{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:52:31Z","timestamp":1775620351912,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aggressive Angiomyxoma is a benign, slowly growing, locally aggressive and recurrent tumour that occurs in the pelvic-perineal region of females in their reproductive years. It presents as a painless, soft, gelatinous mass and metastasizes rarely. Suspicion can be made based on clinical examination and radiological imaging but final diagnosis is confirmed only after histopathology and immunohistochemistry. The choice of treatment is surgical wide local excision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We hereby present a case of a 19-year, unmarried lady, with a body mass index of 21\u00a0kg\/m<jats:sup>2<\/jats:sup>, who presented with a chief complaint of painless mass in left vulva which progressively increased in size in the past one year. Clinical examination revealed a large, cauliflower like, exophytic mass of 10\u00a0cm\u2009\u00d7\u200910\u00a0cm size. Radiological imaging confirmed involvement of lymph nodes. Wide local excision with adequate tumour free margin and depth was used as a treatment modality. The diagnosis was confirmed via histopathological examination of the excised specimen. There is no recurrence in the patient up to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aggressive Angiomyxoma is a rare tumour and it is most often misdiagnosed. This report highlights the importance of considering Aggressive Angiomyxoma as a differential diagnosis of vulval masses and the two-step surgical approach for its treatment in low resource setting.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12905-022-01847-2","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T11:03:12Z","timestamp":1663585392000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vulval Aggressive Angiomyxoma in a 19\u00a0year teenager: a case report"],"prefix":"10.1186","volume":"22","author":[{"given":"Vitasta","family":"Muskan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purbesh","family":"Adhikari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baburam Dixit","family":"Thapa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-2276","authenticated-orcid":false,"given":"Ramesh","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"issue":"6","key":"1847_CR1","first-page":"00128","volume":"4","author":"S Rezai","year":"2016","unstructured":"Rezai S, Kirby C, Chadwick E, Gottimukkala S, Chadee A. Aggressive Angiomyxoma of the vulva in a teenager, a case report and review of literature. Obstet Gynecol Int J. 2016;4(6):00128.","journal-title":"Obstet Gynecol Int J"},{"issue":"7","key":"1847_CR2","doi-asserted-by":"crossref","first-page":"030006052093641","DOI":"10.1177\/0300060520936414","volume":"48","author":"H Xu","year":"2020","unstructured":"Xu H, Sun P, Xu R, Wang L, Shi Y. Aggressive Angiomyxoma in pregnancy: a case report and literature review. J Int Med Res. 2020;48(7):0300060520936414.","journal-title":"J Int Med Res"},{"issue":"2","key":"1847_CR3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1046\/j.1365-2559.2000.00865.x","volume":"36","author":"M Nucci","year":"2000","unstructured":"Nucci M, Fletcher C. Vulvovaginal soft tissue tumours: update and review. Histopathology. 2000;36(2):97\u2013108.","journal-title":"Histopathology"},{"issue":"3","key":"1847_CR4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1034\/j.1600-0412.2000.079003216.x","volume":"79","author":"IM Chan","year":"2000","unstructured":"Chan IM, Hon E, Ngai SW, Ng TY, Wong LC. Aggressive Angiomyxoma in females: is radical resection the only option? Acta Obstet Gynecol Scand. 2000;79(3):216\u201320.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"20","key":"1847_CR5","doi-asserted-by":"publisher","first-page":"e6820","DOI":"10.1097\/MD.0000000000006820","volume":"96","author":"H Chen","year":"2017","unstructured":"Chen H, Zhao H, Xie Y, Jin M. Clinicopathological features and differential diagnosis of Aggressive Angiomyxoma of the female pelvis: 5 case reports and literature review. Medicine (Baltimore). 2017;96(20):e6820.","journal-title":"Medicine (Baltimore)"},{"issue":"9","key":"1847_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.NPR.0000490398.27464.0b","volume":"41","author":"C Chong","year":"2016","unstructured":"Chong C. Aggressive Angiomyxoma. Nurse Pract. 2016;41(9):1\u20134.","journal-title":"Nurse Pract"},{"issue":"3","key":"1847_CR7","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.ygyno.2004.07.051","volume":"95","author":"R Ribaldone","year":"2004","unstructured":"Ribaldone R, Piantanida P, Surico D, Boldorini R, Colombo N, Surico N. Aggressive Angiomyxoma of the vulva. Gynecol Oncol. 2004;95(3):724\u20138.","journal-title":"Gynecol Oncol"},{"key":"1847_CR8","doi-asserted-by":"publisher","unstructured":"Ietto C, Giannini A, Perutelli A, Pistolesi S, Pancetti F, Mannella P, et al. A 19 cm angiomyxoma of the vulva in a 45-year-old. 2020. https:\/\/doi.org\/10.36648\/2471-8165.6.1.88.","DOI":"10.36648\/2471-8165.6.1.88"},{"issue":"1","key":"1847_CR9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s40792-017-0365-4","volume":"3","author":"K Sato","year":"2017","unstructured":"Sato K, Ohira M, Shimizu S, Kuroda S, Ide K, Ishiyama K, et al. Aggressive Angiomyxoma of the liver: a case report and literature review. Surg Case Rep. 2017;3(1):92.","journal-title":"Surg Case Rep"},{"key":"1847_CR10","doi-asserted-by":"crossref","unstructured":"Cao M, Gao Y, Wang X, Yang X. Aggressive Angiomyxoma: two case reports and review of the literature. Int J Radiol Imaging Technol. 2017;3(1). https:\/\/clinmedjournals.org\/articles\/ijrit\/international-journal-of-radiology-and-imaging-technology-ijrit-3-024.php?jid=ijrit.","DOI":"10.23937\/2572-3235.1510024"},{"issue":"4","key":"1847_CR11","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.radcr.2016.10.006","volume":"11","author":"JC Benson","year":"2016","unstructured":"Benson JC, Gilles S, Sanghvi T, Boyum J, Niendorf E. Aggressive Angiomyxoma: case report and review of the literature. Radiol Case Rep. 2016;11(4):332\u20135.","journal-title":"Radiol Case Rep"},{"issue":"1","key":"1847_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/00015458.2012.11680802","volume":"112","author":"Q Wang","year":"2012","unstructured":"Wang Q, Zhao M, Lin X, Zhong W, Gao Y. Aggressive Angiomyxoma of the vulva: intra-operative pathological diagnosis is useful in deciding the scope of surgery and reducing recurrence. 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The patient described in this case report provided us with informed written consent. Identifying data has been excluded to maintain the confidentiality of the patient. All procedures performed were in accordance with the ethical standards of the institution.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed written consent was taken from the patient to publish the relevant data and images related to the case.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"382"}}