{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:39:46Z","timestamp":1790789986813,"version":"4.1.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T00:00:00Z","timestamp":1639785600000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Primary female genital system lymphoma (PFGSL) is an infrequent entity. All genital organs may be affected, and most PFGSLs are localized to the cervix, uterine body, and ovaries. The clinical manifestations are nonspecific, which complicates a timely diagnosis. We report an unexpected case of PFGSL and discuss the disease characteristics by reviewing the literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 48-year-old G3\/P2 woman presented to the Department of Gynecology with a physical examination. Ultrasound examination and CT revealed pelvic masses. The woman underwent surgical treatment because of the pelvic masses and underwent a hysterectomy for a recurrent mucinous borderline ovarian tumor. However, the results of the postoperative pathological examination showed diffuse large B-cell lymphoma of the endometrium. After four courses of chemotherapy, the woman was in good condition. The clinical manifestations were nonspecific, which made a timely diagnosis complex.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This case highlights the importance of the difficulty in detecting early PFGSL early and how easily nonspecific manifestations can be ignored. It may lead to missing the best time for early treatment.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12905-021-01568-y","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T08:02:16Z","timestamp":1639814536000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Primary female genital system lymphoma complicated by a recurrent mucinous borderline ovarian tumor: a case report and review of the literature"],"prefix":"10.1186","volume":"21","author":[{"given":"Erqiu","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-8880","authenticated-orcid":false,"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,18]]},"reference":[{"issue":"1","key":"1568_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.pgp.0000183049.30212.f9","volume":"25","author":"AS Lagoo","year":"2006","unstructured":"Lagoo AS, Robboy SJ. Lymphoma of the female genital tract: current status. Int J Gynecol Pathol. 2006;25(1):1\u201321.","journal-title":"Int J Gynecol Pathol"},{"issue":"11","key":"1568_CR2","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1002\/1097-0142(19840601)53:11<2530::AID-CNCR2820531127>3.0.CO;2-J","volume":"53","author":"NL Harris","year":"1984","unstructured":"Harris NL, Scully RE. Malignant lymphoma and granulocytic sarcoma of the uterus and vagina. A clinicopathologic analysis of 27 cases. Cancer. 1984;53(11):2530\u201345.","journal-title":"Cancer"},{"issue":"11","key":"1568_CR3","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1097\/01.pas.0000178089.77018.a9","volume":"29","author":"F Kosari","year":"2005","unstructured":"Kosari F, Daneshbod Y, Parwaresch R, Krams M, Wacker HH. Lymphomas of the female genital tract: a study of 186 cases and review of the literature. 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Onco Targets Ther. 2015;8:265\u20138.","journal-title":"Onco Targets Ther"},{"issue":"7","key":"1568_CR6","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1097\/IGC.0000000000000201","volume":"24","author":"AK Ahmad","year":"2014","unstructured":"Ahmad AK, Hui P, Litkouhi B, Azodi M, Rutherford T, McCarthy S, Xu ML, Schwartz PE, Ratner E. Institutional review of primary non-hodgkin lymphoma of the female genital tract: a 33-year experience. Int J Gynecol Cancer. 2014;24(7):1250\u20135.","journal-title":"Int J Gynecol Cancer"},{"issue":"2","key":"1568_CR7","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.ygyno.2017.02.043","volume":"145","author":"D Nasioudis","year":"2017","unstructured":"Nasioudis D, Kampaktsis PN, Frey M, Witkin SS, Holcomb K. Primary lymphoma of the female genital tract: An analysis of 697 cases. Gynecol Oncol. 2017;145(2):305\u20139.","journal-title":"Gynecol Oncol"},{"issue":"1","key":"1568_CR8","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1525-1438.2006.00747.x","volume":"17","author":"DE Cohn","year":"2007","unstructured":"Cohn DE, Resnick KE, Eaton LA, deHart J, Zanagnolo V. Non-Hodgkin\u2019s lymphoma mimicking gynecological malignancies of the vagina and cervix: a report of four cases. Int J Gynecol Cancer. 2007;17(1):274\u20139.","journal-title":"Int J Gynecol Cancer"},{"issue":"9","key":"1568_CR9","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/S1470-2045(14)70311-0","volume":"15","author":"A Younes","year":"2014","unstructured":"Younes A, Thieblemont C, Morschhauser F, Flinn I, Friedberg JW, Amorim S, Hivert B, Westin J, Vermeulen J, Bandyopadhyay N, de Vries R, Balasubramanian S, Hellemans P, Smit JW, Fourneau N, Oki Y. Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b study. Lancet Oncol. 2014;15(9):1019\u201326.","journal-title":"Lancet Oncol"},{"issue":"2","key":"1568_CR10","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.3324\/haematol.08846","volume":"92","author":"M Egyed","year":"2007","unstructured":"Egyed M, Koll\u00e1r B, Prievara FT, Viski A, Bajzik G, Pajor L, Torday L. Successful treatment of a primary uterine B-cell lymphoma with rituximab-CHOP immunochemotherapy. Haematologica. 2007;92(2):e26-27.","journal-title":"Haematologica"},{"issue":"9","key":"1568_CR11","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1055\/s-0032-1332961","volume":"138","author":"W Bohle","year":"2013","unstructured":"Bohle W, Meier C, Zoller WG. 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