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Almost 70% of haematological cancer patients reported fatigue.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a parallel-group, non-blinded, randomised control trial at the haemato-oncology unit of University Malaya Medical Centre, from 1st October 2019 to 31st May 2020. Patients included were\u00a0\u2265\u00a018\u2009years, had histopathological diagnosis of haematological cancer, and fatigue score of \u22654 based on the fatigue subscale of Edmonton Symptom Assessment System (ESAS). Patients allocated to the intervention group received standard care plus a guided 30-min mindful breathing session, while those in control group received standard care. The study outcomes include fatigue severity according to the fatigue subscale of ESAS, visual analogue scale of 0 \u2013 10, and Functional Assessment of Chronic Illness Therapy Fatigue Scale Version 4, at minute 0 and minute 30.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 197 patients screened, 80 were eligible and they were equally randomised into 30-min mindful breathing versus standard care. Lymphoma (58.9%) was the commonest haematological malignancy, followed by multiple myeloma (13.8%), acute leukaemia (11.3%), myeloproliferative neoplasm (6.3%), chronic leukaemia (5.0%) and myelodysplastic syndrome (5.0%). There was no difference in the demographic and clinical characteristics between the 2 groups.<\/jats:p>\n                <jats:p>At minute 0, both arms of patients had similar ESAS-fatigue score (median, 5) and FACIT-fatigue score (mean\u2009\u00b1\u2009SD, 24.7\u2009\u00b1\u200910.6 for intervention group versus 24.7\u2009\u00b1\u20099.7 for control group). At minute 30, intervention group had lower ESAS-fatigue score (median, 3 versus 5) and FACIT-fatigue score (mean\u2009\u00b1\u2009SD, 17.1\u2009\u00b1\u200910.5 versus 24.8\u2009\u00b1\u200911.3) compared to control group. Both the ESAS-fatigue score reduction (median, \u2212\u20092 versus 0, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and FACIT-fatigue score reduction (mean\u2009\u00b1\u2009SD, \u2212\u20096.7 versus +\u20090.8; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) for the intervention group were statistically significant. The calculated effect size Cohen\u2019s d was 1.4 for between-group comparison of differences in total FACIT-fatigue score.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our results provide evidence that a single session of 30-min mindful breathing was effective in reducing fatigue in haematological cancer patients. On top of all the currently available methods, 30-min mindful breathing can prove a valuable addition.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05029024?term=NCT+05029024%2C&amp;draw=2&amp;rank=1\">NCT 05029024<\/jats:ext-link>, date of registration 15th August 2021. (Retrospectively registered).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12904-021-00855-7","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T16:04:52Z","timestamp":1634313892000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The effect of a single session of 30-min mindful breathing in reducing fatigue among patients with haematological cancer \u2013 a randomised controlled trial"],"prefix":"10.1186","volume":"20","author":[{"given":"Diana-Leh-Ching","family":"Ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin-Gin","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Adila","family":"Anuar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Zhen","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie-Zi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Norazilah Mohd","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Madihie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee-Shee","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng-Beng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"issue":"2","key":"855_CR1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/modpathol.3880035","volume":"13","author":"NL Harris","year":"2000","unstructured":"Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, et al. 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