{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T03:19:30Z","timestamp":1769311170209,"version":"3.49.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>According to the Brazilian Guidelines on Cervical Cancer Screening, women with cytopathologic diagnosis of high-grade intraepithelial lesion, abnormal colposcopic findings, fully visible squamocolumnar junction and age 25\u00a0years or older should be treated at the first visit (\u201csee and treat\u2014S&amp;T\u201d). The main limitation to this approach is the risk of overtreatment, identified by histology without preinvasive lesion. The objectives of this study were to identify the overtreatment rate in women undergoing S&amp;T in cervical cancer prevention at a referral center with extensive experience with the method and to detect possible factors associated with this rate.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a cross-sectional study that analyzed records from a database with 616 women submitted to S&amp;T from 1996 to 2017. Negative histology was defined as the following histopathologic results: human papillomavirus without cervical intraepithelial neoplasia (CIN), inflammatory, low-grade squamous intraepithelial lesion, and CIN 1.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 616 women, there were 52 (8.44%, 95%CI 6.25\u201310.64%) with a histopathologic report without preinvasive cervical lesion. No statistical association was found between this outcome and age or a significant downward trend over time.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The overtreatment rate in this study can be considered low and consistent with the acceptable rates reported in the literature, reinforcing the prevailing Brazilian guideline, in which the benefits of immediate treatment outweigh the risk of losses following biopsy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12905-021-01552-6","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T10:02:42Z","timestamp":1638871362000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Negative histology in cervical specimens obtained with the \"see and treat\" method among women at a referral center in Rio de Janeiro, Brazil: a cross-sectional study"],"prefix":"10.1186","volume":"21","author":[{"given":"Renata Pereira","family":"Teodoro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jos\u00e9","family":"de Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Carioca","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cec\u00edlia Vianna","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7510-0485","authenticated-orcid":false,"given":"F\u00e1bio","family":"Russomano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"1552_CR1","unstructured":"INCA. Instituto Nacional de C\u00e2ncer\u2014estimativa 2018 [Internet]. [cited december 23, 2018]. Available in: http:\/\/www1.inca.gov.br\/estimativa\/2018\/."},{"key":"1552_CR2","unstructured":"National Cancer Institute Jos\u00e9 Alencar Gomes da Silva. Prevention Coordination. Brazilian Guidelines of Cervical Cancer Screening. National Cancer Institute Jos\u00e9 Alencar Gomes da Silva; 2016."},{"key":"1552_CR3","unstructured":"Cervical intraepithelial neoplasia: Initial approach\u2014UpToDate [Internet]. [cited december 23, 2018]. Available in: https:\/\/www.uptodate.com\/contents\/cervical-intraepithelial-neoplasia-initial-approach."},{"key":"1552_CR4","volume-title":"Colposcopy and treatment of cervical intraepithelial neoplasia: a beginner\u2019s manual","author":"JW Sellors","year":"2003","unstructured":"Sellors JW, Sankaranarayanan R, International Agency for Research on Cancer. Colposcopy and treatment of cervical intraepithelial neoplasia: a beginner\u2019s manual. Lyon: International Agency for Research on Cancer; 2003."},{"issue":"1","key":"1552_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/1471-0528.13530","volume":"123","author":"RMF Ebisch","year":"2016","unstructured":"Ebisch RMF, Rovers MM, Bosgraaf RP, van der Pluijm-Schouten HW, Melchers WJG, van den Akker PJ, et al. Evidence supporting see-and-treat management of cervical intraepithelial neoplasia: a systematic review and meta-analysis. BJOG Int J Obstet Gynaecol. 2016;123(1):59\u201366.","journal-title":"BJOG Int J Obstet Gynaecol"},{"issue":"1","key":"1552_CR6","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1097\/AOG.0b013e318254f90c","volume":"120","author":"J Bornstein","year":"2012","unstructured":"Bornstein J, Bentley J, B\u00f6sze P, Girardi F, Haefner H, Menton M, et al. 2011 Colposcopic terminology of the international federation for cervical pathology and colposcopy. Obstet Gynecol. 2012;120(1):166\u201372.","journal-title":"Obstet Gynecol"},{"key":"1552_CR7","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/1097-0142(196508)18:8<950::AID-CNCR2820180805>3.0.CO;2-T","volume":"18","author":"RM Richart","year":"1965","unstructured":"Richart RM. Colpomicroscopic studies of the distribution of dysplasia and carcinoma in situ on the exposed portion of the human uterine cervix. Cancer. 1965;18:950\u20134.","journal-title":"Cancer"},{"issue":"5","key":"1552_CR8","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1590\/S0034-89102009000500014","volume":"43","author":"ACS Monteiro","year":"2009","unstructured":"Monteiro ACS, Russomano F, Reis A, de Camargo MJ, Fialho SA, Trist\u00e3o MA, et al. Effectiveness of see-and-treat for approaching pre-invasive lesions of uterine cervix. Rev Saude Publica. 2009;43(5):846\u201350.","journal-title":"Rev Saude Publica"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-021-01552-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12905-021-01552-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-021-01552-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T10:06:18Z","timestamp":1638871578000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/s12905-021-01552-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1552"],"URL":"https:\/\/doi.org\/10.1186\/s12905-021-01552-6","relation":{},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"5 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by Research Ethics Committee of the Fernandes Figueira National Institute of Women's, Child and Adolescent Healthin March 21, 2019 (CAAE 86164118.3.0000.5269) without informed consent of each participant, as the data was retrospectively recovered. The head of Woman\u2019s Health Care Area and Information and Documentation Department of the Fernandes Figueira National Institute of Women's, Child and Adolescent Health gave consent to access medical records to develop the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no potential conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"400"}}