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We obtained informed consent from all donors and their legal guardians prior to collecting samples. All animal experiments conducted in this study followed standard procedures and adhered to ethical principles for animal welfare. The animal experimental protocols were approved by the Institutional Animal Care and Use Committee of Peking University (LA2022288). All methods are reported in accordance with ARRIVE guidelines for the reporting of animal experiments [\n                      \n                      ].","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1603"}}