{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:51:53Z","timestamp":1781646713628,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Leukemia is correlated with alveolar bone loss, while remission is reportedly associated with an increase in alveolar bone volume. However, there have been no reports from Japan detailing substantial recovery of the alveolar bone following remission from leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 14-year-old male patient presented to our clinic with fatigue, a low-grade fever, and bilateral mandibular molar tooth movement with gingival swelling around the molars that affected his ability to eat. Panoramic radiography revealed alveolar bone resorption in both jaws, while the alveolar hard line, mandibular canal wall, and trabecular structure were indistinct. The patient had an elevated white blood cell count and blasts were observed in the peripheral blood. Additionally, C-reactive protein, lactate dehydrogenase, and ferritin levels were elevated. These findings suggested leukemia. Bone marrow biopsy confirmed acute lymphocytic leukemia (ALL). ALL invasion had caused alveolar bone resorption and loose teeth, resulting in difficulty eating. He was started on IA4 remission induction therapy and consolidation therapy. The patient experienced successful remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After chemotherapy, the patient recovered oral function, which allowed him to resume normal food intake. Notably, the alveolar bone recovered considerably and tooth movement disappeared. Clinicians should consider alveolar bone resorption and tooth mobility as potential early signs of ALL in pediatric patients and recognize that timely chemotherapy can offer substantial oral recovery and alveolar bone regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-07998-0","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T08:32:24Z","timestamp":1774513944000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of marked alveolar bone augmentation after chemotherapy in a pediatric patient with acute lymphocytic leukemia"],"prefix":"10.1186","volume":"26","author":[{"given":"Shinya","family":"Koshinuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Asada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takato","family":"Murai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Takaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"7998_CR1","unstructured":"Number of pediatric cancer patients (Cancer Statistics). 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A case of childhood acute lymphocytic leukemia with abnormal healing of tooth extracted socket and loosened teeth as initial symptoms. J Tokyo Dent Coll Soc. 1992;92:691\u2013706.","journal-title":"J Tokyo Dent Coll Soc"},{"key":"7998_CR5","doi-asserted-by":"publisher","first-page":"897","DOI":"10.5794\/jjoms.30.897","volume":"30","author":"M Fujino","year":"1984","unstructured":"Fujino M, Nagai T, Miura T. A case of childhood acute lymphocytic leukemia with significant radiographic changes in jaws and legs. Jpn J Oral Maxillofac Surg. 1984;30:897\u2013903.","journal-title":"Jpn J Oral Maxillofac Surg"},{"key":"7998_CR6","first-page":"108","volume":"47","author":"K Okamoto","year":"1998","unstructured":"Okamoto K, Wada T, Oomta T, Morita N, Sakamoto T. Clinical observation of leukemia found by oral manifestation. 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Childhood leukemias: osseous changes in jaw on panoramic dental radiographs. J Am Dent Assoc. 1971;83:844\u20137.","journal-title":"J Am Dent Assoc"},{"key":"7998_CR10","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/0030-4220(73)90212-0","volume":"36","author":"MH Stern","year":"1973","unstructured":"Stern MH, Cole WL. Radiographic changes in the mandible associated with leukemic cell infiltration in a case of acute myelogenous leukemia. Oral Surg Oral Med Oral Pathol. 1973;36:343\u20138.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"7998_CR11","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1093\/jjco\/hyx070","volume":"47","author":"K Katanoda","year":"2017","unstructured":"Katanoda K, Shibata A, Matsuda T, Hori M, Nakata K, Narita Y, et al. Childhood, adolescent and young adult cancer incidence in Japan in 2009\u20132011. 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Oral manifestations of acute myelomonocytic leukemia: A case report and review of the classification of leukemias. 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Ethical approval was obtained from the Ethics Committee of Shiga University of Medical Science Hospital (R2023-051).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient and his parents to publish this case report, laboratory data, and accompanying clinical images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"788"}}