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We present a reliable imaging method that provides reproducible, sensitive and unbiased assessments of cervical appearance characteristics. Colorimetric and morphometric data of colposcopic patterns after the application of acetic acid and iodine were acquired using ImageJ software and the surrounding normal regions were used as controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The differences in red, green, blue and mean greyscale values in acetowhite epithelium obtained from ImageJ were not significant between the HPV16 and HPV18 groups (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt; 0.05). The differences in red, green, and mean greyscale values in iodine staining were significant between the HPV18 and the other groups (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt; 0.05). The frequency of the occurrence of the coarse mosaic patterns was significantly different among groups (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt; 0.05), reducing in sequence were the HPV16, HPV-negative, HPV18, HPV31\/33 and HPV52\/58 groups. For the lesion area of HSILs, the HPV-negative group was the largest. The sensitivity of colposcopic impression varied among HPV genotypes (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt; 0.01), being lowest in the HPV52 group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although being nonspecific, iodine negativity should be concerned in HPV18-positive lesions which is closely related to glandular epithelium. Vascular patterns in HPV52\/58-positive HSIL are quite occult and tend to be missed by colposcopists. HPV-negative lesions are prone to be large and present typical vascular patterns despite being rare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12905-021-01565-1","type":"journal-article","created":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T04:02:15Z","timestamp":1643515335000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Visual appearance of the uterine cervix differs on the basis of HPV type status in high-grade squamous intraepithelial lesion: the results of a reliable method"],"prefix":"10.1186","volume":"22","author":[{"given":"Qi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangmei","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Sui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Diao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,30]]},"reference":[{"key":"1565_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, et al. 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The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"The study was provided ethical approval by the Institutional Review Board at Obstetrics and Gynecology Hospital of Fudan\u00a0University (China). This ethics committee is constituted and performs duties in accordance with the Chinese GCP and relevant\u00a0regulations, and its review process is not influenced by any other organization or individual. The cervical disease centre chief\u00a0administrator allowed to collect the data from the cervical disease centre records. Written consent was obtained from all participants and they were fully informed before agreeing to participate. The methods were carried out in accordance with the relevant guidelines and regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval\u00a0and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"24"}}