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This study investigated oral manifestations in children undergoing chemotherapy and assessed dental awareness among their parents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The study sample included 441 pediatric cancer patients aged 1- to 14-years-old who were receiving chemotherapy. Oral assessments were systematically conducted on eligible patients using the Oral Assessment Guide (OAG) criteria and the World Health Organization Mucositis (WHO) grading system to ensure objective measurement. A detailed survey evaluating parental awareness of dental care practices was distributed and completed by caregivers accompanying the children. Subsequently, all collected data and values underwent a comprehensive statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Regarding the OAG score, oral manifestations were observed in children who underwent chemotherapy treatment with a mean score of 11.66. Statistical analysis revealed no significant correlation between age or gender in relation to oral manifestations. A significant association was found between the type of cancer and saliva score (\n                      <jats:italic>p<\/jats:italic>\n                      -value 0.005). Most parents reported that their children experienced oral complications, received nutritional advice from a pediatrician or dietitian, and showed an interest in their child\u2019s dental care. Regarding the relationship between oral manifestation scores and frequency of teeth brushing per day, children who brushed their teeth only once had significantly lower scores in voice (p-value 0.018) and saliva (p-value 0.026) compared to other children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children undergoing chemotherapy frequently experience oral complications, with tooth debris and dry lips being the most commonly observed manifestations. Although parents demonstrated an interest in their children\u2019s dental care, they lacked sufficient awareness of appropriate oral health practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Clinicaltrials.gov registration number was: NCT05224882. Clinicaltrials.gov registration date was: November 26, 2022.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-07983-7","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:48:36Z","timestamp":1774604916000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral manifestations of pediatric cancer patients receiving chemotherapy and dental awareness among their parents-a cross-sectional study"],"prefix":"10.1186","volume":"26","author":[{"given":"Amira Mohammed","family":"Al-Sayed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif Bahgat","family":"El-Tawil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Madney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin Mohamed","family":"Yousry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"7983_CR1","doi-asserted-by":"publisher","unstructured":"Seyfried TN, Shelton LM. 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Prevention of Oral Manifestations in Acute Lymphoblastic Leukemic Children (ALL) by Meticulous Mouth Preparation including Fluoride Application. 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All procedures were conducted in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. We confirm that the purpose and procedures of the study were explained to the legal guardians, and written consent was obtained from them after the inclusion criteria were met. Additionally, children capable of comprehension received an age-appropriate explanation of the procedures, and verbal assent was obtained prior to examination.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"633"}}