{"key":"7905_CR5","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1001\/archneur.1988.00520290115023","volume":"45","author":"DA Stumpf","year":"1988","unstructured":"Stumpf DA, Alksne JF, Annegers JF, et al. Neurofibromatosis conference statement. Arch Neurol. 1988;45:575\u20138. NIH consensus development conference.","journal-title":"Arch Neurol"},{"issue":"5","key":"7905_CR6","doi-asserted-by":"publisher","first-page":"e20190660","DOI":"10.1542\/peds.2019-0660","volume":"143","author":"DT Miller","year":"2019","unstructured":"Miller DT, Freedenberg D, Schorry E, et al. Health supervision for children with neurofibromatosis type 1. Pediatrics. 2019;143(5):e20190660.","journal-title":"Pediatrics"},{"issue":"5","key":"7905_CR7","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.pcl.2010.07.002","volume":"57","author":"KN Shah","year":"2010","unstructured":"Shah KN. The diagnostic and clinical significance of caf\u00e9-au-lait macules. Pediatr Clin North Am. 2010;57(5):1131\u201353.","journal-title":"Pediatr Clin North Am"},{"key":"7905_CR8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/archdischild-2014-308084","volume":"101","author":"BM Dunning-Davies","year":"2016","unstructured":"Dunning-Davies BM, Parker APJ. Annual review of children with neurofibromatosis type 1. Arch Dis Child Educ Pract Ed. 2016;101:102\u201311.","journal-title":"Arch Dis Child Educ Pract Ed"},{"issue":"6","key":"7905_CR9","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.jaad.2020.07.105","volume":"84","author":"BN Wilson","year":"2021","unstructured":"Wilson BN, John AM, Handler MZ, Schwartz RA. Neurofibromatosis type 1: new developments in genetics and treatment. J Am Acad Dermatol. 2021;84(6):1667\u201376. https:\/\/doi.org\/10.1016\/j.jaad.2020.07.105.","journal-title":"J Am Acad Dermatol"},{"key":"7905_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1010-5182(02)00160-9","volume":"31","author":"RE Friedrich","year":"2003","unstructured":"Friedrich RE, Giese M, Schmelzle R, Mautner VF, Scheuer HA. Jaw malformations plus displacement and numerical aberrations of teeth in neurofibromatosis type 1: a descriptive analysis of 48 patients based on panoramic radiographs and oral findings. J Craniomaxillofac Surg. 2003;31:1\u20139.","journal-title":"J Craniomaxillofac Surg"},{"key":"7905_CR11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13023-015-0239-4","volume":"10","author":"KS Cunha","year":"2015","unstructured":"Cunha KS, Rozza-De-Menezes RE, Luna EB, et al. High prevalence of hyposalivation in individuals with neurofibromatosis 1: a case-control study. Orphanet J Rare Dis. 2015;10:8\u201311.","journal-title":"Orphanet J Rare Dis"},{"key":"7905_CR12","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/0030-4220(84)90350-5","volume":"58","author":"SD Shapiro","year":"1984","unstructured":"Shapiro SD, Abramovitch K, Van Dis ML, et al. Neurofibromatosis: oral and radiographic manifestations. Oral Surg Oral Med Oral Pathol. 1984;58:493\u20138.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"7905_CR13","first-page":"381","volume-title":"Oral and maxillofacial pathology","author":"BW Neville","year":"1995","unstructured":"Neville BW, Damm DD, Allen CM, et al. Oral and maxillofacial pathology. Philadelphia: WB Saunders Company; 1995. pp. 381\u20133."},{"key":"7905_CR14","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0030-4220(83)90324-9","volume":"55","author":"SD Vincent","year":"1983","unstructured":"Vincent SD, Williams TP. Mandibular abnormalities in neurofibromatosis. Oral Surg Oral Med Oral Pathol. 1983;55:253\u20138.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"7905_CR15","first-page":"353","volume-title":"Syndromes of the head and neck","author":"RJ Gorlin","year":"1990","unstructured":"Gorlin RJ, Cohen MM, Levin LF. Syndromes of the head and neck. Oxford: Oxford University Press; 1990. pp. 353\u2013416."},{"key":"7905_CR16","unstructured":"World Health Organization. Regional Office for the Eastern Mediterranean. Concepts and methods of community-based initiatives. Cairo: WHO; 2003."},{"issue":"1","key":"7905_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13023-020-1310-3","volume":"15","author":"C Bergqvist","year":"2020","unstructured":"Bergqvist C, Servy A, Valeyrie-Allanore L, Ferkal S, Combemale P, Wolkenstein P, et al. Neurofibromatosis 1 French National guidelines based on an extensive literature review since 1966. Orphanet J Rare Dis. 2020;15(1):37.","journal-title":"Orphanet J Rare Dis"},{"key":"7905_CR18","volume-title":"The KIDSCREEN questionnaires\u2014Quality of life questionnaires for children and adolescents. Handbook","author":"The KIDSCREEN Group Europe","year":"2006","unstructured":"The KIDSCREEN Group Europe. The KIDSCREEN questionnaires\u2014Quality of life questionnaires for children and adolescents. Handbook. Lengerich: Pabst Science; 2006."},{"issue":"3","key":"7905_CR19","first-page":"185","volume":"71","author":"NL Huntington","year":"2011","unstructured":"Huntington NL, Spetter D, Jones JA, Rich SE, Garcia RI, Spiro A 3rd. Development and validation of a measure of pediatric oral health-related quality of life: the POQL. J Public Health Dent. 2011;71(3):185\u201393.","journal-title":"J Public Health Dent"},{"issue":"3","key":"7905_CR20","first-page":"173","volume":"74","author":"BT Pahel","year":"2007","unstructured":"Pahel BT, Rozier RG, Slade GD. Parental perceptions of children\u2019s oral health: the early childhood oral health impact scale (ECOHIS). J Dent Child (Chic). 2007;74(3):173\u201382.","journal-title":"J Dent Child (Chic)"},{"issue":"1","key":"7905_CR21","doi-asserted-by":"publisher","first-page":"25","DOI":"10.26650\/eor.2018.53923","volume":"52","author":"\u0130 Yaz\u0131c\u0131o\u011flu","year":"2018","unstructured":"Yaz\u0131c\u0131o\u011flu \u0130, Jones J, Do\u011fan C, Rich S, Garcia R\u0130. Validity and reliability of a Turkish pediatric oral health-related quality of life measure. Eur Oral Res. 2018;52(1):25\u201332.","journal-title":"Eur Oral Res"},{"issue":"Suppl 1","key":"7905_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1159\/000351673","volume":"47","author":"MW Genderson","year":"2013","unstructured":"Genderson MW, Sischo L, Markowitz K, Fine D. An overview of children\u2019s oral health-related quality of life assessment: from scale development to measuring outcomes. Caries Res. 2013;47(Suppl 1):13\u201321. https:\/\/doi.org\/10.1159\/000351673.","journal-title":"Caries Res"},{"issue":"2","key":"7905_CR23","doi-asserted-by":"publisher","first-page":"479","DOI":"10.15311\/selcukdentj.987468","volume":"9","author":"Y Kas\u0131mo\u011flu","year":"2022","unstructured":"Kas\u0131mo\u011flu Y, Yav\u015fan Z\u015e, Peker K, G\u00fcven Y, Tuna \u0130nce EB. Evaluation of the impact of oral health on the quality of life of preschool children with malocclusion. Selcuk Dent J. 2022;9(2):479\u201387.","journal-title":"Selcuk Dent J"},{"issue":"3","key":"7905_CR24","first-page":"157","volume":"57","author":"KB \u00c7arman","year":"2017","unstructured":"\u00c7arman KB, Yarar C, Ekici A, Yimenicio\u011flu S, Ko\u00e7ak O, I\u015f\u0131k \u0130, \u015e\u00f6hret C, La\u00e7inel G\u00fcrlevik S, Yakut A. N\u00f6rofibromatozis tip 1: 49 Olgunun de\u011ferlendirilmesi. Haydarpa\u015fa Numune Med J. 2017;57(3):157\u201360.","journal-title":"Haydarpa\u015fa Numune Med J"},{"key":"7905_CR25","doi-asserted-by":"publisher","first-page":"181","DOI":"10.12956\/tchd.635116","volume":"15","author":"\u015e Y\u0131lmaz","year":"2021","unstructured":"Y\u0131lmaz \u015e, Ar\u0131ba\u015f \u00d6z N, Akmaz \u00dcnl\u00fc H, Al\u0131ml\u0131 AG, Sivri M. N\u00f6rofibromatozis tip 1: \u00c7ocuk Hastalarda klinik ve Beyin MRG bulgular\u0131. T\u00fcrkiye \u00c7ocuk Hast Derg. 2021;15:181\u20136.","journal-title":"T\u00fcrkiye \u00c7ocuk Hast Derg"},{"issue":"4","key":"7905_CR26","doi-asserted-by":"publisher","first-page":"339","DOI":"10.5152\/TurkArchPediatr.2021.20165","volume":"56","author":"AG Ka\u00e7ar","year":"2021","unstructured":"Ka\u00e7ar AG, K\u0131l\u0131n\u00e7 Oktay B, \u00c7\u0131nar \u00d6zel S, et al. Neurofibromatosis type 1 in children: a single-center experience. Turk Arch Pediatr. 2021;56(4):339\u201343.","journal-title":"Turk Arch Pediatr"},{"issue":"2","key":"7905_CR27","doi-asserted-by":"publisher","first-page":"646","DOI":"10.17826\/cumj.876942","volume":"46","author":"\u015e \u00c7al\u0131\u015fkan Kam\u0131\u015f","year":"2021","unstructured":"\u00c7al\u0131\u015fkan Kam\u0131\u015f \u015e, Ya\u011fc\u0131-K\u00fcpeli B. Factors affecting clinical phenotype in children with neurofibromatosis type 1. Cukurova Med J. 2021;46(2):646\u201353.","journal-title":"Cukurova Med J"},{"issue":"2","key":"7905_CR28","doi-asserted-by":"publisher","first-page":"192","DOI":"10.5472\/marumj.1302264","volume":"36","author":"N Eker","year":"2023","unstructured":"Eker N, Tokuc AG, Tufan BT, Senay E. Is neurofibromatosis type 1 diagnosed in every patient who presents with caf\u00e9 Au Lait macules? A single-center experience. Marmara Med J. 2023;36(2):192\u20136.","journal-title":"Marmara Med J"},{"issue":"5","key":"7905_CR29","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1600-0722.2007.00474.x","volume":"115","author":"M Lammert","year":"2007","unstructured":"Lammert M, Friedrich RE, et al. Early primary tooth eruption in neurofibromatosis 1 individuals. Eur J Oral Sci. 2007;115(5):425\u20136.","journal-title":"Eur J Oral Sci"},{"issue":"14","key":"7905_CR30","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.3390\/app10144687","volume":"10","author":"R Santoro","year":"2020","unstructured":"Santoro R, Santoro C, Loffredo F, et al. Oral clinical manifestations of neurofibromatosis type 1 in children and adolescents. Appl Sci. 2020;10(14):4687.","journal-title":"Appl Sci"},{"key":"7905_CR31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/BF03262818","volume":"12","author":"E Bardellini","year":"2011","unstructured":"Bardellini E, Amadori F, Flocchini P, et al. Oral findings in 50 children with neurofibromatosis type 1: a case-control study. Eur J Paediatr Dent. 2011;12:256\u201360.","journal-title":"Eur J Paediatr Dent"},{"issue":"6","key":"7905_CR32","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/j.1600-0722.2012.01000.x","volume":"120","author":"P J\u00e4\u00e4saari","year":"2012","unstructured":"J\u00e4\u00e4saari P, Visnapuu V, Nystr\u00f6m M, Peltonen S, Peltonen J, Happonen RP. Dental age in patients with neurofibromatosis 1. Eur J Oral Sci. 2012;120(6):549\u201352.","journal-title":"Eur J Oral Sci"},{"issue":"4","key":"7905_CR33","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00784-009-0361-6","volume":"14","author":"ES Tsang","year":"2010","unstructured":"Tsang ES, Birch P, Friedman JM, et al. Prevalence of dental caries in children with neurofibromatosis 1. Clin Oral Investig. 2010;14(4):479\u201380.","journal-title":"Clin Oral Investig"},{"issue":"6","key":"7905_CR34","first-page":"455","volume":"8","author":"E Thota","year":"2022","unstructured":"Thota E, Veeravalli JJ, Manchala SK, et al. Segmental neurofibromatosis is caused by somatic mutation of the neurofibromatosis type 1 (NF1) gene. Eur J Hum Genet. 2022;8(6):455\u20139.","journal-title":"Eur J Hum Genet"},{"issue":"2","key":"7905_CR35","first-page":"e107","volume":"10","author":"RE Friedrich","year":"2018","unstructured":"Friedrich RE, Reul A. Decayed, missing, and restored teeth in patients with neurofibromatosis type 1. J Clin Exp Dent. 2018;10(2):e107\u201315.","journal-title":"J Clin Exp Dent"},{"issue":"1","key":"7905_CR36","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s00784-009-0341-x","volume":"15","author":"V Visnapuu","year":"2011","unstructured":"Visnapuu V, Pienih\u00e4kkinen K, Peltonen S, Happonen RP, Peltonen J. Neurofibromatosis 1 and dental caries. Clin Oral Investig. 2011;15(1):119\u201321.","journal-title":"Clin Oral Investig"},{"key":"7905_CR37","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13023-018-0881-8","volume":"13","author":"V Visnapuu","year":"2018","unstructured":"Visnapuu V, Peltonen S, Alivuotila L, Happonen RP, Peltonen J. Craniofacial and oral alterations in patients with neurofibromatosis 1. Orphanet J Rare Dis. 2018;13:131.","journal-title":"Orphanet J Rare Dis"},{"issue":"3","key":"7905_CR38","doi-asserted-by":"publisher","first-page":"e300","DOI":"10.4317\/jced.61363","volume":"16","author":"RE Friedrich","year":"2024","unstructured":"Friedrich RE, Sch\u00f6n M. Dental developmental stages and decayed, missing, and restored teeth in neurofibromatosis type 1-affected children and adolescents. J Clin Exp Dent. 2024;16(3):e300\u201322.","journal-title":"J Clin Exp Dent"},{"issue":"2","key":"7905_CR39","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00784-011-0519-x","volume":"16","author":"EM Jouhilahti","year":"2012","unstructured":"Jouhilahti EM, Visnapuu V, Soukka T, et al. Oral soft tissue alterations in patients with neurofibromatosis. Clin Oral Investig. 2012;16(2):551\u20138.","journal-title":"Clin Oral Investig"},{"key":"7905_CR40","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.joms.2011.06.204","volume":"70","author":"V Visnapuu","year":"2012","unstructured":"Visnapuu V, Peltonen S, Tammisalo T, Peltonen J, Happonen RP. Radiographic findings in the jaws of patients with neurofibromatosis 1. J Oral Maxillofac Surg. 2012;70:1351\u20137.","journal-title":"J Oral Maxillofac Surg"},{"issue":"7","key":"7905_CR41","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.jcms.2018.04.018","volume":"46","author":"RE Friedrich","year":"2018","unstructured":"Friedrich RE, Reul A. A combination of skeletal deformations of the dorsal mandible and temporomandibular region detected in orthopantomograms of patients with neurofibromatosis type 1 indicates an associated ipsilateral plexiform neurofibroma. J Craniomaxillofac Surg. 2018;46(7):1091\u2013104.","journal-title":"J Craniomaxillofac Surg"},{"issue":"4","key":"7905_CR42","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.21873\/anticanres.13308","volume":"39","author":"RE Friedrich","year":"2019","unstructured":"Friedrich RE, Scheuer HT. Non-odontogenic intraosseous radiolucent lesions of the mandibular body are rare findings on panoramic views of patients with neurofibromatosis type 1. Anticancer Res. 2019;39(4):1971\u201385.","journal-title":"Anticancer Res"},{"issue":"1","key":"7905_CR43","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jcms.2019.12.006","volume":"48","author":"RE Friedrich","year":"2020","unstructured":"Friedrich RE, Scheuer HT, Kersten JF, Scheuer HA. Supernumerary teeth of permanent dentition in patients with neurofibromatosis type 1. J Craniomaxillofac Surg. 2020;48(1):98\u2013104.","journal-title":"J Craniomaxillofac Surg"},{"issue":"4","key":"7905_CR44","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.5037\/jomr.2017.8405","volume":"8","author":"RE Friedrich","year":"2017","unstructured":"Friedrich RE, Reul A. Supernumerary molars and wisdom tooth shape alterations in patients with neurofibromatosis type 1. J Oral Maxillofac Res. 2017;8(4):e5.","journal-title":"J Oral Maxillofac Res"},{"issue":"1","key":"7905_CR45","first-page":"25","volume":"24","author":"S Salt\u0131k","year":"2013","unstructured":"Salt\u0131k S, Ba\u015fg\u00fcl \u015eS. N\u00f6rofibromatozis tip 1 tan\u0131l\u0131 \u00e7ocuklarda Annelerin de\u011ferlendirmesine g\u00f6re ya\u015fam kalitesi. Turk Psikiyatri Derg. 2013;24(1):25\u201334.","journal-title":"Turk Psikiyatri Derg"},{"issue":"1","key":"7905_CR46","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1186\/s13023-021-02051-5","volume":"16","author":"A Roy","year":"2021","unstructured":"Roy A, Roulin JL, Gras-Le Guen C, Corbat ML, Barbarot S. Executive functions and quality of life in children with neurofibromatosis type 1. Orphanet J Rare Dis. 2021;16(1):420.","journal-title":"Orphanet J Rare Dis"},{"key":"7905_CR47","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1111\/1346-8138.16510","volume":"49","author":"Y Yoshida","year":"2022","unstructured":"Yoshida Y, Ehara Y, Koga M, Imafuku S. Health-related quality of life in patients with neurofibromatosis 1 in japan: a questionnaire survey using EQ-5D-5L. J Dermatol. 2022;49:1228\u201332.","journal-title":"J Dermatol"},{"key":"7905_CR48","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ejpn.2023.05.010","volume":"45","author":"BAE Dhaenens","year":"2023","unstructured":"Dhaenens BAE, Rietman A, Husson O, Oostenbrink R. Health-related quality of life of children with neurofibromatosis type 1: analysis of proxy-rated PedsQL and CHQ questionnaires. Eur J Paediatr Neurol. 2023;45:36\u201346.","journal-title":"Eur J Paediatr Neurol"},{"issue":"8","key":"7905_CR49","first-page":"1033","volume":"11","author":"ND Cavallo","year":"2024","unstructured":"Cavallo ND, Maietta P, Perrotta S, Moretta P, Carotenuto M, Esposito M, Santangelo G, Santoro C. Quality of life in children with neurofibromatosis type 1: agreement between parents and patients, and the role of disease severity and visibility. Child (Basel). 2024;11(8):1033.","journal-title":"Child (Basel)"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-026-07905-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-07905-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-07905-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:12:53Z","timestamp":1781633573000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12903-026-07905-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7905"],"URL":"https:\/\/doi.org\/10.1186\/s12903-026-07905-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7664683\/v1","asserted-by":"object"}]},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"20 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This clinical study was conducted at the Department of Pediatric Dentistry, Faculty of Dentistry, Marmara University. Ethical approval was obtained from the Clinical Research Ethics Committee of the Faculty of Dentistry at Marmara University for both the clinical and quality of life components of the study (Approval Number: 2022-93, Date: October 12, 2022). All procedures were performed in accordance with the ethical standards of the Declaration of Helsinki. Written informed consent to participate was obtained from the legal guardians of all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"505"}}