{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:16:36Z","timestamp":1789038996732,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:00:00Z","timestamp":1725667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:00:00Z","timestamp":1725667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Palliat Care"],"DOI":"10.1186\/s12904-024-01554-9","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T10:01:52Z","timestamp":1725703312000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and safety of fentanyl inhalant for the treatment of breakthrough cancer pain: a multicenter, randomized, double-blind, placebo-controlled trial"],"prefix":"10.1186","volume":"23","author":[{"given":"Rongbo","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biaoxue","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,7]]},"reference":[{"issue":"Supplement_4","key":"1554_CR1","doi-asserted-by":"publisher","first-page":"iv166","DOI":"10.1093\/annonc\/mdy152","volume":"29","author":"M Fallon","year":"2018","unstructured":"Fallon M, Giusti R, Aielli F, et al. Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2018;29(Supplement_4):iv166\u201391.","journal-title":"Ann Oncol"},{"issue":"1","key":"1554_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jpainsymman.2013.02.015","volume":"47","author":"S Deandrea","year":"2014","unstructured":"Deandrea S, Corli O, Consonni D, et al. Prevalence of breakthrough cancer pain: a systematic review and a pooled analysis of published literature. J Pain Symptom Manage. 2014;47(1):57\u201376.","journal-title":"J Pain Symptom Manage"},{"key":"1554_CR3","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1007\/s12094-019-02268-8","volume":"22","author":"C Camps Herrero","year":"2020","unstructured":"Camps Herrero C, Batista N, D\u00edaz Fern\u00e1ndez N, et al. Breakthrough cancer pain: review and calls to action to improve its management. Clin Transl Oncol. 2020;22:1216\u201326.","journal-title":"Clin Transl Oncol"},{"issue":"4","key":"1554_CR4","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3390\/jcm9041003","volume":"9","author":"A Cuomo","year":"2020","unstructured":"Cuomo A, Cascella M, Forte CA, et al. Careful breakthrough cancer pain treatment through rapid-onset transmucosal fentanyl improves the quality of life in cancer patients: results from the BEST multicenter study. J Clin Med. 2020;9(4):1003.","journal-title":"J Clin Med"},{"issue":"11","key":"1554_CR5","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1089\/jpm.2017.0675","volume":"21","author":"K Tagami","year":"2018","unstructured":"Tagami K, Okizaki A, Miura T, et al. Breakthrough cancer pain influences general activities and pain management: a comparison of patients with and without breakthrough cancer pain. J Palliat Med. 2018;21(11):1636\u201340.","journal-title":"J Palliat Med"},{"key":"1554_CR6","doi-asserted-by":"crossref","unstructured":"Vellucci R, Mediati R D, Gasperoni S, et al. Assessment and treatment of breakthrough cancer pain: from theory to clinical practice. J Pain Res. 2017;2147\u20132155.\u00a0https:\/\/www.tandfonline.com\/doi\/full\/10.2147\/JPR.S135807?scroll=top&needAccess=true.","DOI":"10.2147\/JPR.S135807"},{"issue":"8","key":"1554_CR7","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1093\/jnci\/90.8.611","volume":"90","author":"JT Farrar","year":"1998","unstructured":"Farrar JT, Cleary J, Rauck R, et al. Oral transmucosal fentanyl citrate: randomized, double-blinded, placebo-controlled trial for treatment of breakthrough pain in cancer patients. J Natl Cancer Inst. 1998;90(8):611\u20136.","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"1554_CR8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.pain.2010.07.028","volume":"151","author":"RK Portenoy","year":"2010","unstructured":"Portenoy RK, Burton AW, Gabrail N, et al. A multicenter, placebo-controlled, double-blind, multiple-crossover study of Fentanyl Pectin Nasal Spray (FPNS) in the treatment of breakthrough cancer pain. Pain. 2010;151(3):617\u201324.","journal-title":"Pain"},{"issue":"3","key":"1554_CR9","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.clinthera.2014.01.006","volume":"36","author":"S Novotna","year":"2014","unstructured":"Novotna S, Valentova K, Fricova J, et al. A randomized, placebo-controlled study of a new sublingual formulation of fentanyl citrate (fentanyl ethypharm) for breakthrough pain in opioid-treated patients with cancer. Clin Ther. 2014;36(3):357\u201367.","journal-title":"Clin Ther"},{"issue":"9","key":"1554_CR10","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/01.ajp.0000210932.27945.4a","volume":"22","author":"RK Portenoy","year":"2006","unstructured":"Portenoy RK, Taylor D, Messina J, et al. A randomized, placebo-controlled study of fentanyl buccal tablet for breakthrough pain in opioid-treated patients with cancer. Clin J Pain. 2006;22(9):805\u201311.","journal-title":"Clin J Pain"},{"issue":"5","key":"1554_CR11","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1185\/03007995.2012.683111","volume":"28","author":"R Rauck","year":"2012","unstructured":"Rauck R, Reynolds L, Geach J, et al. Efficacy and safety of fentanyl sublingual spray for the treatment of breakthrough cancer pain: a randomized, double-blind, placebo-controlled study. Curr Med Res Opin. 2012;28(5):859\u201370.","journal-title":"Curr Med Res Opin"},{"issue":"6","key":"1554_CR12","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1093\/annonc\/mdp541","volume":"21","author":"R Rauck","year":"2010","unstructured":"Rauck R, North J, Gever LN, et al. Fentanyl buccal soluble film (FBSF) for breakthrough pain in patients with cancer: a randomized, double-blind, placebo-controlled study. Ann Oncol. 2010;21(6):1308\u201314.","journal-title":"Ann Oncol"},{"issue":"5","key":"1554_CR13","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1213\/ANE.0b013e3182691898","volume":"115","author":"DB MacLeod","year":"2012","unstructured":"MacLeod DB, Habib AS, Ikeda K, et al. Inhaled fentanyl aerosol in healthy volunteers: pharmacokinetics and pharmacodynamics. Anesth Analg. 2012;115(5):1071\u20137.","journal-title":"Anesth Analg"},{"key":"1554_CR14","doi-asserted-by":"crossref","unstructured":"Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. J Pharm Pharmacol. 2010;1(2):100\u20137.","DOI":"10.4103\/0976-500X.72352"},{"issue":"8","key":"1554_CR15","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1093\/annonc\/mdp001","volume":"20","author":"H Breivik","year":"2009","unstructured":"Breivik H, Cherny N, Collett B, et al. Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes. Ann Oncol. 2009;20(8):1420\u201333.","journal-title":"Ann Oncol"},{"issue":"2","key":"1554_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cct.2005.10.005","volume":"27","author":"HJM Lemmens","year":"2006","unstructured":"Lemmens HJM, Wada DR, Munera C, et al. Enriched analgesic efficacy studies: an assessment by clinical trial simulation. Contemp Clin Trials. 2006;27(2):165\u201373.","journal-title":"Contemp Clin Trials"},{"issue":"2","key":"1554_CR17","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.eujps.2011.08.044","volume":"5","author":"S Mercadante","year":"2011","unstructured":"Mercadante S. Rapid onset opioids for breakthrough pain: Titrating or not titrating, this is the question! Eur J Pain Suppl. 2011;5(2):443\u20137.","journal-title":"Eur J Pain Suppl"},{"issue":"5","key":"1554_CR18","doi-asserted-by":"publisher","first-page":"513","DOI":"10.5731\/pdajpst.2011.00704","volume":"65","author":"BK Nanjwade","year":"2011","unstructured":"Nanjwade BK, Adichwal SA, Gaikwad KR, et al. Pulmonary drug delivery: novel pharmaceutical technologies breathe new life into the lungs. PDA J Pharm Sci Technol. 2011;65(5):513\u201334.","journal-title":"PDA J Pharm Sci Technol"},{"issue":"6","key":"1554_CR19","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1046\/j.1365-2125.2003.01892.x","volume":"56","author":"NR Labiris","year":"2003","unstructured":"Labiris NR, Dolovich MB. Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol. 2003;56(6):588\u201399.","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"1554_CR20","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1136\/thx.46.4.225","volume":"46","author":"B Schmekel","year":"1991","unstructured":"Schmekel B, Borgstr\u00f6m L, Wollmer P. Difference in pulmonary absorption of inhaled terbutaline in healthy smokers and non-smokers. Thorax. 1991;46(4):225\u20138.","journal-title":"Thorax"},{"key":"1554_CR21","first-page":"230","volume":"13","author":"D K\u00f6hler","year":"1987","unstructured":"K\u00f6hler D, Schl\u00fcter KJ, Kerp L, et al. Nicht radioaktives Verfahren zur Messung der Lungenpermeabilit\u00e4t: Inhalation von Insulin. Atemw Lungenkrkh. 1987;13:230\u20132.","journal-title":"Atemw Lungenkrkh"},{"key":"1554_CR22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.forsciint.2018.05.042","volume":"289","author":"K Kuczy\u0144ska","year":"2018","unstructured":"Kuczy\u0144ska K, Grzonkowski P, Kacprzak \u0141, et al. Abuse of fentanyl: an emerging problem to face. Forensic Sci Int. 2018;289:207\u201314.","journal-title":"Forensic Sci Int"},{"issue":"1","key":"1554_CR23","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41398-019-0625-0","volume":"9","author":"Y Han","year":"2019","unstructured":"Han Y, Yan W, Zheng Y, et al. The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies. Transl Psychiatry. 2019;9(1):282.","journal-title":"Transl Psychiatry"},{"key":"1554_CR24","unstructured":"Karunarathna I. Fentanyl: clinical applications and pharmacological considerations. Uva Clinical Lab. Retrieved from Fentanyl: clinical applications and pharmacological considerations, 2024.\u00a0https:\/\/www.researchgate.net\/profile\/Indunil-Karunarathna\/publication\/380270478_Fentanyl_Clinical_Applications_and_Pharmacological_Considerations\/links\/6633808d7091b94e93ea9108\/Fentanyl-Clinical-Applications-and-Pharmacological-Considerations.pdf."},{"key":"1554_CR25","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1146\/annurev.psych.59.113006.095941","volume":"59","author":"DD Price","year":"2008","unstructured":"Price DD, Finniss DG, Benedetti F. A comprehensive review of the placebo effect: recent advances and current thought. Annu Rev Psychol. 2008;59:565\u201390.","journal-title":"Annu Rev Psychol"},{"issue":"2","key":"1554_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.5055\/jom.2010.0009","volume":"6","author":"RK Portenoy","year":"2010","unstructured":"Portenoy RK, Daniel Bruns PD, Bonnie Shoemaker BSN, et al. Breakthrough pain in community-dwelling patients with cancer pain and noncancer pain, part 1: prevalence and characteristics. J Opioid Manag. 2010;6(2):97\u2013108.","journal-title":"J Opioid Manag"}],"container-title":["BMC Palliative Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12904-024-01554-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12904-024-01554-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12904-024-01554-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T10:02:49Z","timestamp":1725703369000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpalliatcare.biomedcentral.com\/articles\/10.1186\/s12904-024-01554-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,7]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1554"],"URL":"https:\/\/doi.org\/10.1186\/s12904-024-01554-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4104172\/v1","asserted-by":"object"}]},"ISSN":["1472-684X"],"issn-type":[{"value":"1472-684X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,7]]},"assertion":[{"value":"15 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for this study was obtained from Ethics Committee of Sun Yat-sen University Cancer Center (A2021-038\u201301, A2021-038-X02 after major amendment). All participants in this study provided written informed consent for the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"222"}}