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In this retrospective observational study, we analysed the sensitivity of detecting hydatidiform mole by pre-evacuation ultrasound examination or naked eye after surgical uterine evacuation in missed abortion.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Data on 577 cases with histologically confirmed hydatidiform mole were collected over a 10-year period and analysed. Data included serum \u03b2-hCG level before surgical evacuation, the ultrasound examination findings, histology findings and naked eye findings. In addition, serum \u03b2-hCG level on 2398 cases without hydatidiform mole was also collected.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The median maternal age was 29 (range, 17\u201353) years and the range of gestational age was 6 to 12\u2009weeks. The sensitivity of detecting hydatidiform mole by ultrasound examination or by naked eye was 25% or 60% respectively. This sensitivity was not increased by the combination of ultrasound and naked eye. There was no difference in the sensitivity of detecting subtypes of hydatidiform mole. The higher \u03b2-hCG level was seen in cases with hydatidiform mole, compared to cases without hydatidiform mole<jats:bold>.<\/jats:bold> However, there was a lot of overlap in the distributions of \u03b2-hCG between the two groups<jats:bold>.<\/jats:bold><\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In this study, we found lower sensitivity of detecting hydatidiform mole by ultrasound in missed abortion. \u03b2-hCG level was higher in hydatidiform mole than in non- hydatidiform mole in missed abortion. Although higher sensitivity of detecting hydatidiform mole is seen by naked eye (60%), in order to minimise missed opportunity of detecting hydatidiform mole, our study suggests that routine histopathological examination is necessary in missed abortion.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12905-020-01064-9","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T14:03:16Z","timestamp":1599746596000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of pre-evacuation ultrasound examination in histologically confirmed hydatidiform mole in missed abortion"],"prefix":"10.1186","volume":"20","author":[{"given":"Yunhui","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arier","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"issue":"3","key":"1064_CR1","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.ygyno.2008.09.005","volume":"112","author":"RS Berkowitz","year":"2009","unstructured":"Berkowitz RS, Goldstein DP. 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