{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:53:47Z","timestamp":1793840027538,"version":"4.6.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023A04J1190"],"award-info":[{"award-number":["2023A04J1190"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023A03J0326"],"award-info":[{"award-number":["2023A03J0326"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["02-410-2302190XM"],"award-info":[{"award-number":["02-410-2302190XM"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-026-07979-3","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:15:44Z","timestamp":1772194544000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Porphyromonas gingivalis-derived outer membrane vesicles travel from oral to distant organs via blood circulation in a time-dependent manner"],"prefix":"10.1186","volume":"26","author":[{"given":"Congcong","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaikai","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingchan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"issue":"18","key":"7979_CR1","first-page":"5775","volume":"22","author":"R Patini","year":"2018","unstructured":"Patini R, Staderini E, Lajolo C, Lopetuso L, Mohammed H, Rimondini L, et al. Relationship between oral microbiota and periodontal disease: a systematic review. Eur Rev Med Pharmacol Sci. 2018;22(18):5775\u201388.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"11","key":"7979_CR2","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.hlc.2018.05.102","volume":"27","author":"EF Carrizales-Sep\u00falveda","year":"2018","unstructured":"Carrizales-Sep\u00falveda EF, Ordaz-Far\u00edas A, Vera-Pineda R, Flores-Ram\u00edrez R. Periodontal disease, systemic inflammation and the risk of cardiovascular disease. Heart Lung Circ. 2018;27(11):1327\u201334.","journal-title":"Heart Lung Circ"},{"issue":"3","key":"7979_CR3","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s11926-014-0408-9","volume":"16","author":"J Koziel","year":"2014","unstructured":"Koziel J, Mydel P, Potempa J. The link between periodontal disease and rheumatoid arthritis: an updated review. Curr Rheumatol Rep. 2014;16(3):408.","journal-title":"Curr Rheumatol Rep"},{"issue":"9","key":"7979_CR4","doi-asserted-by":"publisher","first-page":"978","DOI":"10.2174\/1567205014666170316163340","volume":"14","author":"M Sochocka","year":"2017","unstructured":"Sochocka M, Sobczy\u0144ski M, Sender-Janeczek A, Zwoli\u0144ska K, B\u0142achowicz O, Tomczyk T, et al. Association between periodontal health status and cognitive abilities. The role of cytokine profile and systemic inflammation. Curr Alzheimer Res. 2017;14(9):978\u201390.","journal-title":"Curr Alzheimer Res"},{"issue":"9","key":"7979_CR5","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1007\/s00784-018-2726-1","volume":"22","author":"MS Alakhali","year":"2018","unstructured":"Alakhali MS, Al-Maweri SA, Al-Shamiri HM, Al-Haddad K, Halboub E. The potential association between periodontitis and non-alcoholic fatty liver disease: a systematic review. Clin Oral Invest. 2018;22(9):2965\u201374.","journal-title":"Clin Oral Invest"},{"issue":"7","key":"7979_CR6","doi-asserted-by":"publisher","first-page":"3728","DOI":"10.3390\/ijms22073728","volume":"22","author":"M Hatasa","year":"2021","unstructured":"Hatasa M, Yoshida S, Takahashi H, Tanaka K, Kubotsu Y, Ohsugi Y, et al. Relationship between NAFLD and periodontal disease from the view of clinical and basic research, and immunological response. Int J Mol Sci. 2021;22(7):3728.","journal-title":"Int J Mol Sci"},{"issue":"12","key":"7979_CR7","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","volume":"16","author":"RJ Lamont","year":"2018","unstructured":"Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol. 2018;16(12):745\u201359.","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"7979_CR8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/jcpe.14061","volume":"52","author":"F Teles","year":"2025","unstructured":"Teles F, Martin L, Patel M, Hu W, Bittinger K, Kallan MJ, et al. Gingival crevicular fluid biomarkers during periodontitis progression and after periodontal treatment. J Clin Periodontol. 2025;52(1):40\u201355.","journal-title":"J Clin Periodontol"},{"issue":"1","key":"7979_CR9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/prd.12427","volume":"89","author":"E Albuquerque-Souza","year":"2022","unstructured":"Albuquerque-Souza E, Sahingur SE. Periodontitis, chronic liver diseases, and the emerging oral-gut-liver axis. Periodontol 2000. 2022;89(1):125\u201341.","journal-title":"Periodontol 2000"},{"issue":"4","key":"7979_CR10","doi-asserted-by":"publisher","first-page":"100825","DOI":"10.1016\/j.identj.2025.03.029","volume":"75","author":"C Lv","year":"2025","unstructured":"Lv C, Shi K, Guo Y, Guo Z, Luo P, Wang L, et al. Emerging roles of periodontal pathogen-derived outer membrane vesicles in NAFLD. Int Dent J. 2025;75(4):100825.","journal-title":"Int Dent J"},{"issue":"16","key":"7979_CR11","doi-asserted-by":"publisher","first-page":"4725","DOI":"10.1128\/JB.181.16.4725-4733.1999","volume":"181","author":"TJ Beveridge","year":"1999","unstructured":"Beveridge TJ. Structures of gram-negative cell walls and their derived membrane vesicles. J Bacteriol. 1999;181(16):4725\u201333.","journal-title":"J Bacteriol"},{"issue":"1","key":"7979_CR12","doi-asserted-by":"publisher","first-page":"10.1128","DOI":"10.1128\/microbiolspec.PSIB-0001-2018","volume":"7","author":"JD Cecil","year":"2019","unstructured":"Cecil JD, Sirisaengtaksin N, O\u2019Brien-Simpson NM, Krachler AM. Outer membrane vesicle-host cell interactions. Microbiol Spectr. 2019;7(1):10.1128.","journal-title":"Microbiol Spectr"},{"issue":"4","key":"7979_CR13","doi-asserted-by":"publisher","first-page":"e0151967","DOI":"10.1371\/journal.pone.0151967","volume":"11","author":"JD Cecil","year":"2016","unstructured":"Cecil JD, O\u2019Brien-Simpson NM, Lenzo JC, Holden JA, Chen YY, Singleton W, et al. Differential responses of pattern recognition receptors to outer membrane vesicles of three periodontal pathogens. PLoS ONE. 2016;11(4):e0151967.","journal-title":"PLoS ONE"},{"issue":"1","key":"7979_CR14","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1128\/MMBR.00031-09","volume":"74","author":"TN Ellis","year":"2010","unstructured":"Ellis TN, Kuehn MJ. Virulence and immunomodulatory roles of bacterial outer membrane vesicles. Microbiol Mol Biol Rev. 2010;74(1):81\u201394.","journal-title":"Microbiol Mol Biol Rev"},{"key":"7979_CR15","doi-asserted-by":"publisher","first-page":"585917","DOI":"10.3389\/fcimb.2020.585917","volume":"10","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Liu D, Liu S, Zhang S, Pan Y. The role of Porphyromonas gingivalis outer membrane vesicles in periodontal disease and related systemic diseases. Front Cell Infect Microbiol. 2020;10:585917.","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"7979_CR16","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1016\/j.bbamcr.2013.12.011","volume":"1843","author":"KE Bonnington","year":"2014","unstructured":"Bonnington KE, Kuehn MJ. Protein selection and export via outer membrane vesicles. Biochim Biophys Acta. 2014;1843(8):1612\u20139.","journal-title":"Biochim Biophys Acta"},{"key":"7979_CR17","doi-asserted-by":"publisher","first-page":"628139","DOI":"10.3389\/fcell.2021.628139","volume":"9","author":"JL Pathak","year":"2021","unstructured":"Pathak JL, Fang Y, Chen Y, Ye Z, Guo X, Yan Y, et al. Downregulation of macrophage-specific Act-1 intensifies periodontitis and alveolar bone loss possibly via TNF\/NF-\u03baB signaling. Front Cell Dev Biol. 2021;9:628139.","journal-title":"Front Cell Dev Biol"},{"key":"7979_CR18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jare.2023.02.006","volume":"54","author":"X Ma","year":"2023","unstructured":"Ma X, Shin YJ, Yoo JW, Park HS, Kim DH. Extracellular vesicles derived from Porphyromonas gingivalis induce trigeminal nerve-mediated cognitive impairment. J Adv Res. 2023;54:293\u2013303.","journal-title":"J Adv Res"},{"issue":"18","key":"7979_CR19","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.1002\/smll.201300171","volume":"9","author":"D Ding","year":"2013","unstructured":"Ding D, Liu J, Feng G, Li K, Hu Y, Liu B. Bright far-red\/near-infrared conjugated polymer nanoparticles for in vivo bioimaging. Small. 2013;9(18):3093\u2013102.","journal-title":"Small"},{"issue":"4","key":"7979_CR20","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/smll.201401803","volume":"11","author":"SC Jang","year":"2015","unstructured":"Jang SC, Kim SR, Yoon YJ, Park KS, Kim JH, Lee J, et al. In vivo kinetic biodistribution of nano-sized outer membrane vesicles derived from bacteria. Small. 2015;11(4):456\u201361.","journal-title":"Small"},{"issue":"6","key":"7979_CR21","doi-asserted-by":"publisher","first-page":"165731","DOI":"10.1016\/j.bbadis.2020.165731","volume":"1866","author":"M Seyama","year":"2020","unstructured":"Seyama M, Yoshida K, Yoshida K, Fujiwara N, Ono K, Eguchi T, et al. Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver. Biochim Biophys Acta. 2020;1866(6):165731.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"7979_CR22","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1021\/pr200842h","volume":"11","author":"DS Choi","year":"2012","unstructured":"Choi DS, Yang JS, Choi EJ, Jang SC, Park S, Kim OY, et al. The protein interaction network of extracellular vesicles derived from human colorectal cancer cells. J Proteome Res. 2012;11(2):1144\u201351.","journal-title":"J Proteome Res"},{"issue":"22","key":"7979_CR23","doi-asserted-by":"publisher","first-page":"7945","DOI":"10.1128\/JB.00858-07","volume":"189","author":"HC Flemming","year":"2007","unstructured":"Flemming HC, Neu TR, Wozniak DJ. The EPS matrix: the \u201chouse of biofilm cells.\u201d J Bacteriol. 2007;189(22):7945\u20137.","journal-title":"J Bacteriol"},{"issue":"1","key":"7979_CR24","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/prd.12387","volume":"87","author":"R Kuraji","year":"2021","unstructured":"Kuraji R, Sekino S, Kapila Y, Numabe Y. Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an emerging concept of oral-liver axis. Periodontol 2000. 2021;87(1):204\u201340.","journal-title":"Periodontol 2000"},{"issue":"19","key":"7979_CR25","doi-asserted-by":"publisher","first-page":"e9416","DOI":"10.1172\/jci.insight.94416","volume":"2","author":"C Acharya","year":"2017","unstructured":"Acharya C, Sahingur SE, Bajaj JS. Microbiota, cirrhosis, and the emerging oral-gut-liver axis. JCI Insight. 2017;2(19):e9416.","journal-title":"JCI Insight"},{"issue":"3","key":"7979_CR26","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/j.jds.2023.03.012","volume":"18","author":"TP Chen","year":"2023","unstructured":"Chen TP, Yu HC, Lin WY, Chang YC. The role of microbiome in the pathogenesis of oral-gut-liver axis between periodontitis and nonalcoholic fatty liver disease. J Dent Sci. 2023;18(3):972\u20135.","journal-title":"J Dent Sci"},{"key":"7979_CR27","doi-asserted-by":"publisher","first-page":"822190","DOI":"10.3389\/fmed.2022.822190","volume":"9","author":"T Wang","year":"2022","unstructured":"Wang T, Ishikawa T, Sasaki M, Chiba T. Oral and gut microbial dysbiosis and non-alcoholic fatty liver disease: the central role of Porphyromonas gingivalis. Front Med (Lausanne). 2022;9:822190.","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"7979_CR28","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3233\/JAD-180319","volume":"65","author":"S Aguayo","year":"2018","unstructured":"Aguayo S, Schuh C, Vicente B, Aguayo LG. Association between Alzheimer\u2019s disease and oral and gut microbiota: are pore forming proteins the missing link? J Alzheimers Dis. 2018;65(1):29\u201346.","journal-title":"J Alzheimers Dis"},{"issue":"null","key":"7979_CR29","first-page":"718222","volume":"8","author":"J Dong","year":"2021","unstructured":"Dong J, Li W, Wang Q, Chen J, Zu Y, Zhou X, et al. Relationships between oral microecosystem and respiratory diseases. Front Mol Biosci. 2021;8(null):718222.","journal-title":"Front Mol Biosci"},{"issue":"1","key":"7979_CR30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/prd.12540","volume":"96","author":"G Baima","year":"2024","unstructured":"Baima G, Minoli M, Michaud DS, Aimetti M, Sanz M, Loos BG, et al. Periodontitis and risk of cancer: mechanistic evidence. Periodontol 2000. 2024;96(1):83\u201394.","journal-title":"Periodontol 2000"},{"issue":"12","key":"7979_CR31","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1177\/00220345221104725","volume":"101","author":"G Baima","year":"2022","unstructured":"Baima G, Marruganti C, Sanz M, Aimetti M, Romandini M. Periodontitis and COVID-19: biological mechanisms and meta-analyses of epidemiological evidence. J Dent Res. 2022;101(12):1430\u201340.","journal-title":"J Dent Res"},{"issue":"8","key":"7979_CR32","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.3109\/10717544.2015.1045103","volume":"23","author":"N Liang","year":"2016","unstructured":"Liang N, Sun S, Hong J, Tian J, Fang L, Cui F. In vivo pharmacokinetics, biodistribution and antitumor effect of paclitaxel-loaded micelles based on alpha-tocopherol succinate-modified chitosan. Drug Deliv. 2016;23(8):2651\u201360.","journal-title":"Drug Deliv"},{"issue":"1-3","key":"7979_CR33","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0168-3659(01)00275-9","volume":"72","author":"SC Kim","year":"2001","unstructured":"Kim SC, Kim DW, Shim YH, Bang JS, Oh HS, Wan Kim S, et al. In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy. J Control Release. 2001;72(1\u20133):191\u2013202.","journal-title":"J Control Release"},{"issue":"3","key":"7979_CR34","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/s41591-023-02227-5","volume":"29","author":"AJ Macpherson","year":"2023","unstructured":"Macpherson AJ, Sauer U. Secrets of microbiota drug metabolism. Nat Med. 2023;29(3):537\u20138.","journal-title":"Nat Med"},{"issue":"5","key":"7979_CR35","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nrmicro.2016.17","volume":"14","author":"P Spanogiannopoulos","year":"2016","unstructured":"Spanogiannopoulos P, Bess EN, Carmody RN, Turnbaugh PJ. The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism. Nat Rev Microbiol. 2016;14(5):273\u201387.","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"7979_CR36","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.apsb.2019.10.001","volume":"9","author":"Y Li","year":"2019","unstructured":"Li Y, Meng Q, Yang M, Liu D, Hou X, Tang L, et al. Current trends in drug metabolism and pharmacokinetics. Acta Pharm Sin B. 2019;9(6):1113\u201344.","journal-title":"Acta Pharm Sin B"},{"issue":"7","key":"7979_CR37","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1111\/jcpe.13303","volume":"47","author":"WC Lee","year":"2020","unstructured":"Lee WC, Fu E, Li CH, Huang RY, Chiu HC, Cheng WC, et al. Association between periodontitis and pulmonary function based on the Third National Health and Nutrition Examination Survey (NHANES III). J Clin Periodontol. 2020;47(7):788\u201395.","journal-title":"J Clin Periodontol"},{"key":"7979_CR38","doi-asserted-by":"publisher","first-page":"121165","DOI":"10.1016\/j.talanta.2020.121165","volume":"221","author":"S Mayr","year":"2021","unstructured":"Mayr S, Schmelzer J, Kirchler CG, Pezzei CK, Bec KB, Grabska J, et al. Theae nigrae folium: comparing the analytical performance of benchtop and handheld near-infrared spectrometers. Talanta. 2021;221:121165.","journal-title":"Talanta"},{"key":"7979_CR39","doi-asserted-by":"publisher","first-page":"339900","DOI":"10.1016\/j.aca.2022.339900","volume":"1211","author":"G Gorla","year":"2022","unstructured":"Gorla G, Taiana A, Boque R, Bani P, Gachiuta O, Giussani B. Unravelling error sources in miniaturized NIR spectroscopic measurements: the case study of forages. Anal Chim Acta. 2022;1211:339900.","journal-title":"Anal Chim Acta"},{"issue":"6","key":"7979_CR40","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nri3837","volume":"15","author":"M Kaparakis-Liaskos","year":"2015","unstructured":"Kaparakis-Liaskos M, Ferrero RL. Immune modulation by bacterial outer membrane vesicles. Nat Rev Immunol. 2015;15(6):375\u201387.","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"7979_CR41","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nrmicro3525","volume":"13","author":"C Schwechheimer","year":"2015","unstructured":"Schwechheimer C, Kuehn MJ. Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions. Nat Rev Microbiol. 2015;13(10):605\u201319.","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"7979_CR42","doi-asserted-by":"publisher","first-page":"e1000724","DOI":"10.1371\/journal.ppat.1000724","volume":"6","author":"ML Vidakovics","year":"2010","unstructured":"Vidakovics ML, Jendholm J, Morgelin M, Mansson A, Larsson C, Cardell LO, et al. B cell activation by outer membrane vesicles\u2013a novel virulence mechanism. PLoS Pathog. 2010;6(1):e1000724.","journal-title":"PLoS Pathog"},{"issue":"4","key":"7979_CR43","doi-asserted-by":"publisher","first-page":"e0003222","DOI":"10.1128\/mmbr.00032-22","volume":"86","author":"R Juodeikis","year":"2022","unstructured":"Juodeikis R, Carding SR. Outer membrane vesicles: biogenesis, functions, and issues. Microbiol Mol Biol Rev. 2022;86(4):e0003222.","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1","key":"7979_CR44","doi-asserted-by":"publisher","first-page":"e12407","DOI":"10.1002\/jev2.12407","volume":"13","author":"HY Kim","year":"2024","unstructured":"Kim HY, Lim Y, Jang JS, Ko YK, Choi Y, Kim HH, et al. Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll-like receptor 2 and plasminogen activator inhibitor-1. J Extracell Vesicles. 2024;13(1):e12407.","journal-title":"J Extracell Vesicles"},{"issue":"4","key":"7979_CR45","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3343\/alm.2019.39.4.345","volume":"39","author":"AY Gasparyan","year":"2019","unstructured":"Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD. The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann Lab Med. 2019;39(4):345\u201357.","journal-title":"Ann Lab Med"},{"issue":"16","key":"7979_CR46","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1161\/CIRCULATIONAHA.119.045102","volume":"141","author":"M Siedlinski","year":"2020","unstructured":"Siedlinski M, Jozefczuk E, Xu X, Teumer A, Evangelou E, Schnabel RB, et al. White blood cells and blood pressure: a Mendelian randomization study. Circulation. 2020;141(16):1307\u201317.","journal-title":"Circulation"},{"issue":"12","key":"7979_CR47","first-page":"1123","volume":"323","author":"R Rubin","year":"2020","unstructured":"Rubin R. White blood cells might provide clues to breast cancer risk. JAMA. 2020;323(12):1123.","journal-title":"JAMA"},{"issue":"2","key":"7979_CR48","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s12072-021-10153-2","volume":"15","author":"M Duan","year":"2021","unstructured":"Duan M, Chi X, Xiao H, Liu X, Zhuang H. High-normal alanine aminotransferase is an indicator for liver histopathology in HBeAg-negative chronic hepatitis B. Hepatol Int. 2021;15(2):318\u201327.","journal-title":"Hepatol Int"},{"issue":"2","key":"7979_CR49","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3904\/kjim.2020.050","volume":"35","author":"PS Sung","year":"2020","unstructured":"Sung PS. A different detection method reveals a new role of alanine aminotransferase as an indicator of liver fibrosis. Korean J Intern Med. 2020;35(2):295\u20137.","journal-title":"Korean J Intern Med"},{"issue":"3","key":"7979_CR50","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/jvh.13640","volume":"29","author":"XD Wang","year":"2022","unstructured":"Wang XD, Pan CW, Zhou GY, Gao F, Wang FL, Fu RQ, et al. Effect of liver steatosis on liver stiffness measurement in chronic hepatitis B patients with normal serum alanine aminotransferase levels: a multicentre cohort study. J Viral Hepat. 2022;29(3):196\u2013204.","journal-title":"J Viral Hepat"},{"issue":"1","key":"7979_CR51","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/s41467-023-35861-1","volume":"14","author":"M Yang","year":"2023","unstructured":"Yang M, Qi X, Li N, Kaifi JT, Chen S, Wheeler AA, et al. Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol. Nat Commun. 2023;14(1):228.","journal-title":"Nat Commun"},{"issue":"3","key":"7979_CR52","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000505099","volume":"98","author":"P Uciechowski","year":"2020","unstructured":"Uciechowski P, Dempke WCM. Interleukin-6: a masterplayer in the cytokine network. Oncology. 2020;98(3):131\u20137.","journal-title":"Oncology"},{"issue":"5","key":"7979_CR53","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1097\/HJH.0b013e32833992ef","volume":"28","author":"MJ Hung","year":"2010","unstructured":"Hung MJ, Cherng WJ, Hung MY, Wu HT, Pang JH. Interleukin-6 inhibits endothelial nitric oxide synthase activation and increases endothelial nitric oxide synthase binding to stabilized caveolin-1 in human vascular endothelial cells. J Hypertens. 2010;28(5):940\u201351.","journal-title":"J Hypertens"},{"issue":"7","key":"7979_CR54","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s00011-013-0633-0","volume":"62","author":"H Zelova","year":"2013","unstructured":"Zelova H, Hosek J. TNF-alpha signalling and inflammation: interactions between old acquaintances. Inflamm Res. 2013;62(7):641\u201351.","journal-title":"Inflamm Res"},{"issue":"8","key":"7979_CR55","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1161\/01.RES.86.8.906","volume":"86","author":"W Young","year":"2000","unstructured":"Young W, Mahboubi K, Haider A, Li I, Ferreri NR. Cyclooxygenase-2 is required for tumor necrosis factor-alpha- and angiotensin II-mediated proliferation of vascular smooth muscle cells. Circ Res. 2000;86(8):906\u201314.","journal-title":"Circ Res"},{"key":"7979_CR56","doi-asserted-by":"publisher","first-page":"179","DOI":"10.2147\/IJN.S12760","volume":"6","author":"SY Lee","year":"2011","unstructured":"Lee SY, Zaske AM, Novellino T, Danila D, Ferrari M, Conyers J, et al. Probing the mechanical properties of TNF-alpha stimulated endothelial cell with atomic force microscopy. Int J Nanomedicine. 2011;6:179\u201395.","journal-title":"Int J Nanomedicine"},{"issue":"43","key":"7979_CR57","doi-asserted-by":"publisher","first-page":"36099","DOI":"10.1074\/jbc.M505291200","volume":"280","author":"AL Theiss","year":"2005","unstructured":"Theiss AL, Simmons JG, Jobin C, Lund PK. Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem. 2005;280(43):36099\u2013109.","journal-title":"J Biol Chem"},{"issue":"5","key":"7979_CR58","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1177\/1358863X13508336","volume":"18","author":"M Cortez-Cooper","year":"2013","unstructured":"Cortez-Cooper M, Meaders E, Stallings J, Haddow S, Kraj B, Sloan G, et al. Soluble TNF and IL-6 receptors: indicators of vascular health in women without cardiovascular disease. Vasc Med. 2013;18(5):282\u20139.","journal-title":"Vasc Med"},{"issue":"12","key":"7979_CR59","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1002\/2211-5463.12151","volume":"6","author":"WW Yang","year":"2016","unstructured":"Yang WW, Guo B, Jia WY, Jia Y. Porphyromonas gingivalis-derived outer membrane vesicles promote calcification of vascular smooth muscle cells through ERK1\/2-RUNX2. FEBS Open Bio. 2016;6(12):1310\u20139.","journal-title":"FEBS Open Bio"},{"issue":"1","key":"7979_CR60","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1074\/mcp.RA119.001700","volume":"19","author":"DN Larsen","year":"2020","unstructured":"Larsen DN, Mikkelsen CE, Kierkegaard M, Bereta GP, Nowakowska Z, Kaczmarek JZ, et al. Citrullinome of Porphyromonas gingivalis outer membrane vesicles: confident identification of citrullinated peptides. Mol Cell Proteomics. 2020;19(1):167\u201380.","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"7979_CR61","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3233\/ADR-180080","volume":"2","author":"SK Singhrao","year":"2018","unstructured":"Singhrao SK, Olsen I. Are Porphyromonas gingivalis outer membrane vesicles microbullets for sporadic Alzheimer\u2019s disease manifestation? J Alzheimers Dis Rep. 2018;2(1):219\u201328.","journal-title":"J Alzheimers Dis Rep"},{"key":"7979_CR62","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000329669","volume":"15","author":"PI Diaz","year":"2012","unstructured":"Diaz PI. Microbial diversity and interactions in subgingival biofilm communities. Front Oral Biol. 2012;15:17\u201340.","journal-title":"Front Oral Biol"},{"issue":"2","key":"7979_CR63","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1177\/0022034518805739","volume":"98","author":"DT Graves","year":"2019","unstructured":"Graves DT, Correa JD, Silva TA. The oral microbiota is modified by systemic diseases. J Dent Res. 2019;98(2):148\u201356.","journal-title":"J Dent Res"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-026-07979-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-07979-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-07979-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T14:03:43Z","timestamp":1775225023000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12903-026-07979-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7979"],"URL":"https:\/\/doi.org\/10.1186\/s12903-026-07979-3","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"assertion":[{"value":"21 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal protocol (Number IACUC-MIS20230041) was approved by the Animal Care and Use Committee of Guangzhou Medical University. All animal studies adhered to the relevant ethical guidelines for vertebrate research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"588"}}