{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:13:10Z","timestamp":1772503990677,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Contrary to overt hypothyroidism, the true impact of subclinical hypothyroidism on fertility has not been well established. This study aimed to investigate whether serum thyroid stimulating hormone (TSH) values between 2.5 and 4.5 mIU\/L are associated with lower pregnancy rates compared to TSH levels between 0.3 and 2.5 mIU\/L in women undergoing ovulation induction with gonadotropins and intrauterine insemination (IUI) for unexplained infertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of couples with unexplained infertility who underwent IUI treatment between\u00a0January 2013 and December 2018 were reviewed retrospectively. Cycle characteristics and pregnancy outcomes of patients with\u00a0serum TSH levels between 0.3\u20132.5 mIU\/L and 2.5\u20134.5 mIU\/L were compared. Primary outcome measures were clinical pregnancy and live birth rate. Secondary outcome measures were total dose of gonadotropin administration, duration of ovulation induction and miscarriage rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 726 euthyroid women who underwent 1465 cycles of ovulation induction with gonadotropins and IUI were included in the analyses. Patient and cycle characteristics of the two study groups were similar. No statistically significant differences could be detected in the clinical pregnancy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.74)\u00a0and live birth rates (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.38) between the two groups. Duration of ovulation induction, total gonadotropin dosage, number of follicles\u2009&gt;\u200917\u00a0mm on the trigger day and the miscarriage rates were similar in the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In euthyroid women undergoing ovulation induction with gonadotropins and IUI for unexplained infertility, the range of preconceptional serum TSH values between 2.5 and 4.5 mIU\/L is not associated with lower pregnancy rates when compared to TSH levels between 0.3 and 2.5 mIU\/L.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12905-021-01299-0","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T09:10:21Z","timestamp":1618823421000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of preconceptional serum thyroid stimulating hormone values ranging between 2.5 and 4.5 mIU\/L on live birth rates following ovulation induction and intrauterine insemination treatment for unexplained infertility"],"prefix":"10.1186","volume":"21","author":[{"given":"Lale Susan","family":"Karakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Kiyak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berfin","family":"Okmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cagdas","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engin","family":"Turkgeldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"issue":"6","key":"1299_CR1","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/humupd\/dmn042","volume":"14","author":"W Ombelet","year":"2008","unstructured":"Ombelet W, Cooke I, Dyer S, Serour G, Devroey P. 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Lancet Diabetes Endocrinol. 2016;4(1):35\u201343.","journal-title":"Lancet Diabetes Endocrinol"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-021-01299-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12905-021-01299-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-021-01299-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T13:03:09Z","timestamp":1671886989000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/s12905-021-01299-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1299"],"URL":"https:\/\/doi.org\/10.1186\/s12905-021-01299-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-149438\/v1","asserted-by":"object"}]},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,19]]},"assertion":[{"value":"17 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study was carried out at the Kanuni Sultan Suleyman Research and Training Hospital affiliated with the Health Sciences University in Istanbul, Turkey. Ethics approvals was obtained from the local Institutional Review Board of the Kanuni Sultan Suleyman Research and Training Hospital. All patients undergoing treatment at the Inferility Unit of the Kanuni Sultan Suleyman Hospital sign a consent form confirming that they allow their individual data to be used for scientific studies conducted at the hospital. These consent forms are kept in individual patient files. The Instutional Review Board of the Kanuni Sultan S\u00fcleyman Hospital evaluated the protocol of this retrospective study and the readily available consent forms from the potential participants, and approved the study. The ethics approval document can be uploaded upon request. All method were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"162"}}