{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:30:18Z","timestamp":1786512618974,"version":"build-2736575974"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":65,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Oral Health"],"DOI":"10.1186\/s12903-026-08846-x","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:18:03Z","timestamp":1780910283000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Local curcumin\/turmeric-derived delivery adjunctive to scaling and root planing for periodontitis: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"26","author":[{"given":"Shuoyan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"11","key":"8846_CR1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","volume":"93","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum NJ, Bernab\u00e9 E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990\u20132010: a systematic review and meta-regression. J Dent Res. 2014;93(11):1045\u201353.","journal-title":"J Dent Res"},{"issue":"1","key":"8846_CR2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","volume":"15","author":"G Hajishengallis","year":"2015","unstructured":"Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15(1):30\u201344.","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"8846_CR3","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.adaj.2015.01.026","volume":"146","author":"CJ Smiley","year":"2015","unstructured":"Smiley CJ, Tracy SL, Abt E, Michalowicz BS, John MT, Gunsolley J, Cobb CM, Rossmann J, Harrel SK, Forrest JL, et al. Evidence-based clinical practice guideline on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J Am Dent Assoc. 2015;146(7):525\u201335.","journal-title":"J Am Dent Assoc"},{"issue":"Suppl 22","key":"8846_CR4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/jcpe.13290","volume":"47","author":"M Sanz","year":"2020","unstructured":"Sanz M, Herrera D, Kebschull M, Chapple I, Jepsen S, Beglundh T, Sculean A, Tonetti MS. Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline. J Clin Periodontol. 2020;47(Suppl 22):4\u201360.","journal-title":"J Clin Periodontol"},{"issue":"10","key":"8846_CR5","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1002\/JPER.20-0839","volume":"92","author":"CM Cobb","year":"2021","unstructured":"Cobb CM, Sottosanti JS. A re-evaluation of scaling and root planing. J Periodontol. 2021;92(10):1370\u20138.","journal-title":"J Periodontol"},{"issue":"1","key":"8846_CR6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1902\/annals.2003.8.1.79","volume":"8","author":"PJ Hanes","year":"2003","unstructured":"Hanes PJ, Purvis JP. Local anti-infective therapy: pharmacological agents. A systematic review. Ann Periodontol. 2003;8(1):79\u201398.","journal-title":"Ann Periodontol"},{"key":"8846_CR7","doi-asserted-by":"crossref","unstructured":"Amato MS, Polizzi S, Tartaglia A, Ronsivalle GM, Viglianisi V, Grippaudo G, Isola C. G.: Local Delivery and Controlled Release Drugs Systems: A New Approach for the Clinical Treatment of Periodontitis Therapy. Pharmaceutics 2023, 15(4).","DOI":"10.3390\/pharmaceutics15041312"},{"issue":"1","key":"8846_CR8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","volume":"41","author":"BB Aggarwal","year":"2009","unstructured":"Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009;41(1):40\u201359.","journal-title":"Int J Biochem Cell Biol"},{"key":"8846_CR9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-0-387-46401-5_3","volume":"595","author":"VP Menon","year":"2007","unstructured":"Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007;595:105\u201325.","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"8846_CR10","first-page":"141","volume":"14","author":"JS Jurenka","year":"2009","unstructured":"Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141\u201353.","journal-title":"Altern Med Rev"},{"issue":"2","key":"8846_CR11","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1600-0765.2010.01342.x","volume":"46","author":"MR Guimar\u00e3es","year":"2011","unstructured":"Guimar\u00e3es MR, Coimbra LS, de Aquino SG, Spolidorio LC, Kirkwood KL, Rossa C Jr. Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res. 2011;46(2):269\u201379.","journal-title":"J Periodontal Res"},{"issue":"1","key":"8846_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1902\/jop.2015.150260","volume":"87","author":"S Izui","year":"2016","unstructured":"Izui S, Sekine S, Maeda K, Kuboniwa M, Takada A, Amano A, Nagata H. Antibacterial Activity of Curcumin Against Periodontopathic Bacteria. J Periodontol. 2016;87(1):83\u201390.","journal-title":"J Periodontol"},{"key":"8846_CR13","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/978-3-030-56153-6_14","volume":"1291","author":"O Fakheran","year":"2021","unstructured":"Fakheran O, Khademi A, Bagherniya M, Dehghannejad M, Sathyapalan T, Sahebkar A. Antibacterial Activity of Curcumin Against Periodontal Pathogens: A Systematic Review. Adv Exp Med Biol. 2021;1291:239\u201349.","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"8846_CR14","doi-asserted-by":"publisher","first-page":"6652","DOI":"10.1038\/s41598-018-24866-2","volume":"8","author":"LMG Zambrano","year":"2018","unstructured":"Zambrano LMG, Brandao DA, Rocha FRG, Marsiglio RP, Longo IB, Primo FL, Tedesco AC, Guimaraes-Stabili MR, Rossa Junior C. Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease. Sci Rep. 2018;8(1):6652.","journal-title":"Sci Rep"},{"key":"8846_CR15","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.","journal-title":"BMJ"},{"issue":"7","key":"8846_CR16","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.sdentj.2021.07.008","volume":"33","author":"S Terby","year":"2021","unstructured":"Terby S, Shereef M, Ramanarayanan V, Balakrishnan B. The effect of curcumin as an adjunct in the treatment of chronic periodontitis: A systematic review and meta-analysis. Saudi Dent J. 2021;33(7):375\u201385.","journal-title":"Saudi Dent J"},{"issue":"11","key":"8846_CR17","doi-asserted-by":"publisher","first-page":"5980","DOI":"10.1002\/ptr.7208","volume":"35","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Huang L, Mazurel D, Zheng H, Yang J, Deng D. Clinical efficacy of curcumin versus chlorhexidine as an adjunct to scaling and root planing for the treatment of periodontitis: A systematic review and meta-analysis. Phytother Res. 2021;35(11):5980\u201391.","journal-title":"Phytother Res"},{"key":"8846_CR18","doi-asserted-by":"publisher","first-page":"808460","DOI":"10.3389\/fphar.2022.808460","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Huang L, Zhang J, De Souza Rastelli AN, Yang J, Deng D. Anti-Inflammatory Efficacy of Curcumin as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:808460.","journal-title":"Front Pharmacol"},{"key":"8846_CR19","doi-asserted-by":"crossref","unstructured":"Wendorff-Tobolla LM, Wolgin M, Wagner G, Klerings I, Dvornyk A, Kielbassa AM. A Systematic Review and Meta-Analysis on the Efficacy of Locally Delivered Adjunctive Curcumin (Curcuma longa L.) in the Treatment of Periodontitis. Biomedicines. 2023;11(2):481.","DOI":"10.3390\/biomedicines11020481"},{"issue":"1","key":"8846_CR20","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/ije\/31.1.140","volume":"31","author":"DR Elbourne","year":"2002","unstructured":"Elbourne DR, Altman DG, Higgins JP, Curtin F, Worthington HV, Vail A. Meta-analyses involving cross-over trials: methodological issues. Int J Epidemiol. 2002;31(1):140\u20139.","journal-title":"Int J Epidemiol"},{"key":"8846_CR21","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng HY, Corbett MS, Eldridge SM, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.","journal-title":"BMJ"},{"issue":"3","key":"8846_CR22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R DerSimonian","year":"1986","unstructured":"DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177\u201388.","journal-title":"Control Clin Trials"},{"issue":"7414","key":"8846_CR23","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557\u201360.","journal-title":"BMJ"},{"issue":"10","key":"8846_CR24","first-page":"Ed000142","volume":"10","author":"M Cumpston","year":"2019","unstructured":"Cumpston M, Li T, Page MJ, Chandler J, Welch VA, Higgins JP, Thomas J. Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst Rev. 2019;10(10):Ed000142.","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"8846_CR25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4103\/0972-124X.82264","volume":"15","author":"R Behal","year":"2011","unstructured":"Behal R, Mali AM, Gilda SS, Paradkar AR. Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study. J Indian Soc Periodontol. 2011;15(1):35\u20138.","journal-title":"J Indian Soc Periodontol"},{"issue":"12","key":"8846_CR26","first-page":"Zc65","volume":"8","author":"M Bhatia","year":"2014","unstructured":"Bhatia M, Urolagin SS, Pentyala KB, Urolagin SB, Bhoi KBM. Novel therapeutic approach for the treatment of periodontitis by curcumin. J Clin Diagn Res. 2014;8(12):Zc65\u201369.","journal-title":"J Clin Diagn Res"},{"issue":"5","key":"8846_CR27","doi-asserted-by":"publisher","first-page":"575","DOI":"10.4103\/0972-124X.142445","volume":"18","author":"R Jaswal","year":"2014","unstructured":"Jaswal R, Dhawan S, Grover V, Malhotra R. Comparative evaluation of single application of 2% whole turmeric gel versus 1% chlorhexidine gel in chronic periodontitis patients: A pilot study. J Indian Soc Periodontol. 2014;18(5):575\u201380.","journal-title":"J Indian Soc Periodontol"},{"issue":"1","key":"8846_CR28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4103\/0970-9290.156806","volume":"26","author":"V Anitha","year":"2015","unstructured":"Anitha V, Rajesh P, Shanmugam M, Priya BM, Prabhu S, Shivakumar V. Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: a clinical and microbiological study. Indian J Dent Res. 2015;26(1):53\u20136.","journal-title":"Indian J Dent Res"},{"issue":"7","key":"8846_CR29","first-page":"90","volume":"7","author":"BR Anuradha","year":"2015","unstructured":"Anuradha BR, Bai YD, Sailaja S, Sudhakar J, Priyanka M, Deepika V. Evaluation of Anti-Inflammatory Effects of Curcumin Gel as an Adjunct to Scaling and Root Planing: A Clinical Study. J Int Oral Health. 2015;7(7):90\u20133.","journal-title":"J Int Oral Health"},{"issue":"7","key":"8846_CR30","doi-asserted-by":"publisher","first-page":"842","DOI":"10.5005\/jp-journals-10024-2608","volume":"20","author":"KV Raghava","year":"2019","unstructured":"Raghava KV, Sistla KP, Narayan SJ, Yadalam U, Bose A, Mitra K. Efficacy of Curcumin as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients: A Randomized Controlled Clinical Trial. J Contemp Dent Pract. 2019;20(7):842\u20136.","journal-title":"J Contemp Dent Pract"},{"issue":"Suppl 1","key":"8846_CR31","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.4103\/0975-7406.191967","volume":"8","author":"S Elavarasu","year":"2016","unstructured":"Elavarasu S, Suthanthiran T, Thangavelu A, Alex S, Palanisamy VK, Kumar TS. Evaluation of superoxide dismutase levels in local drug delivery system containing 0.2% curcumin strip as an adjunct to scaling and root planing in chronic periodontitis: A clinical and biochemical study. J Pharm Bioallied Sci. 2016;8(Suppl 1):S48\u201352.","journal-title":"J Pharm Bioallied Sci"},{"issue":"1","key":"8846_CR32","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1080\/10717544.2016.1233591","volume":"24","author":"MM Nasra","year":"2017","unstructured":"Nasra MM, Khiri HM, Hazzah HA, Abdallah OY. Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis. Drug Deliv. 2017;24(1):133\u201342.","journal-title":"Drug Deliv"},{"issue":"4","key":"8846_CR33","doi-asserted-by":"publisher","first-page":"188","DOI":"10.4103\/jphi.JPHI_82_17","volume":"7","author":"PK Ravishankar","year":"2017","unstructured":"Ravishankar PK, Anila Y, Chakraborty E, Malakar P, Mahalakshmi M. Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients. Int J Pharm Invest. 2017;7(4):188\u201392.","journal-title":"Int J Pharm Invest"},{"issue":"1","key":"8846_CR34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1089\/acm.2017.0059","volume":"24","author":"AS Singh","year":"2018","unstructured":"Singh AS, Shrihatti R, Mandloy R. Evaluation of Turmeric Chip Compared with Chlorhexidine Chip as a Local Drug Delivery Agent in the Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Clinical Trial. J Altern Complement Med. 2018;24(1):76\u201384.","journal-title":"J Altern Complement Med"},{"issue":"2","key":"8846_CR35","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2174\/1871526518666180601073422","volume":"19","author":"H Kaur","year":"2019","unstructured":"Kaur H, Grover V, Malhotra R, Gupta M. Evaluation of Curcumin Gel as Adjunct to Scaling & Root Planing in Management of Periodontitis- Randomized Clinical & Biochemical Investigation. Infect Disord Drug Targets. 2019;19(2):171\u20138.","journal-title":"Infect Disord Drug Targets"},{"key":"8846_CR36","doi-asserted-by":"crossref","unstructured":"Karthickeyan P, Bhaskar J, Mahalakshmi K, Prasanth BK, Gita B, Valiyathan M, Balaji A. Efficacy of curcumin as an adjunct to scaling and root planing in periodontitis patients \u2013 a clinical and microbiological study. J Biomed Pharma Res. 2019;8(5):75\u201381.","DOI":"10.32553\/jbpr.v8i5.658"},{"issue":"7","key":"8846_CR37","first-page":"5299","volume":"7","author":"AK Desai","year":"2020","unstructured":"Desai AK, Nishat H, Aspalli R, Nagappa S, Kumar G;Anand. Comparative evaluation of efficacy of subgingivally delivered 2% indigenously prepared curcumin gel and 1% commercially available hexigel as an adjunct to scaling and root planing in chronic periodontitis patients: a split mouth randomized controlled clinical trial. Eur J Mol Clin Med. 2020;7(7):5299\u2013312.","journal-title":"Eur J Mol Clin Med"},{"issue":"3","key":"8846_CR38","doi-asserted-by":"publisher","first-page":"244","DOI":"10.4103\/jisp.jisp_207_19","volume":"24","author":"SRAR Guru","year":"2020","unstructured":"Guru SRAR, ;Rao K, Padmanabhan RJ, Guru S, Srinivasa R. Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis: A pilot randomized controlled clinical trial. J Indian Soc Periodontology. 2020;24(3):244\u201352.","journal-title":"J Indian Soc Periodontology"},{"issue":"5","key":"8846_CR39","doi-asserted-by":"publisher","first-page":"494","DOI":"10.5005\/jp-journals-10024-2828","volume":"21","author":"MS Siddharth","year":"2020","unstructured":"Siddharth MS, Gupta P, Sinha R, Shree A, Sharma S. A Comparative Evaluation of Subgingivally Delivered 2% Curcumin and 0.2% Chlorhexidine Gel Adjunctive to Scaling and Root Planing in Chronic Periodontitis. J Contemp Dent Pract. 2020;21(5):494\u20139.","journal-title":"J Contemp Dent Pract"},{"issue":"5","key":"8846_CR40","doi-asserted-by":"publisher","first-page":"75","DOI":"10.32553\/jbpr.v8i5.658","volume":"8","author":"P Karthickeyan","year":"2019","unstructured":"Karthickeyan P, Bhaskar J, Mahalakshmi K, Krishna Prasanth B, Bhagavad G, Valiyathan M, Balaji A. Efficacy of curcumin as an adjunct to scaling and root planing in periodontitis patients: a clinical and microbiological study. J Biomedical Pharm Res. 2019;8(5):75\u201381.","journal-title":"J Biomedical Pharm Res"},{"issue":"6","key":"8846_CR41","doi-asserted-by":"publisher","first-page":"S554","DOI":"10.4103\/0975-7406.163537","volume":"7","author":"MM Nagasri","year":"2015","unstructured":"Nagasri MM, Musalaiah M, Kumar S, Krishna PA, Kumar CHM. Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients: a clinical and microbiological study. J Pharm bioallied Sci. 2015;7(6):S554\u20138.","journal-title":"J Pharm bioallied Sci"},{"key":"8846_CR42","first-page":"83","volume":"8","author":"HT Farhood","year":"2020","unstructured":"Farhood HT, Ali B. Clinical and Anti-Inflammatory Effect of Curcumin Oral Gel as Adjuncts in Treatment of Periodontal Pocket. J Res Med Dent Sci. 2020;8:83\u201390.","journal-title":"J Res Med Dent Sci"},{"issue":"5","key":"8846_CR43","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1007\/s00784-020-03652-3","volume":"25","author":"CGF Perez-Pacheco","year":"2021","unstructured":"Perez-Pacheco CGF, Primo NAR, Tedesco FL, Bellile AC, Retamal-Valdes E, Feres B, Guimaraes-Stabili M, Rossa MR. Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial. Clin Oral Invest. 2021;25(5):3217\u201327.","journal-title":"Clin Oral Invest"},{"issue":"1","key":"8846_CR44","first-page":"287","volume":"13","author":"HB Samal","year":"2022","unstructured":"Samal HB, Patra NC, Sriram S, Das IJ. Curcumin in situ gel for local treatment of periodontitis: preparation, in vitro evaluation and clinical assessment. Int J Pharm Sci Res. 2022;13(1):287\u201396.","journal-title":"Int J Pharm Sci Res"},{"issue":"1","key":"8846_CR45","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1186\/s12903-023-03512-y","volume":"23","author":"RM Abdel-Fatah","year":"2023","unstructured":"Abdel-Fatah RM, Baiomy B, Elmeadawy A. Efficacy of curcumin gel as an adjunct to scaling and root planing on salivary procalcitonin level in the treatment of patients with chronic periodontitis: a randomized controlled clinical trial. BMC Oral Health. 2023;23(1):883.","journal-title":"BMC Oral Health"},{"issue":"Suppl 2","key":"8846_CR46","doi-asserted-by":"publisher","first-page":"S981","DOI":"10.4103\/jpbs.jpbs_259_23","volume":"15","author":"R Borgohain","year":"2023","unstructured":"Borgohain R, Fatima N, Bagde H, Dhanai A, Mukherjee K, Joshi P. Efficacy of Cucurmin and Aloevera Extracts Gel as Local Drugs Delivery Agents. J Pharm Bioallied Sci. 2023;15(Suppl 2):S981\u20133.","journal-title":"J Pharm Bioallied Sci"},{"issue":"2","key":"8846_CR47","first-page":"169","volume":"27","author":"A Abdallah Khalil","year":"2024","unstructured":"Abdallah Khalil A, Alaaeldin E. Sustained Release of Liposomal Curcumin: Enhanced Periodontal Outcomes in Diabetic Patients. Chin J Dent Res. 2024;27(2):169\u201374.","journal-title":"Chin J Dent Res"},{"key":"8846_CR48","unstructured":"Saima S, Sambyal S, Jan SM, Behal R, Parveen I. Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients. Int Archives Integr Med. 2024;11(6):1\u201311."},{"issue":"Suppl 2","key":"8846_CR49","doi-asserted-by":"publisher","first-page":"S1683","DOI":"10.4103\/jpbs.jpbs_255_25","volume":"17","author":"S Gupta","year":"2025","unstructured":"Gupta S, Jyothi SG, Siddiqui A, Dhanai A, Yadav H, Singh U. Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A Clinical Study. J Pharm Bioallied Sci. 2025;17(Suppl 2):S1683\u20135.","journal-title":"J Pharm Bioallied Sci"},{"key":"8846_CR50","doi-asserted-by":"crossref","unstructured":"Kumar P, Prasanth T, Manandhar S. Efficacy of local drug delivery system containing curcumin gel as an adjunct to scaling and root planing in patients with chronic periodontitis: a split mouth RCT. Afr J Biomed Res. 2025;28(1S):2999\u20133007.","DOI":"10.53555\/AJBR.v28i1S.8653"},{"issue":"7","key":"8846_CR51","doi-asserted-by":"publisher","first-page":"622","DOI":"10.5005\/jp-journals-10015-2673","volume":"16","author":"VPB Kumar","year":"2025","unstructured":"Kumar VPB, Aggarwal S, Garg P, Nautiyal A, Sharma A. Effect of 2% Curcumin Gel as a Local Drug Delivery System on Salivary MMP-8 Levels in Nonsurgical Treatment of Chronic Periodontitis: A Double-blind Randomized Controlled Trial. World J Dentistry. 2025;16(7):622\u20138.","journal-title":"World J Dentistry"},{"issue":"3","key":"8846_CR52","doi-asserted-by":"publisher","first-page":"258","DOI":"10.4103\/jisp.jisp_269_24","volume":"29","author":"KD Ramalingam","year":"2025","unstructured":"Ramalingam KD, Saminathan J, Ravi S, Ravindran S, Desingu S. Evaluation of the efficacy of curcuminoids gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A clinicobiochemical study. J Indian Soc Periodontology. 2025;29(3):258\u201364.","journal-title":"J Indian Soc Periodontology"},{"issue":"1","key":"8846_CR53","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4103\/0970-9290.156806","volume":"26","author":"V Anitha","year":"2015","unstructured":"Anitha V, Rajesh P, Shanmugam M, Meena Priya B, Prabhu S, Shivakumar V. Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: a clinical and microbiological study. Indian J Dent Res. 2015;26(1):53\u20136.","journal-title":"Indian J Dent Res"},{"issue":"3","key":"8846_CR54","doi-asserted-by":"publisher","first-page":"197","DOI":"10.4103\/jisp.jisp_158_20","volume":"25","author":"AK Rahalkar","year":"2021","unstructured":"Rahalkar AK, Kumar K. Determination of efficacy of curcumin and Tulsi extracts as local drugs in periodontal pocket reduction: a clinical and microbiological study. J Indian Soc Periodontology. 2021;25(3):197\u2013202.","journal-title":"J Indian Soc Periodontology"},{"issue":"2","key":"8846_CR55","doi-asserted-by":"publisher","first-page":"138","DOI":"10.5005\/jp-journals-10015-1818","volume":"12","author":"K Saini","year":"2021","unstructured":"Saini K, Chopra P, Bhardwaj A, Yadav M, Saini S. Comparative clinical evaluation of two local drug delivery agents (neem chip and turmeric chip) in chronic periodontitis: an experimental study. World J Dentistry. 2021;12(2):138\u201343.","journal-title":"World J Dentistry"},{"issue":"2","key":"8846_CR56","doi-asserted-by":"publisher","first-page":"149","DOI":"10.4103\/0976-9668.184701","volume":"7","author":"SS Hugar","year":"2016","unstructured":"Hugar SS, Patil S, Metgud R, Nanjwade B, Hugar SM. Influence of application of chlorhexidine gel and curcumin gel as an adjunct to scaling and root planing: A interventional study. J Nat Sci Biol Med. 2016;7(2):149\u201354.","journal-title":"J Nat Sci Biol Med"},{"issue":"2","key":"8846_CR57","doi-asserted-by":"publisher","first-page":"59","DOI":"10.5005\/jp-journals-10063-0014","volume":"8","author":"S Prakash","year":"2016","unstructured":"Prakash S, Shivanand P, Vandana KV, Vandana KL. Evaluation of Curcumin 10\u00a0mg (Curenext) as local drug delivery adjunct in the treatment of chronic periodontitis: a clinical trial. CODS J Dentistry. 2016;8(2):59\u201363.","journal-title":"CODS J Dentistry"},{"issue":"1","key":"8846_CR58","doi-asserted-by":"publisher","first-page":"30","DOI":"10.31254\/jahm.2021.7107","volume":"7","author":"VK Vijayapremakumar","year":"2021","unstructured":"Vijayapremakumar VK, Mehta A, Shivanand P, Prakash S. Curcumin: Nature\u2019s anti-inflammatory agent and its use as a local drug delivery agent for treatment of chronic periodontitis: a clinical, microbiological and biochemical study. J Ayurvedic Herb Med. 2021;7(1):30\u20135.","journal-title":"J Ayurvedic Herb Med"}],"container-title":["BMC Oral Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12903-026-08846-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-08846-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12903-026-08846-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:03:05Z","timestamp":1786510985000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12903-026-08846-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8846"],"URL":"https:\/\/doi.org\/10.1186\/s12903-026-08846-x","relation":{},"ISSN":["1472-6831"],"issn-type":[{"value":"1472-6831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"15 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Human Ethics and Consent to Participate declarations: not applicable. This systematic review and meta-analysis synthesized data from published randomized controlled trials and did not involve primary human or animal experiments, so ethical approval and informed consent were not required.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This manuscript does not contain any individual person\u2019s data, images, videos or case report details, thus no consent for publication is needed.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1423"}}