{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:25:03Z","timestamp":1783653903911,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>An autogenous dentine-derived barrier membrane (DDBM), primarily consisting of type I collagen, is a recognized as an osteo-conductive material in implant dentistry. A recently developed method is used to prolong the functional properties of PRF to 4 to 6 months. This newly prepared material is called Albumin-platelet rich fibrin (Alb-PRF) or extended platelet-rich fibrin (e-PRF). The aim of this study was to compare clinical and radiographic results of autogenous demineralized dentine-derived barrier membrane versus extended platelet-rich fibrin membrane for guided bone regeneration (GBR) with immediate implant placement in the posterior mandible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Forty patients with non-restorable mandibular molars indicated for immediate implant placement and GBR were selected and randomly divided into two equal groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920 per group). In Group 1, implants were placed using a dentine-derived barrier membrane, while in Group 2, implants were placed using an extended platelet-rich fibrin membrane. All patients underwent clinical and radiographic assessments immediately after placement and at 3, 6, 12, and 24 months to evaluate implant stability, peri-implant probing depth (PPD), marginal bone loss (MBL), and relative bone density.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All implants achieved a 100% survival rate over the 24-month period. Implant stability increased significantly over time in both groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), with no significant intergroup differences at any point; at 12 months, the median (IQR) was 78.0 (77.0\u201379) for Dentine Group and 79 (75.0\u201381.0) for e-PRF Group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.201,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.207). PPD also increased significantly within both groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), but remained within healthy limits, with no significant differences between groups at any points; at 24 months, the median (IQR) was 3.25\u00a0mm (3.13\u20133.50\u00a0mm) for Dentine Group vs. 3.25\u00a0mm (3.0\u20133.31\u00a0mm) for e-PRF Group; (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.142,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.241). MBL increased significantly over time in both groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). At 24 months, no significant intergroup differences were found for buccal MBL, the median (IQR) was 1.22\u00a0mm (1.20\u20131.30\u00a0mm) for Dentine Group vs. 1.30\u00a0mm (1.25\u20131.39\u00a0mm) for e-PRF Group;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.060,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.300) or lingual MBL, the median (IQR) was 1.27\u00a0mm (1.20\u20131.37\u00a0mm) for Dentine Group vs. 1.27\u00a0mm (1.19\u20131.37\u00a0mm) for e-PRF Group; (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.678,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.069). Similarly, relative bone density showed a significant intragroup increase (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) with no significant intergroup differences at 24 months for buccal density the median (IQR) was 1204.5 (1150.0\u20131261.0) for Dentine Group vs. 1266.0 (1119.0\u20131311.0) for e-PRF Group; (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.183,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.214) or lingual density the median (IQR) was 1180.0 (1156.0\u20131210) for Dentine Group vs. 1212.50 (1112.0\u20131233.0) for e-PRF Group; (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.314,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.163).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both autogenous DDBM and e-PRF membrane demonstrated favorable clinical and radiographic outcomes over 24 months when used for GBR in conjunction with immediate implant placement in the posterior mandible. Both materials represent cost-effective, biological alternatives for GBR, maintaining stable peri-implant tissues over a 2-year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      The study was retrospectively registered at ClinicalTrials.gov PRS (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/register.clinicaltrials.gov\" ext-link-type=\"uri\">https:\/\/register.clinicaltrials.gov<\/jats:ext-link>\n                      ) under the identifier number NCT07396350 on 02\/02\/2026.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-08582-2","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:24:13Z","timestamp":1779377053000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dentine-derived barrier membrane versus extended platelet-rich fibrin for guided bone regeneration: a 2-year randomized clinical trial"],"prefix":"10.1186","volume":"26","author":[{"given":"Sally Elsayed","family":"Abdelsameaa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Maashi","family":"Alruwaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesma","family":"El-Gohary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba Abo-Elfetouh","family":"Elsheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"8582_CR1","doi-asserted-by":"publisher","first-page":"105612","DOI":"10.1016\/j.jdent.2025.105612","volume":"154","author":"MO Elboraey","year":"2025","unstructured":"Elboraey MO, Alqutaibi AY, Aboalrejal AN, Borzangy S, Zafar MS, Al-Gabri R, Alghauli MA, Ramalingam S. 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