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The stability and concentration of domestic-grade products are inconsistent, potentially affecting safety and clinical outcomes. This trial compared the impact of domestic-grade versus medical-grade NaOCl on postoperative pain following endodontic treatment in patients with symptomatic irreversible pulpitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Sixty participants with symptomatic irreversible pulpitis in mandibular molars were randomly distributed into two groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930). Following instrumentation with Edge X7 rotary files, Group A received domestic-grade NaOCl irrigation, while Group B was treated with a medical-grade formulation. Participants recorded pain intensity on an 11-point numerical rating scale (NRS) at 6, 12, 24, 48, and 72\u00a0h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Domestic-grade NaOCl was associated with significantly higher pain levels at 6\u00a0h (median 3 vs. 0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and 12\u00a0h (median 2 vs. 0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) compared to medical-grade NaOCl. No significant differences were observed at 24, 48, or 72\u00a0h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Domestic bleach caused significantly higher early postoperative pain than medical-grade sodium hypochlorite due to its unstandardized, higher concentration. Standardized medical-grade irrigants are recommended to maximize patient comfort and clinical predictability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The protocol for this prospective, parallel group, double blinded, randomized clinical trial was registered at ClinicalTrials.gov (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/register.clinicaltrials.gov\/\" ext-link-type=\"uri\">https:\/\/register.clinicaltrials.gov\/<\/jats:ext-link>\n                      ) on 18\/11\/2025, registration number (NCT07248189). The trial was retrospectively registered.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-08185-x","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:53:39Z","timestamp":1776070419000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Postoperative pain after single visit root canal treatment using domestic vs. medical grade sodium hypochlorite: a randomized controlled trial"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-2224","authenticated-orcid":false,"given":"Maha","family":"Nasr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-343X","authenticated-orcid":false,"given":"Nermine","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"8185_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/J.1601-1546.2004.00062.X","volume":"7","author":"JF Siqueira","year":"2004","unstructured":"Siqueira JF, Barnett F. 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