{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:13:07Z","timestamp":1790615587037,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":82,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-026-08727-3","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:14:10Z","timestamp":1780575250000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["MRI-based volumetric and histogram analysis of parotid and submandibular glands in hypertensive patients: a retrospective study"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-0991","authenticated-orcid":false,"given":"Sedef","family":"Kotanl\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7979-4441","authenticated-orcid":false,"given":"Mina Hilal","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-6670","authenticated-orcid":false,"given":"Ferit","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"issue":"6","key":"8727_CR1","first-page":"113","volume":"71","author":"PK Whelton","year":"2018","unstructured":"Whelton PK, ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA. Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):113\u20135.","journal-title":"Hypertension"},{"issue":"3","key":"8727_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1161\/01.CIR.101.3.329","volume":"101","author":"OA Carretero","year":"2000","unstructured":"Carretero OA, Oparil S. Essential hypertension. Circulation. 2000;101(3):329\u201335. https:\/\/doi.org\/10.1161\/01.CIR.101.3.329.","journal-title":"Circulation"},{"key":"8727_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1469-0691.2007.01798.x","volume":"13","author":"GJ Seymour","year":"2007","unstructured":"Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K. Relationship between periodontal infections and systemic disease. Infect Dis Clin Microbiol. 2007;13:3\u201310. https:\/\/doi.org\/10.1111\/j.1469-0691.2007.01798.x.","journal-title":"Infect Dis Clin Microbiol"},{"issue":"2","key":"8727_CR4","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1067\/mpr.2001.113778","volume":"85","author":"SP Humphrey","year":"2001","unstructured":"Humphrey SP, Williamson RT. A review of saliva: normal composition, flow, and function. Int J Oral Implantol. 2001;85(2):162\u20139. https:\/\/doi.org\/10.1067\/mpr.2001.113778.","journal-title":"Int J Oral Implantol"},{"issue":"3","key":"8727_CR5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1034\/j.1601-0825.2002.02851.x","volume":"8","author":"AM Pedersen","year":"2002","unstructured":"Pedersen AM, Bardow A, Jensen SB, Nauntofte B. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis. 2002;8(3):117\u201329. https:\/\/doi.org\/10.1034\/j.1601-0825.2002.02851.x.","journal-title":"Oral Dis"},{"issue":"10","key":"8727_CR6","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1111\/jgs.13652","volume":"63","author":"RH Affoo","year":"2015","unstructured":"Affoo RH, Foley N, Garrick R, Siqueira WL, Martin RE. Meta-analysis of salivary flow rates in young and older adults. J Am Geriatr Soc. 2015;63(10):2142\u201351. https:\/\/doi.org\/10.1111\/jgs.13652.","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"8727_CR7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.14219\/jada.archive.2003.0018","volume":"134","author":"J Guggenheimer","year":"2003","unstructured":"Guggenheimer J, Moore PA. Xerostomia: etiology, recognition and treatment. J Am Dent Assoc. 2003;134(1):61\u20139. https:\/\/doi.org\/10.14219\/jada.archive.2003.0018.","journal-title":"J Am Dent Assoc"},{"issue":"7","key":"8727_CR8","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1093\/rheumatology\/keh187","volume":"43","author":"RK Niemel\u00e4","year":"2004","unstructured":"Niemel\u00e4 RK, Takalo R, P\u00e4\u00e4kk\u00f6 E, Suramo I, P\u00e4iv\u00e4nsalo M, Salo T, Hakala M. Ultrasonography of salivary glands in primary Sjogren\u2019s syndrome. A comparison with magnetic resonance imaging and magnetic resonance sialography of parotid glands. Rheumatol. 2004;43(7):875\u20139. https:\/\/doi.org\/10.1093\/rheumatology\/keh187.","journal-title":"Rheumatol"},{"issue":"4","key":"8727_CR9","doi-asserted-by":"publisher","first-page":"371","DOI":"10.5606\/ArchRheumatol.2019.7120","volume":"34","author":"I Sezer","year":"2019","unstructured":"Sezer I, Toslak IE, Ya\u011fci B, Erbasan F, Ayan A, Karasu U. The role of real-time tissue elastography and gray-scale ultrasound histogram analysis in the diagnosis of patients with Sj\u00f6gren\u2019s syndrome. Arch Rheumatol. 2019;34(4):371.","journal-title":"Arch Rheumatol"},{"issue":"1","key":"8727_CR10","doi-asserted-by":"publisher","first-page":"68","DOI":"10.28982\/josam.990310","volume":"6","author":"Y Ero\u011flu","year":"2022","unstructured":"Ero\u011flu Y, Baykara M. MRI histogram analysis of optic nerves in children with type 1 neurofibromatosis. J Surg Med. 2022;6(1):68\u201371. https:\/\/doi.org\/10.28982\/josam.990310.","journal-title":"J Surg Med"},{"issue":"1","key":"8727_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cpf.12199","volume":"36","author":"P Afzelius","year":"2016","unstructured":"Afzelius P, Nielsen MY, Ewertsen C, Bloch KP. Imaging of the major salivary glands. Clin Physiol Funct Imaging. 2016;36(1):1\u201310.","journal-title":"Clin Physiol Funct Imaging"},{"key":"8727_CR12","doi-asserted-by":"publisher","unstructured":"\u00c7a\u011flayan A, \u00c7akur A, Harorl\u0131 P. T\u00fck\u00fcr\u00fck bezlerinin radyografik muayene y\u00f6ntemleri ve sialografi. Atat\u00fcrk \u00dcniv Di\u015f. Hek Fak Derg. 2003;2. https:\/\/doi.org\/10.1111\/cpf.12199.","DOI":"10.1111\/cpf.12199"},{"issue":"1","key":"8727_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11282-010-0037-6","volume":"26","author":"A Kondo","year":"2010","unstructured":"Kondo A, Hayakawa Y, Dong J, Honda A. Iterative correction applied to streak artifact reduction in an X-ray computed tomography image of the dento-alveolar region. Oral Radiol. 2010;26(1):61\u20135. https:\/\/doi.org\/10.1007\/s11282-010-0037-6.","journal-title":"Oral Radiol"},{"issue":"1","key":"8727_CR14","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1148\/87.1.116","volume":"87","author":"JC Osmer","year":"1966","unstructured":"Osmer JC, Pleasants JE, Distention sialography. Radiology. 1966;87(1):116\u20138. https:\/\/doi.org\/10.1148\/87.1.116.","journal-title":"Radiology"},{"issue":"2","key":"8727_CR15","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.radonc.2008.02.017","volume":"87","author":"M Tenhunen","year":"2008","unstructured":"Tenhunen M, Collan J, Kouri M, Kangasm\u00e4ki A, Heikkonen J, Kairemo K, Saarilahti K. Scintigraphy in prediction of the salivary gland function after gland-sparing intensity modulated radiation therapy for head and neck cancer. Radiol Oncol. 2008;87(2):260\u20137. https:\/\/doi.org\/10.1016\/j.radonc.2008.02.017.","journal-title":"Radiol Oncol"},{"issue":"3","key":"8727_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/MNM.0b013e32835bc4c4","volume":"34","author":"P Sharma","year":"2013","unstructured":"Sharma P, Jain TK, Singh H, Suman SK, Faizi NA, Kumar R, Malhotra A. Utility of 18F-FDG PET-CT in staging and restaging of patients with malignant salivary gland tumours: a single-institutional experience. Nucl Med Commun. 2013;34(3):211\u20139. https:\/\/doi.org\/10.1097\/MNM.0b013e32835bc4c4.","journal-title":"Nucl Med Commun"},{"key":"8727_CR17","volume-title":"Ultrasound: the requisites","author":"BS Hertzberg","year":"2015","unstructured":"Hertzberg BS, Middleton WD. Ultrasound: the requisites. St. Louis: Elsevier; 2015."},{"key":"8727_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/S1064-9689(02)00015-6","author":"N Freling","year":"2010","unstructured":"Freling N. MRI of the salivary glands. Erasmus Course MRI Head Neck. 2010. https:\/\/doi.org\/10.1016\/S1064-9689(02)00015-6. 1\u20135.","journal-title":"Erasmus Course MRI Head Neck"},{"issue":"1077","key":"8727_CR19","doi-asserted-by":"publisher","first-page":"20160704","DOI":"10.1259\/bjr.20160704","volume":"90","author":"Y Kise","year":"2017","unstructured":"Kise Y, Chikui T, Yamashita Y, Kobayashi K, Yoshiura K. Clinical usefulness of the mDIXON Quant the method for estimation of the salivary gland fat fraction: comparison with MR spectroscopy. Br J Radiol. 2017;90(1077):20160704. https:\/\/doi.org\/10.1259\/bjr.20160704.","journal-title":"Br J Radiol"},{"issue":"11","key":"8727_CR20","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.3390\/healthcare10112310","volume":"10","author":"T Brzoska","year":"2022","unstructured":"Brzoska T, Ittermann T, Ihler F, Koch C, Blaurock M, B\u00fclow R, Beule AG. Population based average parotid gland volume and prevalence of incidental tumors in T1-MRI. Healthc (Basel). 2022;10(11):2310. https:\/\/doi.org\/10.3390\/healthcare10112310.","journal-title":"Healthc (Basel)"},{"issue":"1","key":"8727_CR21","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/odi.12577","volume":"23","author":"I Kojima","year":"2017","unstructured":"Kojima I, Sakamoto M, Likubo M, Kumamoto H, Muroi A, Sugawara Y, Sasano T. Diagnostic performance of MR imaging of three major salivary glands for Sj\u00f6gren\u2019s syndrome. Oral Dis. 2017;23(1):84\u201390. https:\/\/doi.org\/10.1111\/odi.12577.","journal-title":"Oral Dis"},{"issue":"3","key":"8727_CR22","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.radonc.2011.08.020","volume":"100","author":"AC Houweling","year":"2011","unstructured":"Houweling AC, Schakel T, van den Berg CA, Philippens ME, Roesink JM, Terhaard CH, Raaijmakers CP. MRI to quantify early radiation-induced changes in the salivary glands. Radiol Oncol. 2011;100(3):386\u20139. https:\/\/doi.org\/10.1016\/j.radonc.2011.08.020.","journal-title":"Radiol Oncol"},{"key":"8727_CR23","volume-title":"Ten Cate\u2019s oral histology","author":"A Nanci","year":"2007","unstructured":"Nanci A. Ten Cate\u2019s oral histology. 7th ed. St. Louis: Elsevier; 2007.","edition":"7"},{"issue":"5","key":"8727_CR24","doi-asserted-by":"publisher","first-page":"916","DOI":"10.3348\/kjr.2018.19.5.916","volume":"19","author":"RF Sheng","year":"2018","unstructured":"Sheng RF, Jin KP, Yang L, Wang HQ, Liu H, Ji Y, Zeng MS. Histogram analysis of diffusion kurtosis magnetic resonance imaging for diagnosis of hepatic fibrosis. Korean J Radiol. 2018;19(5):916\u201322.","journal-title":"Korean J Radiol"},{"key":"8727_CR25","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1590\/S1678-77572006000400008","volume":"14","author":"GP Elias","year":"2006","unstructured":"Elias GP, Santos OAMD, Sassaki KT, Delbem ACB, Antoniali C. Dental mineralization and salivary activity are reduced in offspring of spontaneously hypertensive rats (SHR). J Appl Oral Sci. 2006;14:253\u20139. https:\/\/doi.org\/10.1590\/S1678-77572006000400008.","journal-title":"J Appl Oral Sci"},{"issue":"3","key":"8727_CR26","first-page":"190","volume":"21","author":"A Mohiti","year":"2020","unstructured":"Mohiti A, Eslami F. Does hypertension affect saliva properties? J Dent. 2020;21(3):190.","journal-title":"J Dent"},{"issue":"9","key":"8727_CR27","doi-asserted-by":"publisher","first-page":"5217","DOI":"10.1007\/s00784-021-03829-4","volume":"25","author":"M Kawamoto","year":"2021","unstructured":"Kawamoto M, Yamada SI, Gibo T, Kajihara R, Nagashio S, Tanaka H, Kurita H. Relationship between dry mouth and hypertension. Clin Oral Investig. 2021;25(9):5217\u201325. https:\/\/doi.org\/10.1007\/s00784-021-03829-4.","journal-title":"Clin Oral Investig"},{"issue":"01","key":"8727_CR28","doi-asserted-by":"publisher","first-page":"01","DOI":"10.1590\/1807-3107BOR-2014.vol28.0012","volume":"28","author":"N Seferos","year":"2014","unstructured":"Seferos N, Daskala I, Kotsiou A, Tsamouri M, Tesseromatis C. Nifedipine-induced histological changes in the parotid glands of hypertensive rats. Braz Oral Res. 2014;28(01):01\u20135. https:\/\/doi.org\/10.1590\/1807-3107BOR-2014.vol28.0012.","journal-title":"Braz Oral Res"},{"key":"8727_CR29","doi-asserted-by":"publisher","unstructured":"Morozova NS, Mamedov AA, Kogan EA, Zakharova NV, Yurchenko PN, Morozova OL. Morphological changes in salivary glands of neonatal rats after intra-abdominal hypertension. Eur Rev Med Pharmacol Sci. 2022;26(2). https:\/\/doi.org\/10.26355\/eurrev_202201_27879.","DOI":"10.26355\/eurrev_202201_27879"},{"issue":"6","key":"8727_CR30","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/0030-4220(94)90321-2","volume":"77","author":"CF Streckfus","year":"1994","unstructured":"Streckfus CF, Wu AJ, Ship JA, Brown LJ. Comparison of stimulated parotid salivary gland flow rates\u2026 Oral. Surg Oral Med Oral Pathol. 1994;77(6):615\u20139.","journal-title":"Surg Oral Med Oral Pathol"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-026-08727-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-08727-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-08727-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:17:37Z","timestamp":1787620657000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12903-026-08727-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8727"],"URL":"https:\/\/doi.org\/10.1186\/s12903-026-08727-3","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"assertion":[{"value":"6 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was obtained from the Ethics Committee of Harran University Faculty of Dentistry (Decision No: HR\u00dc\/25.06.27). All procedures were performed in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1589"}}