{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:15:15Z","timestamp":1790014515164,"version":"4.0.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100032910","name":"Datta Meghe Institute of Higher Education and Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032910","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-026-08287-6","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:55:34Z","timestamp":1776927334000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypoxia and angiogenesis across clinical stages of oral submucous fibrosis: implications for oral carcinogenesis"],"prefix":"10.1186","volume":"26","author":[{"given":"Hande","family":"Alka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonone","family":"Archana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadbail","family":"Amol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patil","family":"Swati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pakhale","family":"Aayushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharma","family":"Preethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"8287_CR1","doi-asserted-by":"crossref","unstructured":"Chhabra AK, Sune R, Reche A. Oral Submucous Fibrosis: A Review of the Current Concepts. PMC; 2023.","DOI":"10.7759\/cureus.47259"},{"key":"8287_CR2","doi-asserted-by":"crossref","unstructured":"Qin X et al. Oral submucous fibrosis: etiological mechanism, malignant transformation into oral cancer, and therapeutic approaches. International Journal of Molecular Sciences. 2023. MDPI.","DOI":"10.3390\/ijms24054992"},{"key":"8287_CR3","doi-asserted-by":"crossref","unstructured":"Nayanar G, Reddy MGS, Kakodkar P, Dony EC. Malignant transformation rate of oral submucous fibrosis: a systematic review and meta-analysis. 2023. Ovid\u2009+\u20091.","DOI":"10.1111\/ors.12771"},{"key":"8287_CR4","doi-asserted-by":"crossref","unstructured":"Murthy V, Mylonas P, Carey B, Yogarajah S, Farnell D. Malignant transformation rate of oral submucous fibrosis: A systematic review and meta-analysis. Journal of Clinical Medicine. 2022. MDPI\u2009+\u20091.","DOI":"10.3390\/jcm11071793"},{"issue":"6","key":"8287_CR5","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3390\/genes16060612","volume":"16","author":"V Zisis","year":"2025","unstructured":"Zisis V, Zisis S, Charisi C, Poulopoulos K, Sarkisian A, Poulopoulos A. Molecular Genomics of Oral Submucous Fibrosis: A Narrative Review. Genes. 2025;16(6):612.","journal-title":"Genes"},{"issue":"1","key":"8287_CR6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41368-024-00344-6","volume":"17","author":"J Tang","year":"2025","unstructured":"Tang J, Liu J, Zhou Z, Cui X, Tu H, Jia J, Chen B, Dai X, Liu O. Oral submucous fibrosis: pathogenesis and therapeutic approaches. Int J Oral Sci. 2025;17(1):8.","journal-title":"Int J Oral Sci"},{"issue":"1","key":"8287_CR7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1600-0714.2006.00485.x","volume":"36","author":"VK Hazarey","year":"2007","unstructured":"Hazarey VK, Erlewad DM, Mundhe KA, Ughade SN. Oral submucous fibrosis: study of 1000 cases from central India. J Oral Pathol Med. 2007;36(1):12\u20137.","journal-title":"J Oral Pathol Med"},{"issue":"6","key":"8287_CR8","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/j.1600-0714.2007.00625.x","volume":"37","author":"WM Tilakaratne","year":"2008","unstructured":"Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Stewart JE, Hagi-Pavli E, Lalli A, Waseem A, Parkinson EK. Upregulation of HIF-1a in malignant transformation of oral Submucous fibrosis. J Oral Pathol Med. 2008;37(6):372\u20137.","journal-title":"J Oral Pathol Med"},{"issue":"6","key":"8287_CR9","first-page":"2283","volume":"31","author":"F Nassiri","year":"2011","unstructured":"Nassiri F, Cusimano MD, Scheithauer BW, Rotondo F, Fazio A, Yousef GM, Syro LV, Kovacs K, Lloyd RV. Endoglin (CD105): A review of its role in angiogenesis and tumor diagnosis, progression and therapy. Anticancer Res. 2011;31(6):2283\u201390.","journal-title":"Anticancer Res"},{"key":"8287_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4103\/jcar.jcar_8_21","volume":"20","author":"AA Motgi","year":"2021","unstructured":"Motgi AA, Shete MV, Chavan MS, Diwaan NN, Sapkal R, Channe P. Assessment of correlation between clinical staging, functional staging, and histopathological grading of oral submucous fibrosis. J Carcinog. 2021;20:16.","journal-title":"J Carcinog"},{"key":"8287_CR11","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/j.1600-0714.1995.tb01209.x","volume":"24","author":"DR Lai","year":"1995","unstructured":"Lai DR, Chen HR, Lin LM, Huang YL, Tsai CC. Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10-year experience with 150 cases. J Oral Pathol Med. 1995;24:402\u20136.","journal-title":"J Oral Pathol Med"},{"issue":"7","key":"8287_CR12","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1111\/j.1365-2559.2011.03806.x","volume":"58","author":"AW Eckert","year":"2011","unstructured":"Eckert AW, Lautner MH, Sch\u00fctze A, Taubert H, Schubert J, Bilkenroth U. Co-expression of hypoxia-inducible factor 1 alpha (HIF1\u03b1) & glucose transporter 1 (GLUT-1) is associated with poor prognosis in oral squamous cell carcinoma patients. Histopathology. 2011;58(7):1136\u201347.","journal-title":"Histopathology"},{"issue":"1","key":"8287_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1056\/NEJM199101033240101","volume":"324","author":"N Weidner","year":"1991","unstructured":"Weidner N, Semple JP, Welch WR. FolkmanJ.Tumor angiogenesis and metastasis\u2013 correlation in invasive breast carcinoma. N Engl J Med. 1991;324(1):1\u20138.","journal-title":"N Engl J Med"},{"issue":"2","key":"8287_CR14","first-page":"122","volume":"19","author":"M Chaudhary","year":"2015","unstructured":"Chaudhary M, Bajaj S, Bohra S, Swastika N, Hande A. The domino effect: Role of hypoxia in malignant transformation of oral submucous fibrosis. JOMFP. 2015;19(2):122\u20137.","journal-title":"JOMFP"},{"key":"8287_CR15","first-page":"1","volume":"1","author":"A Dalmia","year":"2016","unstructured":"Dalmia A, Hazarey VK, Talkalet R. Role of hypoxia inducible factor-1\u03b1 messenger RNA expression in malignant transformation of oral submucous fibrosis: A RT-PCR study. Translational Res Oral Oncol. 2016;1:1\u20135.","journal-title":"Translational Res Oral Oncol"},{"issue":"1","key":"8287_CR16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.4103\/0970-9290.80009","volume":"22","author":"B Sabarinath","year":"2011","unstructured":"Sabarinath B, Sriram G, Saraswathi TR, Sivapathasundharam B. Immunohistochemical evaluation of mast cells and vascular endothelial proliferation in oral submucousfibrosis. Indian J Dent Res. 2011;22(1):116\u201321.","journal-title":"Indian J Dent Res"},{"issue":"7","key":"8287_CR17","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.oraloncology.2010.04.004","volume":"46","author":"RS Desai","year":"2010","unstructured":"Desai RS, Mamatha GS, Khatri MJ, Shetty SJ. Immunohistochemical expression of CD34 for characterization and quantification of mucosal vasculature and its probable role in malignant transformation of atrophic epithelium in oral submucous fibrosis. Oral Oncol. 2010;46(7):553\u20138.","journal-title":"Oral Oncol"},{"issue":"2","key":"8287_CR18","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2334\/josnusd.56.173","volume":"56","author":"VV Murgod","year":"2014","unstructured":"Murgod VV, Kale AD, Angadi PV, Hallikerimath S. Morphometric analysis of the mucosal vasculature in oral submucous fibrosis and its comparison with oral squamous cell carcinoma. J Oral Sci. 2014;56(2):173\u20138.","journal-title":"J Oral Sci"},{"issue":"12","key":"8287_CR19","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.prp.2014.06.009","volume":"210","author":"A Anura","year":"2014","unstructured":"Anura A, Das RK, Pal M, Paul RR, Ray AK. Chartterjee J.Correlated analysis of semiquantitative immunohistochemical features of E-cadherin, VEGF and CD105 in assessing malignant potentiality of oral submucous fibrosis. Pathol Res Pract. 2014;210(12):1054\u201363.","journal-title":"Pathol Res Pract"},{"issue":"11","key":"8287_CR20","first-page":"72","volume":"15","author":"R Madhavannirmal","year":"2016","unstructured":"Madhavannirmal R, Veeravarmal V, Bhavani S, Srinivasan P, Austin RD. Evaluation of Micro-Vessel Density (MVD) and Vascular Endothelial Growth Factor (VEGF) as Possible Indicator of Malignant Transformation in Oral Submucous Fibrosis. J Dent Med Sci (IOSR-JDMS). 2016;15(11):72\u20137.","journal-title":"J Dent Med Sci (IOSR-JDMS)"},{"issue":"1","key":"8287_CR21","first-page":"55","volume":"25","author":"CY Fang","year":"2000","unstructured":"Fang CY, Han WN, Fong DY. A morphometric study on the microvessel in oral submucous fibrosis. Hunan Yi Ke Da Xue Xue Bao. 2000;25(1):55\u20137.","journal-title":"Hunan Yi Ke Da Xue Xue Bao"},{"issue":"3","key":"8287_CR22","first-page":"83","volume":"16","author":"R Rajendran","year":"2005","unstructured":"Rajendran R, Paul S, Mathews PP, Raghul J, Mohanty M. Characterization and quantification of mucosal vasculature in oral submucous fibrosis. Indian J Dent Res. 2005;16(3):83\u201391.","journal-title":"Indian J Dent Res"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-026-08287-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-08287-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-08287-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:32:06Z","timestamp":1783557126000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12903-026-08287-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8287"],"URL":"https:\/\/doi.org\/10.1186\/s12903-026-08287-6","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"27 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Ethics Committee granted its approval to the required procedure for this investigation, which involved a retrospective analysis \u201c((DMIHER (DU)\/IEC\/2023\/1197- dated-02-07-2023)\u201d.All experiments were performed in accordance with relevant guidelines and regulations.Written informed consent was acquired from all the patients for the use of their clinical data and archival tissue samples.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1233"}}