{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:47:16Z","timestamp":1782575236767,"version":"3.54.5"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007950","name":"Tanta University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007950","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare fascia lata allograft (FLA) and subepithelial connective tissue graft (SCTG) for peri-implant mucosal augmentation performed simultaneously with implant placement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This prospective, randomized, examiner-blinded pilot clinical trial enrolled 16 patients requiring single-tooth implant placement with a thin peri-implant soft-tissue phenotype. Participants were randomly allocated (1:1) to SCTG or FLA. The primary outcome was peri-implant mucosal thickness (PMT) measured by using a customized stent-guided transmucosal method at standardized buccal reference points. Secondary outcomes included keratinized mucosal width (KMW), postoperative pain (VAS), and modified wound healing index (MWHI). Follow-up was 24 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both groups demonstrated significant improvements in PMT and KMW over time. Between-group differences were generally non-significant, except localized PMT differences at the intermediate reference level, favoring SCTG at later visits. FLA showed lower postoperative pain at selected time points. Healing outcomes were comparable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both SCTG and FLA were effective for peri-implant mucosal augmentation. FLA may represent a viable alternative that avoids donor-site morbidity. Larger long-term trials are required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>FLA can be considered a viable alternative for enhancing peri-implant mucosal thickness around simultaneously placed dental implants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov NCT04679922, registered on December 22, 2020, and retrospectively registered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12903-026-08829-y","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T08:17:22Z","timestamp":1782202642000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fascia lata allograft versus subepithelial connective tissue graft for peri-implant mucosal augmentation at implant placement: a randomized pilot clinical trial"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-4981","authenticated-orcid":false,"given":"Mohamed H.","family":"Helal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda M.","family":"Elguindy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar F.","family":"Ghoraba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malak Y.","family":"Shoukheba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"8829_CR1","first-page":"712","volume":"24","author":"T Linkevicius","year":"2009","unstructured":"Linkevicius T, Apse P, Grybauskas S, Puisys A. The influence of soft tissue thickness on crestal bone changes around implants: a 1-year prospective controlled clinical trial. Int J Oral Maxillofac Implants. 2009;24:712\u20139.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"8829_CR2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/clr.12301","volume":"26","author":"A Puisys","year":"2015","unstructured":"Puisys A, Linkevicius T. The influence of mucosal tissue thickening on crestal bone stability around bone-level implants. A prospective controlled clinical trial. Clin Oral Implants Res. 2015;26:123\u20139.","journal-title":"Clin Oral Implants Res"},{"key":"8829_CR3","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/clr.12784","volume":"28","author":"P Van Eekeren","year":"2017","unstructured":"Van Eekeren P, Van Elsas P, Tahmaseb A, Wismeijer D. The influence of initial mucosal thickness on crestal bone change in similar macrogeometrical implants: a prospective randomized clinical trial. Clin Oral Implant Res. 2017;28:214\u20138.","journal-title":"Clin Oral Implant Res"},{"key":"8829_CR4","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1111\/cid.12194","volume":"17","author":"M Migliorati","year":"2015","unstructured":"Migliorati M, Amorfini L, Signori A, Biavati AS, Benedicenti S. Clinical and Aesthetic Outcome with Post-Extractive Implants with or without Soft Tissue Augmentation: A 2-Year Randomized Clinical Trial. Clin Implant Dent Relat Res. 2015;17:983\u201395.","journal-title":"Clin Implant Dent Relat Res"},{"key":"8829_CR5","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1600-0501.2009.01784.x","volume":"20","author":"DS Thoma","year":"2009","unstructured":"Thoma DS, Benic GI, Zwahlen M, Hammerle CH, Jung RE. A systematic review assessing soft tissue augmentation techniques. Clin Oral Implant Res. 2009;20:146\u201365.","journal-title":"Clin Oral Implant Res"},{"key":"8829_CR6","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1111\/jcpe.12220","volume":"41","author":"DS Thoma","year":"2014","unstructured":"Thoma DS, Buranawat B, Hammerle CH, Held U, Jung RE. Efficacy of soft tissue augmentation around dental implants and in partially edentulous areas: a systematic review. J Clin Periodontol. 2014;41:S77\u201391.","journal-title":"J Clin Periodontol"},{"key":"8829_CR7","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1034\/j.1600-051X.2002.290910.x","volume":"29","author":"M Del Pizzo","year":"2002","unstructured":"Del Pizzo M, Modica F, Bethaz N, Priotto P, Romagnoli R. The connective tissue graft: a comparative clinical evaluation of wound healing at the palatal donor site. A preliminary study. J Clin Periodontol. 2002;29:848\u201354.","journal-title":"J Clin Periodontol"},{"key":"8829_CR8","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1902\/jop.2006.050129","volume":"77","author":"KM Soileau","year":"2006","unstructured":"Soileau KM, Brannon RB. A histologic evaluation of various stages of palatal healing following subepithelial connective tissue grafting procedures: a comparison of eight cases. J Periodontol. 2006;77:1267\u201373.","journal-title":"J Periodontol"},{"key":"8829_CR9","first-page":"1","volume":"5","author":"S Guta","year":"2015","unstructured":"Guta S, Pratibha PK, Gupta R. Mucosal Substitutes for Periodontal Soft Tissue Regeneration. Dentistry. 2015;5:1\u20136.","journal-title":"Dentistry"},{"key":"8829_CR10","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.rodmex.2018.01.009","volume":"21","author":"AK Hern\u00e1ndez Jim\u00e9nez","year":"2017","unstructured":"Hern\u00e1ndez Jim\u00e9nez AK, Y\u00e1\u00f1ez Ocampo BR, Esquivel Chirino CA. Fascia lata como alternativa en tratamientos odontol\u00f3gicos. Rev Odont Mex. 2017;21:273\u20139.","journal-title":"Rev Odont Mex"},{"key":"8829_CR11","doi-asserted-by":"publisher","first-page":"587","DOI":"10.17219\/acem\/44849","volume":"25","author":"W Bednarz","year":"2016","unstructured":"Bednarz W, \u017burek J, Gedrange T, Dominiak M. A Preliminary Clinical Comparison of the Use of Fascia Lata Allograft and Autogenous Connective Tissue Graft in Multiple Gingival Recession Coverage Based on the Tunnel Technique. Adv Clin Exp Med. 2016;25:587\u201398.","journal-title":"Adv Clin Exp Med"},{"key":"8829_CR12","first-page":"394","volume":"18","author":"LH Silverstein","year":"1992","unstructured":"Silverstein LH, Kraft JD, Wand R. Bone regeneration and tissue acceptance of human fascia lata grafts adjacent to dental implants: a preliminary case report. J Oral Implantol. 1992;18:394\u20138.","journal-title":"J Oral Implantol"},{"key":"8829_CR13","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.aanat.2014.08.003","volume":"199","author":"J \u017burek","year":"2015","unstructured":"\u017burek J, Dominiak M, Botzenhart U, Bednarz W. The use of a biostatic fascia lata thigh allograft as a scaffold for autologous human culture of fibroblasts\u2014An in vitro study. Ann Anat. 2015;199:104\u20138.","journal-title":"Ann Anat"},{"key":"8829_CR14","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1002\/JPER.17-0597","volume":"89","author":"CG Hutton","year":"2018","unstructured":"Hutton CG, Johnson GK, Barwacz CA, Allareddy V, Avila-Ortiz G. Comparison of two different surgical approaches to increase peri-implant mucosal thickness: A randomized controlled clinical trial. J Periodontol. 2018;89:807\u201314.","journal-title":"J Periodontol"},{"key":"8829_CR15","doi-asserted-by":"publisher","first-page":"20140197","DOI":"10.1259\/dmfr.20140197","volume":"44","author":"JB Ludlow","year":"2015","unstructured":"Ludlow JB, Timothy R, Walker C, Hunter R, Benavides E, Samuelson DB, et al. Effective dose of dental CBCT-a meta analysis of published data and additional data for nine CBCT units. Dentomaxillofac Radiol. 2015;44:20140197.","journal-title":"Dentomaxillofac Radiol"},{"key":"8829_CR16","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1067\/mpr.2001.115388","volume":"85","author":"DM Almog","year":"2001","unstructured":"Almog DM, Torrado E, Meitner SW. Fabrication of imaging and surgical guides for dental implants. J Prosthet Dent. 2001;85:504\u20138.","journal-title":"J Prosthet Dent"},{"key":"8829_CR17","first-page":"297","volume":"20","author":"ER Lorenzana","year":"2000","unstructured":"Lorenzana ER, Allen EP. The single-incision palatal harvest technique: a strategy for esthetics and patient comfort. Int J Periodontics Restor Dent. 2000;20:297\u2013305.","journal-title":"Int J Periodontics Restor Dent"},{"key":"8829_CR18","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1600-0501.2012.02540.x","volume":"23","author":"JL Wennstr\u00f6m","year":"2012","unstructured":"Wennstr\u00f6m JL, Derks J. Is there a need for keratinized mucosa around implants to maintain health and tissue stability? Clin Oral Implants Res. 2012;23:136\u201346.","journal-title":"Clin Oral Implants Res"},{"key":"8829_CR19","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1563\/AAID-JOI-D-09-00035.1","volume":"35","author":"M Adibrad","year":"2009","unstructured":"Adibrad M, Shahabuei M, Sahabi M. Significance of the width of keratinized mucosa on the health status of the supporting tissue around implants supporting overdentures. J Oral Implantol. 2009;35:232\u20137.","journal-title":"J Oral Implantol"},{"key":"8829_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1034\/j.1600-0501.1994.050101.x","volume":"5","author":"JL Wennstr\u00f6m","year":"1994","unstructured":"Wennstr\u00f6m JL, Bengazi F, Lekholm U. The influence of the masticatory mucosa on the peri-implant soft tissue condition. Clin Oral Implants Res. 1994;5:1\u20138.","journal-title":"Clin Oral Implants Res"},{"key":"8829_CR21","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1902\/jop.2013.120688","volume":"84","author":"GH Lin","year":"2013","unstructured":"Lin GH, Chan HL, Wang HL. The significance of keratinized mucosa on implant health: a systematic review. J periodontol. 2013;84:1755\u201367.","journal-title":"J periodontol"},{"key":"8829_CR22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1600-051X.2008.01266.x","volume":"35","author":"F Cairo","year":"2008","unstructured":"Cairo F, Pagliaro U, Nieri M. Soft tissue management at implant sites. J Clin Periodontol. 2008;35:163\u20137.","journal-title":"J Clin Periodontol"},{"key":"8829_CR23","first-page":"234","volume":"35","author":"B Sezer","year":"2004","unstructured":"Sezer B, Sel\u00e7uk E, Ert\u00fcrk S, Gomel M. Comparison of autogenous mucosal grafts and collagen-based, solvent-preserved allografts for vestibuloplasty. Quintessence Int. 2004;35:234\u20139.","journal-title":"Quintessence Int"},{"key":"8829_CR24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1600-0501.2007.01413.x","volume":"19","author":"CD Evans","year":"2008","unstructured":"Evans CD, Chen ST. Esthetic outcomes of immediate implant placements. Clin Oral Implants Res. 2008;19:73\u201380.","journal-title":"Clin Oral Implants Res"},{"issue":"4","key":"8829_CR25","doi-asserted-by":"publisher","first-page":"229","DOI":"10.4103\/tdj.tdj_23_22","volume":"19","author":"MH Helal","year":"2022","unstructured":"Helal MH, Elguindy HM, Ghoraba SF, Shoukheba MY, Yasser S. Fascia lata allograft versus subepithelial connective tissue grafts in the peri-implant mucosal thickness enhancement (histological evaluation). Tanta Dent J. 2022;19(4):229\u201334.","journal-title":"Tanta Dent J"},{"key":"8829_CR26","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1111\/jcpe.12750","volume":"44","author":"F Cairo","year":"2017","unstructured":"Cairo F, Barbato L, Tonelli P, Batalocco G, Pagavino G, Nieri M. Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. A randomized, controlled clinical trial. J Clin Periodontol. 2017;44:769\u201376.","journal-title":"J Clin Periodontol"},{"key":"8829_CR27","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4103\/2231-0754.201437","volume":"9","author":"M Panwar","year":"2017","unstructured":"Panwar M, Roy S, Kosala M. Management of peri-implant soft tissue defect with connective tissue graft - A case report. J Int Clin Dent Res Organ. 2017;9:31\u20134.","journal-title":"J Int Clin Dent Res Organ"},{"key":"8829_CR28","doi-asserted-by":"publisher","first-page":"474","DOI":"10.4103\/0970-9290.74208","volume":"21","author":"S Speroni","year":"2010","unstructured":"Speroni S, Cicciu M, Maridati P, Grossi GB, Maiorana C. Clinical investigation of mucosal thickness stability after soft tissue grafting around implants: a 3-year retrospective study. Indian J Dent Res. 2010;21:474\u20139.","journal-title":"Indian J Dent Res"},{"key":"8829_CR29","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/jcpe.12697","volume":"44","author":"M Zeltner","year":"2017","unstructured":"Zeltner M, Jung RE, H\u00e4mmerle CH, H\u00fcsler J, Thoma DS. Randomized controlled clinical study comparing a volume-stable collagen matrix to autogenous connective tissue grafts for soft tissue augmentation at implant sites: linear volumetric soft tissue changes up to 3 months. J Clin Periodontol. 2017;44:446\u201353.","journal-title":"J Clin Periodontol"},{"key":"8829_CR30","doi-asserted-by":"publisher","first-page":"313","DOI":"10.21608\/edj.2020.77549","volume":"66","author":"WM Abbas","year":"2020","unstructured":"Abbas WM. Comparative Randomized Clinical Study of Acellular Dermal Matrix Allograft and Subepithelial Connective Tissue Graft Around Immediate Dental Implants: 12-Months Clinical and Esthetic Outcomes. Egypt Dent J. 2020;66:313\u201325.","journal-title":"Egypt Dent J"},{"key":"8829_CR31","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1902\/jop.2001.72.2.265","volume":"72","author":"EL Batista Jr","year":"2001","unstructured":"Batista EL Jr., Batista FC, Novaes AB. Jr. Management of soft tissue ridge deformities with acellular dermal matrix. Clinical approach and outcome after 6 months of treatment. J Periodontol. 2001;72:265\u201373.","journal-title":"J Periodontol"},{"key":"8829_CR32","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/j.1600-0501.2011.02260.x","volume":"23","author":"R Lorenzo","year":"2012","unstructured":"Lorenzo R, Garc\u00eda V, Orsini M, Martin C, Sanz M. Clinical efficacy of a xenogeneic collagen matrix in augmenting keratinized mucosa around implants: a randomized controlled prospective clinical trial. Clin Oral Implants Res. 2012;23:316\u201324.","journal-title":"Clin Oral Implants Res"},{"key":"8829_CR33","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.11607\/jomi.7497","volume":"34","author":"J Gargallo-Albiol","year":"2019","unstructured":"Gargallo-Albiol J, Barootchi S, Tavelli L, Wang HL. Efficacy of Xenogeneic Collagen Matrix to Augment Peri-Implant Soft Tissue Thickness Compared to Autogenous Connective Tissue Graft: A Systematic Review and Meta-Analysis. Int J Oral Maxillofac Implants. 2019;34:1059\u201369.","journal-title":"Int J Oral Maxillofac Implants"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-026-08829-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-08829-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-08829-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:16:00Z","timestamp":1782573360000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12903-026-08829-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8829"],"URL":"https:\/\/doi.org\/10.1186\/s12903-026-08829-y","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]},"assertion":[{"value":"15 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was reviewed and approved by the Faculty of Dentistry Research Ethics Committee, Tanta University, Egypt (Approval No. OMPDR-07-19-5). Written informed consent was obtained from all participants before enrollment. All procedures were performed in accordance with the Declaration of Helsinki and its subsequent amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1123"}}