{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:43:48Z","timestamp":1786121028381,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bone regeneration plays a critical role in oral and maxillofacial surgical procedures, including implant site preparation, periodontal defect management, and guided bone regeneration. Dexpanthenol (DXP), a well-tolerated derivative of pantothenic acid with antioxidant and wound-healing properties, has demonstrated beneficial effects in soft tissue repair; however, its potential role in bone regeneration remains insufficiently explored. Therefore, this study aimed to evaluate the effects of locally delivered DXP on bone healing using a standardized rabbit defect model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This in vivo experimental study employed an intra-animal paired tibial defect model in eight adult male New Zealand White rabbits. Two standardized monocortical defects (6\u00a0mm in diameter and 8\u00a0mm in depth) were created in the right tibia of each animal. One defect was treated with a gelatin sponge (GS) (control), while the adjacent defect received DXP-impregnated GS. After a 30-day healing period, histomorphometric analysis and immunohistochemical evaluation of vascular endothelial growth factor (VEGF) expression were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DXP-treated defects exhibited significantly improved bone healing parameters compared to controls, including increased total healing area, higher defect closure rate, new bone formation, elevated osteoblast counts, and enhanced collagen deposition (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 for all). VEGF expression was also significantly higher in the DXP group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), suggesting increased angiogenesis-related activity. No significant difference was observed in osteoclast counts (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limitations of this experimental model, locally delivered dexpanthenol was associated with enhanced bone formation healing and increased VEGF expression. However, given the use of a non-craniofacial defect model and the absence of mechanistic analyses, these findings should be interpreted with caution. Further studies using clinically relevant models and molecular approaches are required to clarify the underlying mechanisms and translational potential of DXP in bone regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-08702-y","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:16:28Z","timestamp":1779423388000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Locally delivered dexpanthenol enhances bone regeneration in a rabbit defect model: Implications for oral and maxillofacial surgery"],"prefix":"10.1186","volume":"26","author":[{"given":"Mustafa","family":"Isleyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muge","family":"Cina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunyamin","family":"Alt\u0131ntas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Ozmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"8702_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/jor.24170","volume":"37","author":"CS Bahney","year":"2019","unstructured":"Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley JW, Ahn J, et al. 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This research was done in compliance with the ARRIVE guidelines and regulations (\n                      \n                      ). All national and institutional guidelines for animal care and use have been followed throughout the study procedures. The animals were procured from the Experimental Animal Production and Research Center of Burdur Mehmet Akif Ersoy University strictly for research purposes; therefore, informed consent from a private owner was not applicable to this study.","order":1,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1378"}}