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Conventional anterior repositioning splints (ARS) often lack anatomical adaptation, which may limit their therapeutic precision and patient comfort. This study aimed to compare the efficacy of a digitally designed anatomical repositioning splint (D-ARS) with that of a conventional ARS in adolescent ADDwR patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized controlled trial, 82 adolescents (aged 12\u201316 years) with ADDwR were randomly allocated to receive either a D-ARS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941) or an ARS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941). At the 6\u2011month follow\u2011up, clinical outcomes were evaluated through three modalities: disc recapture was assessed by magnetic resonance imaging (MRI), condylar volume changes were measured using cone\u2011beam computed tomography (CBCT), and patient\u2011reported wearing comfort was quantified with the Oral Impacts on Daily Performance (OIDP) questionnaire. Statistical analyses included chi-square tests, t-tests, and non-parametric tests as appropriate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The D-ARS group achieved a significantly higher disc recapture rate than the ARS group (94.44% vs. 79.63%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). Both groups showed significant increases in condylar volume [D-ARS: +202.17\u00a0mm\u00b3 (95% CI: 177.72\u2013226.63), ARS: +208.9\u00a0mm\u00b3 (95% CI: 178.8\u2013241.25), both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001], with no intergroup difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.5615). Patient-reported comfort was superior in the D-ARS group, with lower OIDP scores (14.43% vs. 35.63%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>At the 6-month follow-up, the D-ARS group exhibited significantly better disc recapture success and patient-reported wearing comfort than the ARS group, while no significant difference was observed between the two groups in terms of condylar growth promotion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      Chinese Clinical Trial Registry (ChiCTR2400080947, registered on February 19, 2024). Available from:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\/\" ext-link-type=\"uri\">http:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-08753-1","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:25:32Z","timestamp":1780673132000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of a digitally designed anatomical repositioning splint for adolescent temporomandibular joint anterior disc displacement with reduction: a randomized controlled trial"],"prefix":"10.1186","volume":"26","author":[{"given":"Wenfang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2019an","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenquan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"issue":"7","key":"8753_CR1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1177\/0333102416686302","volume":"37","author":"T List","year":"2017","unstructured":"List T, Jensen RH. 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The study was conducted in accordance with the Declaration of Helsinki, the ethical guidelines of the Research Ethics Committee, and the CONSORT 2025 guidelines for reporting randomized trials. Participation in this study was entirely voluntary. All participants and their legal guardians were informed that even after agreeing to participate, they could change their mind at any time and withdraw from the study without any consequences. Withdrawal would not result in discrimination or reprisal and would not affect their access to normal medical care. Written informed consent was obtained from the guardians of all participating patients prior to enrollment, and age-appropriate assent was also secured from the participants themselves.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent for the publication of anonymized patient data, including clinical photographs and imaging, was obtained from the parents or legal guardians of all adolescent participants prior to their enrollment in the study.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1410"}}