{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T22:33:33Z","timestamp":1775255613890,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Institut national de cancer france"},{"name":"medecins du monde"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to compare cervical cancer screening by pap smear (PS) versus preliminary HPV testing based on self-collected samples (SC-HPV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Interventional study among underprivileged women from 25 to 65\u00a0years old in four French cities. The control group (CG) was referred for a PS. The experimental group (EG) conducted a SC-HPV test followed by a PS in case of positivity. Differences on screening completion and cytological abnormalities were analysed by logistic and Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>383 women were assigned to the EG and 304 to the CG. The screening completion proportion was 39.5% in the CG compared to 71.3% in the EG (HR\u2009=\u20092.48 (CI 95% [1.99\u20133.08];<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The proportion of cytological abnormalities was 2.0% in the CG and 2.3% in the EG (OR\u2009=\u20091.20 (CI 95% [0.42\u20133.40]; p\u2009=\u20090.7). The proportion of participants lost to follow-up was 60.5% in the CG and 63.2% in the EG HPV positive (<jats:italic>p<\/jats:italic>\u2009=\u20090.18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Providing an SC-HPV-test increased the participation of underprivileged women in CCS. Nevertheless, the significant number of lost to follow-up in both groups can undermine the initial benefits of the strategy for HPV positive women.<\/jats:p><jats:p>Registration: Clinicaltrials.gov: NCT03118258.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12905-021-01356-8","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T21:03:34Z","timestamp":1622063014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of cervical cancer screening by self-sampling papillomavirus test versus pap-smear in underprivileged women in France"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-8012","authenticated-orcid":false,"given":"Laura","family":"Reques","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Rolland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Lallemand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najat","family":"Lahmidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezequiel","family":"Aranda-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Lazzarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Bottero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Hamers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Haguenoer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Launoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Luhmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"1356_CR1","unstructured":"Centre National de R\u00e9f\u00e9rence des Papillomavirus Humains (CNR HPV), Institut Pasteur. R\u00e9f\u00e9rence des Papillomavirus Humains (CNR HPV), Institut Pasteur. In 2018. Disponible sur: www.pasteur.fr\/fr\/centre-medical\/fiches-maladies\/cancer-du-coluterus-papillomavirus"},{"key":"1356_CR2","unstructured":"Garnier A, Brindel P. Pr\u00e9vention et d\u00e9pistage du cancer du col de l\u2019ut\u00e9rus. Boulogne [Internet]. Billancourt: Institut National du Cancer; 2013. Disponible sur: www.ecancer.fr\/publications\/75-prevention\/735-prevention-et-depistage-du-cancer-ducolde-luterus."},{"key":"1356_CR3","unstructured":"Institute National du Cancer. La situation du cancer en France. 2012."},{"key":"1356_CR4","doi-asserted-by":"crossref","unstructured":"Schiffman M, Doorbar J, Wentzensen N, de Sanjos\u00e9 S, Fakhry C, Monk BJ, et al. Carcinogenic human papillomavirus infection. Nat Rev Dis Primer. 01 2016;2:16086.","DOI":"10.1038\/nrdp.2016.86"},{"key":"1356_CR5","unstructured":"GLOBOCAN [Internet]. Disponible sur: https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.3322\/caac.21492)"},{"key":"1356_CR6","unstructured":"Estimations nationales de l\u2019incidence et de la mortalit\u00e9 par cancer en France m\u00e9tropolitaine entre 1990 et 2018\/2019\/Maladies chroniques et traumatismes\/Rapports et synth\u00e8ses\/Publications et outils\/Accueil [Internet]. [cit\u00e9 31 mai 2019]. Disponible sur: http:\/\/invs.santepubliquefrance.fr\/Publications-et-outils\/Rapports-et-syntheses\/Maladies-chroniques-et-traumatismes\/2019\/Estimations-nationales-de-l-incidence-et-de-la-mortalite-par-cancer-en-France-metropolitaine-entre-1990-et-2018"},{"key":"1356_CR7","unstructured":"Haute Autorit\u00e9 de Sant\u00e9. Etat des lieux et recommandations pour le d\u00e9pistage du cancer du col de l\u2019ut\u00e9rus en France. 2010."},{"key":"1356_CR8","unstructured":"European Commission, International Agency for Research on Cancer, World Health Organization, Anttila A, Arbyn M, de Vuyst H, et al. European guidelines for quality assurance in cervical cancer screening. Second edition. Supplements. Luxembourg: European Union; 2015."},{"key":"1356_CR9","first-page":"417","volume":"22\u201323","author":"FF Hamers","year":"2019","unstructured":"Hamers FF, Jezeweski-Serra D. Couverture du d\u00e9pistage du cancer du col de l\u2019ut\u00e9rus en France, 2012\u20132017. Bull Epid\u00e9miol Hebd. 2019;22\u201323:417\u201323.","journal-title":"Bull Epid\u00e9miol Hebd"},{"key":"1356_CR10","unstructured":"Papillomavirus et cancer. Etat des lieux et des connaissances; Fiches rep\u00e8res. Institute National du Cancer; 2018."},{"key":"1356_CR11","unstructured":"Barr\u00e9 S, Massetti M, Leleu H, Catajar N, de Bels F. Caract\u00e9risation des femmes ne r\u00e9alisant pas de d\u00e9pistage du cancer du col de l\u2019ut\u00e9rus par frottis cervico-ut\u00e9rin en France. Centre HPV; 2016."},{"key":"1356_CR12","unstructured":"Medecins du Monde. Rapport de l\u2019Observatoire de l\u2019acc\u00e8s aux droits et aux soins dans les programmes de M\u00e9decins du Monde en France en 2018. In 2019. p. 185."},{"key":"1356_CR13","doi-asserted-by":"crossref","unstructured":"Dalmont, C. et al. Cancer du col et pr\u00e9carit\u00e9, acc\u00e8s aux soins. Bull Cancer.; 2009.","DOI":"10.1684\/bdc.2009.0926"},{"issue":"11","key":"1356_CR14","first-page":"2681","volume":"133","author":"H Sancho-Garnier","year":"2013","unstructured":"Sancho-Garnier H, Tamalet C, Halfon P, Leandri FX, Le Retraite L, Djoufelkit K, et al. HPV self-sampling or the Pap-smear: a randomized study among cervical screening nonattenders from lower socioeconomic groups in France. Int J Cancer. 2013;133(11):2681\u20137.","journal-title":"Int J Cancer"},{"issue":"17","key":"1356_CR15","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1016\/j.ejca.2005.04.050","volume":"41","author":"MFD Baay","year":"2005","unstructured":"Baay MFD, Tjalma WAA, Lambrechts HAJ, Pattyn GGO, Lardon F, Weyler J, et al. Combined Pap and HPV testing in primary screening for cervical abnormalities: should HPV detection be delayed until age 35? Eur J Cancer Oxf Engl. 2005;41(17):2704\u20138.","journal-title":"Eur J Cancer Oxf Engl"},{"key":"1356_CR16","doi-asserted-by":"crossref","unstructured":"Leinonen, M. et al. Age-Specific Evaluation of Primary Human papillomavirus screening versus conventional cytology in randomized setting. Journal of the National Cancer Institut; 2009.","DOI":"10.1093\/jnci\/djp367"},{"key":"1356_CR17","doi-asserted-by":"crossref","unstructured":"Arbyn M, Smith SB, Temin S, Sultana F, Castle P, Collaboration on Self-Sampling and HPV Testing. Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses. BMJ. 05 2018;363:k4823.","DOI":"10.1136\/bmj.k4823"},{"issue":"9","key":"1356_CR18","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1089\/jwh.2015.5469","volume":"25","author":"K Ilangovan","year":"2016","unstructured":"Ilangovan K, Kobetz E, Koru-Sengul T, Marcus EN, Rodriguez B, Alonzo Y, et al. Acceptability and Feasibility of Human Papilloma Virus Self-Sampling for Cervical Cancer Screening. J Womens Health. 2016;25(9):944\u201351.","journal-title":"J Womens Health"},{"key":"1356_CR19","first-page":"883","volume":"7","author":"V Fargnoli","year":"2015","unstructured":"Fargnoli V, Petignat P, Burton-Jeangros C. To what extent will women accept HPV self-sampling for cervical cancer screening? A qualitative study conducted in Switzerland. Int J Womens Health. 2015;7:883\u20138.","journal-title":"Int J Womens Health"},{"key":"1356_CR20","unstructured":"Bonnes Pratiques Epidemiologiques. Rev. Epidemiol Sant\u00e9 Publ; 2008."},{"issue":"5","key":"1356_CR21","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/eurpub\/ckp195","volume":"20","author":"M Norredam","year":"2010","unstructured":"Norredam M, Nielsen SS, Krasnik A. Migrants\u2019 utilization of somatic healthcare services in Europe\u2013a systematic review. Eur J Public Health. 2010;20(5):555\u201363.","journal-title":"Eur J Public Health"},{"issue":"3","key":"1356_CR22","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/ijgo.12067","volume":"136","author":"C Comparetto","year":"2017","unstructured":"Comparetto C, Epifani C, Manca MC, Lachheb A, Bravi S, Cipriani F, et al. Uptake of cervical cancer screening among the migrant population of Prato Province, Italy. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2017;136(3):309\u201314.","journal-title":"Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet"},{"issue":"1","key":"1356_CR23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1467-842X.2001.tb00551.x","volume":"25","author":"RJ Taylor","year":"2001","unstructured":"Taylor RJ, Mamoon HA, Morrell SL, Wain GV. Cervical screening in migrants to Australia. Aust N Z J Public Health. 2001;25(1):55\u201361.","journal-title":"Aust N Z J Public Health"},{"key":"1356_CR24","doi-asserted-by":"crossref","unstructured":"Vuillermoz C, Chauvin P, Vandentorren S. Le recours au d\u00e9pistage des cancers f\u00e9minins dans la population sans logement personnel en Ile-de-FranceRapport pour le Canc\u00e9ropole d\u2019Ile-de-France. Observatoire du Samur sociale de Paris; 2014.","DOI":"10.1016\/j.respe.2014.06.068"},{"key":"1356_CR25","doi-asserted-by":"crossref","unstructured":"Rondet C. D\u00e9terminants de la participation au d\u00e9pistage des cancers du sein et du col de l\u2019ut\u00e9rus dans lagglomeration pariesienne: les origines migratoires sont un facteur d\u2019exclusion. 2012.","DOI":"10.1016\/j.respe.2013.07.019"},{"issue":"4","key":"1356_CR26","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1136\/jfprhc-2011-100144","volume":"38","author":"M Jackowska","year":"2012","unstructured":"Jackowska M, von Wagner C, Wardle J, Juszczyk D, Luszczynska A, Waller J. Cervical screening among migrant women: a qualitative study of Polish, Slovak and Romanian women in London, UK. J Fam Plann Reprod Health Care. 2012;38(4):229\u201338.","journal-title":"J Fam Plann Reprod Health Care"},{"issue":"1","key":"1356_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12905-017-0375-1","volume":"17","author":"EE Idehen","year":"2017","unstructured":"Idehen EE, Korhonen T, Castaneda A, Juntunen T, Kangasniemi M, Pietil\u00e4 A-M, et al. Factors associated with cervical cancer screening participation among immigrants of Russian, Somali and Kurdish origin: a population-based study in Finland. BMC Womens Health. 2017;17(1):19.","journal-title":"BMC Womens Health"},{"key":"1356_CR28","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1186\/1471-2458-14-596","volume":"14","author":"P Bansil","year":"2014","unstructured":"Bansil P, Wittet S, Lim JL, Winkler JL, Paul P, Jeronimo J. Acceptability of self-collection sampling for HPV-DNA testing in low-resource settings: a mixed methods approach. BMC Public Health. 2014;14:596.","journal-title":"BMC Public Health"},{"issue":"4","key":"1356_CR29","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1177\/0969141314555247","volume":"21","author":"R Mullins","year":"2014","unstructured":"Mullins R, Scalzo K, Sultana F. Self-sampling for cervical screening: could it overcome some of the barriers to the Pap test? J Med Screen. 2014;21(4):201\u20136.","journal-title":"J Med Screen"},{"issue":"4","key":"1356_CR30","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1002\/cam4.429","volume":"4","author":"B Sewali","year":"2015","unstructured":"Sewali B, Okuyemi KS, Askhir A, Belinson J, Vogel RI, Joseph A, et al. Cervical cancer screening with clinic-based Pap test versus home HPV test among Somali immigrant women in Minnesota: a pilot randomized controlled trial. Cancer Med. 2015;4(4):620\u201331.","journal-title":"Cancer Med"},{"issue":"2","key":"1356_CR31","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S1470-2045(13)70570-9","volume":"15","author":"M Arbyn","year":"2014","unstructured":"Arbyn M, Verdoodt F, Snijders PJF, Verhoef VMJ, Suonio E, Dillner L, et al. Accuracy of human papillomavirus testing on self-collected versus clinician-collected samples: a meta-analysis. Lancet Oncol. 2014;15(2):172\u201383.","journal-title":"Lancet Oncol"},{"issue":"5","key":"1356_CR32","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1158\/1055-9965.EPI-14-1417","volume":"24","author":"M Arbyn","year":"2015","unstructured":"Arbyn M, Castle PE. Offering Self-Sampling Kits for HPV Testing to Reach Women Who Do Not Attend in the Regular Cervical Cancer Screening Program. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol. 2015;24(5):769\u201372.","journal-title":"Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol."},{"key":"1356_CR33","unstructured":"Haute Autorit\u00e9 de Sant\u00e9. \u00c9valuation de la recherche des papillomavirus humains (HPV) en d\u00e9pistage primaire des l\u00e9sions pr\u00e9canc\u00e9reuses et canc\u00e9reuses du col de l\u2019ut\u00e9rus et de la place du double immunomarquage p16\/Ki67 Synth\u00e8se et recommandations. 2019."},{"key":"1356_CR34","doi-asserted-by":"publisher","first-page":"58","DOI":"10.2174\/1874613601307010058","volume":"7","author":"M Soohoo","year":"2013","unstructured":"Soohoo M, Blas M, Byraiah G, Carcamo C, Brown B. Cervical HPV infection in female sex workers: a global perspective. Open AIDS J. 2013;7:58\u201366.","journal-title":"Open AIDS J"},{"key":"1356_CR35","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fonc.2014.00031","volume":"4","author":"L Tornesello","year":"2014","unstructured":"Tornesello L, Giorgi Rossi P, Buonaguro L, Buonaguro FM. HPV Prevalence Italian Working Group. Human papillomavirus infection and cervical neoplasia among migrant women living in Italy. Front Oncol. 2014;4:31.","journal-title":"Front Oncol"},{"issue":"3","key":"1356_CR36","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1136\/sti.2005.016774","volume":"82","author":"C Gonz\u00e1lez","year":"2006","unstructured":"Gonz\u00e1lez C, Ortiz M, Canals J, Mu\u00f1oz L, Jarr\u00edn I, de la Hera MG, et al. Higher prevalence of human papillomavirus infection in migrant women from Latin America in Spain. Sex Transm Infect. 2006;82(3):260\u20132.","journal-title":"Sex Transm Infect"},{"issue":"3","key":"1356_CR37","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.ygyno.2014.01.006","volume":"132","author":"JL Belinson","year":"2014","unstructured":"Belinson JL, Wang G, Qu X, Du H, Shen J, Xu J, et al. The development and evaluation of a community based model for cervical cancer screening based on self-sampling. Gynecol Oncol. 2014;132(3):636\u201342.","journal-title":"Gynecol Oncol"},{"key":"1356_CR38","doi-asserted-by":"crossref","unstructured":"Lim JNW, Ojo AA. Barriers to utilisation of cervical cancer screening in Sub Sahara Africa: a systematic review. Eur J Cancer Care (Engl). 2017;26(1).","DOI":"10.1111\/ecc.12444"},{"issue":"6","key":"1356_CR39","doi-asserted-by":"publisher","first-page":"e016282","DOI":"10.1136\/bmjopen-2017-016282","volume":"7","author":"R Ndejjo","year":"2017","unstructured":"Ndejjo R, Mukama T, Kiguli J, Musoke D. Knowledge, facilitators and barriers to cervical cancer screening among women in Uganda: a qualitative study. BMJ Open. 2017;7(6):e016282.","journal-title":"BMJ Open"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-021-01356-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12905-021-01356-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-021-01356-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T17:59:12Z","timestamp":1672250352000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/s12905-021-01356-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,26]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1356"],"URL":"https:\/\/doi.org\/10.1186\/s12905-021-01356-8","relation":{},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,26]]},"assertion":[{"value":"16 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research project was approved by the \u00cele de France IV Institutional Review Board (IRB). The study was conducted in compliance with the ethical principles of the Helsinki Declaration. All participants were informed of the study\u2019s objectives and design, and their participation was voluntary after providing verbal informed consent. Verbal informed consent was approved by the IRB as the subjects were members of a distinct cultural community in which signing forms is not the norm, and the research presented no more than minimal risk or harm to subjects and provided there is an appropriate alternative mechanism for documenting that informed consent was obtained.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"221"}}