{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:25:04Z","timestamp":1783653904165,"version":"3.55.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009827","name":"Alexandria University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009827","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alveolar ridge resorption after tooth extraction may compromise implant placement and frequently necessitates guided bone regeneration (GBR). Platelet-rich fibrin (PRF) is widely used in oral surgery; extended PRF (e-PRF) has been proposed to prolong growth factor availability and membrane stability. This randomized clinical trial compared PRF and e-PRF membranes combined with bovine xenograft for horizontal ridge augmentation with simultaneous implant placement in the posterior mandible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty patients with posterior mandibular ridge deficiencies (residual ridge width 4\u20136\u00a0mm) were randomized (1:1) to receive xenograft\u2009+\u2009PRF (control,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) or xenograft\u2009+\u2009e-PRF (study,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) at the time of implant placement. Primary outcome: horizontal bone width gains at 6 months assessed by standardized CBCT measurements 1\u00a0mm apical to implant platform. Secondary outcomes: implant stability quotient (ISQ) at baseline and 6 months, postoperative pain (VAS), and edema. Sample size was calculated to detect the expected difference in ISQ change with 80% power and \u03b1\u2009=\u20090.05. Statistical tests included paired and independent t-tests, repeated measures analyses, and non-parametric tests where appropriate. Significance threshold was\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty patients (30 implants; 8 males, 12 females; mean age 40.2\u2009\u00b1\u20095.3 years) completed the study. Baseline characteristics and residual ridge widths were similar between groups. Implant stability (ISQ) increased significantly within both groups from baseline to 6 months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) but did not differ between groups at either time point (baseline\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.622; 6 months\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.263). Postoperative pain and edema followed similar, transient patterns in both groups (no significant between-group differences). At 6 months, horizontal bone gain was significantly greater in the e-PRF group (mean gain 2.28\u2009\u00b1\u20090.79\u00a0mm) than in the PRF group (0.75\u2009\u00b1\u20090.18\u00a0mm),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this randomized clinical trial, both PRF and e-PRF combined with bovine xenograft and simultaneous implant placement produced favorable clinical outcomes, while e-PRF provided superior horizontal bone gain at 6 months. Further larger and longer-term trials with prospective registration are recommended to confirm these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      The study protocol approved by the Institutional Review Board of the Faculty of Dentistry, Alexandria University, Egypt (IRB No. 0936-06\/2024\u201300010556). This trial was retrospectively registered at ClinicalTrials.gov (ID: NCT07164417, Date of registration: 04\/09\/2025;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT07164417\" ext-link-type=\"uri\">https:\/\/clinicaltrials.gov\/study\/NCT07164417<\/jats:ext-link>\n                      ). All participants provided written informed consent before enrollment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-08043-w","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:05:40Z","timestamp":1774591540000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparing two types of platelet-rich fibrin membranes in the management of dehiscence defects with simultaneous implant placement in the posterior mandible: a randomized controlled trial"],"prefix":"10.1186","volume":"26","author":[{"given":"Mohamad Mhdy A.","family":"Abla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Shaaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Passent A.","family":"Younis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"8043_CR1","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1111\/j.1600-051X.2009.01482.x","volume":"36","author":"F Van der Weijden","year":"2009","unstructured":"Van der Weijden F, Dell\u2019Acqua F, Slot DE. 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