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An in vitro model was established by stimulating human periodontal ligament cells (hPDLCs) with\n                      <jats:italic>Porphyromonas gingivalis (P. g)<\/jats:italic>\n                      -LPS. The expression levels of FAM30A in gingival crevicular fluid (GCF) and hPDLCs were quantified by RT-qPCR. ROC analysis assessed diagnostic accuracy, logistic regression pinpointed risk factors for stage III\/IV periodontitis, and ELISA measured levels of inflammatory cytokines and MMP-1\/MMP-3Cell viability and apoptosis were assessed by CCK-8 and flow cytometry. Osteogenic marker expression was quantified by RT-qPCR. The interaction among FAM30A, miR-28-5p, and KAT6A was confirmed using RIP and DLR assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The FAM30A levels rose significantly in GCF of periodontitis patients and in\n                      <jats:italic>P.g<\/jats:italic>\n                      -LPS-stimulated hPDLCs, while miR-28-5p expression dropped markedly. Elevated FAM30A improves periodontitis diagnosis (sensitivity 82.41%, specificity 96.00%). Its levels are higher in Stage III\/IV periodontitis and independently predict periodontitis progression. Functionally, FAM30A knockdown attenuated\n                      <jats:italic>P.g<\/jats:italic>\n                      -LPS-induced inflammatory cytokine release, increased hPDLC apoptosis, suppressed osteogenic markers, and elevated MMP-1\/MMP-3 secretion. These effects were partially reversed by miR-28-5p inhibition. Mechanistically, miR-28-5p targets FAM30A and KAT6A.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study first demonstrates that FAM30A is a promising diagnostic biomarker, which is strongly linked to periodontitis staging (Stage I\/II vs. Stage III\/IV) and thus offers a new approach for clinical diagnosis. Additionally, silencing FAM30A may alleviate the progression of periodontitis by regulating the miR-28-5p\/KAT6A axis, reducing inflammation, and promoting bone formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-08033-y","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:43:11Z","timestamp":1773358991000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LncRNA FAM30A as a potential biomarker associated with periodontitis and its role in inflammatory responses and osteogenesis"],"prefix":"10.1186","volume":"26","author":[{"given":"Yongbiao","family":"Huo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cancan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"issue":"1","key":"8033_CR1","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1186\/s12903-025-05673-4","volume":"25","author":"M Ocbe","year":"2025","unstructured":"Ocbe M, Celebi E, Ocbe CB. 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