{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:02:48Z","timestamp":1784854968245,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":66,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Through transcriptomic analysis and expression level validation, ubiquitin-related genes with overlapping expression profiles between renal cell carcinoma and periodontitis were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>RNA-seq datasets of renal cell carcinoma from The Cancer Genome Atlas (TCGA) and periodontitis from the Gene Expression Omnibus (GEO) were analyzed to identify differentially expressed genes (DEGs) in each disease. A total of 322 ubiquitination-related genes were integrated with the identified DEGs to screen ubiquitination-related genes with overlapping expression patterns between renal cell carcinoma and periodontitis. Survival analysis, functional enrichment analysis, protein\u2013protein interaction (PPI) network construction, and subsequent expression validation via quantitative real-time PCR (qPCR) and immunohistochemistry (IHC) were performed on these overlapping genes in clinical samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this study, differentially expressed genes (DEGs) in renal cell carcinoma and periodontitis were screened by analyzing the TCGA-KIRC dataset and periodontal disease datasets from the GEO database. Meanwhile, 332 ubiquitination genes collected from published literature were intersected separately with DEGs of renal cell carcinoma and periodontitis. Subsequent Venn diagram analysis identified 10 co-regulated ubiquitination-related genes (ALDOB, FABP5, IFI16, IKZF1, LGALS1, LSP1, MNDA, RPL13, VIM, WAS) as crosstalk genes between renal cell carcinoma and periodontitis. To systematically screen the genes with the strongest comprehensive regulatory capacity, the above 10 crosstalk genes were comprehensively evaluated in parallel from two independent and critical dimensions. In terms of the shared molecular mechanisms underlying periodontitis and renal cell carcinoma, six genes (IKZF1, LGALS1, LSP1, MNDA, VIM and WAS) were consistently upregulated in both disease tissues, indicating their potential involvement in the common pathogenesis of the two diseases. Tumor mutation analysis further indicated that the above 10 URGs were significantly correlated with the tumor immune microenvironment. Functional enrichment analysis revealed that these genes may affect disease progression via ubiquitin-mediated proteolysis and the p53 signaling pathway.With regard to the correlation between gene expression levels and survival outcomes of patients with renal cell carcinoma, subsequent Kaplan\u2013Meier survival analysis verified that among the 10 co-regulated ubiquitination-related genes, six genes (ALDOB, FABP5, IFI16, LGALS1, RPL13, WAS) exhibited significant correlations with the prognosis of RCC.LASSO regression was subsequently performed to screen the four genes (ALDOB, IFI16, WAS, IKZF1) that showed significance in multivariate regression analysis. Finally, WAS and IKZF1 were identified as the key ubiquitination regulatory genes underlying renal cell carcinoma and periodontitis.Consistent high expression levels of WAS and IKZF1 in both periodontitis and renal cell carcinoma tissues were verified by qPCR and immunohistochemistry (IHC), compared with normal control tissues. The protein\u2013protein interaction (PPI) network and miRNA-prognostic gene regulatory network were constructed using Cytoscape software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study firstly reveals that WAS and IKZF1 are ubiquitin-related genes with overlapping expression patterns in renal cell carcinoma and periodontitis, suggesting that they may participate in the occurrence and progression of the two diseases by regulating ubiquitination-related pathways. This finding not only enriches our understanding of the molecular expression characteristics of renal cell carcinoma and periodontitis but also verifies the potential of WAS and IKZF1 as cross-disease targets. It provides novel insights into the screening of potential biomarkers for these two diseases, and offers preliminary references for further exploring the clinical translational value of ubiquitination-related genes in renal cell carcinoma and periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial number<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-08574-2","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:44:05Z","timestamp":1779191045000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Overlapping expression characteristics of ubiquitination-related genes in periodontitis and renal cell carcinoma: transcriptomic analysis and experimental validation"],"prefix":"10.1186","volume":"26","author":[{"given":"Xiaofeng","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"8574_CR1","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1111\/odi.14436","volume":"30","author":"X Zhang","year":"2024","unstructured":"Zhang X, Wang X, Wu J, Wang M, Hu B, Qu H, et al. The global burden of periodontal diseases in 204 countries and territories from 1990 to 2019. Oral Dis. 2024;30:754\u201368.","journal-title":"Oral Dis"},{"key":"8574_CR2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/jcpe.13396","volume":"48","author":"J Jiao","year":"2021","unstructured":"Jiao J, Jing W, Si Y, Feng X, Tai B, Hu D, et al. The prevalence and severity of periodontal disease in Mainland China: Data from the Fourth National Oral Health Survey (2015\u20132016). J Clin Periodontology. 2021;48:168\u201379.","journal-title":"J Clin Periodontology"},{"key":"8574_CR3","doi-asserted-by":"crossref","unstructured":"Salvi GE, Roccuzzo A, Imber J, St\u00e4hli A, Klinge B, Lang NP. Clinical periodontal diagnosis. Periodontology 2000. 2023; prd.12487.","DOI":"10.1111\/prd.12487"},{"key":"8574_CR4","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1111\/jcpe.13447","volume":"48","author":"L Luo","year":"2021","unstructured":"Luo L, Luan H, Wu L, Shi Y, Wang Y, Huang Q, et al. Secular trends in severe periodontitis incidence, prevalence and disability-adjusted life years in five Asian countries: A comparative study from 1990 to 2017. J Clin Periodontology. 2021;48:627\u201337.","journal-title":"J Clin Periodontology"},{"key":"8574_CR5","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.12771\/emj.2025.00101","volume":"48","author":"M-Y Kim","year":"2025","unstructured":"Kim M-Y, Pang E-K. Relationship between periodontitis and systemic health conditions: a narrative review. Ewha Med J. 2025;48:e27.","journal-title":"Ewha Med J"},{"key":"8574_CR6","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1111\/jcpe.13807","volume":"50","author":"D Herrera","year":"2023","unstructured":"Herrera D, Sanz M, Shapira L, Brotons C, Chapple I, Frese T, et al. Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe). J Clin Periodontology. 2023;50:819\u201341.","journal-title":"J Clin Periodontology"},{"key":"8574_CR7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12344","volume":"83","author":"RJ Genco","year":"2020","unstructured":"Genco RJ, Sanz M. Clinical and public health implications of periodontal and systemic diseases: An overview. Periodontol 2000. 2020;83:7\u201313.","journal-title":"Periodontol 2000"},{"key":"8574_CR8","doi-asserted-by":"crossref","unstructured":"El Ayachi H, Barjij I, Cherkaoui A. Immunoinflammatory Mechanisms Connecting Periodontitis and Solid Tumors: A Systematic Review of Original Evidence. Cureus. 2025;17(11):e96491.","DOI":"10.7759\/cureus.96491"},{"key":"8574_CR9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.14740\/wjon1279","volume":"11","author":"SA Padala","year":"2020","unstructured":"Padala SA, Barsouk A, Thandra KC, Saginala K, Mohammed A, Vakiti A, et al. Epidemiology of Renal Cell Carcinoma. World J Oncol. 2020;11:79\u201387.","journal-title":"World J Oncol"},{"key":"8574_CR10","first-page":"7","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7\u201333.","journal-title":"CA Cancer J Clin"},{"key":"8574_CR11","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1007\/s11255-023-03858-w","volume":"56","author":"B Li","year":"2023","unstructured":"Li B, Lin Y, Yang Y, Wang Z, Shi R, Zheng T, et al. Patients with periodontitis might increase the risk of urologic cancers: a bidirectional two-sample Mendelian randomization study. Int Urol Nephrol. 2023;56:1243\u201351.","journal-title":"Int Urol Nephrol"},{"key":"8574_CR12","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.7150\/ijms.46812","volume":"17","author":"H Ma","year":"2020","unstructured":"Ma H, Zheng J, Li X. Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population. Int J Med Sci. 2020;17:2531\u201343.","journal-title":"Int J Med Sci"},{"key":"8574_CR13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s40779-021-00344-1","volume":"8","author":"S Yuan","year":"2021","unstructured":"Yuan S, Fang C, Leng W-D, Wu L, Li B-H, Wang X-H, et al. Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers. Military Med Res. 2021;8:54.","journal-title":"Military Med Res"},{"key":"8574_CR14","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1007\/s00109-022-02229-9","volume":"100","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Li J, Chen J, Ye M, Jin X. Functional roles of E3 ubiquitin ligases in prostate cancer. J Mol Med. 2022;100:1125\u201344.","journal-title":"J Mol Med"},{"key":"8574_CR15","doi-asserted-by":"publisher","first-page":"e13781","DOI":"10.1111\/cpr.13781","volume":"58","author":"Y Ma","year":"2025","unstructured":"Ma Y, Jia R, Chen S, Ma J, Yin L, Pan X, et al. Ubiquitin-Proteasome System in Periodontitis: Mechanisms and Clinical Implications. Cell Prolif. 2025;58:e13781.","journal-title":"Cell Prolif"},{"key":"8574_CR16","doi-asserted-by":"publisher","first-page":"1453191","DOI":"10.3389\/fgene.2024.1453191","volume":"15","author":"H You","year":"2024","unstructured":"You H, Zhang H, Jin X, Yan Z. Dysregulation of ubiquitination modification in renal cell carcinoma. Front Genet. 2024;15:1453191.","journal-title":"Front Genet"},{"key":"8574_CR17","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/dj7010018","volume":"7","author":"RB Brown","year":"2019","unstructured":"Brown RB. Dysregulated Phosphate Metabolism, Periodontal Disease, and Cancer: Possible Global Health Implications. Dentistry J. 2019;7:18.","journal-title":"Dentistry J"},{"key":"8574_CR18","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.3390\/cancers15082212","volume":"15","author":"L Kruk","year":"2023","unstructured":"Kruk L, Mamtimin M, Braun A, Anders H-J, Andrassy J, Gudermann T, et al. Inflammatory Networks in Renal Cell Carcinoma. Cancers. 2023;15:2212.","journal-title":"Cancers"},{"key":"8574_CR19","doi-asserted-by":"publisher","first-page":"112183","DOI":"10.1016\/j.isci.2025.112183","volume":"28","author":"Z Xu","year":"2025","unstructured":"Xu Z, Dong Y, Cui K, Hu B, Lu Y, Liu X, et al. Role of the circular RNAs\/microRNA\/messenger RNA axis in renal cell carcinoma: From gene regulation to metabolism and immunity. iScience. 2025;28:112183.","journal-title":"iScience"},{"key":"8574_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/1029857","volume":"2019","author":"A Hoare","year":"2019","unstructured":"Hoare A, Soto C, Rojas-Celis V, Bravo D. Chronic Inflammation as a Link between Periodontitis and Carcinogenesis. Mediat Inflamm. 2019;2019:1\u201314.","journal-title":"Mediat Inflamm"},{"key":"8574_CR21","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3390\/ijms23020970","volume":"23","author":"BK Sobocki","year":"2022","unstructured":"21, Sobocki BK, Basset CA, Bruhn-Olszewska B, Olszewski P, Szot O, Ka\u017amierczak-Siedlecka K, et al. Molecular Mechanisms Leading from Periodontal Disease to Cancer. IJMS. 2022;23:970.","journal-title":"IJMS"},{"key":"8574_CR22","doi-asserted-by":"crossref","unstructured":"Molnar A, Georgopoulos K. The Ikaros Gene Encodes a Family of Functionally Diverse Zinc Finger DNA-Binding Proteins. Mol Cell Biol. 1994;14(12):8292\u2013303.","DOI":"10.1128\/mcb.14.12.8292-8303.1994"},{"key":"8574_CR23","doi-asserted-by":"publisher","first-page":"785905","DOI":"10.3389\/fimmu.2021.785905","volume":"12","author":"C Faia","year":"2021","unstructured":"Faia C, Plaisance-Bonstaff K, Vittori C, Wyczechowska D, Lassak A, Meyaski-Schluter M, et al. Attenuated Negative Feedback in Monocyte-Derived Macrophages From Persons Living With HIV: A Role for IKAROS. Front Immunol. 2021;12:785905.","journal-title":"Front Immunol"},{"key":"8574_CR24","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1158\/2767-9764.CRC-23-0264","volume":"4","author":"D Kanaoka","year":"2024","unstructured":"Kanaoka D, Yamada M, Yokoyama H, Nishino S, Kunimura N, Satoyoshi H, et al. FPFT-2216, a Novel Anti-lymphoma Compound, Induces Simultaneous Degradation of IKZF1\/3 and CK1\u03b1 to Activate p53 and Inhibit NF\u03baB Signaling. Cancer Res Commun. 2024;4:312\u201327.","journal-title":"Cancer Res Commun"},{"key":"8574_CR25","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3389\/fcimb.2019.00262","volume":"9","author":"L Jia","year":"2019","unstructured":"Jia L, Han N, Du J, Guo L, Luo Z, Liu Y. Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors. Front Cell Infect Microbiol. 2019;9:262.","journal-title":"Front Cell Infect Microbiol"},{"key":"8574_CR26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3390\/cells9010217","volume":"9","author":"W Jin","year":"2020","unstructured":"Jin W. Role of JAK\/STAT3 Signaling in the Regulation of Metastasis, the Transition of Cancer Stem Cells, and Chemoresistance of Cancer by Epithelial\u2013Mesenchymal Transition. Cells. 2020;9:217.","journal-title":"Cells"},{"key":"8574_CR27","doi-asserted-by":"publisher","first-page":"19552","DOI":"10.1038\/s41598-023-46628-5","volume":"13","author":"J Ar\u00e9valo","year":"2023","unstructured":"Ar\u00e9valo J, Campoy I, Dur\u00e1n M, Nemours S, Areny A, Vall-Palomar M, et al. STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness. Sci Rep. 2023;13:19552.","journal-title":"Sci Rep"},{"key":"8574_CR28","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/nrc2734","volume":"9","author":"H Yu","year":"2009","unstructured":"Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9:798\u2013809.","journal-title":"Nat Rev Cancer"},{"key":"8574_CR29","doi-asserted-by":"publisher","first-page":"1383419","DOI":"10.3389\/fonc.2024.1383419","volume":"14","author":"L Feng","year":"2024","unstructured":"Feng L, Zhang H, Liu T. Multifaceted roles of IKZF1 gene, perspectives from bench to bedside. Front Oncol. 2024;14:1383419.","journal-title":"Front Oncol"},{"key":"8574_CR30","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.gene.2018.10.045","volume":"684","author":"Q Chen","year":"2019","unstructured":"Chen Q, Shi Y, Chen Y, Ji T, Li Y, Yu L. Multiple functions of Ikaros in hematological malignancies, solid tumor and autoimmune diseases. Gene. 2019;684:47\u201352.","journal-title":"Gene"},{"key":"8574_CR31","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1016\/j.immuni.2024.07.010","volume":"57","author":"K Ichiyama","year":"2024","unstructured":"Ichiyama K, Long J, Kobayashi Y, Horita Y, Kinoshita T, Nakamura Y, et al. Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity. Immunity. 2024;57:2043\u2013e206010.","journal-title":"Immunity"},{"key":"8574_CR32","doi-asserted-by":"crossref","unstructured":"Derry JMJ, Ochs HD, Francke U. Isolation of a Novel Gene Mutated in Wiskott-Aldrich Syndrome. Cell. 1994;78:635\u201344.","DOI":"10.1016\/0092-8674(94)90528-2"},{"key":"8574_CR33","doi-asserted-by":"publisher","first-page":"151244","DOI":"10.1016\/j.ejcb.2022.151244","volume":"101","author":"DA Kramer","year":"2022","unstructured":"Kramer DA, Piper HK, Chen B. WASP family proteins: Molecular mechanisms and implications in human disease. Eur J Cell Biol. 2022;101:151244.","journal-title":"Eur J Cell Biol"},{"key":"8574_CR34","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1083\/jcb.201701074","volume":"216","author":"LK Fritz-Laylin","year":"2017","unstructured":"Fritz-Laylin LK, Lord SJ, Mullins RD. WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility. J Cell Biol. 2017;216:1673\u201388.","journal-title":"J Cell Biol"},{"key":"8574_CR35","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1080\/00016357.2017.1347823","volume":"75","author":"Y Wu","year":"2017","unstructured":"Wu Y, Zhuang J, Zhao D, Zhang F, Ma J, Xu C. Cyclic stretch-induced the cytoskeleton rearrangement and gene expression of cytoskeletal regulators in human periodontal ligament cells. Acta Odontol Scand. 2017;75:507\u201316.","journal-title":"Acta Odontol Scand"},{"key":"8574_CR36","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1189\/jlb.2A0215-050RR","volume":"99","author":"D Malinova","year":"2016","unstructured":"Malinova D, Fritzsche M, Nowosad CR, Armer H, Munro PMG, Blundell MP, et al. WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts. J Leukoc Biol. 2016;99:699\u2013710.","journal-title":"J Leukoc Biol"},{"key":"8574_CR37","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.3390\/ijms25052763","volume":"25","author":"D Radzki","year":"2024","unstructured":"Radzki D, Negri A, Kusiak A, Obuchowski M. Matrix Metalloproteinases in the Periodontium\u2014Vital in Tissue Turnover and Unfortunate in Periodontitis. IJMS. 2024;25:2763.","journal-title":"IJMS"},{"key":"8574_CR38","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1158\/0008-5472.CAN-13-1729","volume":"74","author":"A Lin","year":"2014","unstructured":"Lin A, Piao H, Zhuang L, Sarbassov DD, Ma L, Gan B. FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K\u2013AKT Pathway. Cancer Res. 2014;74:1682\u201393.","journal-title":"Cancer Res"},{"key":"8574_CR39","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3892\/etm.2021.9972","volume":"21","author":"D Miricescu","year":"2021","unstructured":"Miricescu D, Balan D, Tulin A, Stiru O, Vacaroiu I, Mihai D, et al. PI3K\/AKT\/mTOR signalling pathway involvement in renal cell carcinoma pathogenesis (Review). Exp Ther Med. 2021;21:540.","journal-title":"Exp Ther Med"},{"key":"8574_CR40","first-page":"1779","volume":"25","author":"X Xie","year":"2022","unstructured":"Xie X. Research progress on the role of WASP family in tumorigenesis and progression. Chin Gen Pract. 2022;25:1779.","journal-title":"Chin Gen Pract"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-026-08574-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-08574-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-08574-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:34:14Z","timestamp":1784853254000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12903-026-08574-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8574"],"URL":"https:\/\/doi.org\/10.1186\/s12903-026-08574-2","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"16 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Ethics Committee of Shanxi Provincial People\u2019s Hospital ((2025) Provincial Medical Review No. 335), and adhered to the Declaration of Helsinki. Informed consent was obtained from all individual participants included in the study. participants signed informed consent regarding publishing their data.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1340"}}